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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:FUCA2-SYNCRIP (FusionGDB2 ID:31768) |
Fusion Gene Summary for FUCA2-SYNCRIP |
Fusion gene summary |
Fusion gene information | Fusion gene name: FUCA2-SYNCRIP | Fusion gene ID: 31768 | Hgene | Tgene | Gene symbol | FUCA2 | SYNCRIP | Gene ID | 2519 | 10492 |
Gene name | alpha-L-fucosidase 2 | synaptotagmin binding cytoplasmic RNA interacting protein | |
Synonyms | dJ20N2.5 | GRY-RBP|GRYRBP|HNRNPQ|HNRPQ1|NSAP1|PP68|hnRNP-Q | |
Cytomap | 6q24.2 | 6q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | plasma alpha-L-fucosidaseI+/--L-fucosidase 2a-L-fucosidase 2alpha-L-fucoside fucohydrolase 2fucosidase, alpha-L- 2, plasmaplasma fucosidase | heterogeneous nuclear ribonucleoprotein QNS1-associated protein 1glycine- and tyrosine-rich RNA-binding protein | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | Q9BTY2 | . | |
Ensembl transtripts involved in fusion gene | ENST00000002165, ENST00000367585, ENST00000438118, | ENST00000355238, ENST00000369622, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 10 X 10 X 4=400 |
# samples | 5 | 10 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FUCA2 [Title/Abstract] AND SYNCRIP [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FUCA2(143818525)-SYNCRIP(86333830), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FUCA2 | GO:0006004 | fucose metabolic process | 19666478 |
Hgene | FUCA2 | GO:0016139 | glycoside catabolic process | 19666478 |
Tgene | SYNCRIP | GO:0017148 | negative regulation of translation | 23071094 |
Tgene | SYNCRIP | GO:0071346 | cellular response to interferon-gamma | 15479637 |
Fusion gene breakpoints across FUCA2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SYNCRIP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | TCGA-CG-5721-11A | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
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Fusion Gene ORF analysis for FUCA2-SYNCRIP |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000002165 | ENST00000355238 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
In-frame | ENST00000002165 | ENST00000369622 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
intron-3CDS | ENST00000367585 | ENST00000355238 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
intron-3CDS | ENST00000367585 | ENST00000369622 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
intron-3CDS | ENST00000438118 | ENST00000355238 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
intron-3CDS | ENST00000438118 | ENST00000369622 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000002165 | FUCA2 | chr6 | 143818525 | - | ENST00000355238 | SYNCRIP | chr6 | 86333830 | - | 6889 | 1319 | 44 | 2341 | 765 |
ENST00000002165 | FUCA2 | chr6 | 143818525 | - | ENST00000369622 | SYNCRIP | chr6 | 86333830 | - | 3175 | 1319 | 44 | 2524 | 826 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000002165 | ENST00000355238 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - | 0.000189714 | 0.9998103 |
ENST00000002165 | ENST00000369622 | FUCA2 | chr6 | 143818525 | - | SYNCRIP | chr6 | 86333830 | - | 0.000341066 | 0.99965894 |
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Fusion Genomic Features for FUCA2-SYNCRIP |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FUCA2-SYNCRIP |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:143818525/chr6:86333830) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FUCA2 | . |
FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 431_434 | 222 | 563.0 | Compositional bias | Note=Poly-Tyr | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 431_434 | 222 | 624.0 | Compositional bias | Note=Poly-Tyr | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 243_325 | 222 | 563.0 | Domain | RRM 2 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 338_408 | 222 | 563.0 | Domain | RRM 3 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 243_325 | 222 | 624.0 | Domain | RRM 2 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 338_408 | 222 | 624.0 | Domain | RRM 3 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 564_578 | 222 | 563.0 | Motif | Bipartite nuclear localization signal | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 564_578 | 222 | 624.0 | Motif | Bipartite nuclear localization signal | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 448_559 | 222 | 563.0 | Region | Note=8 X 3 AA repeats of R-G-G | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 460_488 | 222 | 563.0 | Region | Note=3 X 4 AA repeats of Y-Y-G-Y | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 448_559 | 222 | 624.0 | Region | Note=8 X 3 AA repeats of R-G-G | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 460_488 | 222 | 624.0 | Region | Note=3 X 4 AA repeats of Y-Y-G-Y | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 448_450 | 222 | 563.0 | Repeat | Note=1-1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 451_453 | 222 | 563.0 | Repeat | Note=1-2 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 460_464 | 222 | 563.0 | Repeat | Note=2-1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 469_472 | 222 | 563.0 | Repeat | Note=2-2 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 478_480 | 222 | 563.0 | Repeat | Note=1-3 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 485_488 | 222 | 563.0 | Repeat | Note=2-3 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 498_500 | 222 | 563.0 | Repeat | Note=1-4 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 526_528 | 222 | 563.0 | Repeat | Note=1-5 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 539_541 | 222 | 563.0 | Repeat | Note=1-6 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 554_556 | 222 | 563.0 | Repeat | Note=1-7 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 557_559 | 222 | 563.0 | Repeat | Note=1-8 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 448_450 | 222 | 624.0 | Repeat | Note=1-1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 451_453 | 222 | 624.0 | Repeat | Note=1-2 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 460_464 | 222 | 624.0 | Repeat | Note=2-1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 469_472 | 222 | 624.0 | Repeat | Note=2-2 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 478_480 | 222 | 624.0 | Repeat | Note=1-3 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 485_488 | 222 | 624.0 | Repeat | Note=2-3 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 498_500 | 222 | 624.0 | Repeat | Note=1-4 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 526_528 | 222 | 624.0 | Repeat | Note=1-5 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 539_541 | 222 | 624.0 | Repeat | Note=1-6 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 554_556 | 222 | 624.0 | Repeat | Note=1-7 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 557_559 | 222 | 624.0 | Repeat | Note=1-8 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 162_241 | 222 | 563.0 | Domain | RRM 1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 162_241 | 222 | 624.0 | Domain | RRM 1 |
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Fusion Gene Sequence for FUCA2-SYNCRIP |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>31768_31768_1_FUCA2-SYNCRIP_FUCA2_chr6_143818525_ENST00000002165_SYNCRIP_chr6_86333830_ENST00000355238_length(transcript)=6889nt_BP=1319nt CAGCGCTCCCGAGGCCGCGGGAGCCTGCAGAGAGGACAGCCGGCCTGCGCCGGGACATGCGGCCCCAGGAGCTCCCCAGGCTCGCGTTCC CGTTGCTGCTGTTGCTGTTGCTGCTGCTGCCGCCGCCGCCGTGCCCTGCCCACAGCGCCACGCGCTTCGACCCCACCTGGGAGTCCCTGG ACGCCCGCCAGCTGCCCGCGTGGTTTGACCAGGCCAAGTTCGGCATCTTCATCCACTGGGGAGTGTTTTCCGTGCCCAGCTTCGGTAGCG AGTGGTTCTGGTGGTATTGGCAAAAGGAAAAGATACCGAAGTATGTGGAATTTATGAAAGATAATTACCCTCCTAGTTTCAAATATGAAG ATTTTGGACCACTATTTACAGCAAAATTTTTTAATGCCAACCAGTGGGCAGATATTTTTCAGGCCTCTGGTGCCAAATACATTGTCTTAA CTTCCAAACATCATGAAGGCTTTACCTTGTGGGGGTCAGAATATTCGTGGAACTGGAATGCCATAGATGAGGGGCCCAAGAGGGACATTG TCAAGGAACTTGAGGTAGCCATTAGGAACAGAACTGACCTGCGTTTTGGACTGTACTATTCCCTTTTTGAATGGTTTCATCCGCTCTTCC TTGAGGATGAATCCAGTTCATTCCATAAGCGGCAATTTCCAGTTTCTAAGACATTGCCAGAGCTCTATGAGTTAGTGAACAACTATCAGC CTGAGGTTCTGTGGTCGGATGGTGACGGAGGAGCACCGGATCAATACTGGAACAGCACAGGCTTCTTGGCCTGGTTATATAATGAAAGCC CAGTTCGGGGCACAGTAGTCACCAATGATCGTTGGGGAGCTGGTAGCATCTGTAAGCATGGTGGCTTCTATACCTGCAGTGATCGTTATA ACCCAGGACATCTTTTGCCACATAAATGGGAAAACTGCATGACAATAGACAAACTGTCCTGGGGCTATAGGAGGGAAGCTGGAATCTCTG ACTATCTTACAATTGAAGAATTGGTGAAGCAACTTGTAGAGACAGTTTCATGTGGAGGAAATCTTTTGATGAATATTGGGCCCACACTAG ATGGCACCATTTCTGTAGTTTTTGAGGAGCGACTGAGGCAAATGGGGTCCTGGCTAAAAGTCAATGGAGAAGCTATTTATGAAACCCATA CCTGGCGATCCCAGAATGACACTGTCACCCCAGATGTGTGGTACACATCCAAGCCTAAAGAAAAATTAGTCTATGCCATTTTTCTTAAAT GGCCCACATCAGGACAGCTGTTCCTTGGCCATCCCAAAGCTATTCTGGGGGCAACAGAGTATAATAATCATGAAATTCGTTCTGGAAAAC ATATTGGTGTCTGCATCTCAGTTGCCAACAATAGGCTTTTTGTGGGCTCTATTCCTAAGAGTAAAACCAAGGAACAGATTCTTGAAGAAT TTAGCAAAGTAACAGAGGGTCTTACAGACGTCATTTTATACCACCAACCGGATGACAAGAAAAAAAACAGAGGCTTTTGCTTTCTTGAAT ATGAAGATCACAAAACAGCTGCCCAGGCAAGGCGTAGGTTAATGAGTGGTAAAGTCAAGGTCTGGGGGAATGTTGGAACTGTTGAATGGG CTGATCCTATAGAAGATCCTGATCCTGAGGTTATGGCAAAGGTAAAAGTGCTGTTTGTACGCAACCTTGCCAATACTGTAACAGAAGAGA TTTTAGAAAAGGCATTTAGTCAGTTTGGGAAACTGGAACGAGTGAAGAAGTTAAAAGATTATGCGTTCATTCATTTTGATGAGCGAGATG GTGCTGTCAAGGCTATGGAAGAAATGAATGGCAAAGACTTGGAGGGAGAAAATATTGAAATTGTTTTTGCCAAGCCACCAGATCAGAAAA GGAAAGAAAGAAAAGCTCAGAGGCAAGCAGCAAAAAATCAAATGTATGACGATTACTACTATTATGGTCCACCTCATATGCCCCCTCCAA CAAGAGGTCGAGGGCGTGGAGGTAGAGGTGGTTATGGATATCCTCCAGATTATTATGGATATGAAGATTATTATGATTATTATGGTTATG ATTACCATAACTATCGTGGTGGATATGAAGATCCATACTATGGTTATGAAGATTTTCAAGTTGGAGCTAGAGGAAGGGGTGGTAGAGGAG CAAGGGGTGCTGCTCCATCCAGAGGTCGTGGGGCTGCTCCTCCCCGCGGTAGAGCCGGTTATTCACAGAGAGGAGGTCCTGGATCAGCAA GAGGCGTTCGAGGTGCGAGAGGAGGTGCCCAACAACAAAGAGGCCGCGGGCAGGGAAAAGGGGTCGAGGCCGGTCCTGACCTGTTACAAT GAAGACTGACTTGCTATGTGGGATTACACCAGAAGCTTGCAGTGGAGTAATGGTAAGGAAATCAAGCAACCTTAAATATGTCGGCTGTAT AGGAGCATATTCTATTGCAGAAGACCTTCCTATGAAGATCATGGAATCAAATACGGGACATTGAACTAATACTTGGACTTTGATATGAAT TTCTTTAACAATTTTCTCTGCAGTGCAAGTTATTAAACTAAAGCTACTCTATTTTCAAAATGTGTTCCAACAGAAATCCTTCATAACTCC TAGCATGGTATCTTAATAAAGAATAAAGTTCTTTTAAAAATCTGCTCTAAGTAGATTTTTCCCCTTTTTTAAATTAAGGATCCCAACAGT GGTATTTTGAAATATTCTCTTGAATTTGTGCATTTAAATTTTATTGCAGTGGTATAGATGAATGCCACTGATGGTATCCTTAAATTTTAT TTCTGCTCACCAAGGTTAATCATGATTGTCTATATCTTTTTTATAGTGATCACTTTTGAATTGTGTTCAGATATGCAGTTTCAGGTGTAA TCATCAGAGCTGGTTAGTCAGGCATTCCAGATAGTGGTTCTTTTCAGAACCTTTTTAAAAGGGTTGGTTAACTACCTCAGTAGCAGAGGA TTGAACTATACCCTGTCTGTACTGTACATAGAAAATCTTTGTAGATAAAAGCAAGGCTTGTTAAATATGATATGAGGGTAAGATTTTAAT ATACCAAATGTAACATTCTTAGTTGCCTTTAGTTTCAGAGGCTTGTAAGACTTCCTCATGACCATCATAACAGGCCTTGCTTTTGTCGTA TTTTGTGGCTGAAAAAGCAGCCTTGCTTCTTCAGATATTGTAGTTATTTGGATGTATAATAGTTTAGCAAGATGTTACTTTTGTAAGACA TCAGATGTTCAAAAAAGTGCATCCGAACTTGTACTAAATACTGCAGTGTCCCTTTATAAAAAGTCAGACTAAAACTGACAATTGTACAGC GAAGCCTGACATTTGGATATTTTGAAGTTTTTTCATAAATCATAGAAATTAGTATATGGCTGTAGTTTAGCTTTTTAGGTAAAAGGTATG TTTCATTAGTGCATTTCTTCCTGCTGATCACTGTAAACATGTGAATCAGCTTTCCATTTCTTATGCAGGTCATGATAACTTGTAGAGTAG AGTACAATCATTTGTGCTATGTTTTTAATTTTCTAAAGCACCTTGATGACAGTGAGTGTCCAGTGGTGAAGCATCCTCTATTGAACCACC CTCAAAAATTTTTTTGCCAAGTCCTAAGTTGATAGCTTAAAGTAAAAAGTGAAAATTATAGTTTCATTAGGACTTGGTGTAAAGAAATCC CCTCCCCCCTTCCCCAAAGGGATACTGCAGTTATATCACATACCCAATAGGCACCACGATGAAGATCAGAGCTTATACTTAATTAAGGTT TTATACACACCAGTTCCCCAGTAAATGCAAATTTAACAAGAAAATCAGACATGTCATATGTTCAAAATGCTCATGGCAAACAATCATTTT GCATTCCTGCAAATAAAATTGTTTTATACTGTAAGCTGGAGGCGAGTGTAACTTATTTTTGTAATAAAGTTTTTATTTTTTTTATGTGTC ATTAATATAAATGTGTGTTAGTGTAGAAATCTTCTGGTTTAAAAACTTAGAATTGCACACATTTCAGTATGTTTATTTGTACTTACATAA TTTTAGAATAGTGGTTGCCAATAGCCTGTATGTTTCACATTAATTGGTTTTTTGTTATCTAAATAAATCATTTTAGTATGTTGTATGTCA GTTACTGGGATAGCTGGGACATAGAGTGTAATTTAAAATTTGTCAATAAGTATTCATTGGAATATATGTAAATGTGCCTTGCCGGTTATT GAAACTTATCTACAAAATGAGTATGGGGTGACAAAAATTAGTTCCTGGTGCTTAATGAAACTTTCTGCCACTGATTTTATATATTACCCC GTGCTTTTTTAAAGTACATCTCTCTCAAAACTTAGTGTAAGTTTGAGGGCTACACAAAACATTTACATTTCATTCTAACATAATGAATAT AATAGGTTGTGGAAAGTGGGTAAACTAAATGTAGCCTTCAGTAAAATTGAATCTCAGTGTAATCCTTGGTGCTGGCATTTCTCAGTTCCG AGGAGTTAAATGATCCCATCTAAGAGGTCATTGCCATGCCTATTGGCACTTTACTGTCATAGCATTTTTAAGGGACACTGTCAAGGTGTT TAAGTTCTCAGAATTACTTGTTGGGATTTTAGGACAGGTTTGTTTACTTAAAGTAAGAACTGCATTGTCAAAGTTGAAAGAGGAACACTT TTGTGAGTTCACAAATGTGTTCTTAAGAAAACATTAAAATATGGAGCTCTGGGTTTTCAAGACTATTTGGCATTCTTAATTTGGGGACTT GGGAGGGAAACTGATAAAAAGAAATTGAAGAATTGATGGTTATACTTAAAGAAGGGTAATGTAAACAGTGGTGATGAAATATATACACAT CAAGTGAAATTACTTGACAGTGTTCATTTGAATGACTTTGAATTCAAGCCATTATAATTACTTTTAAAATTAAATATCATTTGCACTGTT CTGATAATGGGTGCAGTTTTTGAGCAATATAATCAGAGCTAAATATGCATGTAGTGATTAGTGATGTGAACAATTAACGTTCTGAGAAGA AATACTAACTGTGGTATTTTCAAACTTAAATTTCTGTAGTAAAATCAGTATCAAAGTCTTATCAGATCAAGGAAAAACAGGCAATGCATA TAAACATACTTTTGAATGTTGTGTGGCCTATAAAGCAATAATGCAATTTATATGGAATGTCATGGGATATGAGAAATGGAAATGCAAAAA TAACTAATCCTTTAGTAAAAATGTCAACATGTTAAAGGGGGAATGTTAACTAATGTAGGTTATTGCTATTTGTGATTTGTTTATGGGTTC TTGGCTTTGACAGCTTCAAAGAATGGACAGTGATAAGTTAAAAGAAATTTTGTATATTGTCAAGGAAAGGGTCTTAAATCCGAGTCAAGT CCCTTCCTTGGGGTAAAAAATGTATTCTTAAAGCATTCTGATGTTAAAAAGAAAACTTAAGTTATCTAACCAAAACAGACGCAAGATTTT GTTTCTGCAGACTACTTGGCAATCAAAAGTGATCATAAATTTAGGTTATCAGTTTTCAGAAAGTTGCTTTGTGAGAAAATTTTGTTAGAT ATATTCTCCCAAGCATGCTTTTTGTGGAAGGTTTTCAGCCATTGCCACTGAATCAGATGTTAAAAATGAAGGGAAAATTGAGTGTGCACA CACACAACTGTTGTACACTCATGATTGCAGTTTTTAGCTTAAGAAACTTTTCTACCAGTTACTGTGAATCTGACTTAAAATGTAAAGTTT CCTCATGATAAAATAGGAACAACATAGAAATGGATTGATGGGGTGATCTGAGTTATTGTATATAAAAGTTTTTAAAGAATAGAATGAACA TCAAGCTAGATAGGCAAAAATTGACACATTCAGAACAGCTTTTTTGACTGCGAAGCCAAAAGTTGTCAGAAACAGCAAAAGATCCCTTAT TATTACAGAGTATTTTACGTAGTCTCTATTTTAAGGAGAGAAATTAAATAGAAGGGCTTCATGCATTTAGGGGAGGGTGCTAAAACTTCT CAAGTTCGTCAAACTTACAGGAATACCCACCATGATCATTTTCTCTCTAATTATGTATACCACAAAATTTTCATCTGGCCATAGGAATTC ACTGGTGGGTGTAAAATTAATGACTAAAGAAATTAAGTGACAAATACATAAAAGAAACAGACTTGTGGGGATATTGTTTTAAGGTGTATT AATTACTCAGTGATGATACCACTCAATAGGGCATGCCACTACTTTTCTTAAGATGCTAATTATGAAGCAGTGCTCACAGGCATTTTTTAA CTAGCAAATTAGTAGATGGACTTTTGGGGTCTGTCACTTTTTAAAAGTATTTAAGACTTAAATTCTATTAGCACCACAGTCTGCCTTCAG TAATACACCTAAAATATTTTTCAGGACCAGAAGCATTCAGTTTGAAAATTTGCAGATGCAAACCAGTATTATTACTAACGCTCTGGGTCA AAGATTAGGTTTTTAATATTAACAGTAGTCTGGTAAATATTTAGAAGTCTGGCATTGAGAAACAAAAGCTTGTACCTGACTAGTATTTTT ATTTAAAAAAATTAGTTCTGTTAGCTTATTTAAATTGTGTTTTATTTATCCGTAGAATTTATATTTATTTCATTCCTTTCATCTCACTGA AAACTGTCTGCAGGCCCTTTGATTTGGATTAGATGTGTGAAGTACTGTCTTTTGCCAAAAACCTCAAATTACCTGTTCTTTTCAACGTAG TGGGTTTGTGCTTGTTTGGAGATCAGTTCAAAAACTATCTGTACTATCTGTACTGCCTCTGATGTTAAGATTTTATGTATAGCATAAGGA >31768_31768_1_FUCA2-SYNCRIP_FUCA2_chr6_143818525_ENST00000002165_SYNCRIP_chr6_86333830_ENST00000355238_length(amino acids)=765AA_BP=697 MRRDMRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIHWGVFSVPSFGSEWFWWYWQKEKIPKY VEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLR FGLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTNDRWGAG SICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQM GSWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGATEYNNHEIRSGKHIGVCISVANNRLFV GSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKV KVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQM YDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPP -------------------------------------------------------------- >31768_31768_2_FUCA2-SYNCRIP_FUCA2_chr6_143818525_ENST00000002165_SYNCRIP_chr6_86333830_ENST00000369622_length(transcript)=3175nt_BP=1319nt CAGCGCTCCCGAGGCCGCGGGAGCCTGCAGAGAGGACAGCCGGCCTGCGCCGGGACATGCGGCCCCAGGAGCTCCCCAGGCTCGCGTTCC CGTTGCTGCTGTTGCTGTTGCTGCTGCTGCCGCCGCCGCCGTGCCCTGCCCACAGCGCCACGCGCTTCGACCCCACCTGGGAGTCCCTGG ACGCCCGCCAGCTGCCCGCGTGGTTTGACCAGGCCAAGTTCGGCATCTTCATCCACTGGGGAGTGTTTTCCGTGCCCAGCTTCGGTAGCG AGTGGTTCTGGTGGTATTGGCAAAAGGAAAAGATACCGAAGTATGTGGAATTTATGAAAGATAATTACCCTCCTAGTTTCAAATATGAAG ATTTTGGACCACTATTTACAGCAAAATTTTTTAATGCCAACCAGTGGGCAGATATTTTTCAGGCCTCTGGTGCCAAATACATTGTCTTAA CTTCCAAACATCATGAAGGCTTTACCTTGTGGGGGTCAGAATATTCGTGGAACTGGAATGCCATAGATGAGGGGCCCAAGAGGGACATTG TCAAGGAACTTGAGGTAGCCATTAGGAACAGAACTGACCTGCGTTTTGGACTGTACTATTCCCTTTTTGAATGGTTTCATCCGCTCTTCC TTGAGGATGAATCCAGTTCATTCCATAAGCGGCAATTTCCAGTTTCTAAGACATTGCCAGAGCTCTATGAGTTAGTGAACAACTATCAGC CTGAGGTTCTGTGGTCGGATGGTGACGGAGGAGCACCGGATCAATACTGGAACAGCACAGGCTTCTTGGCCTGGTTATATAATGAAAGCC CAGTTCGGGGCACAGTAGTCACCAATGATCGTTGGGGAGCTGGTAGCATCTGTAAGCATGGTGGCTTCTATACCTGCAGTGATCGTTATA ACCCAGGACATCTTTTGCCACATAAATGGGAAAACTGCATGACAATAGACAAACTGTCCTGGGGCTATAGGAGGGAAGCTGGAATCTCTG ACTATCTTACAATTGAAGAATTGGTGAAGCAACTTGTAGAGACAGTTTCATGTGGAGGAAATCTTTTGATGAATATTGGGCCCACACTAG ATGGCACCATTTCTGTAGTTTTTGAGGAGCGACTGAGGCAAATGGGGTCCTGGCTAAAAGTCAATGGAGAAGCTATTTATGAAACCCATA CCTGGCGATCCCAGAATGACACTGTCACCCCAGATGTGTGGTACACATCCAAGCCTAAAGAAAAATTAGTCTATGCCATTTTTCTTAAAT GGCCCACATCAGGACAGCTGTTCCTTGGCCATCCCAAAGCTATTCTGGGGGCAACAGAGTATAATAATCATGAAATTCGTTCTGGAAAAC ATATTGGTGTCTGCATCTCAGTTGCCAACAATAGGCTTTTTGTGGGCTCTATTCCTAAGAGTAAAACCAAGGAACAGATTCTTGAAGAAT TTAGCAAAGTAACAGAGGGTCTTACAGACGTCATTTTATACCACCAACCGGATGACAAGAAAAAAAACAGAGGCTTTTGCTTTCTTGAAT ATGAAGATCACAAAACAGCTGCCCAGGCAAGGCGTAGGTTAATGAGTGGTAAAGTCAAGGTCTGGGGGAATGTTGGAACTGTTGAATGGG CTGATCCTATAGAAGATCCTGATCCTGAGGTTATGGCAAAGGTAAAAGTGCTGTTTGTACGCAACCTTGCCAATACTGTAACAGAAGAGA TTTTAGAAAAGGCATTTAGTCAGTTTGGGAAACTGGAACGAGTGAAGAAGTTAAAAGATTATGCGTTCATTCATTTTGATGAGCGAGATG GTGCTGTCAAGGCTATGGAAGAAATGAATGGCAAAGACTTGGAGGGAGAAAATATTGAAATTGTTTTTGCCAAGCCACCAGATCAGAAAA GGAAAGAAAGAAAAGCTCAGAGGCAAGCAGCAAAAAATCAAATGTATGACGATTACTACTATTATGGTCCACCTCATATGCCCCCTCCAA CAAGAGGTCGAGGGCGTGGAGGTAGAGGTGGTTATGGATATCCTCCAGATTATTATGGATATGAAGATTATTATGATTATTATGGTTATG ATTACCATAACTATCGTGGTGGATATGAAGATCCATACTATGGTTATGAAGATTTTCAAGTTGGAGCTAGAGGAAGGGGTGGTAGAGGAG CAAGGGGTGCTGCTCCATCCAGAGGTCGTGGGGCTGCTCCTCCCCGCGGTAGAGCCGGTTATTCACAGAGAGGAGGTCCTGGATCAGCAA GAGGCGTTCGAGGTGCGAGAGGAGGTGCCCAACAACAAAGAGGCCGCGGGGTACGTGGTGCGAGGGGTGGCCGCGGTGGAAATGTAGGAG GAAAGCGCAAAGCTGATGGGTACAACCAGCCAGATTCCAAGCGGCGCCAGACCAATAATCAGAACTGGGGCTCCCAACCCATTGCTCAGC AACCGCTCCAAGGTGGTGATCATTCTGGTAACTATGGTTACAAATCTGAAAACCAGGAGTTTTATCAGGATACTTTTGGGCAACAGTGGA AGTAGAAACAGTAGGGCCTCTGTAAAATTGGAGACTGATAGGTTGATCAGAAACTCACCCTAAATCTGAACGGGTGCCGCTATAATTTGT GACATCTGGCAAGATTTCCCTTTATGTATATATTTTAACAATCCGCTTGGACACGAACAAAGCCACACTTCTAACTGCTTCTGGCGAACT GATTTTATTTTTAATTTTTTTCAATAAAGATATTCTTAGATACTGAAAGAAATAGTTAATGAGTTTGCATTTGTGCTTGAGAAAATTTGG CTCAAGTCCATTTGGCTGTAGTGTCAACGATGTTTCCAGTAGTGTTTAGATTTGGTGTCTTCAAAGGTAGTTGATTAAAACCAAGTGTGT CTTTAATATCTTGTATCAGAATAACTTTGTATGTTACCAACTTAAATTGCTAGAATAAGGTAAATTGATACACAACTGCTATTTTTAATT TAGAACTTTGACCTAATTTGGGTTTTCAAAACCATTTTGGCTACTTGTATTCTTTATGCTGTTGTTTATTTCAATAAAAAATTCACACCT AAATGTATACTTACTAAAATTGTGTTTACAATTCGTTTTTCACAAAATTTCCTGCAAATTTGGTTCAAATTGTATAGCATGTCAAGGCCA >31768_31768_2_FUCA2-SYNCRIP_FUCA2_chr6_143818525_ENST00000002165_SYNCRIP_chr6_86333830_ENST00000369622_length(amino acids)=826AA_BP=697 MRRDMRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIHWGVFSVPSFGSEWFWWYWQKEKIPKY VEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLR FGLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTNDRWGAG SICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQM GSWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGATEYNNHEIRSGKHIGVCISVANNRLFV GSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKV KVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQM YDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPP RGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FUCA2-SYNCRIP |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 400_561 | 222.0 | 563.0 | APOBEC1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 400_561 | 222.0 | 624.0 | APOBEC1 | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000355238 | 5 | 12 | 518_549 | 222.0 | 563.0 | SMN | |
Tgene | SYNCRIP | chr6:143818525 | chr6:86333830 | ENST00000369622 | 5 | 11 | 518_549 | 222.0 | 624.0 | SMN |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FUCA2-SYNCRIP |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FUCA2-SYNCRIP |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |