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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FXR1-MCCC1 (FusionGDB2 ID:31873)

Fusion Gene Summary for FXR1-MCCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: FXR1-MCCC1
Fusion gene ID: 31873
HgeneTgene
Gene symbol

FXR1

MCCC1

Gene ID

8087

56922

Gene nameFMR1 autosomal homolog 1methylcrotonoyl-CoA carboxylase 1
SynonymsFXR1PMCC-B|MCCA
Cytomap

3q26.33

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionfragile X mental retardation syndrome-related protein 1fragile X mental retardation, autosomal homolog 1methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial3-methylcrotonyl-CoA carboxylase 13-methylcrotonyl-CoA carboxylase biotin-containing subunit3-methylcrotonyl-CoA:carbon dioxide ligase subunit alphaMCCase subunit alphamethylcrotonoyl-CoA ca
Modification date2020032020200313
UniProtAcc.

Q96RQ3

Ensembl transtripts involved in fusion geneENST00000357559, ENST00000445140, 
ENST00000491062, ENST00000491674, 
ENST00000305586, ENST00000468861, 
ENST00000480918, 		ENST00000539926, 
ENST00000489909, ENST00000265594, 
ENST00000492597, 
Fusion gene scores* DoF score17 X 9 X 7=10718 X 8 X 4=256
# samples 208
** MAII scorelog2(20/1071*10)=-2.42088657497553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FXR1 [Title/Abstract] AND MCCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFXR1(180630524)-MCCC1(182790275), # samples:4
MCCC1(182788787)-FXR1(180679256), # samples:3
Anticipated loss of major functional domain due to fusion event.MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MCCC1-FXR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFXR1

GO:2000637

positive regulation of gene silencing by miRNA

17057366


check buttonFusion gene breakpoints across FXR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MCCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8580-01AFXR1chr3

180630524

-MCCC1chr3

182790275

-
ChimerDB4LUSCTCGA-85-8580-01AFXR1chr3

180630524

+MCCC1chr3

182790275

-
ChimerDB4LUSCTCGA-85-8580FXR1chr3

180630524

+MCCC1chr3

182790275

-


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Fusion Gene ORF analysis for FXR1-MCCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000357559ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-5UTRENST00000445140ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-5UTRENST00000491062ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-5UTRENST00000491674ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-intronENST00000357559ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-intronENST00000445140ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-intronENST00000491062ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-
5CDS-intronENST00000491674ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-3CDSENST00000305586ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-3CDSENST00000305586ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-3CDSENST00000468861ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-3CDSENST00000468861ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-5UTRENST00000305586ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-5UTRENST00000468861ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-intronENST00000305586ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-
5UTR-intronENST00000468861ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000357559ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000357559ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000445140ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000445140ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000491062ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000491062ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000491674ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
In-frameENST00000491674ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
intron-3CDSENST00000480918ENST00000265594FXR1chr3

180630524

+MCCC1chr3

182790275

-
intron-3CDSENST00000480918ENST00000492597FXR1chr3

180630524

+MCCC1chr3

182790275

-
intron-5UTRENST00000480918ENST00000539926FXR1chr3

180630524

+MCCC1chr3

182790275

-
intron-intronENST00000480918ENST00000489909FXR1chr3

180630524

+MCCC1chr3

182790275

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357559FXR1chr3180630524+ENST00000265594MCCC1chr3182790275-246443502243747
ENST00000357559FXR1chr3180630524+ENST00000492597MCCC1chr3182790275-246443502243747
ENST00000491674FXR1chr3180630524+ENST00000265594MCCC1chr3182790275-2228199972007636
ENST00000491674FXR1chr3180630524+ENST00000492597MCCC1chr3182790275-2228199972007636
ENST00000491062FXR1chr3180630524+ENST00000265594MCCC1chr3182790275-209566151874619
ENST00000491062FXR1chr3180630524+ENST00000492597MCCC1chr3182790275-209566151874619
ENST00000445140FXR1chr3180630524+ENST00000265594MCCC1chr3182790275-209465141873619
ENST00000445140FXR1chr3180630524+ENST00000492597MCCC1chr3182790275-209465141873619

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357559ENST00000265594FXR1chr3180630524+MCCC1chr3182790275-0.003838270.9961617
ENST00000357559ENST00000492597FXR1chr3180630524+MCCC1chr3182790275-0.003838270.9961617
ENST00000491674ENST00000265594FXR1chr3180630524+MCCC1chr3182790275-0.0015768570.9984231
ENST00000491674ENST00000492597FXR1chr3180630524+MCCC1chr3182790275-0.0015768570.9984231
ENST00000491062ENST00000265594FXR1chr3180630524+MCCC1chr3182790275-0.0018747990.99812526
ENST00000491062ENST00000492597FXR1chr3180630524+MCCC1chr3182790275-0.0018747990.99812526
ENST00000445140ENST00000265594FXR1chr3180630524+MCCC1chr3182790275-0.0018835880.9981165
ENST00000445140ENST00000492597FXR1chr3180630524+MCCC1chr3182790275-0.0018835880.9981165

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Fusion Genomic Features for FXR1-MCCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FXR1-MCCC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:180630524/chr3:182790275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MCCC1

Q96RQ3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMCCC1chr3:180630524chr3:182790275ENST00000265594319167_364123726.0DomainATP-grasp
TgeneMCCC1chr3:180630524chr3:182790275ENST00000265594319643_715123726.0DomainBiotinyl-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+118502_5100537.0Compositional biasNote=Poly-Arg
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+11850_530537.0Compositional biasNote=Poly-Pro
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+117502_51017622.0Compositional biasNote=Poly-Arg
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+11750_5317622.0Compositional biasNote=Poly-Pro
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+116502_51017540.0Compositional biasNote=Poly-Arg
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+11650_5317540.0Compositional biasNote=Poly-Pro
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+118222_2510537.0DomainKH 1
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+118285_3140537.0DomainKH 2
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+1184_500537.0DomainAgenet-like 1
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+11863_1150537.0DomainAgenet-like 2
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+117222_25117622.0DomainKH 1
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+117285_31417622.0DomainKH 2
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+1174_5017622.0DomainAgenet-like 1
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+11763_11517622.0DomainAgenet-like 2
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+116222_25117540.0DomainKH 1
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+116285_31417540.0DomainKH 2
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+1164_5017540.0DomainAgenet-like 1
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+11663_11517540.0DomainAgenet-like 2
HgeneFXR1chr3:180630524chr3:182790275ENST00000305586+118442_4570537.0RegionNote=RNA-binding RGG-box
HgeneFXR1chr3:180630524chr3:182790275ENST00000357559+117442_45717622.0RegionNote=RNA-binding RGG-box
HgeneFXR1chr3:180630524chr3:182790275ENST00000445140+116442_45717540.0RegionNote=RNA-binding RGG-box
TgeneMCCC1chr3:180630524chr3:182790275ENST0000026559431948_494123726.0DomainNote=Biotin carboxylation


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Fusion Gene Sequence for FXR1-MCCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31873_31873_1_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000357559_MCCC1_chr3_182790275_ENST00000265594_length(transcript)=2464nt_BP=435nt
ATGCCGATGCGCCGGGCAGGCTGTGCCTGGGCAGTTCATTCTGTGGCAGCTGGAGGCACTACTCGGCCGCCGCGGTGCGAACTGCGGGCA
CTGTGGGGCGGAGACCTAGGGGCGGGTCAACAAAGGTCGGGCGATTGTGTCTGGAGGCAAATCCGACGTAGACGGCGGCAGGCGGAGCCC
AAAGCCGGTGATGCAGGGTGCGCAGGGATCCCACCTGGAGAGTCGGGGCGGCACGTTGAGACCCCAGGGGTGAAGGGCGGGGGATCCCAA
TCCCAGCCCTGTTTTCCCCTCCCCTTTCCCCGCCTCCTTCTCGCCCCTCCCCCCTCCTCCCCTCTGGTTGGAAAGTTTCTAGAATCTCTT
CCCAGCGGCCTTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTCTAACGGGGCTTTCTACAAGGCTATCCATCCAGGA
TGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGA
GACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGAC
CAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTT
AGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAG
TTTGTAGACACACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTG
CAGAGGCGACATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGAAGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGA
GCTGCTAAAGCTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTCAAAACATAATTTCTGTTTCATGGAGATGAATACA
AGGCTGCAAGTGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATT
CCTTTGAGCCAGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACTTCATGCCTGTG
GCAGGCCCATTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGAAACTGGAGTACGGCAAGGAGACGAAGTTTCCGTG
CATTATGACCCCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGCATTGACAAAACTGAGGTACAGCCTTCGTCAGTAC
AATATTGTTGGACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTC
ATCCCTCAACACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAG
GAGAAAGCCATGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATTTTCGTCTAGCAGTGGAAGAAGACTGAATATCTCG
TATACCAGAAACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAACGTATAACCATGATGGGTCTTATAGCATGCAGATT
GAAGATAAAACTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAA
GCGAAGCTGATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGACATTCCAGTCCCCAAATACTTATCT
TCTGTGAGCTCACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTG
AAAGCGGGAGATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTC
TACAGAGAAGGTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAATCGGAATAAACTCCA
GCAAGGAAATGGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGCCTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGT
TTTACTAAATGATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCATTTGGGTCACTAATTATCTCAAAATATTTCATAC

>31873_31873_1_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000357559_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=747AA_BP=145
MPMRRAGCAWAVHSVAAGGTTRPPRCELRALWGGDLGAGQQRSGDCVWRQIRRRRRQAEPKAGDAGCAGIPPGESGRHVETPGVKGGGSQ
SQPCFPLPFPRLLLAPPPSSPLVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIR
DMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK
FVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNT
RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV
HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILK
EKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASK
AKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVF

--------------------------------------------------------------
>31873_31873_2_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000357559_MCCC1_chr3_182790275_ENST00000492597_length(transcript)=2464nt_BP=435nt
ATGCCGATGCGCCGGGCAGGCTGTGCCTGGGCAGTTCATTCTGTGGCAGCTGGAGGCACTACTCGGCCGCCGCGGTGCGAACTGCGGGCA
CTGTGGGGCGGAGACCTAGGGGCGGGTCAACAAAGGTCGGGCGATTGTGTCTGGAGGCAAATCCGACGTAGACGGCGGCAGGCGGAGCCC
AAAGCCGGTGATGCAGGGTGCGCAGGGATCCCACCTGGAGAGTCGGGGCGGCACGTTGAGACCCCAGGGGTGAAGGGCGGGGGATCCCAA
TCCCAGCCCTGTTTTCCCCTCCCCTTTCCCCGCCTCCTTCTCGCCCCTCCCCCCTCCTCCCCTCTGGTTGGAAAGTTTCTAGAATCTCTT
CCCAGCGGCCTTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTCTAACGGGGCTTTCTACAAGGCTATCCATCCAGGA
TGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGA
GACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGAC
CAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTT
AGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAG
TTTGTAGACACACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTG
CAGAGGCGACATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGAAGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGA
GCTGCTAAAGCTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTCAAAACATAATTTCTGTTTCATGGAGATGAATACA
AGGCTGCAAGTGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATT
CCTTTGAGCCAGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACTTCATGCCTGTG
GCAGGCCCATTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGAAACTGGAGTACGGCAAGGAGACGAAGTTTCCGTG
CATTATGACCCCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGCATTGACAAAACTGAGGTACAGCCTTCGTCAGTAC
AATATTGTTGGACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTC
ATCCCTCAACACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAG
GAGAAAGCCATGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATTTTCGTCTAGCAGTGGAAGAAGACTGAATATCTCG
TATACCAGAAACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAACGTATAACCATGATGGGTCTTATAGCATGCAGATT
GAAGATAAAACTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAA
GCGAAGCTGATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGACATTCCAGTCCCCAAATACTTATCT
TCTGTGAGCTCACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTG
AAAGCGGGAGATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTC
TACAGAGAAGGTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAATCGGAATAAACTCCA
GCAAGGAAATGGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGCCTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGT
TTTACTAAATGATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCATTTGGGTCACTAATTATCTCAAAATATTTCATAC

>31873_31873_2_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000357559_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=747AA_BP=145
MPMRRAGCAWAVHSVAAGGTTRPPRCELRALWGGDLGAGQQRSGDCVWRQIRRRRRQAEPKAGDAGCAGIPPGESGRHVETPGVKGGGSQ
SQPCFPLPFPRLLLAPPPSSPLVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIR
DMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK
FVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNT
RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV
HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILK
EKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASK
AKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVF

--------------------------------------------------------------
>31873_31873_3_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000445140_MCCC1_chr3_182790275_ENST00000265594_length(transcript)=2094nt_BP=65nt
TTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTCTAACGGGGCTTTCTACAAGGCTATCCATCCAGGATGCGGTTTTC
TCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTA
TAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGA
AGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAAC
AAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACA
CACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTGCAGAGGCGAC
ATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGAAGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGAGCTGCTAAAG
CTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTCAAAACATAATTTCTGTTTCATGGAGATGAATACAAGGCTGCAAG
TGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGCC
AGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACTTCATGCCTGTGGCAGGCCCAT
TAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGAAACTGGAGTACGGCAAGGAGACGAAGTTTCCGTGCATTATGACC
CCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGCATTGACAAAACTGAGGTACAGCCTTCGTCAGTACAATATTGTTG
GACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCTCAAC
ACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAGGAGAAAGCCA
TGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATTTTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGAA
ACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAACGTATAACCATGATGGGTCTTATAGCATGCAGATTGAAGATAAAA
CTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAAGCGAAGCTGA
TTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGACATTCCAGTCCCCAAATACTTATCTTCTGTGAGCT
CACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGGGAG
ATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTCTACAGAGAAG
GTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAATCGGAATAAACTCCAGCAAGGAAAT
GGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGCCTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGTTTTACTAAAT
GATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCATTTGGGTCACTAATTATCTCAAAATATTTCATACTAATAAAGTT

>31873_31873_3_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000445140_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------
>31873_31873_4_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000445140_MCCC1_chr3_182790275_ENST00000492597_length(transcript)=2094nt_BP=65nt
TTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTCTAACGGGGCTTTCTACAAGGCTATCCATCCAGGATGCGGTTTTC
TCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTA
TAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGA
AGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAAC
AAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACA
CACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTGCAGAGGCGAC
ATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGAAGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGAGCTGCTAAAG
CTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTCAAAACATAATTTCTGTTTCATGGAGATGAATACAAGGCTGCAAG
TGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGCC
AGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACTTCATGCCTGTGGCAGGCCCAT
TAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGAAACTGGAGTACGGCAAGGAGACGAAGTTTCCGTGCATTATGACC
CCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGCATTGACAAAACTGAGGTACAGCCTTCGTCAGTACAATATTGTTG
GACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCTCAAC
ACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAGGAGAAAGCCA
TGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATTTTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGAA
ACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAACGTATAACCATGATGGGTCTTATAGCATGCAGATTGAAGATAAAA
CTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAAGCGAAGCTGA
TTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGACATTCCAGTCCCCAAATACTTATCTTCTGTGAGCT
CACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGGGAG
ATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTCTACAGAGAAG
GTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAATCGGAATAAACTCCAGCAAGGAAAT
GGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGCCTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGTTTTACTAAAT
GATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCATTTGGGTCACTAATTATCTCAAAATATTTCATACTAATAAAGTT

>31873_31873_4_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000445140_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------
>31873_31873_5_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491062_MCCC1_chr3_182790275_ENST00000265594_length(transcript)=2095nt_BP=66nt
CTTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTCTAACGGGGCTTTCTACAAGGCTATCCATCCAGGATGCGGTTTT
CTCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGT
ATAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTG
AAGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAA
CAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGAC
ACACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTGCAGAGGCGA
CATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGAAGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGAGCTGCTAAA
GCTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTCAAAACATAATTTCTGTTTCATGGAGATGAATACAAGGCTGCAA
GTGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGC
CAGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACTTCATGCCTGTGGCAGGCCCA
TTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGAAACTGGAGTACGGCAAGGAGACGAAGTTTCCGTGCATTATGAC
CCCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGCATTGACAAAACTGAGGTACAGCCTTCGTCAGTACAATATTGTT
GGACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCTCAA
CACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAGGAGAAAGCC
ATGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATTTTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGA
AACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAACGTATAACCATGATGGGTCTTATAGCATGCAGATTGAAGATAAA
ACTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAAGCGAAGCTG
ATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGACATTCCAGTCCCCAAATACTTATCTTCTGTGAGC
TCACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGGGA
GATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTCTACAGAGAA
GGTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAATCGGAATAAACTCCAGCAAGGAAA
TGGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGCCTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGTTTTACTAAA
TGATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCATTTGGGTCACTAATTATCTCAAAATATTTCATACTAATAAAGT

>31873_31873_5_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491062_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------
>31873_31873_6_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491062_MCCC1_chr3_182790275_ENST00000492597_length(transcript)=2095nt_BP=66nt
CTTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTCTAACGGGGCTTTCTACAAGGCTATCCATCCAGGATGCGGTTTT
CTCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGT
ATAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTG
AAGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAA
CAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAAGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGAC
ACACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTGCAGAGGCGA
CATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGAAGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGAGCTGCTAAA
GCTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTCAAAACATAATTTCTGTTTCATGGAGATGAATACAAGGCTGCAA
GTGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGC
CAGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACTTCATGCCTGTGGCAGGCCCA
TTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGAAACTGGAGTACGGCAAGGAGACGAAGTTTCCGTGCATTATGAC
CCCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGCATTGACAAAACTGAGGTACAGCCTTCGTCAGTACAATATTGTT
GGACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCTCAA
CACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAGGAGAAAGCC
ATGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATTTTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGA
AACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAACGTATAACCATGATGGGTCTTATAGCATGCAGATTGAAGATAAA
ACTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAAGCGAAGCTG
ATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGACATTCCAGTCCCCAAATACTTATCTTCTGTGAGC
TCACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGGGA
GATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTCTACAGAGAA
GGTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAATCGGAATAAACTCCAGCAAGGAAA
TGGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGCCTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGTTTTACTAAA
TGATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCATTTGGGTCACTAATTATCTCAAAATATTTCATACTAATAAAGT

>31873_31873_6_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491062_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------
>31873_31873_7_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491674_MCCC1_chr3_182790275_ENST00000265594_length(transcript)=2228nt_BP=199nt
TGAGACCCCAGGGGTGAAGGGCGGGGGATCCCAATCCCAGCCCTGTTTTCCCCTCCCCTTTCCCCGCCTCCTTCTCGCCCCTCCCCCCTC
CTCCCCTCTGGTTGGAAAGTTTCTAGAATCTCTTCCCAGCGGCCTTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTC
TAACGGGGCTTTCTACAAGGCTATCCATCCAGGATGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAAT
TATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGT
TGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGT
CCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAA
GTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAA
TGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTGCAGAGGCGACATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGA
AGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGAGCTGCTAAAGCTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTC
AAAACATAATTTCTGTTTCATGGAGATGAATACAAGGCTGCAAGTGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGA
GTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGCCAGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATA
TGCAGAAGATCCTAGCAATAACTTCATGCCTGTGGCAGGCCCATTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGA
AACTGGAGTACGGCAAGGAGACGAAGTTTCCGTGCATTATGACCCCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGC
ATTGACAAAACTGAGGTACAGCCTTCGTCAGTACAATATTGTTGGACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCC
AGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCTCAACACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTC
TTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAGGAGAAAGCCATGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATT
TTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGAAACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAAC
GTATAACCATGATGGGTCTTATAGCATGCAGATTGAAGATAAAACTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTA
CCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAAGCGAAGCTGATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTAT
TGAGATTGACATTCCAGTCCCCAAATACTTATCTTCTGTGAGCTCACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCAT
TGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGGGAGATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAA
GTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTCTACAGAGAAGGTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGA
AGAATCAGACAAAAGGGAATCGGAATAAACTCCAGCAAGGAAATGGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGC
CTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGTTTTACTAAATGATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCA

>31873_31873_7_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491674_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=636AA_BP=34
MVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE
GYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAV
YLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQ
LRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALT
KLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSS
SSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEI
DIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEES

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>31873_31873_8_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491674_MCCC1_chr3_182790275_ENST00000492597_length(transcript)=2228nt_BP=199nt
TGAGACCCCAGGGGTGAAGGGCGGGGGATCCCAATCCCAGCCCTGTTTTCCCCTCCCCTTTCCCCGCCTCCTTCTCGCCCCTCCCCCCTC
CTCCCCTCTGGTTGGAAAGTTTCTAGAATCTCTTCCCAGCGGCCTTTGCGGTTCCAACATGGCGGAGCTGACGGTGGAGGTTCGCGGCTC
TAACGGGGCTTTCTACAAGGCTATCCATCCAGGATGCGGTTTTCTCTCAGAAAACATGGAATTTGCTGAACTTTGTAAGCAAGAAGGAAT
TATTTTTATAGGCCCTCCTCCATCTGCAATTAGAGACATGGGTATAAAGAGCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGT
TGTGGAGGGTTATCATGGTGAGGACCAATCAGACCAGTGCCTGAAGGAACACGCCAGGAGAATTGGCTATCCTGTCATGATTAAAGCCGT
CCGGGGTGGAGGAGGAAAAGGAATGAGGATTGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAGAAGCTAAGAA
GTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGCATGTAGAAGTCCAGGTGTTTGGTGATCACCATGGCAA
TGCTGTGTACTTGTTTGAAAGAGACTGTAGTGTGCAGAGGCGACATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATCTGA
AGTAAGAAAAAAGCTGGGAGAAGCTGCAGTCAGAGCTGCTAAAGCTGTAAATTATGTTGGAGCAGGGACTGTGGAGTTTATTATGGACTC
AAAACATAATTTCTGTTTCATGGAGATGAATACAAGGCTGCAAGTGGAACATCCTGTTACTGAGATGATCACAGGAACTGACTTGGTGGA
GTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGCCAGGAAGAAATAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATA
TGCAGAAGATCCTAGCAATAACTTCATGCCTGTGGCAGGCCCATTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACCAGGATTGA
AACTGGAGTACGGCAAGGAGACGAAGTTTCCGTGCATTATGACCCCATGATTGCGAAGCTGGTCGTGTGGGCAGCAGATCGCCAGGCGGC
ATTGACAAAACTGAGGTACAGCCTTCGTCAGTACAATATTGTTGGACTGCACACCAACATTGACTTCTTACTCAACCTGTCTGGCCACCC
AGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCTCAACACCACAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTC
TTTATGCCAGGCAGCCCTGGGTCTCATCCTCAAGGAGAAAGCCATGACCGACACTTTCACTCTTCAGGCACATGATCAATTCTCTCCATT
TTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGAAACATGACTCTTAAAGATGGTAAAAACAATGTAGCCATAGCTGTAAC
GTATAACCATGATGGGTCTTATAGCATGCAGATTGAAGATAAAACTTTCCAAGTCCTTGGTAATCTTTACAGCGAGGGAGACTGCACTTA
CCTGAAATGTTCTGTTAATGGAGTTGCTAGTAAAGCGAAGCTGATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTAT
TGAGATTGACATTCCAGTCCCCAAATACTTATCTTCTGTGAGCTCACAAGAAACTCAGGGCGGCCCCTTAGCTCCTATGACTGGAACCAT
TGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGGGAGATTCCCTCATGGTTATGATCGCCATGAAGATGGAGCATACCATAAA
GTCTCCAAAGGATGGCACAGTAAAGAAAGTGTTCTACAGAGAAGGTGCTCAGGCCAACAGACACACTCCTTTAGTCGAGTTTGAGGAGGA
AGAATCAGACAAAAGGGAATCGGAATAAACTCCAGCAAGGAAATGGCCAGTTAAGTAGTGTCTTCTCTCTCCACCAAAAAGAGGAAGTGC
CTCCAGCTTTTCTGGGGGTCTCATAAAGAGCAGTTTTACTAAATGATTGTATGCTTATGCTGAACACCTTTCATATTGGAGAATCATGCA

>31873_31873_8_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491674_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=636AA_BP=34
MVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE
GYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAV
YLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQ
LRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALT
KLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSS
SSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEI
DIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEES

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Fusion Gene PPI Analysis for FXR1-MCCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FXR1-MCCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FXR1-MCCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource