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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:G2E3-NAP1L1 (FusionGDB2 ID:31983)

Fusion Gene Summary for G2E3-NAP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: G2E3-NAP1L1
Fusion gene ID: 31983
HgeneTgene
Gene symbol

G2E3

NAP1L1

Gene ID

55632

4673

Gene nameG2/M-phase specific E3 ubiquitin protein ligasenucleosome assembly protein 1 like 1
SynonymsKIAA1333|PHF7BNAP1|NAP1L|NRP
Cytomap

14q12

12q21.2

Type of geneprotein-codingprotein-coding
DescriptionG2/M phase-specific E3 ubiquitin-protein ligaseG2/M phase-specific HECT-type E3 ubiquitin transferaseG2/M-phase specific E3 ubiquitin ligasePHD finger protein 7Bnucleosome assembly protein 1-like 1HSP22-like protein interacting proteinNAP-1-related protein
Modification date2020031320200322
UniProtAcc

Q7L622

P55209

Ensembl transtripts involved in fusion geneENST00000544007, ENST00000206595, 
ENST00000438909, ENST00000553504, 
ENST00000261182, ENST00000393263, 
ENST00000431879, ENST00000535020, 
ENST00000542344, ENST00000544816, 
ENST00000547773, ENST00000547993, 
ENST00000548044, ENST00000549596, 
ENST00000552342, 
Fusion gene scores* DoF score7 X 4 X 5=14018 X 20 X 6=2160
# samples 722
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2160*10)=-3.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: G2E3 [Title/Abstract] AND NAP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointG2E3(31050322)-NAP1L1(76443565), # samples:3
Anticipated loss of major functional domain due to fusion event.G2E3-NAP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
G2E3-NAP1L1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
G2E3-NAP1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across G2E3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NAP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7760-01AG2E3chr14

31028478

+NAP1L1chr12

76443565

-
ChimerDB4LUADTCGA-69-7760-01AG2E3chr14

31050322

+NAP1L1chr12

76443565

-
ChimerDB4LUADTCGA-69-7760G2E3chr14

31050322

+NAP1L1chr12

76443565

-


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Fusion Gene ORF analysis for G2E3-NAP1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000544007ENST00000261182G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000393263G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000431879G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000535020G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000542344G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000544816G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000547773G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000547993G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000548044G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000549596G2E3chr14

31028478

+NAP1L1chr12

76443565

-
3UTR-3CDSENST00000544007ENST00000552342G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000261182G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000393263G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000431879G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000535020G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000542344G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000544816G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000547773G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000547993G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000548044G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000549596G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000206595ENST00000552342G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000261182G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000393263G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000431879G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000535020G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000542344G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000544816G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000547773G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000547993G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000548044G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000549596G2E3chr14

31028478

+NAP1L1chr12

76443565

-
5UTR-3CDSENST00000438909ENST00000552342G2E3chr14

31028478

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000261182G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000393263G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000431879G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000535020G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000542344G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000544816G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000547773G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000547993G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000548044G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000206595ENST00000549596G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000261182G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000393263G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000431879G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000535020G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000542344G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000544816G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000547773G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000547993G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000548044G2E3chr14

31050322

+NAP1L1chr12

76443565

-
Frame-shiftENST00000553504ENST00000549596G2E3chr14

31050322

+NAP1L1chr12

76443565

-
In-frameENST00000206595ENST00000552342G2E3chr14

31050322

+NAP1L1chr12

76443565

-
In-frameENST00000553504ENST00000552342G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000261182G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000393263G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000431879G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000535020G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000542344G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000544816G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000547773G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000547993G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000548044G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000549596G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000438909ENST00000552342G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000261182G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000393263G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000431879G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000535020G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000542344G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000544816G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000547773G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000547993G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000548044G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000549596G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000544007ENST00000552342G2E3chr14

31050322

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000261182G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000393263G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000431879G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000535020G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000542344G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000544816G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000547773G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000547993G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000548044G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000549596G2E3chr14

31028478

+NAP1L1chr12

76443565

-
intron-3CDSENST00000553504ENST00000552342G2E3chr14

31028478

+NAP1L1chr12

76443565

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000206595G2E3chr1431050322+ENST00000552342NAP1L1chr1276443565-5121914619549
ENST00000553504G2E3chr1431050322+ENST00000552342NAP1L1chr1276443565-1895157412940190

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000206595ENST00000552342G2E3chr1431050322+NAP1L1chr1276443565-0.814252560.18574744
ENST00000553504ENST00000552342G2E3chr1431050322+NAP1L1chr1276443565-0.762216870.23778318

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Fusion Genomic Features for G2E3-NAP1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for G2E3-NAP1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:31050322/chr12:76443565)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
G2E3

Q7L622

NAP1L1

P55209

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. {ECO:0000269|PubMed:18511420}.FUNCTION: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:26841755). Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). {ECO:0000250|UniProtKB:P28656, ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:26841755, ECO:0000269|PubMed:28369616}.; FUNCTION: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression. {ECO:0000269|PubMed:23691099}.; FUNCTION: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA. {ECO:0000269|PubMed:27599637}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneG2E3chr14:31050322chr12:76443565ENST00000206595+215371_69812707.0DomainHECT
HgeneG2E3chr14:31050322chr12:76443565ENST00000206595+21511_5112707.0Zinc fingerC2HC pre-PHD-type
HgeneG2E3chr14:31050322chr12:76443565ENST00000206595+215143_19312707.0Zinc fingerNote=PHD-type 2%3B degenerate
HgeneG2E3chr14:31050322chr12:76443565ENST00000206595+215237_28612707.0Zinc fingerNote=PHD-type 3
HgeneG2E3chr14:31050322chr12:76443565ENST00000206595+21579_12812707.0Zinc fingerPHD-type 1
TgeneNAP1L1chr14:31050322chr12:76443565ENST00000261182111510_30353392.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNAP1L1chr14:31050322chr12:76443565ENST000002611821115129_145353392.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNAP1L1chr14:31050322chr12:76443565ENST000002611821115348_378353392.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNAP1L1chr14:31050322chr12:76443565ENST00000393263111610_30353558.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNAP1L1chr14:31050322chr12:76443565ENST000003932631116129_145353558.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNAP1L1chr14:31050322chr12:76443565ENST000003932631116348_378353558.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNAP1L1chr14:31050322chr12:76443565ENST000002611821115273_279353392.0MotifNuclear localization signal
TgeneNAP1L1chr14:31050322chr12:76443565ENST000003932631116273_279353558.3333333333334MotifNuclear localization signal


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Fusion Gene Sequence for G2E3-NAP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31983_31983_1_G2E3-NAP1L1_G2E3_chr14_31050322_ENST00000206595_NAP1L1_chr12_76443565_ENST00000552342_length(transcript)=512nt_BP=191nt
GACCGCTCTTTCCGGGTTTGCGAGCGGAAGTGGACGAATTTGAATCCTGTGGGCCGTTGAATGTGGCTGCTCGCGGTCGGCGTGCCCCGA
CGTACAGCGGGCCGGGAAAAGTGGCACTGAGGCTCTGGAACTTCTGCCCAGCTCTCCTTGTAAAATGAATGAAAGTAAACCTGGTGACTC
ACAGAACCTTGTATGATGAAGAAGGTGAAGAAGCGGATGAGGTAATGTTTACCAAATGAGCAAATAATTCTCTGTGGTTAACACATTGAG
AAGCAAATTGAATGACTTATGTATTCCTTTGCTATAATCATTCTGTGATTTGGGATAAAAACATTTTGGAAAACATGATTTTAGAATTCT
ACAGCCAAACAATGTATGTATAAGGTTTCAATAAATAAATTGCAAAACTCAGCAACATTTTTTTATTTCAAATAATTTTGTTCTGCTGCA

>31983_31983_1_G2E3-NAP1L1_G2E3_chr14_31050322_ENST00000206595_NAP1L1_chr12_76443565_ENST00000552342_length(amino acids)=49AA_BP=

--------------------------------------------------------------
>31983_31983_2_G2E3-NAP1L1_G2E3_chr14_31050322_ENST00000553504_NAP1L1_chr12_76443565_ENST00000552342_length(transcript)=1895nt_BP=1574nt
AGAGAGAGAAGCAGGACCGTGGGGTGGGAGAGGGTGTCAGGAGGCCGGACGTCGCAGCCGGGGCCTCGCAGTGCTTTTGGGGACGTCTGG
TGCTGGGGCCCGGCCTGGAGACTAAGGGAATTCGGGGCACTGGGGGCGTTTGCTGGACCAGCGCTCTCGACGGTTGCGCACGCCAGCCAG
CTCTCAGTGTTGAGGATTCGGAGGCCCTGCCGGTCCCCCGCGAGTAAACCTTGTTTATACGCATCCTCCGTGGCTTTTTTTAAACCCGTA
GTTTATTATTTCCACCAATTCGGCTCGAATGCTGAAATTTTAACAGTAGTTAAATCTCACTGTGAAGGCGTTGCCACGTTTAAACAAATC
TCTTTTAATGAAAGATGGAAGGTTGGGGCGGGTTTAGAATGAAAAGATGCTCTACGTGGCTCCGCGTTCCTCCTGAGAGAGATACCCGGG
CAACCTTGATTAACTCTGGACTGCAGGGAAGTGACAGTCTTTGAAATGCCTGAGTGGGATTTAAACTGAAATTCGAGTGTCCTTTGTATT
TAAAACCCGGATATTTTTCTTTCACGGTTGACATTTTTCATGTACCGCAAAAATCCGAGACTCCTATTTAAACCGGCTGTGGTAACAGCG
GTGGTGATTAACTAGGGTCTTAGTTTGCAAACAATAGGGATAAGGTTTAGTTCCACCGCCCTGCCTTTTCGCCTCCCTCATTCATTGGCC
AACTGGGTTATTATGGAGTCTTTTTGGAAGTAATCCACTAATGCTTTGAGCATCTGTTTCTTTGGGTTTTATTGTTTTGGGCTTTTTTTT
TTTTAATTTTTAATGATGAACTATCTGAAATATGGAACTCTGTCTAACCCAGTAGTAAAGTCATGCCTTCTGGAATGGTTTAAAAGTGTG
CCATAAATGTAAACTATAAATGGGAACTTTAAATGTGTACAAGTTTTACATCTTTATTAAAAATCGTCAGTTTTGTGTAGCTTAATACGA
AAAGATATTTTAAGTTCCTTTTAAGGTTTTAACACCAGGATATTGTACCATTTAAATGTATAAATATATTTTTAAAAGTAGGACTTCATA
ATAATCAGAATAAAAACATTCCTTCATCCAGTGCTGGCTATTCCAGCACCCCCATTCTTCCTGCTATTGAACTTTTAAGTGTTAGCCAGG
AAGAATAGACTTAAATACTCGGTGTTTAGGATAGTTAAAATATGAGCATTTTTCATATAGTGTCTTTGTAACAGAGACATTGGCTATACT
TCTCTAAGCCTTTCTGCTCATTTCATATGTGCTGTCAACAAATGGTAATTTTTAAAAATTGATCGCTATATCCTAATCTCTTTATTTTTT
TCTACCTGAATTATTTTCATTGGATTTTTGCTCTTTCTTAAATCAGTGAGTTTCAGAATTTATTGTGTATACACTACCTTGAAGGATTTG
TTCAACAATGCTGATTCCTGCACTTCAGATCTCAGATTCTGAATCAGTAGGTCTGGAGGATGGCATTGAACAGTCTGCATATTTAACTGA
AAGTAAAATGAATGAAAGTAAACCTGGTGACTCACAGAACCTTGTATGATGAAGAAGGTGAAGAAGCGGATGAGGTAATGTTTACCAAAT
GAGCAAATAATTCTCTGTGGTTAACACATTGAGAAGCAAATTGAATGACTTATGTATTCCTTTGCTATAATCATTCTGTGATTTGGGATA
AAAACATTTTGGAAAACATGATTTTAGAATTCTACAGCCAAACAATGTATGTATAAGGTTTCAATAAATAAATTGCAAAACTCAGCAACA
TTTTTTTATTTCAAATAATTTTGTTCTGCTGCAGGGTTATCAGCTCTTTGAAGAAGTCAAAAGCTGCAGTAAACTTTTCCAACGTTGGCT

>31983_31983_2_G2E3-NAP1L1_G2E3_chr14_31050322_ENST00000553504_NAP1L1_chr12_76443565_ENST00000552342_length(amino acids)=90AA_BP=
MGAFAGPALSTVAHASQLSVLRIRRPCRSPASKPCLYASSVAFFKPVVYYFHQFGSNAEILTVVKSHCEGVATFKQISFNERWKVGAGLE

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Fusion Gene PPI Analysis for G2E3-NAP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for G2E3-NAP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for G2E3-NAP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource