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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUT10-SH2D4A (FusionGDB2 ID:31832)

Fusion Gene Summary for FUT10-SH2D4A

check button Fusion gene summary
Fusion gene informationFusion gene name: FUT10-SH2D4A
Fusion gene ID: 31832
HgeneTgene
Gene symbol

FUT10

SH2D4A

Gene ID

84750

63898

Gene namefucosyltransferase 10SH2 domain containing 4A
SynonymsFUCTXPPP1R38|SH2A
Cytomap

8p12

8p21.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-(1,3)-fucosyltransferase 10alpha (1,3) fucosyltransferasealpha 1,3-fucosyl transferasefuc-TXfucT-Xfucosyltransferase Xgalactoside 3-L-fucosyltransferase 10SH2 domain-containing protein 4Aprotein SH(2)Aprotein phosphatase 1 regulatory subunit 38
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000518076, ENST00000327671, 
ENST00000335589, ENST00000518672, 
ENST00000524021, 		ENST00000265807, 
ENST00000518040, ENST00000519207, 
Fusion gene scores* DoF score9 X 8 X 7=5042 X 2 X 2=8
# samples 112
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: FUT10 [Title/Abstract] AND SH2D4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUT10(33310733)-SH2D4A(19221582), # samples:1
Anticipated loss of major functional domain due to fusion event.FUT10-SH2D4A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FUT10-SH2D4A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSH2D4A

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across FUT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SH2D4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A49SFUT10chr8

33310733

-SH2D4Achr8

19221582

+


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Fusion Gene ORF analysis for FUT10-SH2D4A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000518076ENST00000265807FUT10chr8

33310733

-SH2D4Achr8

19221582

+
5UTR-3CDSENST00000518076ENST00000518040FUT10chr8

33310733

-SH2D4Achr8

19221582

+
5UTR-3CDSENST00000518076ENST00000519207FUT10chr8

33310733

-SH2D4Achr8

19221582

+
Frame-shiftENST00000327671ENST00000265807FUT10chr8

33310733

-SH2D4Achr8

19221582

+
Frame-shiftENST00000327671ENST00000518040FUT10chr8

33310733

-SH2D4Achr8

19221582

+
Frame-shiftENST00000327671ENST00000519207FUT10chr8

33310733

-SH2D4Achr8

19221582

+
Frame-shiftENST00000335589ENST00000265807FUT10chr8

33310733

-SH2D4Achr8

19221582

+
Frame-shiftENST00000335589ENST00000518040FUT10chr8

33310733

-SH2D4Achr8

19221582

+
Frame-shiftENST00000335589ENST00000519207FUT10chr8

33310733

-SH2D4Achr8

19221582

+
In-frameENST00000518672ENST00000265807FUT10chr8

33310733

-SH2D4Achr8

19221582

+
In-frameENST00000518672ENST00000518040FUT10chr8

33310733

-SH2D4Achr8

19221582

+
In-frameENST00000518672ENST00000519207FUT10chr8

33310733

-SH2D4Achr8

19221582

+
In-frameENST00000524021ENST00000265807FUT10chr8

33310733

-SH2D4Achr8

19221582

+
In-frameENST00000524021ENST00000518040FUT10chr8

33310733

-SH2D4Achr8

19221582

+
In-frameENST00000524021ENST00000519207FUT10chr8

33310733

-SH2D4Achr8

19221582

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000518672FUT10chr833310733-ENST00000265807SH2D4Achr819221582+27705352431193316
ENST00000518672FUT10chr833310733-ENST00000518040SH2D4Achr819221582+15795352431193316
ENST00000518672FUT10chr833310733-ENST00000519207SH2D4Achr819221582+15055352431193316
ENST00000524021FUT10chr833310733-ENST00000265807SH2D4Achr819221582+29006651391323394
ENST00000524021FUT10chr833310733-ENST00000518040SH2D4Achr819221582+17096651391323394
ENST00000524021FUT10chr833310733-ENST00000519207SH2D4Achr819221582+16356651391323394

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000518672ENST00000265807FUT10chr833310733-SH2D4Achr819221582+0.0043605090.99563944
ENST00000518672ENST00000518040FUT10chr833310733-SH2D4Achr819221582+0.0108003740.98919964
ENST00000518672ENST00000519207FUT10chr833310733-SH2D4Achr819221582+0.011604180.9883958
ENST00000524021ENST00000265807FUT10chr833310733-SH2D4Achr819221582+0.0046050150.995395
ENST00000524021ENST00000518040FUT10chr833310733-SH2D4Achr819221582+0.0115646930.98843527
ENST00000524021ENST00000519207FUT10chr833310733-SH2D4Achr819221582+0.0124368440.98756313

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Fusion Genomic Features for FUT10-SH2D4A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FUT10chr833310733-SH2D4Achr819221582+0.95205870.047941342
FUT10chr833310733-SH2D4Achr819221582+0.95205870.047941342

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FUT10-SH2D4A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:33310733/chr8:19221582)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUT10chr8:33310733chr8:19221582ENST00000327671-351_8125480.0Topological domainCytoplasmic
HgeneFUT10chr8:33310733chr8:19221582ENST00000335589-351_850358.0Topological domainCytoplasmic
HgeneFUT10chr8:33310733chr8:19221582ENST00000518672-241_897452.0Topological domainCytoplasmic
HgeneFUT10chr8:33310733chr8:19221582ENST00000524021-351_897452.0Topological domainCytoplasmic
HgeneFUT10chr8:33310733chr8:19221582ENST00000327671-359_31125480.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneFUT10chr8:33310733chr8:19221582ENST00000335589-359_3150358.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneFUT10chr8:33310733chr8:19221582ENST00000518672-249_3197452.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneFUT10chr8:33310733chr8:19221582ENST00000524021-359_3197452.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSH2D4Achr8:33310733chr8:19221582ENST00000265807510347_440235455.0DomainSH2
TgeneSH2D4Achr8:33310733chr8:19221582ENST0000051804049347_440190410.0DomainSH2
TgeneSH2D4Achr8:33310733chr8:19221582ENST00000519207510347_440235455.0DomainSH2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUT10chr8:33310733chr8:19221582ENST00000327671-3532_479125480.0Topological domainLumenal
HgeneFUT10chr8:33310733chr8:19221582ENST00000335589-3532_47950358.0Topological domainLumenal
HgeneFUT10chr8:33310733chr8:19221582ENST00000518672-2432_47997452.0Topological domainLumenal
HgeneFUT10chr8:33310733chr8:19221582ENST00000524021-3532_47997452.0Topological domainLumenal
TgeneSH2D4Achr8:33310733chr8:19221582ENST00000265807510172_177235455.0Compositional biasNote=Poly-Ser
TgeneSH2D4Achr8:33310733chr8:19221582ENST0000051804049172_177190410.0Compositional biasNote=Poly-Ser
TgeneSH2D4Achr8:33310733chr8:19221582ENST00000519207510172_177235455.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for FUT10-SH2D4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31832_31832_1_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000518672_SH2D4A_chr8_19221582_ENST00000265807_length(transcript)=2770nt_BP=535nt
AGAATTTTTTTGATTCCTTCTTATTTGGAGAAATCTCCAGCTGCTCTGATGATAGCCTAAGAAGACTGCATGCTGCTTCCTCTCGATGCC
AAGCCAGACCCTCTCACAACCTCGGATCTCAGTCCTTCATGGAGACCTGGTCCCAGCAGGAATGGCAGTGCAGGAAATTGGCGCCCAGAT
GGTTCTTCCATGTGAAGTTGTCTCGGGCTCTGGGCTGACGAGAGAACACCTGGTAACCAGGTCATGGTTGAGCTGGGGAAGTTTGAAAGG
AAGGAGTTTAAAAGTTCCAGTTTGCAAGATGGACATACAAAAATGGAGGAAGCACCTACGCATCTTAATTCATTTCTTAAGAAAGAAGGA
TTGACCTTCAACAGGAAAAGAAAATGGGAATTGGACAGCTACCCCATTATGCTCTGGTGGTCCCCGCTGACGGGGGAGACTGGGAGGTTA
GGCCAATGTGGAGCAGATGCTTGTTTCTTCACCATCAACCGGACCTACCTCCATCATCACATGACCAAAGCATTCCTCTTCTATGTGCGA
AAATCCAAAGCAGCTGATGAGAAGAGACGCTCCTTGGCTAAACAAGCACGAGAAGACTACAAGAGGTTATCCCTCGGGGCCCAGAAAGGA
AGAGGCGGTGAGAGGCTGCAAAGCCCCTTGCGTGTTCCGCAGAAACCAGAAAGACCTCCCCTTCCACCCAAGCCTCAGTTCCTAAACTCA
GGGGCATATCCTCAAAAACCTCTTAGAAATCAGGGAGTGGTGAGGACACTGTCCAGCTCTGCCCAAGAGGACATCATCCGGTGGTTTAAA
GAGGAGCAGCTACCACTTCGAGCGGGCTACCAGAAAACCTCAGACACCATAGCCCCCTGGTTCCATGGAATTCTCACACTCAAGAAAGCA
AATGAACTTCTTCTGAGCACAGGCATGCCCGGCAGTTTTCTCATCCGAGTCAGTGAAAGGATCAAAGGCTATGCCCTGTCCTATCTGTCG
GAGGACGGCTGTAAACATTTCCTCATCGATGCCTCTGCAGACGCCTACAGCTTCCTGGGCGTGGACCAGCTACAGCATGCCACCTTGGCG
GATTTGGTGGAATATCACAAGGAGGAACCCATCACTTCCCTGGGGAAGGAGCTCCTTCTCTATCCCTGTGGTCAGCAGGACCAGCTGCCT
GACTACCTGGAGCTGTTTGAGTGACAGCCTCCATCAGGGTCATCCTACAGCCTCCAAGCGGGCTTTCCCCTGGACAAATGCCACTGCAAC
ATTTATGTGTGAAGCCAAAATCACCCTGCAGCAGAGCCAATACTGATCAACTGAAAGTAAAGTATCCATGGAGTCCTCATTGACACCTCT
TTTCTGCACAAATACTGGAATTCAATGTCAAGAGAAAATGACCTCTGCTCAAAAGGGAGAAGAGTCTCAATTTCAGCAAGTACCTGTCAT
GAAGGGTATGACCTTAATGATGTACATAAAATAAAACAAATGAAGAAATGGAAAACTTTTAGAAATTAAGGTGTACTTGAAAACGAATAT
CTATCATATGACCCCTGCACTCCCTCTGTATCATCTCAGGAGGTTTCAGGGGCCTGTTGACATGAAGTTTCGAAGTTTCATGTTGGCTTT
GGAATGGTAGCAAAAGCCTTTCCTGGCTGAGATGATGCTTAAAACACACCTCACTTATTGTACATGTTGGAACCAGGACATGAGAGACAT
AGAAAAACAGAAGTCATGAATGTAAATTGAATGAGAGGCTTAACATGCATGAAAATACAGATGGACCTGCAGGAAAGTGAGCAAACATCG
CTGAGTTTGTTTTCTTGTTCGGGAGAATGGGGCCGGGGCTGGCCTGGCCTCCCCTGGATATACTCTATAGTGCACCAAAAGGATAAAGCA
TCTGTACATGTATTTTTTTATTTTTTATCAGAAGTGCTTAGACAAGAACAGAATAAGCAGGCTGTTTGGATGCTACTTGTGGTTGAATTG
TGTTCCCCCAAAATATATGGTGAAGTCTTAACCCCCATCCCCGTGAATGGGACCTTGTTTGGAAATAGGGTCTTTGCAGATATAGTCAAG
ATGAGGTCACATTGGATTAGGGTGGGCCCCAAATCCAATGACTGGCATCCTTAGGAGAAGAGAGAGTTTTGGTAATAGACACAAATGCAG
TGGGAAGAAGACCAGGGGACAAGAGGCAAGTTGGAGTGATGCAGCCGGAAGGGAAGGGACACCAAGGATCTCCGGCCACCAGCAGAAGCC
AGCAGAGAGGCATGGGACAGGTTCCCCACAAGCCTTAGAAGGAAGCATGGCCCTGACTTCAGAATTCCAGACTCCAGAACTGGAAGAATA
AATGTCTGTTGTTTTAAGCTGCTTAGTTCATGCTGAGTTCATGCTGACTTGTTACTATAGCCCCAGAAAGCTAATACAGTCGTTTATGTA
ATTACATAACCTGACACACAAGATCGACCCATTCACTGCTGCCCAGTCCACCATTTTCATAATGAAGTAGAAATGGGAGGTAAGAAAAAC
ATTCCAGCCAGTTCTGTTTAGCCCTGGCACACATATTTGTCCCGTCAGGAATCTTATGCCCTCCTGGAACCCCCGCCCACCTCAGTCCAG
TCCCAGTCAGGCGAACGGCCTCTGGACAGGGACTGAGGTGGCTCTGAGCCACTGGAGATCATTTTTCTTGGAGGATGGAGATTGGCTAGT

>31832_31832_1_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000518672_SH2D4A_chr8_19221582_ENST00000265807_length(amino acids)=316AA_BP=95
MVELGKFERKEFKSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHM
TKAFLFYVRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSA
QEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGV

--------------------------------------------------------------
>31832_31832_2_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000518672_SH2D4A_chr8_19221582_ENST00000518040_length(transcript)=1579nt_BP=535nt
AGAATTTTTTTGATTCCTTCTTATTTGGAGAAATCTCCAGCTGCTCTGATGATAGCCTAAGAAGACTGCATGCTGCTTCCTCTCGATGCC
AAGCCAGACCCTCTCACAACCTCGGATCTCAGTCCTTCATGGAGACCTGGTCCCAGCAGGAATGGCAGTGCAGGAAATTGGCGCCCAGAT
GGTTCTTCCATGTGAAGTTGTCTCGGGCTCTGGGCTGACGAGAGAACACCTGGTAACCAGGTCATGGTTGAGCTGGGGAAGTTTGAAAGG
AAGGAGTTTAAAAGTTCCAGTTTGCAAGATGGACATACAAAAATGGAGGAAGCACCTACGCATCTTAATTCATTTCTTAAGAAAGAAGGA
TTGACCTTCAACAGGAAAAGAAAATGGGAATTGGACAGCTACCCCATTATGCTCTGGTGGTCCCCGCTGACGGGGGAGACTGGGAGGTTA
GGCCAATGTGGAGCAGATGCTTGTTTCTTCACCATCAACCGGACCTACCTCCATCATCACATGACCAAAGCATTCCTCTTCTATGTGCGA
AAATCCAAAGCAGCTGATGAGAAGAGACGCTCCTTGGCTAAACAAGCACGAGAAGACTACAAGAGGTTATCCCTCGGGGCCCAGAAAGGA
AGAGGCGGTGAGAGGCTGCAAAGCCCCTTGCGTGTTCCGCAGAAACCAGAAAGACCTCCCCTTCCACCCAAGCCTCAGTTCCTAAACTCA
GGGGCATATCCTCAAAAACCTCTTAGAAATCAGGGAGTGGTGAGGACACTGTCCAGCTCTGCCCAAGAGGACATCATCCGGTGGTTTAAA
GAGGAGCAGCTACCACTTCGAGCGGGCTACCAGAAAACCTCAGACACCATAGCCCCCTGGTTCCATGGAATTCTCACACTCAAGAAAGCA
AATGAACTTCTTCTGAGCACAGGCATGCCCGGCAGTTTTCTCATCCGAGTCAGTGAAAGGATCAAAGGCTATGCCCTGTCCTATCTGTCG
GAGGACGGCTGTAAACATTTCCTCATCGATGCCTCTGCAGACGCCTACAGCTTCCTGGGCGTGGACCAGCTACAGCATGCCACCTTGGCG
GATTTGGTGGAATATCACAAGGAGGAACCCATCACTTCCCTGGGGAAGGAGCTCCTTCTCTATCCCTGTGGTCAGCAGGACCAGCTGCCT
GACTACCTGGAGCTGTTTGAGTGACAGCCTCCATCAGGGTCATCCTACAGCCTCCAAGCGGGCTTTCCCCTGGACAAATGCCACTGCAAC
ATTTATGTGTGAAGCCAAAATCACCCTGCAGCAGAGCCAATACTGATCAACTGAAAGTAAAGTATCCATGGAGTCCTCATTGACACCTCT
TTTCTGCACAAATACTGGAATTCAATGTCAAGAGAAAATGACCTCTGCTCAAAAGGGAGAAGAGTCTCAATTTCAGCAAGTACCTGTCAT
GAAGGGTATGACCTTAATGATGTACATAAAATAAAACAAATGAAGAAATGGAAAACTTTTAGAAATTAAGGTGTACTTGAAAACGAATAT

>31832_31832_2_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000518672_SH2D4A_chr8_19221582_ENST00000518040_length(amino acids)=316AA_BP=95
MVELGKFERKEFKSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHM
TKAFLFYVRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSA
QEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGV

--------------------------------------------------------------
>31832_31832_3_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000518672_SH2D4A_chr8_19221582_ENST00000519207_length(transcript)=1505nt_BP=535nt
AGAATTTTTTTGATTCCTTCTTATTTGGAGAAATCTCCAGCTGCTCTGATGATAGCCTAAGAAGACTGCATGCTGCTTCCTCTCGATGCC
AAGCCAGACCCTCTCACAACCTCGGATCTCAGTCCTTCATGGAGACCTGGTCCCAGCAGGAATGGCAGTGCAGGAAATTGGCGCCCAGAT
GGTTCTTCCATGTGAAGTTGTCTCGGGCTCTGGGCTGACGAGAGAACACCTGGTAACCAGGTCATGGTTGAGCTGGGGAAGTTTGAAAGG
AAGGAGTTTAAAAGTTCCAGTTTGCAAGATGGACATACAAAAATGGAGGAAGCACCTACGCATCTTAATTCATTTCTTAAGAAAGAAGGA
TTGACCTTCAACAGGAAAAGAAAATGGGAATTGGACAGCTACCCCATTATGCTCTGGTGGTCCCCGCTGACGGGGGAGACTGGGAGGTTA
GGCCAATGTGGAGCAGATGCTTGTTTCTTCACCATCAACCGGACCTACCTCCATCATCACATGACCAAAGCATTCCTCTTCTATGTGCGA
AAATCCAAAGCAGCTGATGAGAAGAGACGCTCCTTGGCTAAACAAGCACGAGAAGACTACAAGAGGTTATCCCTCGGGGCCCAGAAAGGA
AGAGGCGGTGAGAGGCTGCAAAGCCCCTTGCGTGTTCCGCAGAAACCAGAAAGACCTCCCCTTCCACCCAAGCCTCAGTTCCTAAACTCA
GGGGCATATCCTCAAAAACCTCTTAGAAATCAGGGAGTGGTGAGGACACTGTCCAGCTCTGCCCAAGAGGACATCATCCGGTGGTTTAAA
GAGGAGCAGCTACCACTTCGAGCGGGCTACCAGAAAACCTCAGACACCATAGCCCCCTGGTTCCATGGAATTCTCACACTCAAGAAAGCA
AATGAACTTCTTCTGAGCACAGGCATGCCCGGCAGTTTTCTCATCCGAGTCAGTGAAAGGATCAAAGGCTATGCCCTGTCCTATCTGTCG
GAGGACGGCTGTAAACATTTCCTCATCGATGCCTCTGCAGACGCCTACAGCTTCCTGGGCGTGGACCAGCTACAGCATGCCACCTTGGCG
GATTTGGTGGAATATCACAAGGAGGAACCCATCACTTCCCTGGGGAAGGAGCTCCTTCTCTATCCCTGTGGTCAGCAGGACCAGCTGCCT
GACTACCTGGAGCTGTTTGAGTGACAGCCTCCATCAGGGTCATCCTACAGCCTCCAAGCGGGCTTTCCCCTGGACAAATGCCACTGCAAC
ATTTATGTGTGAAGCCAAAATCACCCTGCAGCAGAGCCAATACTGATCAACTGAAAGTAAAGTATCCATGGAGTCCTCATTGACACCTCT
TTTCTGCACAAATACTGGAATTCAATGTCAAGAGAAAATGACCTCTGCTCAAAAGGGAGAAGAGTCTCAATTTCAGCAAGTACCTGTCAT

>31832_31832_3_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000518672_SH2D4A_chr8_19221582_ENST00000519207_length(amino acids)=316AA_BP=95
MVELGKFERKEFKSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHM
TKAFLFYVRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSA
QEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGV

--------------------------------------------------------------
>31832_31832_4_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000524021_SH2D4A_chr8_19221582_ENST00000265807_length(transcript)=2900nt_BP=665nt
ATAGGGAGAAAGGAAGCTGCGCTGCATTCTGCGGGACGAACCCTGCTCCGCGCGAGAATTTTTTTGATTCCTTCTTATTTGGAGAAATCT
CCAGCTGCTCTGATGATAGCCTAAGAAGACTGCATGCTGCTTCCTCTCGATGCCAAGCCAGACCCTCTCACAACCTCGGATCTCAGTCCT
TCATGGAGACCTGGTCCCAGCAGGAATGGCAGTGCAGGAAATTGGCGCCCAGATGGTTCTTCCATGTGAAGTTGTCTCGGGCTCTGGGCT
GACGAGAGAACACCTGGTAACCAGGTTAGCCCTCTGTCAGTCACCCAGGGCAGGGCAGCATGGTGCGGATTCAGAGGAGGAAGCTTTTGG
CATCTTGCCTGTCATGGTTGAGCTGGGGAAGTTTGAAAGGAAGGAGTTTAAAAGTTCCAGTTTGCAAGATGGACATACAAAAATGGAGGA
AGCACCTACGCATCTTAATTCATTTCTTAAGAAAGAAGGATTGACCTTCAACAGGAAAAGAAAATGGGAATTGGACAGCTACCCCATTAT
GCTCTGGTGGTCCCCGCTGACGGGGGAGACTGGGAGGTTAGGCCAATGTGGAGCAGATGCTTGTTTCTTCACCATCAACCGGACCTACCT
CCATCATCACATGACCAAAGCATTCCTCTTCTATGTGCGAAAATCCAAAGCAGCTGATGAGAAGAGACGCTCCTTGGCTAAACAAGCACG
AGAAGACTACAAGAGGTTATCCCTCGGGGCCCAGAAAGGAAGAGGCGGTGAGAGGCTGCAAAGCCCCTTGCGTGTTCCGCAGAAACCAGA
AAGACCTCCCCTTCCACCCAAGCCTCAGTTCCTAAACTCAGGGGCATATCCTCAAAAACCTCTTAGAAATCAGGGAGTGGTGAGGACACT
GTCCAGCTCTGCCCAAGAGGACATCATCCGGTGGTTTAAAGAGGAGCAGCTACCACTTCGAGCGGGCTACCAGAAAACCTCAGACACCAT
AGCCCCCTGGTTCCATGGAATTCTCACACTCAAGAAAGCAAATGAACTTCTTCTGAGCACAGGCATGCCCGGCAGTTTTCTCATCCGAGT
CAGTGAAAGGATCAAAGGCTATGCCCTGTCCTATCTGTCGGAGGACGGCTGTAAACATTTCCTCATCGATGCCTCTGCAGACGCCTACAG
CTTCCTGGGCGTGGACCAGCTACAGCATGCCACCTTGGCGGATTTGGTGGAATATCACAAGGAGGAACCCATCACTTCCCTGGGGAAGGA
GCTCCTTCTCTATCCCTGTGGTCAGCAGGACCAGCTGCCTGACTACCTGGAGCTGTTTGAGTGACAGCCTCCATCAGGGTCATCCTACAG
CCTCCAAGCGGGCTTTCCCCTGGACAAATGCCACTGCAACATTTATGTGTGAAGCCAAAATCACCCTGCAGCAGAGCCAATACTGATCAA
CTGAAAGTAAAGTATCCATGGAGTCCTCATTGACACCTCTTTTCTGCACAAATACTGGAATTCAATGTCAAGAGAAAATGACCTCTGCTC
AAAAGGGAGAAGAGTCTCAATTTCAGCAAGTACCTGTCATGAAGGGTATGACCTTAATGATGTACATAAAATAAAACAAATGAAGAAATG
GAAAACTTTTAGAAATTAAGGTGTACTTGAAAACGAATATCTATCATATGACCCCTGCACTCCCTCTGTATCATCTCAGGAGGTTTCAGG
GGCCTGTTGACATGAAGTTTCGAAGTTTCATGTTGGCTTTGGAATGGTAGCAAAAGCCTTTCCTGGCTGAGATGATGCTTAAAACACACC
TCACTTATTGTACATGTTGGAACCAGGACATGAGAGACATAGAAAAACAGAAGTCATGAATGTAAATTGAATGAGAGGCTTAACATGCAT
GAAAATACAGATGGACCTGCAGGAAAGTGAGCAAACATCGCTGAGTTTGTTTTCTTGTTCGGGAGAATGGGGCCGGGGCTGGCCTGGCCT
CCCCTGGATATACTCTATAGTGCACCAAAAGGATAAAGCATCTGTACATGTATTTTTTTATTTTTTATCAGAAGTGCTTAGACAAGAACA
GAATAAGCAGGCTGTTTGGATGCTACTTGTGGTTGAATTGTGTTCCCCCAAAATATATGGTGAAGTCTTAACCCCCATCCCCGTGAATGG
GACCTTGTTTGGAAATAGGGTCTTTGCAGATATAGTCAAGATGAGGTCACATTGGATTAGGGTGGGCCCCAAATCCAATGACTGGCATCC
TTAGGAGAAGAGAGAGTTTTGGTAATAGACACAAATGCAGTGGGAAGAAGACCAGGGGACAAGAGGCAAGTTGGAGTGATGCAGCCGGAA
GGGAAGGGACACCAAGGATCTCCGGCCACCAGCAGAAGCCAGCAGAGAGGCATGGGACAGGTTCCCCACAAGCCTTAGAAGGAAGCATGG
CCCTGACTTCAGAATTCCAGACTCCAGAACTGGAAGAATAAATGTCTGTTGTTTTAAGCTGCTTAGTTCATGCTGAGTTCATGCTGACTT
GTTACTATAGCCCCAGAAAGCTAATACAGTCGTTTATGTAATTACATAACCTGACACACAAGATCGACCCATTCACTGCTGCCCAGTCCA
CCATTTTCATAATGAAGTAGAAATGGGAGGTAAGAAAAACATTCCAGCCAGTTCTGTTTAGCCCTGGCACACATATTTGTCCCGTCAGGA
ATCTTATGCCCTCCTGGAACCCCCGCCCACCTCAGTCCAGTCCCAGTCAGGCGAACGGCCTCTGGACAGGGACTGAGGTGGCTCTGAGCC
ACTGGAGATCATTTTTCTTGGAGGATGGAGATTGGCTAGTACCTCTGGCCTAACTGTGTAGGTCAATACTCTTTTACATTGCCTTCTAAT

>31832_31832_4_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000524021_SH2D4A_chr8_19221582_ENST00000265807_length(amino acids)=394AA_BP=173
MPSQTLSQPRISVLHGDLVPAGMAVQEIGAQMVLPCEVVSGSGLTREHLVTRLALCQSPRAGQHGADSEEEAFGILPVMVELGKFERKEF
KSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHMTKAFLFYVRKSK
AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQ
LPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV

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>31832_31832_5_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000524021_SH2D4A_chr8_19221582_ENST00000518040_length(transcript)=1709nt_BP=665nt
ATAGGGAGAAAGGAAGCTGCGCTGCATTCTGCGGGACGAACCCTGCTCCGCGCGAGAATTTTTTTGATTCCTTCTTATTTGGAGAAATCT
CCAGCTGCTCTGATGATAGCCTAAGAAGACTGCATGCTGCTTCCTCTCGATGCCAAGCCAGACCCTCTCACAACCTCGGATCTCAGTCCT
TCATGGAGACCTGGTCCCAGCAGGAATGGCAGTGCAGGAAATTGGCGCCCAGATGGTTCTTCCATGTGAAGTTGTCTCGGGCTCTGGGCT
GACGAGAGAACACCTGGTAACCAGGTTAGCCCTCTGTCAGTCACCCAGGGCAGGGCAGCATGGTGCGGATTCAGAGGAGGAAGCTTTTGG
CATCTTGCCTGTCATGGTTGAGCTGGGGAAGTTTGAAAGGAAGGAGTTTAAAAGTTCCAGTTTGCAAGATGGACATACAAAAATGGAGGA
AGCACCTACGCATCTTAATTCATTTCTTAAGAAAGAAGGATTGACCTTCAACAGGAAAAGAAAATGGGAATTGGACAGCTACCCCATTAT
GCTCTGGTGGTCCCCGCTGACGGGGGAGACTGGGAGGTTAGGCCAATGTGGAGCAGATGCTTGTTTCTTCACCATCAACCGGACCTACCT
CCATCATCACATGACCAAAGCATTCCTCTTCTATGTGCGAAAATCCAAAGCAGCTGATGAGAAGAGACGCTCCTTGGCTAAACAAGCACG
AGAAGACTACAAGAGGTTATCCCTCGGGGCCCAGAAAGGAAGAGGCGGTGAGAGGCTGCAAAGCCCCTTGCGTGTTCCGCAGAAACCAGA
AAGACCTCCCCTTCCACCCAAGCCTCAGTTCCTAAACTCAGGGGCATATCCTCAAAAACCTCTTAGAAATCAGGGAGTGGTGAGGACACT
GTCCAGCTCTGCCCAAGAGGACATCATCCGGTGGTTTAAAGAGGAGCAGCTACCACTTCGAGCGGGCTACCAGAAAACCTCAGACACCAT
AGCCCCCTGGTTCCATGGAATTCTCACACTCAAGAAAGCAAATGAACTTCTTCTGAGCACAGGCATGCCCGGCAGTTTTCTCATCCGAGT
CAGTGAAAGGATCAAAGGCTATGCCCTGTCCTATCTGTCGGAGGACGGCTGTAAACATTTCCTCATCGATGCCTCTGCAGACGCCTACAG
CTTCCTGGGCGTGGACCAGCTACAGCATGCCACCTTGGCGGATTTGGTGGAATATCACAAGGAGGAACCCATCACTTCCCTGGGGAAGGA
GCTCCTTCTCTATCCCTGTGGTCAGCAGGACCAGCTGCCTGACTACCTGGAGCTGTTTGAGTGACAGCCTCCATCAGGGTCATCCTACAG
CCTCCAAGCGGGCTTTCCCCTGGACAAATGCCACTGCAACATTTATGTGTGAAGCCAAAATCACCCTGCAGCAGAGCCAATACTGATCAA
CTGAAAGTAAAGTATCCATGGAGTCCTCATTGACACCTCTTTTCTGCACAAATACTGGAATTCAATGTCAAGAGAAAATGACCTCTGCTC
AAAAGGGAGAAGAGTCTCAATTTCAGCAAGTACCTGTCATGAAGGGTATGACCTTAATGATGTACATAAAATAAAACAAATGAAGAAATG

>31832_31832_5_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000524021_SH2D4A_chr8_19221582_ENST00000518040_length(amino acids)=394AA_BP=173
MPSQTLSQPRISVLHGDLVPAGMAVQEIGAQMVLPCEVVSGSGLTREHLVTRLALCQSPRAGQHGADSEEEAFGILPVMVELGKFERKEF
KSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHMTKAFLFYVRKSK
AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQ
LPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV

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>31832_31832_6_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000524021_SH2D4A_chr8_19221582_ENST00000519207_length(transcript)=1635nt_BP=665nt
ATAGGGAGAAAGGAAGCTGCGCTGCATTCTGCGGGACGAACCCTGCTCCGCGCGAGAATTTTTTTGATTCCTTCTTATTTGGAGAAATCT
CCAGCTGCTCTGATGATAGCCTAAGAAGACTGCATGCTGCTTCCTCTCGATGCCAAGCCAGACCCTCTCACAACCTCGGATCTCAGTCCT
TCATGGAGACCTGGTCCCAGCAGGAATGGCAGTGCAGGAAATTGGCGCCCAGATGGTTCTTCCATGTGAAGTTGTCTCGGGCTCTGGGCT
GACGAGAGAACACCTGGTAACCAGGTTAGCCCTCTGTCAGTCACCCAGGGCAGGGCAGCATGGTGCGGATTCAGAGGAGGAAGCTTTTGG
CATCTTGCCTGTCATGGTTGAGCTGGGGAAGTTTGAAAGGAAGGAGTTTAAAAGTTCCAGTTTGCAAGATGGACATACAAAAATGGAGGA
AGCACCTACGCATCTTAATTCATTTCTTAAGAAAGAAGGATTGACCTTCAACAGGAAAAGAAAATGGGAATTGGACAGCTACCCCATTAT
GCTCTGGTGGTCCCCGCTGACGGGGGAGACTGGGAGGTTAGGCCAATGTGGAGCAGATGCTTGTTTCTTCACCATCAACCGGACCTACCT
CCATCATCACATGACCAAAGCATTCCTCTTCTATGTGCGAAAATCCAAAGCAGCTGATGAGAAGAGACGCTCCTTGGCTAAACAAGCACG
AGAAGACTACAAGAGGTTATCCCTCGGGGCCCAGAAAGGAAGAGGCGGTGAGAGGCTGCAAAGCCCCTTGCGTGTTCCGCAGAAACCAGA
AAGACCTCCCCTTCCACCCAAGCCTCAGTTCCTAAACTCAGGGGCATATCCTCAAAAACCTCTTAGAAATCAGGGAGTGGTGAGGACACT
GTCCAGCTCTGCCCAAGAGGACATCATCCGGTGGTTTAAAGAGGAGCAGCTACCACTTCGAGCGGGCTACCAGAAAACCTCAGACACCAT
AGCCCCCTGGTTCCATGGAATTCTCACACTCAAGAAAGCAAATGAACTTCTTCTGAGCACAGGCATGCCCGGCAGTTTTCTCATCCGAGT
CAGTGAAAGGATCAAAGGCTATGCCCTGTCCTATCTGTCGGAGGACGGCTGTAAACATTTCCTCATCGATGCCTCTGCAGACGCCTACAG
CTTCCTGGGCGTGGACCAGCTACAGCATGCCACCTTGGCGGATTTGGTGGAATATCACAAGGAGGAACCCATCACTTCCCTGGGGAAGGA
GCTCCTTCTCTATCCCTGTGGTCAGCAGGACCAGCTGCCTGACTACCTGGAGCTGTTTGAGTGACAGCCTCCATCAGGGTCATCCTACAG
CCTCCAAGCGGGCTTTCCCCTGGACAAATGCCACTGCAACATTTATGTGTGAAGCCAAAATCACCCTGCAGCAGAGCCAATACTGATCAA
CTGAAAGTAAAGTATCCATGGAGTCCTCATTGACACCTCTTTTCTGCACAAATACTGGAATTCAATGTCAAGAGAAAATGACCTCTGCTC
AAAAGGGAGAAGAGTCTCAATTTCAGCAAGTACCTGTCATGAAGGGTATGACCTTAATGATGTACATAAAATAAAACAAATGAAGAAATG

>31832_31832_6_FUT10-SH2D4A_FUT10_chr8_33310733_ENST00000524021_SH2D4A_chr8_19221582_ENST00000519207_length(amino acids)=394AA_BP=173
MPSQTLSQPRISVLHGDLVPAGMAVQEIGAQMVLPCEVVSGSGLTREHLVTRLALCQSPRAGQHGADSEEEAFGILPVMVELGKFERKEF
KSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHMTKAFLFYVRKSK
AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQ
LPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV

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Fusion Gene PPI Analysis for FUT10-SH2D4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUT10-SH2D4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FUT10-SH2D4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource