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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUS-GBAS (FusionGDB2 ID:31804)

Fusion Gene Summary for FUS-GBAS

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS-GBAS
Fusion gene ID: 31804
HgeneTgene
Gene symbol

FUS

GBAS

Gene ID

2521

2631

Gene nameFUS RNA binding proteinnipsnap homolog 2
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSGBAS
Cytomap

16p11.2

7p11.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma proteinprotein NipSnap homolog 24-nitrophenylphosphatase domain and non-neuronal SNAP25-like 2glioblastoma amplified sequence
Modification date2020032920200313
UniProtAcc

P35637

.
Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000487370, ENST00000322090, 
ENST00000446778, 
Fusion gene scores* DoF score37 X 37 X 16=2190410 X 8 X 6=480
# samples 4411
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/480*10)=-2.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FUS [Title/Abstract] AND GBAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUS(31196500)-GBAS(56062586), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GBAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AP-A1DHFUSchr16

31196500

+GBASchr7

56062586

+


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Fusion Gene ORF analysis for FUS-GBAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000254108ENST00000487370FUSchr16

31196500

+GBASchr7

56062586

+
5CDS-intronENST00000380244ENST00000487370FUSchr16

31196500

+GBASchr7

56062586

+
5CDS-intronENST00000568685ENST00000487370FUSchr16

31196500

+GBASchr7

56062586

+
In-frameENST00000254108ENST00000322090FUSchr16

31196500

+GBASchr7

56062586

+
In-frameENST00000254108ENST00000446778FUSchr16

31196500

+GBASchr7

56062586

+
In-frameENST00000380244ENST00000322090FUSchr16

31196500

+GBASchr7

56062586

+
In-frameENST00000380244ENST00000446778FUSchr16

31196500

+GBASchr7

56062586

+
In-frameENST00000568685ENST00000322090FUSchr16

31196500

+GBASchr7

56062586

+
In-frameENST00000568685ENST00000446778FUSchr16

31196500

+GBASchr7

56062586

+
intron-3CDSENST00000474990ENST00000322090FUSchr16

31196500

+GBASchr7

56062586

+
intron-3CDSENST00000474990ENST00000446778FUSchr16

31196500

+GBASchr7

56062586

+
intron-intronENST00000474990ENST00000487370FUSchr16

31196500

+GBASchr7

56062586

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254108FUSchr1631196500+ENST00000446778GBASchr756062586+2222869271112361
ENST00000254108FUSchr1631196500+ENST00000322090GBASchr756062586+2222869271112361
ENST00000380244FUSchr1631196500+ENST00000446778GBASchr756062586+2190837521080342
ENST00000380244FUSchr1631196500+ENST00000322090GBASchr756062586+2190837521080342
ENST00000568685FUSchr1631196500+ENST00000446778GBASchr756062586+2181828401071343
ENST00000568685FUSchr1631196500+ENST00000322090GBASchr756062586+2181828401071343

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254108ENST00000446778FUSchr1631196500+GBASchr756062586+0.0023335120.9976665
ENST00000254108ENST00000322090FUSchr1631196500+GBASchr756062586+0.0023335120.9976665
ENST00000380244ENST00000446778FUSchr1631196500+GBASchr756062586+0.0005994240.9994006
ENST00000380244ENST00000322090FUSchr1631196500+GBASchr756062586+0.0005994240.9994006
ENST00000568685ENST00000446778FUSchr1631196500+GBASchr756062586+0.002315430.9976846
ENST00000568685ENST00000322090FUSchr1631196500+GBASchr756062586+0.002315430.9976846

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Fusion Genomic Features for FUS-GBAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FUSchr1631196500+GBASchr756062586+1.40E-131
FUSchr1631196500+GBASchr756062586+1.40E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FUS-GBAS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:31196500/chr7:56062586)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

.
FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31196500chr7:56062586ENST00000254108+6151_165254527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneFUSchr16:31196500chr7:56062586ENST00000380244+6151_165253526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31196500chr7:56062586ENST00000254108+615166_267254527.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31196500chr7:56062586ENST00000254108+615371_526254527.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31196500chr7:56062586ENST00000380244+615166_267253526.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31196500chr7:56062586ENST00000380244+615371_526253526.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31196500chr7:56062586ENST00000254108+615285_371254527.0DomainRRM
HgeneFUSchr16:31196500chr7:56062586ENST00000380244+615285_371253526.0DomainRRM
HgeneFUSchr16:31196500chr7:56062586ENST00000254108+615422_453254527.0Zinc fingerRanBP2-type
HgeneFUSchr16:31196500chr7:56062586ENST00000380244+615422_453253526.0Zinc fingerRanBP2-type


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Fusion Gene Sequence for FUS-GBAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31804_31804_1_FUS-GBAS_FUS_chr16_31196500_ENST00000254108_GBAS_chr7_56062586_ENST00000322090_length(transcript)=2222nt_BP=869nt
ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG
CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT
TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT
TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG
AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC
AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG
CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGT
AACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGC
GGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGC
AGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGGGCTCGTGCAATCCGCTTCAGACAGGATGGT
AACGAAGCCGTCGGAGGATTCTTCTCTCAGATTGGGCAGCTGTACATGGTGCACCATCTTTGGGCTTACAGGGATCTTCAGACCAGGGAA
GACATACGGAATGCAGCATGGCACAAACATGGCTGGGAGGAATTGGTATATTACACAGTTCCACTTATTCAGGAAATGGAATCCAGAATC
ATGATCCCACTGAAGACCTCGCCCCTCCAGTAAAGCTGTAGAGTTTCTATGTGCCTACATACATTTCTGTGACAAGTATTTGTCGTAAAT
TAATTTTAATTGTGTATCAAGTGAAAAAGAAACACTGAGGTTTTAAGCTGCTGTATATAGCTTGTGAGAAACCTCTTTTCTTTAAAATTT
ACATAATCACAAGAAAGGAAAGAATTACAGTTGGACTGATTGTGACAGTGCCTTGTCGTCCTCTTTGAAACACCCCGTGTTGTCCAGTAT
ACCTTATAACACTGAGCCACTTCTCCCCACCCTCCAGAAGGGGTCCACGTTGAATTCTGAATCATCTTGAAAATAAGATTCCAACCACAA
AAAAAATTTAGCCATTTCTTTACTAAAAAAAACCAAAAAACAAATCTGTTTTATAATCACAGATTTTTAGACAAATTTCTTGTATCAGGA
AGAAATACAAATTTTGTCATGTTTCTCAAGCAGTTTTTCTGAGTAGTTTCTGAGGAGGAACAAATTACAAGTGTACCCAATAACTGAAAA
TGTTTTAACTCACTCTCATTTGTAAGCAGTCCACATAGTAGACAATGGGTTTTCCAAGCTGGGCAAGGTACATTTAATCAGTAAATCAGT
TTCACATCATGTATTGTGATGTTTCAATGTGAGACACAAAAACAATGGCTTGAAACTTGTGTATCATATGTGATTTTGAAATGAACACCT
TGAATAGCACTAATTTTTATTTGTGGTATTTTTCTATAACAAAACAAGTAGCTCTAGGAAAAGAGGTTTTATTTTGTAAACGATCATTTG
TGACCTCAGACACTCTCTGGCTAATATTTTAATAAGCTCACAGCAGATAATTCTGAGATCATGGGTGAGGGGTGGTGCATGTTGAGATTT
AAATTGGCATAAAGCTGCATACTTTTTGTCTAGCTGTTTGATTTCATTTTTTAATATAGTATGCCAATTTTGTGACTGTTACCATGTGAA
AGTCCTGTTGAAATGAACAATTGTCTGCCCCACAATCAAGAATGTATGTGTAAAGTGTGAATAAATCTCATATCAAATGTCAAACTTTTA

>31804_31804_1_FUS-GBAS_FUS_chr16_31196500_ENST00000254108_GBAS_chr7_56062586_ENST00000322090_length(amino acids)=361AA_BP=238
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPL

--------------------------------------------------------------
>31804_31804_2_FUS-GBAS_FUS_chr16_31196500_ENST00000254108_GBAS_chr7_56062586_ENST00000446778_length(transcript)=2222nt_BP=869nt
ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG
CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT
TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT
TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG
AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC
AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG
CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGT
AACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGC
GGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGC
AGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGGGCTCGTGCAATCCGCTTCAGACAGGATGGT
AACGAAGCCGTCGGAGGATTCTTCTCTCAGATTGGGCAGCTGTACATGGTGCACCATCTTTGGGCTTACAGGGATCTTCAGACCAGGGAA
GACATACGGAATGCAGCATGGCACAAACATGGCTGGGAGGAATTGGTATATTACACAGTTCCACTTATTCAGGAAATGGAATCCAGAATC
ATGATCCCACTGAAGACCTCGCCCCTCCAGTAAAGCTGTAGAGTTTCTATGTGCCTACATACATTTCTGTGACAAGTATTTGTCGTAAAT
TAATTTTAATTGTGTATCAAGTGAAAAAGAAACACTGAGGTTTTAAGCTGCTGTATATAGCTTGTGAGAAACCTCTTTTCTTTAAAATTT
ACATAATCACAAGAAAGGAAAGAATTACAGTTGGACTGATTGTGACAGTGCCTTGTCGTCCTCTTTGAAACACCCCGTGTTGTCCAGTAT
ACCTTATAACACTGAGCCACTTCTCCCCACCCTCCAGAAGGGGTCCACGTTGAATTCTGAATCATCTTGAAAATAAGATTCCAACCACAA
AAAAAATTTAGCCATTTCTTTACTAAAAAAAACCAAAAAACAAATCTGTTTTATAATCACAGATTTTTAGACAAATTTCTTGTATCAGGA
AGAAATACAAATTTTGTCATGTTTCTCAAGCAGTTTTTCTGAGTAGTTTCTGAGGAGGAACAAATTACAAGTGTACCCAATAACTGAAAA
TGTTTTAACTCACTCTCATTTGTAAGCAGTCCACATAGTAGACAATGGGTTTTCCAAGCTGGGCAAGGTACATTTAATCAGTAAATCAGT
TTCACATCATGTATTGTGATGTTTCAATGTGAGACACAAAAACAATGGCTTGAAACTTGTGTATCATATGTGATTTTGAAATGAACACCT
TGAATAGCACTAATTTTTATTTGTGGTATTTTTCTATAACAAAACAAGTAGCTCTAGGAAAAGAGGTTTTATTTTGTAAACGATCATTTG
TGACCTCAGACACTCTCTGGCTAATATTTTAATAAGCTCACAGCAGATAATTCTGAGATCATGGGTGAGGGGTGGTGCATGTTGAGATTT
AAATTGGCATAAAGCTGCATACTTTTTGTCTAGCTGTTTGATTTCATTTTTTAATATAGTATGCCAATTTTGTGACTGTTACCATGTGAA
AGTCCTGTTGAAATGAACAATTGTCTGCCCCACAATCAAGAATGTATGTGTAAAGTGTGAATAAATCTCATATCAAATGTCAAACTTTTA

>31804_31804_2_FUS-GBAS_FUS_chr16_31196500_ENST00000254108_GBAS_chr7_56062586_ENST00000446778_length(amino acids)=361AA_BP=238
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPL

--------------------------------------------------------------
>31804_31804_3_FUS-GBAS_FUS_chr16_31196500_ENST00000380244_GBAS_chr7_56062586_ENST00000322090_length(transcript)=2190nt_BP=837nt
GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA
TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA
GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA
TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC
CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA
GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG
ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAG
TGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCG
CGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGG
TGGCCGTGGAGGCAGAGGTGGCATGGGGGCTCGTGCAATCCGCTTCAGACAGGATGGTAACGAAGCCGTCGGAGGATTCTTCTCTCAGAT
TGGGCAGCTGTACATGGTGCACCATCTTTGGGCTTACAGGGATCTTCAGACCAGGGAAGACATACGGAATGCAGCATGGCACAAACATGG
CTGGGAGGAATTGGTATATTACACAGTTCCACTTATTCAGGAAATGGAATCCAGAATCATGATCCCACTGAAGACCTCGCCCCTCCAGTA
AAGCTGTAGAGTTTCTATGTGCCTACATACATTTCTGTGACAAGTATTTGTCGTAAATTAATTTTAATTGTGTATCAAGTGAAAAAGAAA
CACTGAGGTTTTAAGCTGCTGTATATAGCTTGTGAGAAACCTCTTTTCTTTAAAATTTACATAATCACAAGAAAGGAAAGAATTACAGTT
GGACTGATTGTGACAGTGCCTTGTCGTCCTCTTTGAAACACCCCGTGTTGTCCAGTATACCTTATAACACTGAGCCACTTCTCCCCACCC
TCCAGAAGGGGTCCACGTTGAATTCTGAATCATCTTGAAAATAAGATTCCAACCACAAAAAAAATTTAGCCATTTCTTTACTAAAAAAAA
CCAAAAAACAAATCTGTTTTATAATCACAGATTTTTAGACAAATTTCTTGTATCAGGAAGAAATACAAATTTTGTCATGTTTCTCAAGCA
GTTTTTCTGAGTAGTTTCTGAGGAGGAACAAATTACAAGTGTACCCAATAACTGAAAATGTTTTAACTCACTCTCATTTGTAAGCAGTCC
ACATAGTAGACAATGGGTTTTCCAAGCTGGGCAAGGTACATTTAATCAGTAAATCAGTTTCACATCATGTATTGTGATGTTTCAATGTGA
GACACAAAAACAATGGCTTGAAACTTGTGTATCATATGTGATTTTGAAATGAACACCTTGAATAGCACTAATTTTTATTTGTGGTATTTT
TCTATAACAAAACAAGTAGCTCTAGGAAAAGAGGTTTTATTTTGTAAACGATCATTTGTGACCTCAGACACTCTCTGGCTAATATTTTAA
TAAGCTCACAGCAGATAATTCTGAGATCATGGGTGAGGGGTGGTGCATGTTGAGATTTAAATTGGCATAAAGCTGCATACTTTTTGTCTA
GCTGTTTGATTTCATTTTTTAATATAGTATGCCAATTTTGTGACTGTTACCATGTGAAAGTCCTGTTGAAATGAACAATTGTCTGCCCCA
CAATCAAGAATGTATGTGTAAAGTGTGAATAAATCTCATATCAAATGTCAAACTTTTACATGTGAATGATTTTCTCAAAGAACATAGAAA

>31804_31804_3_FUS-GBAS_FUS_chr16_31196500_ENST00000380244_GBAS_chr7_56062586_ENST00000322090_length(amino acids)=342AA_BP=219
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGARAIRFRQ

--------------------------------------------------------------
>31804_31804_4_FUS-GBAS_FUS_chr16_31196500_ENST00000380244_GBAS_chr7_56062586_ENST00000446778_length(transcript)=2190nt_BP=837nt
GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA
TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA
GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA
TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC
CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA
GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG
ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAG
TGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCG
CGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGG
TGGCCGTGGAGGCAGAGGTGGCATGGGGGCTCGTGCAATCCGCTTCAGACAGGATGGTAACGAAGCCGTCGGAGGATTCTTCTCTCAGAT
TGGGCAGCTGTACATGGTGCACCATCTTTGGGCTTACAGGGATCTTCAGACCAGGGAAGACATACGGAATGCAGCATGGCACAAACATGG
CTGGGAGGAATTGGTATATTACACAGTTCCACTTATTCAGGAAATGGAATCCAGAATCATGATCCCACTGAAGACCTCGCCCCTCCAGTA
AAGCTGTAGAGTTTCTATGTGCCTACATACATTTCTGTGACAAGTATTTGTCGTAAATTAATTTTAATTGTGTATCAAGTGAAAAAGAAA
CACTGAGGTTTTAAGCTGCTGTATATAGCTTGTGAGAAACCTCTTTTCTTTAAAATTTACATAATCACAAGAAAGGAAAGAATTACAGTT
GGACTGATTGTGACAGTGCCTTGTCGTCCTCTTTGAAACACCCCGTGTTGTCCAGTATACCTTATAACACTGAGCCACTTCTCCCCACCC
TCCAGAAGGGGTCCACGTTGAATTCTGAATCATCTTGAAAATAAGATTCCAACCACAAAAAAAATTTAGCCATTTCTTTACTAAAAAAAA
CCAAAAAACAAATCTGTTTTATAATCACAGATTTTTAGACAAATTTCTTGTATCAGGAAGAAATACAAATTTTGTCATGTTTCTCAAGCA
GTTTTTCTGAGTAGTTTCTGAGGAGGAACAAATTACAAGTGTACCCAATAACTGAAAATGTTTTAACTCACTCTCATTTGTAAGCAGTCC
ACATAGTAGACAATGGGTTTTCCAAGCTGGGCAAGGTACATTTAATCAGTAAATCAGTTTCACATCATGTATTGTGATGTTTCAATGTGA
GACACAAAAACAATGGCTTGAAACTTGTGTATCATATGTGATTTTGAAATGAACACCTTGAATAGCACTAATTTTTATTTGTGGTATTTT
TCTATAACAAAACAAGTAGCTCTAGGAAAAGAGGTTTTATTTTGTAAACGATCATTTGTGACCTCAGACACTCTCTGGCTAATATTTTAA
TAAGCTCACAGCAGATAATTCTGAGATCATGGGTGAGGGGTGGTGCATGTTGAGATTTAAATTGGCATAAAGCTGCATACTTTTTGTCTA
GCTGTTTGATTTCATTTTTTAATATAGTATGCCAATTTTGTGACTGTTACCATGTGAAAGTCCTGTTGAAATGAACAATTGTCTGCCCCA
CAATCAAGAATGTATGTGTAAAGTGTGAATAAATCTCATATCAAATGTCAAACTTTTACATGTGAATGATTTTCTCAAAGAACATAGAAA

>31804_31804_4_FUS-GBAS_FUS_chr16_31196500_ENST00000380244_GBAS_chr7_56062586_ENST00000446778_length(amino acids)=342AA_BP=219
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGARAIRFRQ

--------------------------------------------------------------
>31804_31804_5_FUS-GBAS_FUS_chr16_31196500_ENST00000568685_GBAS_chr7_56062586_ENST00000322090_length(transcript)=2181nt_BP=828nt
AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA
AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG
TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA
GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG
CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG
CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA
CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGG
CAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGG
TGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGG
AGGCAGAGGTGGCATGGGGGCTCGTGCAATCCGCTTCAGACAGGATGGTAACGAAGCCGTCGGAGGATTCTTCTCTCAGATTGGGCAGCT
GTACATGGTGCACCATCTTTGGGCTTACAGGGATCTTCAGACCAGGGAAGACATACGGAATGCAGCATGGCACAAACATGGCTGGGAGGA
ATTGGTATATTACACAGTTCCACTTATTCAGGAAATGGAATCCAGAATCATGATCCCACTGAAGACCTCGCCCCTCCAGTAAAGCTGTAG
AGTTTCTATGTGCCTACATACATTTCTGTGACAAGTATTTGTCGTAAATTAATTTTAATTGTGTATCAAGTGAAAAAGAAACACTGAGGT
TTTAAGCTGCTGTATATAGCTTGTGAGAAACCTCTTTTCTTTAAAATTTACATAATCACAAGAAAGGAAAGAATTACAGTTGGACTGATT
GTGACAGTGCCTTGTCGTCCTCTTTGAAACACCCCGTGTTGTCCAGTATACCTTATAACACTGAGCCACTTCTCCCCACCCTCCAGAAGG
GGTCCACGTTGAATTCTGAATCATCTTGAAAATAAGATTCCAACCACAAAAAAAATTTAGCCATTTCTTTACTAAAAAAAACCAAAAAAC
AAATCTGTTTTATAATCACAGATTTTTAGACAAATTTCTTGTATCAGGAAGAAATACAAATTTTGTCATGTTTCTCAAGCAGTTTTTCTG
AGTAGTTTCTGAGGAGGAACAAATTACAAGTGTACCCAATAACTGAAAATGTTTTAACTCACTCTCATTTGTAAGCAGTCCACATAGTAG
ACAATGGGTTTTCCAAGCTGGGCAAGGTACATTTAATCAGTAAATCAGTTTCACATCATGTATTGTGATGTTTCAATGTGAGACACAAAA
ACAATGGCTTGAAACTTGTGTATCATATGTGATTTTGAAATGAACACCTTGAATAGCACTAATTTTTATTTGTGGTATTTTTCTATAACA
AAACAAGTAGCTCTAGGAAAAGAGGTTTTATTTTGTAAACGATCATTTGTGACCTCAGACACTCTCTGGCTAATATTTTAATAAGCTCAC
AGCAGATAATTCTGAGATCATGGGTGAGGGGTGGTGCATGTTGAGATTTAAATTGGCATAAAGCTGCATACTTTTTGTCTAGCTGTTTGA
TTTCATTTTTTAATATAGTATGCCAATTTTGTGACTGTTACCATGTGAAAGTCCTGTTGAAATGAACAATTGTCTGCCCCACAATCAAGA
ATGTATGTGTAAAGTGTGAATAAATCTCATATCAAATGTCAAACTTTTACATGTGAATGATTTTCTCAAAGAACATAGAAAAGTCAATAA

>31804_31804_5_FUS-GBAS_FUS_chr16_31196500_ENST00000568685_GBAS_chr7_56062586_ENST00000322090_length(amino acids)=343AA_BP=220
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGARAIRFR

--------------------------------------------------------------
>31804_31804_6_FUS-GBAS_FUS_chr16_31196500_ENST00000568685_GBAS_chr7_56062586_ENST00000446778_length(transcript)=2181nt_BP=828nt
AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA
AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG
TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA
GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG
CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG
CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA
CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGG
CAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGG
TGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGG
AGGCAGAGGTGGCATGGGGGCTCGTGCAATCCGCTTCAGACAGGATGGTAACGAAGCCGTCGGAGGATTCTTCTCTCAGATTGGGCAGCT
GTACATGGTGCACCATCTTTGGGCTTACAGGGATCTTCAGACCAGGGAAGACATACGGAATGCAGCATGGCACAAACATGGCTGGGAGGA
ATTGGTATATTACACAGTTCCACTTATTCAGGAAATGGAATCCAGAATCATGATCCCACTGAAGACCTCGCCCCTCCAGTAAAGCTGTAG
AGTTTCTATGTGCCTACATACATTTCTGTGACAAGTATTTGTCGTAAATTAATTTTAATTGTGTATCAAGTGAAAAAGAAACACTGAGGT
TTTAAGCTGCTGTATATAGCTTGTGAGAAACCTCTTTTCTTTAAAATTTACATAATCACAAGAAAGGAAAGAATTACAGTTGGACTGATT
GTGACAGTGCCTTGTCGTCCTCTTTGAAACACCCCGTGTTGTCCAGTATACCTTATAACACTGAGCCACTTCTCCCCACCCTCCAGAAGG
GGTCCACGTTGAATTCTGAATCATCTTGAAAATAAGATTCCAACCACAAAAAAAATTTAGCCATTTCTTTACTAAAAAAAACCAAAAAAC
AAATCTGTTTTATAATCACAGATTTTTAGACAAATTTCTTGTATCAGGAAGAAATACAAATTTTGTCATGTTTCTCAAGCAGTTTTTCTG
AGTAGTTTCTGAGGAGGAACAAATTACAAGTGTACCCAATAACTGAAAATGTTTTAACTCACTCTCATTTGTAAGCAGTCCACATAGTAG
ACAATGGGTTTTCCAAGCTGGGCAAGGTACATTTAATCAGTAAATCAGTTTCACATCATGTATTGTGATGTTTCAATGTGAGACACAAAA
ACAATGGCTTGAAACTTGTGTATCATATGTGATTTTGAAATGAACACCTTGAATAGCACTAATTTTTATTTGTGGTATTTTTCTATAACA
AAACAAGTAGCTCTAGGAAAAGAGGTTTTATTTTGTAAACGATCATTTGTGACCTCAGACACTCTCTGGCTAATATTTTAATAAGCTCAC
AGCAGATAATTCTGAGATCATGGGTGAGGGGTGGTGCATGTTGAGATTTAAATTGGCATAAAGCTGCATACTTTTTGTCTAGCTGTTTGA
TTTCATTTTTTAATATAGTATGCCAATTTTGTGACTGTTACCATGTGAAAGTCCTGTTGAAATGAACAATTGTCTGCCCCACAATCAAGA
ATGTATGTGTAAAGTGTGAATAAATCTCATATCAAATGTCAAACTTTTACATGTGAATGATTTTCTCAAAGAACATAGAAAAGTCAATAA

>31804_31804_6_FUS-GBAS_FUS_chr16_31196500_ENST00000568685_GBAS_chr7_56062586_ENST00000446778_length(amino acids)=343AA_BP=220
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGARAIRFR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FUS-GBAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUS-GBAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FUS-GBAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource