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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FZD6-DCAF13 (FusionGDB2 ID:31961)

Fusion Gene Summary for FZD6-DCAF13

check button Fusion gene summary
Fusion gene informationFusion gene name: FZD6-DCAF13
Fusion gene ID: 31961
HgeneTgene
Gene symbol

FZD6

DCAF13

Gene ID

8323

25879

Gene namefrizzled class receptor 6DDB1 and CUL4 associated factor 13
SynonymsFZ-6|FZ6|HFZ6|NDNC1|NDNC10GM83|HSPC064|Sof1|WDSOF1
Cytomap

8q22.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionfrizzled-6frizzled 6, seven transmembrane spanning receptorfrizzled family receptor 6frizzled homolog 6seven transmembrane helix receptorDDB1- and CUL4-associated factor 13WD repeat and SOF domain-containing protein 1WD repeats and SOF1 domain containing
Modification date2020032720200313
UniProtAcc.

Q9NV06

Ensembl transtripts involved in fusion geneENST00000358755, ENST00000522566, 
ENST00000523739, ENST00000540287, 
ENST00000521999, ENST00000519682, 
ENST00000521716, ENST00000521971, 
ENST00000297579, 
Fusion gene scores* DoF score8 X 4 X 6=1927 X 7 X 4=196
# samples 87
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FZD6 [Title/Abstract] AND DCAF13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFZD6(104312512)-DCAF13(104447854), # samples:1
Anticipated loss of major functional domain due to fusion event.FZD6-DCAF13 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FZD6-DCAF13 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFZD6

GO:0035567

non-canonical Wnt signaling pathway

14747478

HgeneFZD6

GO:0043433

negative regulation of DNA-binding transcription factor activity

14747478


check buttonFusion gene breakpoints across FZD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCAF13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-SY-A9G5-01AFZD6chr8

104312512

+DCAF13chr8

104447854

+


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Fusion Gene ORF analysis for FZD6-DCAF13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000358755ENST00000521999FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-3UTRENST00000522566ENST00000521999FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-3UTRENST00000523739ENST00000521999FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-3UTRENST00000540287ENST00000521999FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000358755ENST00000519682FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000358755ENST00000521716FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000358755ENST00000521971FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000522566ENST00000519682FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000522566ENST00000521716FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000522566ENST00000521971FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000523739ENST00000519682FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000523739ENST00000521716FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000523739ENST00000521971FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000540287ENST00000519682FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000540287ENST00000521716FZD6chr8

104312512

+DCAF13chr8

104447854

+
5CDS-intronENST00000540287ENST00000521971FZD6chr8

104312512

+DCAF13chr8

104447854

+
Frame-shiftENST00000358755ENST00000297579FZD6chr8

104312512

+DCAF13chr8

104447854

+
Frame-shiftENST00000522566ENST00000297579FZD6chr8

104312512

+DCAF13chr8

104447854

+
Frame-shiftENST00000523739ENST00000297579FZD6chr8

104312512

+DCAF13chr8

104447854

+
In-frameENST00000540287ENST00000297579FZD6chr8

104312512

+DCAF13chr8

104447854

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540287FZD6chr8104312512+ENST00000297579DCAF13chr8104447854+15734494171001194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540287ENST00000297579FZD6chr8104312512+DCAF13chr8104447854+0.0012486220.9987514

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Fusion Genomic Features for FZD6-DCAF13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FZD6chr8104312512+DCAF13chr8104447853+0.000348670.9996513
FZD6chr8104312512+DCAF13chr8104447853+0.000348670.9996513

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FZD6-DCAF13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:104312512/chr8:104447854)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DCAF13

Q9NV06

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16949367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+2719_13259707.0DomainFZ
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+2719_13259707.0DomainFZ
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+3819_13227675.0DomainFZ
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+2719_20159707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27223_23359707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27255_28459707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27306_32459707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27346_37059707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27392_41659707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27438_47359707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27495_70659707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+2719_20159707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27223_23359707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27255_28459707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27306_32459707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27346_37059707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27392_41659707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27438_47359707.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27495_70659707.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+3819_20127675.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38223_23327675.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38255_28427675.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38306_32427675.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38346_37027675.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38392_41627675.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38438_47327675.0Topological domainExtracellular
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38495_70627675.0Topological domainCytoplasmic
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27202_22259707.0TransmembraneHelical%3B Name%3D1
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27234_25459707.0TransmembraneHelical%3B Name%3D2
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27285_30559707.0TransmembraneHelical%3B Name%3D3
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27325_34559707.0TransmembraneHelical%3B Name%3D4
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27371_39159707.0TransmembraneHelical%3B Name%3D5
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27417_43759707.0TransmembraneHelical%3B Name%3D6
HgeneFZD6chr8:104312512chr8:104447854ENST00000358755+27474_49459707.0TransmembraneHelical%3B Name%3D7
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27202_22259707.0TransmembraneHelical%3B Name%3D1
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27234_25459707.0TransmembraneHelical%3B Name%3D2
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27285_30559707.0TransmembraneHelical%3B Name%3D3
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27325_34559707.0TransmembraneHelical%3B Name%3D4
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27371_39159707.0TransmembraneHelical%3B Name%3D5
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27417_43759707.0TransmembraneHelical%3B Name%3D6
HgeneFZD6chr8:104312512chr8:104447854ENST00000522566+27474_49459707.0TransmembraneHelical%3B Name%3D7
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38202_22227675.0TransmembraneHelical%3B Name%3D1
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38234_25427675.0TransmembraneHelical%3B Name%3D2
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38285_30527675.0TransmembraneHelical%3B Name%3D3
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38325_34527675.0TransmembraneHelical%3B Name%3D4
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38371_39127675.0TransmembraneHelical%3B Name%3D5
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38417_43727675.0TransmembraneHelical%3B Name%3D6
HgeneFZD6chr8:104312512chr8:104447854ENST00000523739+38474_49427675.0TransmembraneHelical%3B Name%3D7
TgeneDCAF13chr8:104312512chr8:104447854ENST00000297579611107_146413598.0RepeatNote=WD 2
TgeneDCAF13chr8:104312512chr8:104447854ENST00000297579611149_191413598.0RepeatNote=WD 3
TgeneDCAF13chr8:104312512chr8:104447854ENST00000297579611194_234413598.0RepeatNote=WD 4
TgeneDCAF13chr8:104312512chr8:104447854ENST00000297579611236_276413598.0RepeatNote=WD 5
TgeneDCAF13chr8:104312512chr8:104447854ENST00000297579611280_319413598.0RepeatNote=WD 6
TgeneDCAF13chr8:104312512chr8:104447854ENST00000297579611323_362413598.0RepeatNote=WD 7
TgeneDCAF13chr8:104312512chr8:104447854ENST0000029757961164_104413598.0RepeatNote=WD 1


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Fusion Gene Sequence for FZD6-DCAF13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31961_31961_1_FZD6-DCAF13_FZD6_chr8_104312512_ENST00000540287_DCAF13_chr8_104447854_ENST00000297579_length(transcript)=1573nt_BP=449nt
GTGCGGCTCTCGAGGCAGCTCCAGTCCCGGACGCAACCCCGGAGCCGTCTCAGGTCCCTGGGGGGAACGGTGGGTTAGACGGGGACGGGA
AGGGACAGCGGCCTTCGACCGCCCCCCGAGTAATTGACCCAGGACTCATTTTCAGGAAAGCCTGAAAATGAGTAAAATAGTGAAATGAGG
AATTTGAACATTTTATCTTTGGATGGGGATCTTCTGAGGATGCAAAGAGTGATTCATCCAAGCCATGTGGTAAAATCAGGAATTTGAAGA
AAATGGAAATGTTTACATTTTTGTTGACGTGTATTTTTCTACCCCTCCTAAGAGGGCACAGTCTCTTCACCTGTGAACCAATTACTGTTC
CCAGATGTATGAAAATGGCCTACAACATGACGTTTTTCCCTAATCTGATGGGTCATTATGACCAGAGTATTGCCGCGGTGGAAATGGAGC
TTATATACTTTTGATATGCGTGCACTGGACACTCCTGTAATGGTCCATATGGATCATGTATCTGCAGTGCTTGATGTGGATTACTCTCCC
ACTGGGAAGGAGTTTGTGTCTGCTAGTTTCGATAAATCTATTCGAATCTTTCCTGTAGACAAAAGTCGAAGCAGGGAGGTATATCATACA
AAGAGAATGCAACATGTTATCTGTGTAAAATGGACTTCTGACAGCAAGTATATTATGTGTGGATCTGATGAAATGAACATTCGCCTGTGG
AAAGCTAATGCTTCTGAAAAATTGGGTGTGCTTACATCACGAGAAAAAGCAGCCAAGGATTATAACCAGAAATTGAAGGAGAAATTTCAG
CATTATCCTCATATAAAACGTATAGCTCGTCATCGACATCTACCAAAATCTATCTATAGCCAGATTCAGGAACAGCGCATCATGAAAGAA
GCTCGTCGACGAAAGGAAGTGAATCGTATTAAACACAGCAAGCCTGGATCTGTGCCACTTGTGTCAGAGAAGAAGAAACACGTAGTGGCA
GTTGTAAAATAATTGGTATTCCTAACAATCCTGATGTATAATTATTTGTTACTTTTGATTTGAGAACTCTACAAATAAAAGTGCTGGGAC
TAGATTAATTGCAAACATTTTAGTTATATGTGTAGAGCTTTATTGTTACTCCTTTTAGCTACCCTGAAAAATGATCCTTAAAGGTGGCCT
AGTTGGTAAGACTGTTTTATCCTTAATCTGCATTCTTCTTTCATTGTAGAATACAGTATTTGCAACTCATTTTTTCTTGTTTTTATTACA
GATATACTTACTTTCTCTTTGATCTATTATTGTAGACACTATACATTCAAATTGACATTTAAGACCAAACATCTCTTATGTTATCTTTAA
TATTACTTTGAATAATGATTGCAATGATGTTTCTTCCTGTGATTCCACATAACATTTAGAATAATGATGTCAATTTTTTACAACTGAATT
TATTTCTAGTGCTTTACTTATATTTGGCTTTTTGACTCTTTTAAAACAATCAGCCTGCATTTATATAACTTTTATAAATAATAATATAAT

>31961_31961_1_FZD6-DCAF13_FZD6_chr8_104312512_ENST00000540287_DCAF13_chr8_104447854_ENST00000297579_length(amino acids)=194AA_BP=0
MTRVLPRWKWSLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIM
CGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FZD6-DCAF13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FZD6-DCAF13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FZD6-DCAF13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource