FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GABARAPL2-TP63 (FusionGDB2 ID:32059)

Fusion Gene Summary for GABARAPL2-TP63

check button Fusion gene summary
Fusion gene informationFusion gene name: GABARAPL2-TP63
Fusion gene ID: 32059
HgeneTgene
Gene symbol

GABARAPL2

TP63

Gene ID

11345

8626

Gene nameGABA type A receptor associated protein like 2tumor protein p63
SynonymsATG8|ATG8C|GATE-16|GATE16|GEF-2|GEF2AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
Cytomap

16q23.1

3q28

Type of geneprotein-codingprotein-coding
Descriptiongamma-aminobutyric acid receptor-associated protein-like 2GABA(A) receptor-associated protein-like 2MAP1 light chain 3 related proteinganglioside expression factor 2general protein transport factor p16golgi-associated ATPase enhancer of 16 kDatumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
Modification date2020032720200329
UniProtAcc

P60520

.
Ensembl transtripts involved in fusion geneENST00000037243, ENST00000563744, 
ENST00000565985, ENST00000565057, 
ENST00000568455, 		ENST00000264731, 
ENST00000354600, ENST00000382063, 
ENST00000320472, ENST00000392460, 
ENST00000392461, ENST00000392463, 
ENST00000418709, ENST00000437221, 
ENST00000440651, ENST00000449992, 
ENST00000456148, 
Fusion gene scores* DoF score1 X 1 X 1=113 X 11 X 8=1144
# samples 115
** MAII scorelog2(1/1*10)=3.32192809488736log2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GABARAPL2 [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGABARAPL2(75611449)-TP63(189614740), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

TgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

TgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

TgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

TgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check buttonFusion gene breakpoints across GABARAPL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TP63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE843564GABARAPL2chr16

75611449

+TP63chr3

189614740

+


Top

Fusion Gene ORF analysis for GABARAPL2-TP63

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000037243ENST00000264731GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000037243ENST00000354600GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000037243ENST00000382063GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000563744ENST00000264731GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000563744ENST00000354600GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000563744ENST00000382063GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000565985ENST00000264731GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000565985ENST00000354600GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-3UTRENST00000565985ENST00000382063GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000320472GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000392460GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000392461GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000392463GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000418709GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000437221GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000440651GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000449992GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000037243ENST00000456148GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000320472GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000392460GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000392461GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000392463GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000418709GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000437221GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000440651GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000449992GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000563744ENST00000456148GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000320472GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000392460GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000392461GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000392463GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000418709GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000437221GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000440651GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000449992GABARAPL2chr16

75611449

+TP63chr3

189614740

+
3UTR-intronENST00000565985ENST00000456148GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-3UTRENST00000565057ENST00000264731GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-3UTRENST00000565057ENST00000354600GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-3UTRENST00000565057ENST00000382063GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-3UTRENST00000568455ENST00000264731GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-3UTRENST00000568455ENST00000354600GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-3UTRENST00000568455ENST00000382063GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000320472GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000392460GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000392461GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000392463GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000418709GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000437221GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000440651GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000449992GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000565057ENST00000456148GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000320472GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000392460GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000392461GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000392463GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000418709GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000437221GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000440651GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000449992GABARAPL2chr16

75611449

+TP63chr3

189614740

+
intron-intronENST00000568455ENST00000456148GABARAPL2chr16

75611449

+TP63chr3

189614740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for GABARAPL2-TP63


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GABARAPL2-TP63


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:75611449/:189614740)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GABARAPL2

P60520

.
FUNCTION: Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). {ECO:0000250|UniProtKB:P60519, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for GABARAPL2-TP63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for GABARAPL2-TP63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GABARAPL2-TP63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GABARAPL2-TP63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource