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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FTO-TMEM231 (FusionGDB2 ID:31719)

Fusion Gene Summary for FTO-TMEM231

check button Fusion gene summary
Fusion gene informationFusion gene name: FTO-TMEM231
Fusion gene ID: 31719
HgeneTgene
Gene symbol

FTO

TMEM231

Gene ID

79068

79583

Gene nameFTO alpha-ketoglutarate dependent dioxygenasetransmembrane protein 231
SynonymsALKBH9|BMIQ14|GDFDALYE870|JBTS20|MKS11|PRO1886
Cytomap

16q12.2

16q23.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTOU6 small nuclear RNA N(6)-methyladenosine-demethylase FTOfat mass and obesity associatedfat mass and obesity-associated proteitransmembrane protein 231
Modification date2020032920200313
UniProtAcc

Q9C0B1

.
Ensembl transtripts involved in fusion geneENST00000471389, ENST00000394647, 
ENST00000431610, ENST00000460382, 
ENST00000463855, ENST00000472835, 
ENST00000569294, ENST00000258173, 
ENST00000565067, ENST00000568377, 
Fusion gene scores* DoF score5 X 2 X 5=504 X 5 X 3=60
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FTO [Title/Abstract] AND TMEM231 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFTO(53738141)-TMEM231(75589871), # samples:1
Anticipated loss of major functional domain due to fusion event.FTO-TMEM231 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFTO

GO:0006307

DNA dealkylation involved in DNA repair

18775698|20376003

HgeneFTO

GO:0035552

oxidative single-stranded DNA demethylation

18775698|20376003

HgeneFTO

GO:0035553

oxidative single-stranded RNA demethylation

18775698|22002720|25452335|26457839|28002401|30197295

HgeneFTO

GO:0042245

RNA repair

18775698

HgeneFTO

GO:0061157

mRNA destabilization

28002401|30197295

HgeneFTO

GO:0070989

oxidative demethylation

18775698

HgeneFTO

GO:0080111

DNA demethylation

18775698


check buttonFusion gene breakpoints across FTO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM231 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A3YS-01AFTOchr16

53738141

+TMEM231chr16

75589871

-


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Fusion Gene ORF analysis for FTO-TMEM231

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000471389ENST00000569294FTOchr16

53738141

+TMEM231chr16

75589871

-
5UTR-3CDSENST00000394647ENST00000258173FTOchr16

53738141

+TMEM231chr16

75589871

-
5UTR-3CDSENST00000394647ENST00000565067FTOchr16

53738141

+TMEM231chr16

75589871

-
5UTR-3CDSENST00000394647ENST00000568377FTOchr16

53738141

+TMEM231chr16

75589871

-
5UTR-intronENST00000394647ENST00000569294FTOchr16

53738141

+TMEM231chr16

75589871

-
Frame-shiftENST00000471389ENST00000258173FTOchr16

53738141

+TMEM231chr16

75589871

-
Frame-shiftENST00000471389ENST00000565067FTOchr16

53738141

+TMEM231chr16

75589871

-
In-frameENST00000471389ENST00000568377FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000431610ENST00000258173FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000431610ENST00000565067FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000431610ENST00000568377FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000460382ENST00000258173FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000460382ENST00000565067FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000460382ENST00000568377FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000463855ENST00000258173FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000463855ENST00000565067FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000463855ENST00000568377FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000472835ENST00000258173FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000472835ENST00000565067FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-3CDSENST00000472835ENST00000568377FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-intronENST00000431610ENST00000569294FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-intronENST00000460382ENST00000569294FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-intronENST00000463855ENST00000569294FTOchr16

53738141

+TMEM231chr16

75589871

-
intron-intronENST00000472835ENST00000569294FTOchr16

53738141

+TMEM231chr16

75589871

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000471389FTOchr1653738141+ENST00000568377TMEM231chr1675589871-292226717531085222

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000471389ENST00000568377FTOchr1653738141+TMEM231chr1675589871-0.381576270.6184237

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Fusion Genomic Features for FTO-TMEM231


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FTO-TMEM231


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:53738141/chr16:75589871)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FTO

Q9C0B1

.
FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM231chr16:53738141chr16:75589871ENST0000025817307262_28246317.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFTOchr16:53738141chr16:75589871ENST00000431610+15213_2240107.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
HgeneFTOchr16:53738141chr16:75589871ENST00000431610+15231_2340107.0RegionSubstrate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000431610+15316_3180107.0RegionAlpha-ketoglutarate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000431610+1532_3270107.0RegionFe2OG dioxygenase domain
HgeneFTOchr16:53738141chr16:75589871ENST00000460382+14213_2240107.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
HgeneFTOchr16:53738141chr16:75589871ENST00000460382+14231_2340107.0RegionSubstrate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000460382+14316_3180107.0RegionAlpha-ketoglutarate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000460382+1432_3270107.0RegionFe2OG dioxygenase domain
HgeneFTOchr16:53738141chr16:75589871ENST00000463855+13213_2240128.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
HgeneFTOchr16:53738141chr16:75589871ENST00000463855+13231_2340128.0RegionSubstrate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000463855+13316_3180128.0RegionAlpha-ketoglutarate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000463855+1332_3270128.0RegionFe2OG dioxygenase domain
HgeneFTOchr16:53738141chr16:75589871ENST00000471389+19213_22415506.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
HgeneFTOchr16:53738141chr16:75589871ENST00000471389+19231_23415506.0RegionSubstrate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000471389+19316_31815506.0RegionAlpha-ketoglutarate binding
HgeneFTOchr16:53738141chr16:75589871ENST00000471389+1932_32715506.0RegionFe2OG dioxygenase domain
TgeneTMEM231chr16:53738141chr16:75589871ENST000002581730723_4346317.0TransmembraneHelical


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Fusion Gene Sequence for FTO-TMEM231


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31719_31719_1_FTO-TMEM231_FTO_chr16_53738141_ENST00000471389_TMEM231_chr16_75589871_ENST00000568377_length(transcript)=2922nt_BP=267nt
CTACGCTCTTCCAGCTGTCGGACCTGGGAAATTCTCCTGTGCTAAATCCCGTGGCGCTCGCGGGTGTCGCCGCGGTGCATCCTGGGAGTT
GTAGTTTTTTCTACTCAGAGGGAGAATAGCTCCAGACGGGAGCAGGACGCTGAGAGAACTACATGCAGGAGGCGGGGTCCAGGGCGAGGG
ATCTACGCAGCTTGCGGTGGCGAAGGCGGCTTTAGTGGCAGCATGAAGCGCACCCCGACTGCCGAGGAACGAGAGCGCGAAGCTAAGTTA
TCAGCCAGGATTCTGGGAGATGGTAAAGTTCGCCTGGGTGCAGTATGTCAGCATCCTGCTTATCTTCCTCTGGGTGTTTGAAAGAATCAA
GATCTTCGTGTTTCAGAATCAGGTGGTGACCACCATTCCTGTGACAGTGACGCCCCGGGGAGACTTGTGTAAGGAGCACTTATCCTAGAA
AGGCCATTTCTGAAGACTCAGCAGGACCGTGGCTGCCTCATTGTCATCTTCTGGGAACATCTTAGGACCTTTTGAAAGAGCCCAGCGGAC
ACCTGCGGGCTTGTGTGCTTTTCCCTCAGAGACAACGGTTCTTTCCGGTTTTGCTCTACACAGTTCCGTATCTTCAGAGCTCCTGCAGAA
TTGTCAGGGACTAGTTTGTGGAAAGGTCTGAGAGTTCCTGGAGGCTATAATTAGCTTTTTGGGTTTTCCTTCTTTGCCTTAGCGTTGAAT
TTCAGGAGAAAATTGCAGTCAGTTCAGACATCTTGGAAAGAGTCCCATCTCTGGTCAAGCAGAGACTTTTCCTCTGTTGAACTGAGGAAC
ACACTGTGCATTTCTACCTTCTGTTGTGAGCCACTCTTACTCTTTTCAGGGCTCTCTTGTGACAAACATGCCAATCACTAGCACTTTGCA
CCCCTGGGCTTCTCCATTTCCCATTCACAGCTTTGATTTCCAGAGCTGAGGCCTTTAACTGGAGACCTGGAGGGGCAGGGCCCAAGGGCA
AGGGCCGCATTAGCACAGGCAATCAGGGAGGGCCGCTGAAGGACACTTGGACCGTCCACCTGCCCCAGCCCAACAGTCAGTCATCTGTCA
TCAGCTCAGCTGAGCAGCCCTGGATCTTTGCCGTACTGTGACTGGGCTCTTTGCCCTATTTTTCCCTCTGTCTGTGCCCCTGGATGGCAG
GCTGAAGTCAGAGGGGCTGTTTCATTCTCAGCCCCCTCAGCAGCACTGGGGGAAGAAAGCATTGTCACAACAGGTTCTTTCTGGCCCTCA
CCCAACAGCCTGGGCACTTGGCCCTCCTCCTCCTTGACAGCCCTCCCCCTTCCTGCAAAGGACAGGGGCGACAGGGGTTGGTGTTGGGAT
TGGCTCCCGCTGCCTGACAACCACAAGTTTATTTGGAAGGCTAGCGGGAAGCCCAGCGGCTGGCGTTTCCCTTGACTAAGGAACAGGGTG
CCCATCAGAGTGGGGCGGGCAGCTTTGGGAAGGACACAAGAAGCAGTAAGAGTGTAAAGAGGATGCTGGCCTGGGCAGGCCAGTCCAGCC
TGGCCACTAGCAGAATACCAAGCAGTCCAGTGGATTACCCTCGTGGCTAAGCAAGTGTCTGCAGGAGCAGAGATGGCTGGAAGGGGCCTC
TGCACACGGAAGATGGCTTGTTCAGCCCATTCACCTCCTGAGGATGTGGGCAGTCTCCTCCAAGAACACATGGAGCTGCTTCCTGATCCC
AAGCAGGTCATTGCCACTGGAAGGACATGGCCCCGGTGATCCATGCTTCATGCCCACCCAGAAACACACCCCTCAGTGTGTGCCTCAGTT
TACTTTGGAGATCAGTTGTCGTTTTTAGTGCTCCTTTAGGCTTACTAAAACAGTTTTGGAAACAAAGCTATTTTGAAGTATTCAAGCAGA
GGAATTCCCTAACACTGACCCCCTTGTCTTTTTTTAATATTCAGGCTGTTTTATATGCCTAAATTTTTTTCTTAAGATCTAAACGAAAAA
TAGTTTCTTGTTTAAATTCACATAAGGCAATGAGATATGGAAAGATGACAAGATACGTATAAACATTGGTTTGCATTTTATTAAATTATT
CTAATGCAAATCTTGTATAAAGAACCCATGATGTTTTGTAACTTTCTAATTAAAATGTTCAAAATGAGGCCGAGCATGGTGGTTCATTCC
TGTAATCTCAACACTTTGGGAGGCCAAGGTGGGAGGATCACTTGAGCCCAGGAGCTTGAGGCTGCAGTGTGCTATGATTGCACCACTGTA
CTGTAGCCTGGGTGACAGAGTGAGACCCTATCTGTTAAAATTTACCACCGTCCTGAATGATCCCAACCCCATCTGGCTGGTGGGCAGGGC
CGCAGATGCTCCATTTGTGATTAATGCTATCATCCGATACCCTGTGGAAGTCATTTCATATCCGTGATCAACGGGACCAGCCCCTTTGCC
TATGACTACGACCTCACCCATATTGTTGCTGCCTACCAGGAGAGGAACGAGGATGGCGACCCTCGTGATGCAGAGCATGGCGTTTCTCCA
GTCCTCCTTTCCTGTCCCGGGATCCCAGTTATACGTGAACGGAGACCTGAGGCTGCAGCAGAAGCAGCCGCTGAGCTGTGGTGGCCTAGA
TGCCCGATACAACACTAGAGAAGAAGACAGGAACCAGGATGGGAAGACGGACATGTTACATTTTAAGCTGGAGCTTCCCCTGCAGTCCAC
GGAGCACGTTCTCGGTGTGCAGCTCATCCTGACTTTCTCCTATCGATTACACGGTTTTGGCTGAAGCGGAGCAGCTACGAGGAGCAGCCG
ACCGTGCGCTTCCAACACCAGGTGCTGCTCGTGGCCCTGCTCGGACCCGAAAGCGACGGGTTCCTCGCCTGGAGCACGTTCCCCGCCTTC

>31719_31719_1_FTO-TMEM231_FTO_chr16_53738141_ENST00000471389_TMEM231_chr16_75589871_ENST00000568377_length(amino acids)=222AA_BP=
MDHRGHVLPVAMTCLGSGSSSMCSWRRLPTSSGGEWAEQAIFRVQRPLPAISAPADTCLATRVIHWTAWYSASGQAGLACPGQHPLYTLT
ASCVLPKAARPTLMGTLFLSQGKRQPLGFPLAFQINLWLSGSGSQSQHQPLSPLSFAGRGRAVKEEEGQVPRLLGEGQKEPVVTMLSSPS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FTO-TMEM231


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FTO-TMEM231


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FTO-TMEM231


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource