FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FXYD3-FAR1 (FusionGDB2 ID:31896)

Fusion Gene Summary for FXYD3-FAR1

check button Fusion gene summary
Fusion gene informationFusion gene name: FXYD3-FAR1
Fusion gene ID: 31896
HgeneTgene
Gene symbol

FXYD3

FAR1

Gene ID

5349

84188

Gene nameFXYD domain containing ion transport regulator 3fatty acyl-CoA reductase 1
SynonymsMAT8|PLMLMLSTD2|PFCRD|SDR10E1
Cytomap

19q13.12

11p15.3

Type of geneprotein-codingprotein-coding
DescriptionFXYD domain-containing ion transport regulator 3chloride conductance inducer protein Mat-8mammary tumor 8 kDa proteinphospholemman-like proteinsodium/potassium-transporting ATPase subunit FXYD3fatty acyl-CoA reductase 1male sterility domain-containing protein 2short chain dehydrogenase/reductase family 10E, member 1
Modification date2020031320200313
UniProtAcc

Q14802

Q8WVX9

Ensembl transtripts involved in fusion geneENST00000344013, ENST00000346446, 
ENST00000435734, ENST00000604404, 
ENST00000406988, ENST00000535103, 
ENST00000603181, ENST00000603524, 
ENST00000604255, ENST00000604621, 
ENST00000406242, ENST00000454903, 
ENST00000603449, ENST00000604804, 
ENST00000605550, ENST00000605552, 
ENST00000605677, 		ENST00000354817, 
ENST00000527202, ENST00000532502, 
Fusion gene scores* DoF score7 X 8 X 5=28032 X 11 X 13=4576
# samples 733
** MAII scorelog2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/4576*10)=-3.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FXYD3 [Title/Abstract] AND FAR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFXYD3(35614557)-FAR1(13744912), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAR1

GO:0008611

ether lipid biosynthetic process

24108123

TgeneFAR1

GO:0035336

long-chain fatty-acyl-CoA metabolic process

15220348

TgeneFAR1

GO:0046474

glycerophospholipid biosynthetic process

20071337


check buttonFusion gene breakpoints across FXYD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FAR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-F5-6861-01AFXYD3chr19

35614557

-FAR1chr11

13744912

+


Top

Fusion Gene ORF analysis for FXYD3-FAR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000344013ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000344013ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000344013ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000346446ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000346446ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000346446ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000435734ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000435734ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000435734ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000604404ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000604404ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
3UTR-intronENST00000604404ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000406988ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000406988ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000406988ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000535103ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000535103ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000535103ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000603181ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000603181ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000603181ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000603524ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000603524ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000603524ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000604255ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000604255ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000604255ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000604621ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000604621ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
5CDS-intronENST00000604621ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000406242ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000406242ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000406242ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000454903ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000454903ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000454903ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000603449ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000603449ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000603449ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000604804ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000604804ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000604804ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605550ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605550ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605550ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605552ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605552ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605552ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605677ENST00000354817FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605677ENST00000527202FXYD3chr19

35614557

-FAR1chr11

13744912

+
intron-intronENST00000605677ENST00000532502FXYD3chr19

35614557

-FAR1chr11

13744912

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for FXYD3-FAR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FXYD3-FAR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35614557/:13744912)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FXYD3

Q14802

FAR1

Q8WVX9

FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.FUNCTION: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity). {ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for FXYD3-FAR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for FXYD3-FAR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FXYD3-FAR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FXYD3-FAR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource