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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FUNDC2-ITPR2 (FusionGDB2 ID:31775)

Fusion Gene Summary for FUNDC2-ITPR2

Fusion gene summary

Fusion gene information	Fusion gene name: FUNDC2-ITPR2
	Fusion gene ID: 31775
		Hgene	Tgene
	Gene symbol	FUNDC2	ITPR2
	Gene ID	65991	3709
	Gene name	FUN14 domain containing 2	inositol 1,4,5-trisphosphate receptor type 2
	Synonyms	DC44\|HCBP6\|HCC3\|PD03104	ANHD\|CFAP48\|INSP3R2\|IP3R2
	Cytomap	Xq28	12p11.23
	Type of gene	protein-coding	protein-coding
	Description	FUN14 domain-containing protein 2HCC-3cervical cancer oncogene 3cervical cancer proto-oncogene 3 proteinhepatitis C virus core-binding protein 6	inositol 1,4,5-trisphosphate receptor type 2IP3 receptorIP3R 2cilia and flagella associated protein 48type 2 InsP3 receptor
	Modification date	20200313	20200313
	UniProtAcc	Q9BWH2	Q14571
	Ensembl transtripts involved in fusion gene	ENST00000484175, ENST00000369498,	ENST00000381340, ENST00000242737, ENST00000545902,
Fusion gene scores	* DoF score	1 X 1 X 1=1	27 X 21 X 12=6804
	# samples	1	27
	** MAII score	log2(1/1*10)=3.32192809488736	log2(27/6804*10)=-4.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FUNDC2 [Title/Abstract] AND ITPR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FUNDC2(154261828)-ITPR2(26943160), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ITPR2	GO:0001666	response to hypoxia	19120137

Fusion gene breakpoints across FUNDC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITPR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A1KZ	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-

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Fusion Gene ORF analysis for FUNDC2-ITPR2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000484175	ENST00000381340	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-
3UTR-intron	ENST00000484175	ENST00000242737	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-
3UTR-intron	ENST00000484175	ENST00000545902	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-
5CDS-intron	ENST00000369498	ENST00000242737	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-
5CDS-intron	ENST00000369498	ENST00000545902	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-
In-frame	ENST00000369498	ENST00000381340	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000369498

FUNDC2

chrX

154261828

ENST00000381340

ITPR2

chr12

26943160

10540

538

254

8551

2765

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369498	ENST00000381340	FUNDC2	chrX	154261828	+	ITPR2	chr12	26943160	-	0.000456962	0.9995431

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Fusion Genomic Features for FUNDC2-ITPR2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FUNDC2-ITPR2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:154261828/chr12:26943160)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FUNDC2 Q9BWH2	ITPR2 Q14571
	FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250\|UniProtKB:Q9Z329}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

112_166

182.0

Domain

MIR 1

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

173_223

182.0

Domain

MIR 2

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

231_287

182.0

Domain

MIR 3

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

294_372

182.0

Domain

MIR 4

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

378_434

182.0

Domain

MIR 5

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

112_166

2702.0

Domain

MIR 1

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

173_223

2702.0

Domain

MIR 2

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

231_287

2702.0

Domain

MIR 3

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

294_372

2702.0

Domain

MIR 4

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

378_434

2702.0

Domain

MIR 5

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

265_269

182.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

507_510

182.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

567_569

182.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

265_269

2702.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

507_510

2702.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

567_569

2702.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2249_2260

182.0

Topological domain

Extracellular

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2282_2307

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2329_2351

182.0

Topological domain

Extracellular

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2373_2394

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2416_2521

182.0

Topological domain

Extracellular

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2543_2701

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2249_2260

2702.0

Topological domain

Extracellular

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2282_2307

2702.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2329_2351

2702.0

Topological domain

Extracellular

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2373_2394

2702.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2416_2521

2702.0

Topological domain

Extracellular

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2543_2701

2702.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2228_2248

182.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2261_2281

182.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2308_2328

182.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2352_2372

182.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2395_2415

182.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

2522_2542

182.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2228_2248

2702.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2261_2281

2702.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2308_2328

2702.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2352_2372

2702.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2395_2415

2702.0

Transmembrane

Helical

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

2522_2542

2702.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000242737

1_2227

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chrX:154261828

chr12:26943160

ENST00000381340

1_2227

2702.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for FUNDC2-ITPR2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>31775_31775_1_FUNDC2-ITPR2_FUNDC2_chrX_154261828_ENST00000369498_ITPR2_chr12_26943160_ENST00000381340_length(transcript)=10540nt_BP=538nt
TGAGCGAGCGAGCCCCGACGGCCGCGGTGGGTGGAGGGGGGAAAGTGGGGGAGAGTGGGGCGGGAGTAGAGGGAGAGCGAGGGAGGGAGC
CTCACCCCCGGGACGCTTTCTGCGCACGCGCATCTCGGTGCATCTGTTGGGCGGGACCGCGGGGCCTGTGACACCGCACGCTGAGCTCTG
TGATGTAGCCGCTTGCGGAGACTGCAAGCAGCCGCGGCGCGCCCGGCCCTCCCTCTTCCGCTGCCGCCGTGGGAATGGAAACATCTGCCC
CACGTGCCGGAAGCCAAGTGGTGGCGACAACTGCGCGCCACTCCGCGGCCTACCGCGCAGATCCTCTACGTGTGTCCTCGCGAGACAAGC
TCACCGAAATGGCCGCGTCCAGTCAAGGAAACTTTGAGGGAAATTTTGAGTCACTGGACCTTGCGGAATTTGCTAAGAAGCAGCCATGGT
GGCGTAAGCTGTTCGGGCAGGAATCTGGACCTTCAGCAGAAAAGTATAGCGTGGCAACCCAGCTGTTCATTGGAGGTGTCACTGGATGGT
TAGTGGATGACAGATGTGTGGTGCACCCAGAGGCCGGGGACCTTGCCAACCCTCCCAAGAAGTTCAGAGACTGCCTTTTCAAGGTGTGCC
CTATGAACAGATATTCTGCCCAGAAGCAATATTGGAAAGCAAAGCAAGCCAAACAAGGGAACCACACCGAGGCAGCCTTGCTGAAGAAAC
TACAGCACGCTGCAGAACTGGAACAAAAACAAAATGAATCGGAGAATAAGAAACTGTTGGGAGAAATTGTAAAATACAGTAATGTTATAC
AACTACTGCATATAAAAAGCAACAAATATCTTACTGTCAACAAGAGATTACCTGCTTTACTGGAGAAGAATGCCATGCGTGTGTCCTTGG
ATGCTGCAGGAAATGAAGGGTCTTGGTTTTATATTCATCCGTTCTGGAAACTGAGAAGCGAGGGTGACAATATTGTTGTAGGAGATAAAG
TTGTTTTGATGCCTGTGAATGCAGGGCAGCCACTACATGCCAGCAACATAGAGCTTCTTGATAACCCAGGGTGTAAAGAGGTGAATGCTG
TCAATTGCAACACCAGCTGGAAAATCACTTTATTCATGAAATATAGTTCCTATCGAGAGGATGTATTAAAAGGAGGGGACGTTGTTAGAT
TATTTCATGCGGAACAAGAGAAGTTTTTGACTTGTGATGAATATGAGAAAAAACAGCACATTTTCCTTCGTACGACCTTGCGCCAATCAG
CTACTTCTGCTACTAGTTCTAAAGCACTCTGGGAAATAGAGGTGGTTCATCATGACCCATGCCGTGGGGGTGCAGGACAGTGGAACAGCT
TGTTCAGATTTAAGCATCTTGCAACTGGAAACTATTTAGCTGCAGAGCTTAATCCTGATTATCGAGATGCCCAAAATGAAGGAAAAAATG
TGAGAGATGGAGTCCCTCCAACTTCAAAGAAAAAACGCCAGGCAGGGGAGAAGATCATGTATACTTTGGTTTCAGTCCCGCATGGCAATG
ACATTGCATCCCTTTTTGAACTAGATGCCACAACTCTTCAGAGAGCTGACTGCCTGGTTCCAAGGAACTCATATGTTCGGTTAAGGCATT
TATGCACCAACACATGGGTAACCAGTACTAGTATCCCCATAGACACAGATGAAGAGAGGCCTGTTATGTTAAAGATTGGAACCTGCCAAA
CCAAAGAAGATAAAGAAGCGTTCGCAATCGTGTCTGTTCCACTGTCTGAAGTTCGAGACTTAGACTTTGCCAATGATGCCAATAAAGTAC
TAGCGACCACAGTTAAAAAGCTAGAAAACGGCACAATAACTCAGAATGAAAGGAGGTTTGTAACCAAATTATTGGAAGATCTCATATTCT
TTGTTGCTGATGTGCCTAATAATGGACAAGAAGTTCTGGATGTGGTTATCACTAAGCCAAACCGAGAGCGTCAAAAATTGATGAGGGAAC
AAAACATACTGGCACAGGTATTTGGAATTCTTAAAGCACCCTTTAAAGAGAAAGCAGGAGAAGGCTCGATGCTGAGACTTGAAGATCTGG
GGGATCAAAGATATGCACCCTACAAGTACATGCTGCGGCTCTGTTACCGCGTCCTGAGACACTCGCAGCAGGATTACCGGAAAAATCAGG
AATATATTGCTAAGAATTTCTGTGTCATGCAGTCCCAGATTGGCTATGATATTTTGGCAGAAGATACTATCACAGCTTTGTTGCACAACA
ACAGAAAACTACTAGAGAAACATATCACAGCAAAAGAAATAGAAACATTTGTCAGTTTACTCAGGAGAAATCGGGAGCCAAGGTTTTTGG
ATTATTTGTCAGATCTGTGTGTGTCTAATACCACTGCTATCCCTGTAACTCAAGAACTCATCTGTAAATTTATGTTGAGTCCAGGCAATG
CAGACATTCTCATTCAAACTAAGGTGGTCTCAATGCAAGCAGACAACCCCATGGAGAGCTCCATCCTTTCAGATGACATTGATGATGAAG
AAGTTTGGCTCTATTGGATTGACAGCAACAAGGAACCTCATGGCAAAGCTATCAGGCACCTTGCTCAAGAGGCAAAAGAAGGCACCAAAG
CTGACTTAGAAGTTCTTACCTATTACAGGTACCAGCTAAACCTCTTTGCAAGGATGTGCTTGGATCGCCAGTATCTGGCCATAAACCAGA
TTTCTACACAGCTGTCTGTAGACCTGATCCTGCGGTGTGTGTCGGATGAGAGCCTGCCGTTCGACCTCCGAGCGTCCTTCTGTCGCCTCA
TGCTCCACATGCACGTTGACCGGGATCCCCAGGAGTCCGTGGTGCCTGTTCGCTATGCCAGGCTCTGGACAGAAATCCCCACAAAGATCA
CAATTCATGAATATGATTCTATAACAGACTCTTCCAGAAATGATATGAAGAGGAAATTTGCCCTGACAATGGAATTTGTTGAAGAATATT
TGAAAGAAGTTGTAAACCAGCCCTTTCCTTTTGGGGATAAAGAAAAAAATAAACTGACATTTGAGGTGGTCCACTTGGCTCGGAATCTTA
TATACTTTGGATTTTATAGTTTCAGTGAGTTATTAAGGCTAACAAGAACACTTCTGGCTATTTTAGACATTGTACAGGCCCCCATGTCAT
CATACTTTGAAAGATTAAGCAAATTTCAAGATGGAGGAAACAATGTGATGAGAACCATTCATGGGGTGGGAGAGATGATGACCCAGATGG
TACTCAGTAGAGGCTCCATCTTCCCCATGAGCGTGCCGGATGTGCCACCCAGCATCCACCCGAGCAAGCAAGGGAGCCCCACCGAGCACG
AGGATGTGACTGTGATGGACACCAAGCTGAAGATCATTGAGATTTTGCAGTTTATCCTGAGTGTCAGACTGGATTATAGGATCTCATATA
TGCTGTCAATATATAAGAAGGAGTTTGGAGAGGACAATGACAATGCGGAGACATCTGCCAGTGGATCTCCAGACACTTTACTACCATCAG
CTATTGTTCCTGATATAGATGAAATTGCAGCTCAGGCAGAAACTATGTTTGCGGGAAGAAAAGAAAAAAATCCAGTTCAACTTGACGATG
AAGGAGGCAGGACGTTTTTACGGGTCCTCATTCATCTGATCATGCACGACTACCCGCCTTTGCTGTCTGGAGCCCTGCAGCTGTTGTTTA
AGCACTTCAGCCAGAGGGCAGAGGTTTTACAGGCATTTAAGCAGGTGCAATTACTGGTGTCTAATCAAGACGTAGATAACTACAAGCAAA
TCAAGGCAGATCTAGACCAGCTTCGACTGACAGTAGAAAAGTCTGAGCTATGGGTGGAGAAGAGCAGCAACTATGAGAATGGAGAAATAG
GGGAAAGTCAAGTGAAAGGTGGTGAAGAGCCAATTGAGGAATCAAACATTTTAAGTCCAGTGCAGGATGGAACAAAGAAACCTCAGATTG
ACAGCAACAAGAGCAATAACTACCGGATTGTAAAGGAGATTTTGATCAGGCTAAGTAAACTCTGTGTGCAGAATAAAAAGTGTCGGAATC
AACATCAACGATTACTGAAAAATATGGGGGCGCATTCGGTGGTGTTGGATCTTCTGCAGATACCCTATGAAAAGAATGATGAAAAGATGA
ATGAAGTAATGAATCTAGCCCATACATTTCTGCAGAATTTCTGTCGAGGAAATCCACAGAATCAAGTTCTTCTTCATAAACATCTGAATT
TGTTTTTAACTCCAGGTCTCCTTGAAGCAGAAACCATGCGGCACATCTTCATGAACAATTACCATCTGTGCAACGAAATTAGCGAGAGAG
TTGTACAACACTTTGTGCACTGCATTGAGACACATGGCCGCCACGTGGAGTACCTGAGGTTTTTGCAAACAATTGTAAAAGCAGATGGTA
AATATGTGAAGAAATGCCAGGATATGGTAATGACAGAGTTGATAAATGGGGGTGAAGACGTGCTGATATTTTACAATGATAGAGCATCAT
TTCCAATCCTTCTCCATATGATGTGTTCAGAGAGAGACCGAGGGGATGAGAGTGGCCCCTTAGCCTACCACATCACCCTGGTGGAGTTGC
TGGCAGCATGCACAGAGGGGAAAAATGTCTACACTGAAATCAAGTGTAATTCCCTTCTCCCGCTGGACGACATAGTGAGGGTGGTGACCC
ATGACGACTGCATCCCTGAGGTTAAAATTGCTTATGTGAACTTTGTTAATCACTGTTATGTTGACACTGAAGTGGAAATGAAAGAAATCT
ATACAAGTAACCACATTTGGAAATTATTTGAGAACTTCTTGGTGGATATGGCAAGGGTTTGCAACACAACTACAGACAGGAAACATGCAG
ACATCTTTTTGGAAAAGTGTGTTACTGAGTCAATAATGAATATTGTGAGCGGCTTCTTTAATTCTCCCTTTTCAGACAATAGTACCAGCC
TCCAGACACATCAGCCAGTTTTTATTCAGCTACTGCAATCTGCCTTCAGAATTTACAATTGCACCTGGCCAAACCCAGCGCAGAAAGCCT
CAGTGGAATCCTGTATCAGAACTTTGGCTGAAGTGGCAAAAAATCGTGGAATTGCCATTCCAGTGGATTTGGACAGCCAAGTTAATACTC
TTTTCATGAAGAGCCATTCAAATATGGTGCAGAGAGCAGCAATGGGTTGGAGACTATCAGCTCGCTCTGGGCCACGCTTTAAGGAAGCTC
TTGGAGGGCCTGCTTGGGATTACAGAAATATTATTGAAAAGTTACAGGATGTAGTGGCCTCCTTGGAGCACCAGTTCAGCCCAATGATGC
AGGCTGAATTCTCAGTGTTGGTTGATGTATTGTACAGTCCAGAACTGCTGTTCCCTGAGGGAAGCGATGCAAGAATAAGATGTGGCGCTT
TCATGTCGAAGTTGATTAATCATACAAAGAAACTAATGGAGAAAGAAGAAAAACTGTGCATTAAAATTCTTCAGACATTACGAGAAATGT
TAGAGAAGAAAGACAGCTTTGTGGAAGAGGGTAACACATTAAGAAAGATACTTCTGAATCGATACTTTAAAGGTGATTATAGTATTGGTG
TGAATGGACACCTATCAGGAGCCTACTCCAAAACTGCACAGGTGGGAGGAAGCTTTTCTGGACAAGATTCAGATAAGATGGGGATATCAA
TGTCAGACATTCAGTGTCTGCTGGATAAAGAAGGTGCATCAGAACTTGTCATCGATGTTATAGTGAACACCAAAAATGACAGAATTTTTT
CAGAAGGCATTTTCCTCGGCATTGCCTTGCTTGAAGGAGGAAATACACAAACACAGTATTCTTTCTACCAGCAGTTGCATGAACAAAAAA
AGTCAGAAAAATTCTTTAAAGTTCTCTATGATCGAATGAAGGCTGCTCAGAAAGAAATAAGATCAACAGTGACAGTTAATACCATAGATT
TAGGTAACAAAAAAAGGGACGATGACAATGAATTGATGACATCTGGTCCACGAATGAGAGTAAGAGATTCAACACTACATTTAAAAGAGG
GAATGAAAGGGCAATTAACAGAAGCTTCTTCAGCAACATCCAAAGCATATTGTGTATACAGAAGAGAAATGGATCCAGAAATAGACATTA
TGTGCACAGGACCAGAAGCGGGAAACACTGAGGAAAAATCCGCAGAGGAAGTAACAATGAGTCCCGCAATTGCCATCATGCAGCCAATAC
TGAGATTTCTTCAGTTACTGTGTGAGAATCACAACCGGGAATTGCAGAACTTCTTGAGGAATCAAAACAACAAAACAAATTACAACCTAG
TCTGTGAGACCCTTCAGTTTCTGGACTGCATTTGTGGAAGTACAACCGGTGGCCTGGGCCTGTTGGGTCTCTACATCAATGAGAAGAATG
TAGCGCTGGTCAACCAGAACCTGGAGAGCTTGACTGAGTATTGCCAGGGCCCTTGCCATGAAAATCAGACCTGTATCGCTACACATGAGT
CTAATGGGATTGATATCATCATTGCTTTGATTCTGAATGACATAAACCCTCTTGGTAAATACCGAATGGACCTGGTGCTCCAGCTAAAGA
ACAATGCATCTAAACTTTTGCTGGCCATTATGGAAAGCAGACATGACAGTGAGAATGCAGAAAGAATTCTTTTTAACATGAGACCCAGAG
AACTGGTGGATGTGATGAAGAATGCCTATAACCAAGGATTGGAATGTGACCATGGGGATGATGAGGGTGGAGATGATGGTGTTTCTCCAA
AAGATGTTGGACACAATATCTATATTCTGGCCCATCAGTTGGCCCGCCACAATAAACTGTTGCAGCAGATGCTCAAACCAGGATCGGATC
CAGATGAAGGAGATGAAGCCTTAAAGTATTATGCCAACCACACTGCACAGATTGAGATTGTCCGGCATGATAGGACCATGGAACAAATAG
TTTTTCCTGTCCCCAATATATGTGAATACCTCACTCGAGAATCCAAGTGCCGTGTGTTCAATACAACTGAAAGGGATGAACAAGGAAGTA
AAGTGAATGACTTTTTCCAGCAAACAGAAGATCTCTACAATGAAATGAAGTGGCAGAAGAAAATCAGGAATAACCCTGCACTGTTCTGGT
TCTCGAGGCACATCTCTCTCTGGGGGAGCATTTCCTTCAACCTGGCTGTGTTCATCAATTTAGCTGTTGCTCTCTTCTACCCATTTGGGG
ATGATGGAGATGAAGGTACACTTTCTCCATTGTTCTCGGTTCTTCTTTGGATAGCAGTTGCGATCTGCACATCTATGCTGTTTTTCTTCT
CCAAGCCTGTGGGTATTCGGCCGTTTCTTGTATCAATAATGCTCAGATCAATATATACAATAGGTCTTGGGCCTACATTAATACTTCTTG
GTGCAGCTAATCTTTGTAATAAAATTGTTTTTCTGGTGAGTTTTGTTGGAAATCGTGGCACGTTCACCCGTGGGTACCGAGCAGTCATCC
TGGATATGGCCTTTCTCTATCACGTGGCGTATGTCCTGGTTTGCATGCTGGGCCTTTTTGTCCATGAATTCTTCTATAGCTTCCTGCTTT
TTGATTTGGTGTACAGGGAAGAGACTTTGCTGAATGTCATAAAAAGTGTCACACGAAATGGCCGCTCTATTATTCTAACTGCAGTCCTGG
CTCTCATCCTCGTCTACCTGTTTTCCATTATTGGGTTCCTTTTTTTGAAGGATGACTTCACTATGGAAGTTGATAGGCTGAAAAACCGAA
CTCCTGTTACAGGCAGTCATCAAGTGCCTACTATGACTTTAACTACCATGATGGAAGCATGTGCCAAGGAGAACTGTTCACCCACAATTC
CAGCTTCAAATACAGCTGATGAAGAGTATGAAGATGGAATTGAAAGGACGTGTGACACTCTCCTTATGTGCATTGTCACCGTGCTGAACC
AGGGCCTCAGGAATGGCGGTGGTGTGGGGGATGTGCTAAGAAGGCCATCGAAAGATGAGCCCTTGTTTGCTGCCCGAGTGGTTTATGACC
TTCTTTTTTATTTCATTGTTATCATTATTGTTCTGAACTTGATTTTTGGTGTTATCATCGATACTTTTGCTGATCTCAGAAGCGAAAAAC
AGAAAAAAGAAGAAATTCTAAAGACAACTTGTTTCATCTGTGGACTTGAGAGAGACAAGTTTGATAATAAAACGGTTTCATTTGAGGAGC
ACATTAAGTCAGAACACAATATGTGGCATTATTTGTACTTCATAGTCCTGGTGAAAGTTAAAGACCCAACAGAATACACTGGACCTGAAA
GTTATGTGGCTCAAATGATTGTGGAGAAGAATTTGGATTGGTTTCCTCGGATGCGAGCCATGTCCCTCGTTAGCAATGAAGGCGACAGTG
AGCAAAATGAAATTCGGAGCCTTCAGGAGAAGTTGGAATCGACCATGAGTCTGGTCAAACAGCTGTCGGGTCAGCTGGCGGAGCTCAAGG
AGCAGATGACAGAACAAAGGAAGAATAAGCAGAGACTGGGCTTCCTCGGATCAAACACACCCCATGTGAATCATCACATGCCACCACACT
GATACCATGGGGGGAAGCCGTGACTAGCCTTTCATCAGTGTCCTGCCTGATCACTGAATAAAGAACTGAGATGGAGGGGAGTGAACAGTG
CCTATTGTTGAAAAGTTAAAAACAACCAAGTGCCAAGATGTTGAGTGGGTTAGCTCCGAGAACAATTTATAACTGTGTTTTCATGGTTGC
GAAGACCTAACCTCAAATGCATCTGCTAGAAAGCGTACATCACACATTCGCAATGCATCAGGAAGAAAAGGCTTGCCCAAAAGGCTGGAG
AGGGCAGGGAGCGGCAGGATGGAAGGAGACACGGGGCAGGGAGAACTCTCTTCTGCTAAATCGATAGGAGTCAGTTTTGTCTTAAATGCT
GACTACAGCCACTGACATGGTTGGCTGGAATTTCTTTCTTTTAATTGTGGCATATAGGTTTGTGACACAAGAAGTCATACTTTGGTGGCT
AAGTTTTACTAAGGAAAATAACTGAAAAGATTAAAAGTGAGAGCTGAAAAGAGAAATGATAATGCTTCCAAACTGTAGCTGTCACAGGGC
AATTTCTTTATTTATAACATGAAGCACAATGGATTTACAGCTCTAGGAACTTAGTACTTTGGAGCTTTTGCCTCTCACACTGACAACATA
ACAGGATGTGATTGCCTTCTCTGGGATTCAGACAGGCTCTGTCAATGTGGAGCACAAAAGGAGATTTTCATATAACTTGTTAAAAACATG
TTCTAAGTCATGTATAGGCTAAGATTTTAAGAAGATCTGGGGGAATAAAAAGCCAACAGTAAGCCCCAGGAAAGGGTTTTTTGAGACCAT
ATGTATGCTATTAAAATATATTGAGATTAATACATGAAAATGCTTAAAAGTGATAGGAATTATTGAGAAACTTATGATGGTGGCATTGCC
TTTTATAAACATGGAGTGAAAGCCATTTGACTCAACGTTTGCTGTGCTTAAAGAATTGCTTCAGGACCCGAGCGTTTTTATGTATGCTGT
TCCTGCAGTTAGGAAAAAAAAATCCAAGAAATGTATTGAATACTCAAGAAAATGCCACATTTCAATTACATATTTAAAACTGTATCTGTA
AGGGCTTTTCAAAATGTAGCAAGATAAAAATCTCTTATTCAAATTGTTTTTGTATTAAATCATGCACTCAGAATTTGTCGAGGGAGAGAA
TAACCTGGTGTGTTCAGGTTATTCTTAGAGACTACACATTTGGAATAGCAGAGCAAAATATGGATAATGAAAGTGTTGGGAAAAAAGTGA
TGTGACAGGGAGTGAAGACACTTGATACCAGACTCTGGGAGATACTCTGCAAGTTGACCTGGCCTCTCCCCCACAGGAACAAAACACTGC
CTCCAGAGTCTTTAAATTCTCAGTTATCAACGCCAAGGTTTAAGGTCTAGATAGGGTTTGCTATAGGGTTTGCTCTGACAATTTTTAAAG
CTTTTGGATTGTTCTAACATAGCTTAAGCTATTGGTTCCTAAAAATCCCAAATCAAGATCTATGTAGAATATAAAGGAAGCCTGAACCAA
TCCTTCCACATACTGTTAAGATGTAGACTTGGAACAAAGCTGTTGGGACCCAGAGCAATGAATTTTTGAACTGAAGCTACTGGTACTCCC
CAGCACCACCTCATACTAAGAATTCCTCACTCTGACATGACAGTATTTTTTCTGACCAGGAGCTGAAAGACCCTGACATTCATGATCCAA
AGATATAAGAAATTTTGATATGTCTGCATGCAGCACAGAACTTTGAACCTAGGAGGCAGTCAATAAATACATGAGAAATTCAGCTGTCAT
TCAGTTACTCTTAATTCTTTATAAAACTTTAAATGATACCACATATTTGTTTGTTTAAAATGGCTTTCCCAAAATCAAAGTAGACTAAAG
CAGCCATCTTTAAAATCCAGGATCATCAATGCTATTAACAGTATCAGGTAAAAAGTACACTTTAAAATATTTTAATCAGGCAGAGTTTTA

>31775_31775_1_FUNDC2-ITPR2_FUNDC2_chrX_154261828_ENST00000369498_ITPR2_chr12_26943160_ENST00000381340_length(amino acids)=2765AA_BP=95
METSAPRAGSQVVATTARHSAAYRADPLRVSSRDKLTEMAASSQGNFEGNFESLDLAEFAKKQPWWRKLFGQESGPSAEKYSVATQLFIG
GVTGWLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVK
YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGC
KEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGA
GQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSY
VRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLL
EDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQD
YRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFM
LSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQY
LAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTME
FVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGE
MMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPD
TLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDV
DNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQN
KKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCN
EISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHI
TLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTT
DRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLD
SQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDAR
IRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSD
KMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVT
VNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIA
IMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTC
IATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGD
DGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTER
DEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTS
MLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFF
YSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKEN
CSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFAD
LRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FUNDC2-ITPR2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FUNDC2-ITPR2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FUNDC2-ITPR2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source