FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FUT3-FUT3 (FusionGDB2 ID:31838)

Fusion Gene Summary for FUT3-FUT3

check button Fusion gene summary
Fusion gene informationFusion gene name: FUT3-FUT3
Fusion gene ID: 31838
HgeneTgene
Gene symbol

FUT3

FUT3

Gene ID

2525

2525

Gene namefucosyltransferase 3 (Lewis blood group)fucosyltransferase 3 (Lewis blood group)
SynonymsCD174|FT3B|FucT-III|LE|LesCD174|FT3B|FucT-III|LE|Les
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiongalactoside 3(4)-L-fucosyltransferaseLewis FTalpha-(1,3/1,4)-fucosyltransferaseblood group Lewis alpha-4-fucosyltransferasefucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)fucosyltransferase IIIgalactoside 3(4)-L-fucosyltransferaseLewis FTalpha-(1,3/1,4)-fucosyltransferaseblood group Lewis alpha-4-fucosyltransferasefucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)fucosyltransferase III
Modification date2020032720200327
UniProtAcc

P21217

P21217

Ensembl transtripts involved in fusion geneENST00000303225, ENST00000458379, 
ENST00000589620, ENST00000589918, 
ENST00000593144, 		ENST00000303225, 
ENST00000458379, ENST00000589620, 
ENST00000589918, ENST00000593144, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 3=12
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUT3 [Title/Abstract] AND FUT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUT3(5851465)-FUT3(5843724), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUT3

GO:0006672

ceramide metabolic process

7721776|12668675

HgeneFUT3

GO:0009312

oligosaccharide biosynthetic process

1977660

HgeneFUT3

GO:0043413

macromolecule glycosylation

1977660|12668675

TgeneFUT3

GO:0006672

ceramide metabolic process

7721776|12668675

TgeneFUT3

GO:0009312

oligosaccharide biosynthetic process

1977660

TgeneFUT3

GO:0043413

macromolecule glycosylation

1977660|12668675


check buttonFusion gene breakpoints across FUT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FUT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW375778FUT3chr19

5851465

+FUT3chr19

5843724

-


Top

Fusion Gene ORF analysis for FUT3-FUT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000303225ENST00000303225FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000303225ENST00000458379FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000303225ENST00000589620FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000303225ENST00000589918FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000458379ENST00000303225FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000458379ENST00000458379FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000458379ENST00000589620FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000458379ENST00000589918FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589620ENST00000303225FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589620ENST00000458379FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589620ENST00000589620FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589620ENST00000589918FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589918ENST00000303225FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589918ENST00000458379FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589918ENST00000589620FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000589918ENST00000589918FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000593144ENST00000303225FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000593144ENST00000458379FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000593144ENST00000589620FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-3UTRENST00000593144ENST00000589918FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-intronENST00000303225ENST00000593144FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-intronENST00000458379ENST00000593144FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-intronENST00000589620ENST00000593144FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-intronENST00000589918ENST00000593144FUT3chr19

5851465

+FUT3chr19

5843724

-
intron-intronENST00000593144ENST00000593144FUT3chr19

5851465

+FUT3chr19

5843724

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for FUT3-FUT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FUT3-FUT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:5851465/:5843724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUT3

P21217

FUT3

P21217

FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:12668675, PubMed:1977660, PubMed:11058871). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:12668675, PubMed:11058871, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660). {ECO:0000269|PubMed:11058871, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:1977660, ECO:0000269|PubMed:27453266, ECO:0000269|PubMed:7721776}.FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:12668675, PubMed:1977660, PubMed:11058871). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:12668675, PubMed:11058871, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660). {ECO:0000269|PubMed:11058871, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:1977660, ECO:0000269|PubMed:27453266, ECO:0000269|PubMed:7721776}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for FUT3-FUT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for FUT3-FUT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FUT3-FUT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FUT3-FUT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource