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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GAB2-CERS6 (FusionGDB2 ID:32027)

Fusion Gene Summary for GAB2-CERS6

check button Fusion gene summary
Fusion gene informationFusion gene name: GAB2-CERS6
Fusion gene ID: 32027
HgeneTgene
Gene symbol

GAB2

CERS6

Gene ID

9846

253782

Gene nameGRB2 associated binding protein 2ceramide synthase 6
Synonyms-CERS5|LASS6
Cytomap

11q14.1

2q24.3

Type of geneprotein-codingprotein-coding
DescriptionGRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100ceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6
Modification date2020032720200313
UniProtAcc

Q9UQC2

Q6ZMG9

Ensembl transtripts involved in fusion geneENST00000526030, ENST00000361507, 
ENST00000340149, 		ENST00000305747, 
ENST00000392687, 
Fusion gene scores* DoF score25 X 12 X 7=21005 X 5 X 3=75
# samples 275
** MAII scorelog2(27/2100*10)=-2.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAB2 [Title/Abstract] AND CERS6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGAB2(78128691)-CERS6(169547543), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAB2

GO:0008284

positive regulation of cell proliferation

19172738

TgeneCERS6

GO:0046513

ceramide biosynthetic process

17609214|17977534


check buttonFusion gene breakpoints across GAB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CERS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2M6GAB2chr11

78128691

-CERS6chr2

169547543

+


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Fusion Gene ORF analysis for GAB2-CERS6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000526030ENST00000305747GAB2chr11

78128691

-CERS6chr2

169547543

+
5UTR-3CDSENST00000526030ENST00000392687GAB2chr11

78128691

-CERS6chr2

169547543

+
In-frameENST00000361507ENST00000305747GAB2chr11

78128691

-CERS6chr2

169547543

+
In-frameENST00000361507ENST00000392687GAB2chr11

78128691

-CERS6chr2

169547543

+
intron-3CDSENST00000340149ENST00000305747GAB2chr11

78128691

-CERS6chr2

169547543

+
intron-3CDSENST00000340149ENST00000392687GAB2chr11

78128691

-CERS6chr2

169547543

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361507GAB2chr1178128691-ENST00000305747CERS6chr2169547543+632316120850276
ENST00000361507GAB2chr1178128691-ENST00000392687CERS6chr2169547543+634716120874284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361507ENST00000305747GAB2chr1178128691-CERS6chr2169547543+0.010188540.9898115
ENST00000361507ENST00000392687GAB2chr1178128691-CERS6chr2169547543+0.0112841690.9887158

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Fusion Genomic Features for GAB2-CERS6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GAB2chr1178128691-CERS6chr2169547543+3.95E-081
GAB2chr1178128691-CERS6chr2169547543+3.95E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GAB2-CERS6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:78128691/chr2:169547543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAB2

Q9UQC2

CERS6

Q6ZMG9

FUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250|UniProtKB:Q8C172, ECO:0000269|PubMed:17609214, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:31916624}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCERS6chr11:78128691chr2:169547543ENST00000305747310324_384155385.0Topological domainCytoplasmic
TgeneCERS6chr11:78128691chr2:169547543ENST00000392687311324_384155393.0Topological domainCytoplasmic
TgeneCERS6chr11:78128691chr2:169547543ENST00000305747310178_198155385.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000305747310205_225155385.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000305747310263_283155385.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000305747310303_323155385.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000392687311178_198155393.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000392687311205_225155393.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000392687311263_283155393.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST00000392687311303_323155393.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAB2chr11:78128691chr2:169547543ENST00000340149-1106_1170639.0DomainPH
HgeneGAB2chr11:78128691chr2:169547543ENST00000361507-1106_11725677.0DomainPH
HgeneGAB2chr11:78128691chr2:169547543ENST00000340149-110351_3580639.0MotifNote=SH3-binding
HgeneGAB2chr11:78128691chr2:169547543ENST00000340149-110510_5190639.0MotifNote=SH3-binding
HgeneGAB2chr11:78128691chr2:169547543ENST00000361507-110351_35825677.0MotifNote=SH3-binding
HgeneGAB2chr11:78128691chr2:169547543ENST00000361507-110510_51925677.0MotifNote=SH3-binding
TgeneCERS6chr11:78128691chr2:169547543ENST00000305747310130_331155385.0DomainTLC
TgeneCERS6chr11:78128691chr2:169547543ENST00000392687311130_331155393.0DomainTLC
TgeneCERS6chr11:78128691chr2:169547543ENST0000030574731066_127155385.0RegionHomeobox-like
TgeneCERS6chr11:78128691chr2:169547543ENST0000039268731166_127155393.0RegionHomeobox-like
TgeneCERS6chr11:78128691chr2:169547543ENST000003057473101_34155385.0Topological domainLumenal
TgeneCERS6chr11:78128691chr2:169547543ENST000003926873111_34155393.0Topological domainLumenal
TgeneCERS6chr11:78128691chr2:169547543ENST0000030574731035_55155385.0TransmembraneHelical
TgeneCERS6chr11:78128691chr2:169547543ENST0000039268731135_55155393.0TransmembraneHelical


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Fusion Gene Sequence for GAB2-CERS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32027_32027_1_GAB2-CERS6_GAB2_chr11_78128691_ENST00000361507_CERS6_chr2_169547543_ENST00000305747_length(transcript)=6323nt_BP=161nt
GAGCTGCGCACCGCCGGCCGCTGCCCCAGCTGCCCGAGCCCGCGCCCTCGTCCGCGCGACCCGGCGGGGGGCTCCAGGCCGGCAGCATGA
GCGGCGGCGGCGACGTGGTGTGCACCGGCTGGCTGAGGAAATCGCCTCCCGAGAAGAAGTTGAGGCGCTATACCCCCTGGTTGTGGAATA
CGAGGCATTGCTGGTACAACTACCCCTATCAGCCACTCACAACTGACCTTCACTACTATTACATCCTGGAGCTGTCGTTTTATTGGTCTT
TGATGTTTTCTCAGTTCACTGATATCAAAAGAAAGGACTTTGGCATTATGTTCCTGCACCACCTTGTATCTATTTTCTTGATTACCTTTT
CATATGTCAACAATATGGCCCGAGTAGGAACGCTGGTCCTTTGTCTTCATGATTCAGCTGATGCTCTTCTGGAGGCTGCCAAAATGGCAA
ATTATGCCAAGTTTCAGAAAATGTGTGATCTCCTGTTTGTTATGTTTGCCGTGGTTTTTATCACCACACGACTGGGTATATTTCCTCTCT
GGGTGTTAAATACCACATTATTTGAAAGCTGGGAGATCGTTGGACCTTACCCTTCCTGGTGGGTTTTTAACCTACTGCTATTGCTAGTAC
AAGGGTTGAACTGCTTCTGGTCTTACTTGATTGTGAAAATAGCTTGCAAAGCTGTTTCAAGAGGCAAGGTGTCCAAGGATGATCGAAGTG
ATATTGAGTCTAGCTCAGATGAGGAGGACTCAGAACCTCCGGGAAAGAATCCCCACACTGCGACAACCACCAATGGGACCAGTGGTACCA
ACGGGTATCTCCTGACTGGCTCCTGCTCCATGGATGATTAATTACTCAAAACTACAAGTCCCAAGCAAAGTGAACTATTTGTTCCTGGAA
GTATTTAATAAGTTGCAAATGCAGTTCCTTTCATAATATCTCAGCACCAGAAACAAAAATTAAGATTATCAAAGCATTTTGAATAGTGCA
CTGCCATGTGTCCTGTCTGTGAATGAAGAAGAATTACCATTCTCTCTTTGTAGGCATGCTGTATGTAATTGACACAAGGGAACAGTATTT
GCATTTGTACTGTCTTAGAATATTATTTATTTTTTTGTATTTGTAAATCTGTGGACAAAAGAGGGTTTCCTCACTCCTTTTACTCACTGG
GCTCATGACAGTGAAGGAGATGCTCCATCTGCTTCTCCCCCTTTCTCTTGCTGTAGTCCAATGTGCTATGAGCATCAGCTTACTTTGTCA
CTTAGAGCAAGCAAAACCCAGTGCAAGAGTCTCGTTCAGCTCTAAATAGGTTTGCTTTCTTTTAGTTACAGTGCCCATTTTGAAATTGCC
TATACAGTCTTAGTGACCATTTAAACCGGACGAACTAGGTGTTTAATTTTCACTCTTCATGTTCAATTAGCAGTTCAAATTAAAGAAGAT
GGTTATTGGAGAACTTTTTTGAATGGTTTTGTATTAAATTGCTTTGAAATAGATTTCATTTCTTGTGCACACAGCCAAGATTTCTTCAAT
GGGTGTGAGCTAGTTGAGGGTTAACCTTGTAGGTTGCAGAGTGTATTTGTTTGTTTGTTTGTTTTTCTCTGTGATGAGGTCAGTGCTCTG
ATTTTGAAGGAGGATATTCACTGAAGCTCATAGTTATAAACAAGGAAATCACTGTTAAGAATGGGAATTTGTCCTGTGTTCTGGGAATAA
CATAAAGAGAGCAACTGATTTCAGCCAGGTTTTGCCACTACCCTATAATTAGTGCAGTCTTATGTTATAAAAGAAAGAAGTTAACTATAT
TTGGGGACAAAAAAATATTTCAAGAGTTGATAAAGATTACCTGTGCAGTGCAGAGCACTTTAATGCAACCAGCTTTCAAGAAAAAGCCCT
ATCTAGTACTTGATGTTGATGTTTTTATTTTGCTGAGCAAAATAAAGCCAATGGGAGAAAGACTATTTTACCCTTTGCTTTTCTCCTTAA
ACGTAATCCAGATGACTTTCCTGTTACTAAACACTGAGCAGCATTACACTACAATGCTTCTTTGGTTTCCAGGAATTTTTTTCAAATGGG
GCTGTTTCTGGAAAAATGAAAAATTCTATTGGACAATGGCAATATCAACAATGAGGAAAATTACTGAAGAATAAGTTTCCATAAGTCTCC
TACATAGCAGTGTTATTTATGTACAGATAAGAAAACCATATGTCAGCCAAAGATTTTATCTCTTCTTCTAACTTTTAGTAAGAGGAAAAA
GGGATTATAAAACCCTTCATAAATCAAGAAGGCCATCACTTAGAACGAACCCCAAACAAAAATGCCATAATATAAATGTGTGAATCAGGG
CTGTGAAGACAACAGCAGAAATGCTAACAAGCGTGCAGAAACACCAGAGAGTGCGTATCCTGCTCAGAACCATTCACATTTAATTCAATT
CTTGGAAAAAATTAAAGCTTTTTGCCCACAATTTGCAATCTGTGGGTTAATAGTTAAAAGAATGTTCCCAACCAAAAAATTCTTACCGTA
ATATTATATCTTGCCCTACTTATTTACAAAATAATATGTTTCTGTTATGGTCCTTAGTAATAATTGAAGAGGCTTAGAAATACATCTGCT
TGTTTATTGAGAAAACGATGCAAATAATTCTGCTTTTAGAGCCTTGTTATTTTATTTCACAAAACAGGCATATGTCTAGGAGTGTAATTT
GTGGATGGTTGAGTTTGTAAGAACAATCATAAAAGGACTTGTTAGTCTCCAGAACATCTGCTAAAATGCAAGTATATGTATAAGGTAATA
GCATATTACAGCTGAAAATTTTGAGAAGGTAAAAGTTTCTTAATTAAAATATGAACATATTTAGCTTGCTTTAGTGTCTGGGGCAAGTCC
TCTCAATGGCTAAAATTAACTTTAGAGATCCATGTGTTCAGGTTTAGATCATATGACACTCGAGCACAGAAGAATAATTTCAAGGAGGTC
ATCTTGTAAATTAAAGGTTTAGAAGAATTGCATAAAACGTAGTAAATGGGGTCTGTCATTAGCAAAGGCAAATCTAAGCAATCATTTTTC
CCCCCAGAAGTTACTTAGAAGGAGAACTGGGAACACTTGGGGTCTCTCTAACTGATGGCATTCACTTCACACAGTCGTCTATGTTATCCA
GAGATTTTTATTTCATTTTACATTTTAGGGCACAGTTCTTTGGGGCTAATTAAAATGGGGTTTGCAGGCTTTTTATGGTGAAGAATAATA
TATCTCTGTCTATAGCTTTCCCATGGTAGCCTGATAAGGCTGAGAGAGAAAAATATGTGCAGTATCTCATCCTCCCCCTGTACCAGGCCA
TAGCTTTGAAGTGTATTTTGTAAATTCAACTATAGGTTAGTCAGAATGCTGTTTTTCGTTAATTAACTTAGCCTGTGTTGATATCTCCTC
CTTCCTGGTCACATTCAAACCTTCCCAGAGTACAAAGGGGTATGTAGAAAGGATTCCAGAAGAAGTAATACTTTATTCTCTAATGTTAAT
AGCTTTTCTGGATCTCTTAGTAGGGGGAAAGTAGAAAATCGAGTAGAATTTGGCCTCAGGTCAATAAATGATATAAAAACATGTGTTCTA
TTTATGTATATATATGTATGTTTCTCCAAAAAGTGATAAAACCAAAATATCACTGACTCATCCCTACCCATATTCTTTTCATAAAACCCA
CTCACCAGGTACAATAGAAACTTCCCTCCTTGTTTGTCAGCCTCCTGTTCATGTTCCCCACACACCTGAAGGTGGTAGAATCTTTTCAGC
CTCTTAGCCAGTGAGCTAAATATGGCTAAGCACAGGTCATAAGAGCACCTAAGGCCAGCATATAAGCCAACTACAGTTCACCTTTCCAAA
TTTGGTCCTATGGATGTTGAGCATAGGGAAGCAACTCTCAGTATTTTGGATTATTCAAGTGTATGTGGTAAAAATGCAGATGATTGCTGC
TTTACCCCAGGGTTTATTAGCATCCTACTTCTGCTGGGCTGCATCATTATATAATGCCACAGGCATCTAGTCAAGGTAAAGAAGCCAGAA
AGGTTAGGCAAGAAGTGAGATAAAATCAGATCACCTTTGATCAAAATGGTTGGTGAACCTCCACATGTCCAGTTCTGTTGCCAAACTTTC
CATTCAGAGTATTTGGTGGAGTTTGAATTTGAGCAAACTAAATGCCTTCATCTTAGGTAGAAAGGGCCTGAATCTTCCATTTTATATTCA
AACCTCATTGTTATTTGGCCTAAGTAAAAAGTCAGATTTCATTTCCATTTACCTGAGTTCGCTTTAAAGAGCTTTTCAAAGAGAGCTTTA
TAGACACCCACAATTGTCCCCAATCTCTTCATGATGTTGCATTAATAGTTGTTTTTGTCCCTTTCTTGGAAATGTTAATGCCAAAGTTGC
CTGAACATTGGGCGGTTTTCTTAATTTGAAGTATAAAAATTATAAAGAGTAATTCCAAAGGTATTAAAAGATTGTTTAACAGTATGTGTG
GTGATGTCATTATCTCCAGAGAGGCTTCAAGAAATCCTTTGGAAATAAAAAGTTAAATGTTTACATTTCATGTGGTATTTCAGGTCTTCA
GGTTCTGATTAGCTTACTTTTTTCCTTTGTCTTTGGCTGATTTCTGCTTTGTAGATAAATAATAATAGCCCTGAGATGTTTCTAACATTT
AAATAAGAAAAAAATCAAATCGAAGTCAGCCTGCTGGAAAAGTGATCACATGGCAGTTGCAGTAACTTGTATGGAAAGAGAAAATGCAAT
GAGCCCAGTTACTGCACTTGCCACTACCATGCTGTCCATGGAAGGAATAATCAGCAGTTCAGTTGTCACAAGCCGCCCTTGAAGAAAACG
CAGCAAAATATTTTAAAATGAAGATATTGCAGTCCCCAGAGCCAGTGAAGGTTTCTTTTGGTAAAATGAAATTGTGCCATTGTCAAAGTA
CCCCGTAGTGATGAGCACTGACTGGTTCACTGGCCACATTTTAGTTCTTCATAATAATAGGCCACAAAAGGGCTCTGTGGTTTGCCTCCA
TGTGCACTGGCCCCTCCCCACCCCTAGGGGGCACTCAGTAGCTGCTGAGAAGGCCTGTCCACGAGGCTGTTGGAACCCCTCCAATAAATA
CTTAGAGGTAGTGTATCTGATGCTTGTTTTCGTGGAGAAAATTGTATTGGAGAACTTAAAACATCACGAATATTTTTAATAGGATCCGCA
GACACCCAAAGGAGAAGCTTGGTCTTTTCCAGGTATTTCCAACTTGAGTTCAACCCAAAGCCTTTGAAAGGAATGCATTACCACATGACC
ACATGCTGAGACCCCATGGGGTCTAACACGGGACCTAAGAAAGTCTCTGCAGCCAGATAGTACATGGTGTCTCCACAAAACTAGGCATTC
TGGAGATTGCCCAGAAAGGGATGTGAGGGGACCGTTAAGATCTGTCTTGCTTATCTCATGCACTCACATTCCTTCAGCCTCCTGGAGTTC
CTGATAAAAGGAAGCCAGGGTGTGGACATTTTTTAGCTATTGATTTCCCAATAGCTTGTGGATCAGTTGTACACCCACACTTCCTTCTCT
GCCTAATTCCGTTTTTCTGGAAAAAGTAGTATGCCCATGTATGTGTGTTTTTCTTAACACAGGTCCATGAAAGTTTGGCTTCCTGGTTTG
ATGTCTGTTGCGTGGCCTGGAAACCAGGGAGCAGCAACTATTGAGATGGTTTCTGTGTTCAGTGAAAAATTCTATTTCATTGAGACAATT
TTTTCTTTATCCACAGTAATTTTTTGACACTGTCATCATGAAACTACCCTTAGGAAAATAAGATTACCTGCAAAAAAAAAAAAGAAATGA
GTTATGGAATAGGAACAGTTATGTGATGATTCTGAAACTTTAACTTAGAGCTTCATTACTTTAAGAATGGAAAACAACCTCTGAGTTTGA
TTTCCCAAAGTTTCATAAAGCCCCTAAGCTCATGATTTTCATCAACTCTTTGCCCACATAGTCATTTACCTCCACAGCCGTTTGTTGTCA
TAGAAGGGGTGGTGGTGTTTGGATTTGATTTTTTTCAACTTGCAGTGAGAAATAGGATAGGTGACAAAACCTTACTTGTTTTCTTAAGAC
AATTCAGTGCTTGAGCATCTCTGTCAGAAATGGAATGAAATACTGTTAGCCAATTAGAATTATTTTATGTATTGTTATTGTGTTTTGCTG
ATTTTTATATGAAAATATAATTATTCATTCTTGATCTCTGGAAGCAATCATTATTATGAGGATCATTTTACTTTGGAAACACTTTCATAA

>32027_32027_1_GAB2-CERS6_GAB2_chr11_78128691_ENST00000361507_CERS6_chr2_169547543_ENST00000305747_length(amino acids)=276AA_BP=47
MPQLPEPAPSSARPGGGLQAGSMSGGGDVVCTGWLRKSPPEKKLRRYTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFT
DIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTL
FESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTG

--------------------------------------------------------------
>32027_32027_2_GAB2-CERS6_GAB2_chr11_78128691_ENST00000361507_CERS6_chr2_169547543_ENST00000392687_length(transcript)=6347nt_BP=161nt
GAGCTGCGCACCGCCGGCCGCTGCCCCAGCTGCCCGAGCCCGCGCCCTCGTCCGCGCGACCCGGCGGGGGGCTCCAGGCCGGCAGCATGA
GCGGCGGCGGCGACGTGGTGTGCACCGGCTGGCTGAGGAAATCGCCTCCCGAGAAGAAGTTGAGGCGCTATACCCCCTGGTTGTGGAATA
CGAGGCATTGCTGGTACAACTACCCCTATCAGCCACTCACAACTGACCTTCACTACTATTACATCCTGGAGCTGTCGTTTTATTGGTCTT
TGATGTTTTCTCAGTTCACTGATATCAAAAGAAAGGACTTTGGCATTATGTTCCTGCACCACCTTGTATCTATTTTCTTGATTACCTTTT
CATATGTCAACAATATGGCCCGAGTAGGAACGCTGGTCCTTTGTCTTCATGATTCAGCTGATGCTCTTCTGGAGGCTGCCAAAATGGCAA
ATTATGCCAAGTTTCAGAAAATGTGTGATCTCCTGTTTGTTATGTTTGCCGTGGTTTTTATCACCACACGACTGGGTATATTTCCTCTCT
GGGTGTTAAATACCACATTATTTGAAAGCTGGGAGATCGTTGGACCTTACCCTTCCTGGTGGGTTTTTAACCTACTGCTATTGCTAGTAC
AAGGGTTGAACTGCTTCTGGTCTTACTTGATTGTGAAAATAGCTTGCAAAGCTGTTTCAAGAGGCAAGGCTGGGAAGTGGAACCCTTTAC
ATGTGTCCAAGGATGATCGAAGTGATATTGAGTCTAGCTCAGATGAGGAGGACTCAGAACCTCCGGGAAAGAATCCCCACACTGCGACAA
CCACCAATGGGACCAGTGGTACCAACGGGTATCTCCTGACTGGCTCCTGCTCCATGGATGATTAATTACTCAAAACTACAAGTCCCAAGC
AAAGTGAACTATTTGTTCCTGGAAGTATTTAATAAGTTGCAAATGCAGTTCCTTTCATAATATCTCAGCACCAGAAACAAAAATTAAGAT
TATCAAAGCATTTTGAATAGTGCACTGCCATGTGTCCTGTCTGTGAATGAAGAAGAATTACCATTCTCTCTTTGTAGGCATGCTGTATGT
AATTGACACAAGGGAACAGTATTTGCATTTGTACTGTCTTAGAATATTATTTATTTTTTTGTATTTGTAAATCTGTGGACAAAAGAGGGT
TTCCTCACTCCTTTTACTCACTGGGCTCATGACAGTGAAGGAGATGCTCCATCTGCTTCTCCCCCTTTCTCTTGCTGTAGTCCAATGTGC
TATGAGCATCAGCTTACTTTGTCACTTAGAGCAAGCAAAACCCAGTGCAAGAGTCTCGTTCAGCTCTAAATAGGTTTGCTTTCTTTTAGT
TACAGTGCCCATTTTGAAATTGCCTATACAGTCTTAGTGACCATTTAAACCGGACGAACTAGGTGTTTAATTTTCACTCTTCATGTTCAA
TTAGCAGTTCAAATTAAAGAAGATGGTTATTGGAGAACTTTTTTGAATGGTTTTGTATTAAATTGCTTTGAAATAGATTTCATTTCTTGT
GCACACAGCCAAGATTTCTTCAATGGGTGTGAGCTAGTTGAGGGTTAACCTTGTAGGTTGCAGAGTGTATTTGTTTGTTTGTTTGTTTTT
CTCTGTGATGAGGTCAGTGCTCTGATTTTGAAGGAGGATATTCACTGAAGCTCATAGTTATAAACAAGGAAATCACTGTTAAGAATGGGA
ATTTGTCCTGTGTTCTGGGAATAACATAAAGAGAGCAACTGATTTCAGCCAGGTTTTGCCACTACCCTATAATTAGTGCAGTCTTATGTT
ATAAAAGAAAGAAGTTAACTATATTTGGGGACAAAAAAATATTTCAAGAGTTGATAAAGATTACCTGTGCAGTGCAGAGCACTTTAATGC
AACCAGCTTTCAAGAAAAAGCCCTATCTAGTACTTGATGTTGATGTTTTTATTTTGCTGAGCAAAATAAAGCCAATGGGAGAAAGACTAT
TTTACCCTTTGCTTTTCTCCTTAAACGTAATCCAGATGACTTTCCTGTTACTAAACACTGAGCAGCATTACACTACAATGCTTCTTTGGT
TTCCAGGAATTTTTTTCAAATGGGGCTGTTTCTGGAAAAATGAAAAATTCTATTGGACAATGGCAATATCAACAATGAGGAAAATTACTG
AAGAATAAGTTTCCATAAGTCTCCTACATAGCAGTGTTATTTATGTACAGATAAGAAAACCATATGTCAGCCAAAGATTTTATCTCTTCT
TCTAACTTTTAGTAAGAGGAAAAAGGGATTATAAAACCCTTCATAAATCAAGAAGGCCATCACTTAGAACGAACCCCAAACAAAAATGCC
ATAATATAAATGTGTGAATCAGGGCTGTGAAGACAACAGCAGAAATGCTAACAAGCGTGCAGAAACACCAGAGAGTGCGTATCCTGCTCA
GAACCATTCACATTTAATTCAATTCTTGGAAAAAATTAAAGCTTTTTGCCCACAATTTGCAATCTGTGGGTTAATAGTTAAAAGAATGTT
CCCAACCAAAAAATTCTTACCGTAATATTATATCTTGCCCTACTTATTTACAAAATAATATGTTTCTGTTATGGTCCTTAGTAATAATTG
AAGAGGCTTAGAAATACATCTGCTTGTTTATTGAGAAAACGATGCAAATAATTCTGCTTTTAGAGCCTTGTTATTTTATTTCACAAAACA
GGCATATGTCTAGGAGTGTAATTTGTGGATGGTTGAGTTTGTAAGAACAATCATAAAAGGACTTGTTAGTCTCCAGAACATCTGCTAAAA
TGCAAGTATATGTATAAGGTAATAGCATATTACAGCTGAAAATTTTGAGAAGGTAAAAGTTTCTTAATTAAAATATGAACATATTTAGCT
TGCTTTAGTGTCTGGGGCAAGTCCTCTCAATGGCTAAAATTAACTTTAGAGATCCATGTGTTCAGGTTTAGATCATATGACACTCGAGCA
CAGAAGAATAATTTCAAGGAGGTCATCTTGTAAATTAAAGGTTTAGAAGAATTGCATAAAACGTAGTAAATGGGGTCTGTCATTAGCAAA
GGCAAATCTAAGCAATCATTTTTCCCCCCAGAAGTTACTTAGAAGGAGAACTGGGAACACTTGGGGTCTCTCTAACTGATGGCATTCACT
TCACACAGTCGTCTATGTTATCCAGAGATTTTTATTTCATTTTACATTTTAGGGCACAGTTCTTTGGGGCTAATTAAAATGGGGTTTGCA
GGCTTTTTATGGTGAAGAATAATATATCTCTGTCTATAGCTTTCCCATGGTAGCCTGATAAGGCTGAGAGAGAAAAATATGTGCAGTATC
TCATCCTCCCCCTGTACCAGGCCATAGCTTTGAAGTGTATTTTGTAAATTCAACTATAGGTTAGTCAGAATGCTGTTTTTCGTTAATTAA
CTTAGCCTGTGTTGATATCTCCTCCTTCCTGGTCACATTCAAACCTTCCCAGAGTACAAAGGGGTATGTAGAAAGGATTCCAGAAGAAGT
AATACTTTATTCTCTAATGTTAATAGCTTTTCTGGATCTCTTAGTAGGGGGAAAGTAGAAAATCGAGTAGAATTTGGCCTCAGGTCAATA
AATGATATAAAAACATGTGTTCTATTTATGTATATATATGTATGTTTCTCCAAAAAGTGATAAAACCAAAATATCACTGACTCATCCCTA
CCCATATTCTTTTCATAAAACCCACTCACCAGGTACAATAGAAACTTCCCTCCTTGTTTGTCAGCCTCCTGTTCATGTTCCCCACACACC
TGAAGGTGGTAGAATCTTTTCAGCCTCTTAGCCAGTGAGCTAAATATGGCTAAGCACAGGTCATAAGAGCACCTAAGGCCAGCATATAAG
CCAACTACAGTTCACCTTTCCAAATTTGGTCCTATGGATGTTGAGCATAGGGAAGCAACTCTCAGTATTTTGGATTATTCAAGTGTATGT
GGTAAAAATGCAGATGATTGCTGCTTTACCCCAGGGTTTATTAGCATCCTACTTCTGCTGGGCTGCATCATTATATAATGCCACAGGCAT
CTAGTCAAGGTAAAGAAGCCAGAAAGGTTAGGCAAGAAGTGAGATAAAATCAGATCACCTTTGATCAAAATGGTTGGTGAACCTCCACAT
GTCCAGTTCTGTTGCCAAACTTTCCATTCAGAGTATTTGGTGGAGTTTGAATTTGAGCAAACTAAATGCCTTCATCTTAGGTAGAAAGGG
CCTGAATCTTCCATTTTATATTCAAACCTCATTGTTATTTGGCCTAAGTAAAAAGTCAGATTTCATTTCCATTTACCTGAGTTCGCTTTA
AAGAGCTTTTCAAAGAGAGCTTTATAGACACCCACAATTGTCCCCAATCTCTTCATGATGTTGCATTAATAGTTGTTTTTGTCCCTTTCT
TGGAAATGTTAATGCCAAAGTTGCCTGAACATTGGGCGGTTTTCTTAATTTGAAGTATAAAAATTATAAAGAGTAATTCCAAAGGTATTA
AAAGATTGTTTAACAGTATGTGTGGTGATGTCATTATCTCCAGAGAGGCTTCAAGAAATCCTTTGGAAATAAAAAGTTAAATGTTTACAT
TTCATGTGGTATTTCAGGTCTTCAGGTTCTGATTAGCTTACTTTTTTCCTTTGTCTTTGGCTGATTTCTGCTTTGTAGATAAATAATAAT
AGCCCTGAGATGTTTCTAACATTTAAATAAGAAAAAAATCAAATCGAAGTCAGCCTGCTGGAAAAGTGATCACATGGCAGTTGCAGTAAC
TTGTATGGAAAGAGAAAATGCAATGAGCCCAGTTACTGCACTTGCCACTACCATGCTGTCCATGGAAGGAATAATCAGCAGTTCAGTTGT
CACAAGCCGCCCTTGAAGAAAACGCAGCAAAATATTTTAAAATGAAGATATTGCAGTCCCCAGAGCCAGTGAAGGTTTCTTTTGGTAAAA
TGAAATTGTGCCATTGTCAAAGTACCCCGTAGTGATGAGCACTGACTGGTTCACTGGCCACATTTTAGTTCTTCATAATAATAGGCCACA
AAAGGGCTCTGTGGTTTGCCTCCATGTGCACTGGCCCCTCCCCACCCCTAGGGGGCACTCAGTAGCTGCTGAGAAGGCCTGTCCACGAGG
CTGTTGGAACCCCTCCAATAAATACTTAGAGGTAGTGTATCTGATGCTTGTTTTCGTGGAGAAAATTGTATTGGAGAACTTAAAACATCA
CGAATATTTTTAATAGGATCCGCAGACACCCAAAGGAGAAGCTTGGTCTTTTCCAGGTATTTCCAACTTGAGTTCAACCCAAAGCCTTTG
AAAGGAATGCATTACCACATGACCACATGCTGAGACCCCATGGGGTCTAACACGGGACCTAAGAAAGTCTCTGCAGCCAGATAGTACATG
GTGTCTCCACAAAACTAGGCATTCTGGAGATTGCCCAGAAAGGGATGTGAGGGGACCGTTAAGATCTGTCTTGCTTATCTCATGCACTCA
CATTCCTTCAGCCTCCTGGAGTTCCTGATAAAAGGAAGCCAGGGTGTGGACATTTTTTAGCTATTGATTTCCCAATAGCTTGTGGATCAG
TTGTACACCCACACTTCCTTCTCTGCCTAATTCCGTTTTTCTGGAAAAAGTAGTATGCCCATGTATGTGTGTTTTTCTTAACACAGGTCC
ATGAAAGTTTGGCTTCCTGGTTTGATGTCTGTTGCGTGGCCTGGAAACCAGGGAGCAGCAACTATTGAGATGGTTTCTGTGTTCAGTGAA
AAATTCTATTTCATTGAGACAATTTTTTCTTTATCCACAGTAATTTTTTGACACTGTCATCATGAAACTACCCTTAGGAAAATAAGATTA
CCTGCAAAAAAAAAAAAGAAATGAGTTATGGAATAGGAACAGTTATGTGATGATTCTGAAACTTTAACTTAGAGCTTCATTACTTTAAGA
ATGGAAAACAACCTCTGAGTTTGATTTCCCAAAGTTTCATAAAGCCCCTAAGCTCATGATTTTCATCAACTCTTTGCCCACATAGTCATT
TACCTCCACAGCCGTTTGTTGTCATAGAAGGGGTGGTGGTGTTTGGATTTGATTTTTTTCAACTTGCAGTGAGAAATAGGATAGGTGACA
AAACCTTACTTGTTTTCTTAAGACAATTCAGTGCTTGAGCATCTCTGTCAGAAATGGAATGAAATACTGTTAGCCAATTAGAATTATTTT
ATGTATTGTTATTGTGTTTTGCTGATTTTTATATGAAAATATAATTATTCATTCTTGATCTCTGGAAGCAATCATTATTATGAGGATCAT

>32027_32027_2_GAB2-CERS6_GAB2_chr11_78128691_ENST00000361507_CERS6_chr2_169547543_ENST00000392687_length(amino acids)=284AA_BP=47
MPQLPEPAPSSARPGGGLQAGSMSGGGDVVCTGWLRKSPPEKKLRRYTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFT
DIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTL
FESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSG

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Fusion Gene PPI Analysis for GAB2-CERS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GAB2-CERS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GAB2-CERS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource