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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GABBR1-PLSCR1 (FusionGDB2 ID:32066)

Fusion Gene Summary for GABBR1-PLSCR1

Fusion gene summary

Fusion gene information	Fusion gene name: GABBR1-PLSCR1
	Fusion gene ID: 32066
		Hgene	Tgene
	Gene symbol	GABBR1	PLSCR1
	Gene ID	10537	5359
	Gene name	ubiquitin D	phospholipid scramblase 1
	Synonyms	FAT10\|GABBR1\|UBD-3	MMTRA1B
	Cytomap	6p22.1	3q24
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin Ddiubiquitinubiquitin-like protein FAT10	phospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblase
	Modification date	20200313	20200313
	UniProtAcc	Q9UBS5	.
	Ensembl transtripts involved in fusion gene	ENST00000355973, ENST00000376977, ENST00000377012, ENST00000377016, ENST00000377034, ENST00000383537, ENST00000383541, ENST00000383542, ENST00000383543, ENST00000383636, ENST00000383637, ENST00000383638, ENST00000383639, ENST00000414980, ENST00000417759, ENST00000418225, ENST00000419674, ENST00000423604, ENST00000425097, ENST00000434660, ENST00000438094, ENST00000439457, ENST00000440316, ENST00000443440, ENST00000446436, ENST00000448754, ENST00000449163, ENST00000452300, ENST00000458612, ENST00000464091, ENST00000471103, ENST00000486623, ENST00000489750, ENST00000493602, ENST00000495153, ENST00000546913, ENST00000547410, ENST00000548767, ENST00000550428, ENST00000550820, ENST00000551140, ENST00000551423, ENST00000552399,	ENST00000342435, ENST00000448205, ENST00000448787, ENST00000484560, ENST00000487389,
Fusion gene scores	* DoF score	4 X 4 X 1=16	11 X 9 X 2=198
	# samples	4	11
	** MAII score	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(11/198*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GABBR1 [Title/Abstract] AND PLSCR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GABBR1(29577842)-PLSCR1(146232967), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GABBR1	GO:0006511	ubiquitin-dependent protein catabolic process	17889673
Hgene	GABBR1	GO:0016567	protein ubiquitination	15831455\|17889673
Hgene	GABBR1	GO:0070842	aggresome assembly	19033385
Tgene	PLSCR1	GO:0006915	apoptotic process	10770950
Tgene	PLSCR1	GO:0017121	phospholipid scrambling	9218461\|10770950\|18629440
Tgene	PLSCR1	GO:0045944	positive regulation of transcription by RNA polymerase II	16091359
Tgene	PLSCR1	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	17567603

Fusion gene breakpoints across GABBR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLSCR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AX381845	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+

Top

Fusion Gene ORF analysis for GABBR1-PLSCR1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000355973	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000355973	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000355973	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000355973	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000355973	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000376977	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000376977	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000376977	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000376977	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000376977	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377012	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377012	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377012	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377012	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377012	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377016	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377016	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377016	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377016	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377016	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377034	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377034	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377034	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377034	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000377034	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383537	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383537	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383537	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383537	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383537	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383541	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383541	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383541	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383541	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383541	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383542	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383542	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383542	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383542	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383542	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383543	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383543	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383543	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383543	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383543	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383636	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383636	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383636	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383636	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383636	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383637	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383637	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383637	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383637	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383637	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383638	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383638	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383638	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383638	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383638	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383639	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383639	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383639	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383639	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000383639	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000414980	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000414980	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000414980	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000414980	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000414980	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000417759	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000417759	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000417759	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000417759	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000417759	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000418225	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000418225	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000418225	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000418225	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000418225	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000419674	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000419674	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000419674	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000419674	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000419674	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000423604	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000423604	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000423604	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000423604	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000423604	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000425097	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000425097	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000425097	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000425097	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000425097	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000434660	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000434660	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000434660	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000434660	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000434660	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000438094	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000438094	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000438094	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000438094	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000438094	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000439457	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000439457	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000439457	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000439457	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000439457	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000440316	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000440316	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000440316	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000440316	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000440316	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000443440	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000443440	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000443440	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000443440	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000443440	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000446436	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000446436	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000446436	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000446436	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000446436	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000448754	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000448754	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000448754	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000448754	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000448754	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000449163	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000449163	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000449163	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000449163	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000449163	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000452300	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000452300	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000452300	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000452300	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000452300	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000458612	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000458612	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000458612	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000458612	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000458612	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000464091	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000464091	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000464091	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000464091	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000464091	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000471103	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000471103	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000471103	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000471103	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000471103	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000486623	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000486623	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000486623	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000486623	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000486623	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000489750	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000489750	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000489750	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000489750	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000489750	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000493602	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000493602	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000493602	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000493602	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000493602	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000495153	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000495153	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000495153	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000495153	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000495153	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000546913	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000546913	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000546913	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000546913	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000546913	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000547410	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000547410	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000547410	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000547410	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000547410	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000548767	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000548767	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000548767	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000548767	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000548767	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550428	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550428	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550428	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550428	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550428	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550820	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550820	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550820	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550820	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000550820	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551140	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551140	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551140	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551140	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551140	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551423	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551423	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551423	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551423	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000551423	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000552399	ENST00000342435	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000552399	ENST00000448205	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000552399	ENST00000448787	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000552399	ENST00000484560	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+
intron-intron	ENST00000552399	ENST00000487389	GABBR1	chr6	29577842	-	PLSCR1	chr3	146232967	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for GABBR1-PLSCR1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GABBR1-PLSCR1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29577842/:146232967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GABBR1 Q9UBS5	.
FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054). {ECO:0000250\|UniProtKB:Q9Z0U4, ECO:0000269\|PubMed:10075644, ECO:0000269\|PubMed:10773016, ECO:0000269\|PubMed:10906333, ECO:0000269\|PubMed:15617512, ECO:0000269\|PubMed:18165688, ECO:0000269\|PubMed:22660477, ECO:0000269\|PubMed:24305054, ECO:0000269\|PubMed:9844003, ECO:0000269\|PubMed:9872316, ECO:0000269\|PubMed:9872744, ECO:0000305}.; FUNCTION: Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for GABBR1-PLSCR1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GABBR1-PLSCR1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GABBR1-PLSCR1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GABBR1-PLSCR1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source