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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GABBR2-ANKS6 (FusionGDB2 ID:32069)

Fusion Gene Summary for GABBR2-ANKS6

Fusion gene summary

Fusion gene information	Fusion gene name: GABBR2-ANKS6
	Fusion gene ID: 32069
		Hgene	Tgene
	Gene symbol	GABBR2	ANKS6
	Gene ID	9568	203286
	Gene name	gamma-aminobutyric acid type B receptor subunit 2	ankyrin repeat and sterile alpha motif domain containing 6
	Synonyms	EIEE59\|GABABR2\|GPR51\|GPRC3B\|HG20\|HRIHFB2099\|NDPLHS	ANKRD14\|NPHP16\|PKDR1\|SAMD6
	Cytomap	9q22.33	9q22.33
	Type of gene	protein-coding	protein-coding
	Description	gamma-aminobutyric acid type B receptor subunit 2G-protein coupled receptor 51GABA-B receptor 2GABA-B receptor, R2 subunitGABA-B-R2GABA-BR2gamma-aminobutyric acid (GABA) B receptor, 2gamma-aminobutyric acid B receptor 2gb2	ankyrin repeat and SAM domain-containing protein 6SAM domain-containing protein 6ankyrin repeat domain 14samCystin
	Modification date	20200313	20200320
	UniProtAcc	O75899	Q68DC2
	Ensembl transtripts involved in fusion gene	ENST00000259455, ENST00000477471,	ENST00000471846, ENST00000353234, ENST00000375018, ENST00000375019, ENST00000540940,
Fusion gene scores	* DoF score	5 X 5 X 3=75	2 X 2 X 2=8
	# samples	5	2
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: GABBR2 [Title/Abstract] AND ANKS6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GABBR2(101304155)-ANKS6(101498905), # samples:1
Anticipated loss of major functional domain due to fusion event.	GABBR2-ANKS6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GABBR2-ANKS6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GABBR2	GO:0007214	gamma-aminobutyric acid signaling pathway	9872316

Fusion gene breakpoints across GABBR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A1EB-01A	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-

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Fusion Gene ORF analysis for GABBR2-ANKS6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000259455	ENST00000471846	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
5UTR-3CDS	ENST00000477471	ENST00000353234	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
5UTR-3CDS	ENST00000477471	ENST00000375018	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
5UTR-3CDS	ENST00000477471	ENST00000375019	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
5UTR-3CDS	ENST00000477471	ENST00000540940	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
5UTR-intron	ENST00000477471	ENST00000471846	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
Frame-shift	ENST00000259455	ENST00000540940	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
In-frame	ENST00000259455	ENST00000353234	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
In-frame	ENST00000259455	ENST00000375018	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-
In-frame	ENST00000259455	ENST00000375019	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000259455	GABBR2	chr9	101304155	-	ENST00000375019	ANKS6	chr9	101498905	-	1745	1090	460	1236	258
ENST00000259455	GABBR2	chr9	101304155	-	ENST00000375018	ANKS6	chr9	101498905	-	5705	1090	460	1194	244
ENST00000259455	GABBR2	chr9	101304155	-	ENST00000353234	ANKS6	chr9	101498905	-	5695	1090	460	1194	244

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000259455	ENST00000375019	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-	0.06775583	0.9322442
ENST00000259455	ENST00000375018	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-	0.041378688	0.9586214
ENST00000259455	ENST00000353234	GABBR2	chr9	101304155	-	ANKS6	chr9	101498905	-	0.050965864	0.94903415

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Fusion Genomic Features for GABBR2-ANKS6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GABBR2-ANKS6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:101304155/chr9:101498905)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GABBR2 O75899	ANKS6 Q68DC2
FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269\|PubMed:10075644, ECO:0000269\|PubMed:10328880, ECO:0000269\|PubMed:15617512, ECO:0000269\|PubMed:18165688, ECO:0000269\|PubMed:22660477, ECO:0000269\|PubMed:24305054, ECO:0000269\|PubMed:9872316, ECO:0000269\|PubMed:9872744, ECO:0000305}.	FUNCTION: Required for renal function. {ECO:0000269\|PubMed:23793029}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

781_819

210

942.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

42_483

210

942.0

Topological domain

Extracellular

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

505_522

210

942.0

Topological domain

Cytoplasmic

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

544_551

210

942.0

Topological domain

Extracellular

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

573_597

210

942.0

Topological domain

Cytoplasmic

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

619_654

210

942.0

Topological domain

Extracellular

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

676_691

210

942.0

Topological domain

Cytoplasmic

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

713_720

210

942.0

Topological domain

Extracellular

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

742_941

210

942.0

Topological domain

Cytoplasmic

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

484_504

210

942.0

Transmembrane

Helical%3B Name%3D1

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

523_543

210

942.0

Transmembrane

Helical%3B Name%3D2

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

552_572

210

942.0

Transmembrane

Helical%3B Name%3D3

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

598_618

210

942.0

Transmembrane

Helical%3B Name%3D4

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

655_675

210

942.0

Transmembrane

Helical%3B Name%3D5

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

692_712

210

942.0

Transmembrane

Helical%3B Name%3D6

Hgene

GABBR2

chr9:101304155

chr9:101498905

ENST00000259455

721_741

210

942.0

Transmembrane

Helical%3B Name%3D7

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

617_769

837

872.0

Compositional bias

Note=Ser-rich

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

617_769

838

873.0

Compositional bias

Note=Ser-rich

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

773_836

837

872.0

Domain

SAM

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

773_836

838

873.0

Domain

SAM

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

110_139

837

872.0

Repeat

Note=ANK 3

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

143_172

837

872.0

Repeat

Note=ANK 4

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

190_219

837

872.0

Repeat

Note=ANK 5

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

224_253

837

872.0

Repeat

Note=ANK 6

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

257_289

837

872.0

Repeat

Note=ANK 7

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

291_321

837

872.0

Repeat

Note=ANK 8

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

325_354

837

872.0

Repeat

Note=ANK 9

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

359_388

837

872.0

Repeat

Note=ANK 10

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

392_423

837

872.0

Repeat

Note=ANK 11

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

77_106

837

872.0

Repeat

Note=ANK 2

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000353234

8_37

837

872.0

Repeat

Note=ANK 1

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

110_139

838

873.0

Repeat

Note=ANK 3

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

143_172

838

873.0

Repeat

Note=ANK 4

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

190_219

838

873.0

Repeat

Note=ANK 5

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

224_253

838

873.0

Repeat

Note=ANK 6

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

257_289

838

873.0

Repeat

Note=ANK 7

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

291_321

838

873.0

Repeat

Note=ANK 8

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

325_354

838

873.0

Repeat

Note=ANK 9

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

359_388

838

873.0

Repeat

Note=ANK 10

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

392_423

838

873.0

Repeat

Note=ANK 11

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

77_106

838

873.0

Repeat

Note=ANK 2

Tgene

ANKS6

chr9:101304155

chr9:101498905

ENST00000375018

8_37

838

873.0

Repeat

Note=ANK 1

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Fusion Gene Sequence for GABBR2-ANKS6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>32069_32069_1_GABBR2-ANKS6_GABBR2_chr9_101304155_ENST00000259455_ANKS6_chr9_101498905_ENST00000353234_length(transcript)=5695nt_BP=1090nt
GCCGCCCCTGAGCAGCCTCGCCTTCGCCTCCCGCGTTTCCTGCCGTCCGCCCTCCCCCGGCCGAGCTCCAGGGGCTGCCGCCTAGCAGCT
CCCGGCGGGAGAGCGGTTCAGAGCGCGCACGGGGGCGGGCGGAGGCGGCCCGGTGCGGGGCGGCCGCGCTGGAGAGAGGCGCGCGCGGAG
ACGCCGGCCCCCCTCTCCGCGTTTGCTCGCTTGCTCCCCGCCTCCCGCACTCCGCTCGCTCCCACCCCTTCCCGGCGTGATTGATCCGTC
ACGGGCGCCGCCGCTGCCGCCGCCGCCGCCGCGGCCGTTCTGAGCCGAGCCGGAACCCTAGCCCGAGACGGAGCCGGGGCCCGGGCCGGC
GCCATTGCGCGGGCGCCGCGGGAAGACCTTGGCGCGGGGCGGCGGGCCGGGCCAGGCCATGCGGGCCGAGTGAGCCGGCGCCCGCAGCCC
GCGGCGCGGCATGGCTTCCCCGCGGAGCTCCGGGCAGCCCGGGCCGCCGCCGCCGCCGCCACCGCCGCCCGCGCGCCTGCTACTGCTACT
GCTGCTGCCGCTGCTGCTGCCTCTGGCGCCCGGGGCCTGGGGCTGGGCGCGGGGCGCCCCCCGGCCGCCGCCCAGCAGCCCGCCGCTCTC
CATCATGGGCCTCATGCCGCTCACCAAGGAGGTGGCCAAGGGCAGCATCGGGCGCGGTGTGCTCCCCGCCGTGGAACTGGCCATCGAGCA
GATCCGCAACGAGTCACTCCTGCGCCCCTACTTCCTCGACCTGCGGCTCTATGACACGGAGTGCGACAACGCAAAAGGGTTGAAAGCCTT
CTACGATGCAATAAAATACGGGCCTAACCACTTGATGGTGTTTGGAGGCGTCTGTCCATCCGTCACATCCATCATTGCAGAGTCCCTCCA
AGGCTGGAATCTGGTGCAGCTTTCTTTTGCTGCAACCACGCCTGTTCTAGCCGATAAGAAAAAATACCCTTATTTCTTTCGGACCGTCCC
ATCAGACAATGCGGTGAATCCAGCCATTCTGAAGTTGCTCAAGCACTACCAGTGGAAGCGCGTGGGCACGCTGACGCAAGACGTTCAGAG
GTTCTCTGAGGGACGCGAGAGACAAATTTTACAGGAAACCATTCACAACTTTCACTCTTCCTTTGAGAGCAGTGCCAGCAACACCAGGGC
CCCTGGCAACAGCCCCTGTGCGTGATCCTCCTTCCCGCAGCCACCAGCGTGAGCTCTCTGAATCCCGGGACCCCTTCACGTGGCCACAGC
CCCAGCCCTGCCCCCGTCACACTGCTGTGCCTTAGTCATGTTGTTCCCTTTGCTCGGGATGCCCACTTCACGTCGACGGCATTCATTGGT
AGTACTTCTTGCTGCAACAAACTTCAACACACAGAGACAGATTCCCATGTAACAGTCCAGTGGGGGTGCTTCTGCTTGGCAGGTTGGTTC
ACACAGTGATGCAGGGACTCAGCTCCTTTCATCCTGTGCTCTGCCCTCCCCGGGAGCCTCAGAGTTTGCTTCTGGCTGGCGGCAAGGGAA
AGGGACGATGGAGAAGGCACGGCTGCTTCTTACCTGCCTTGCTCTTAACTGACACACATCACTCCTGCTCACGTCCTCTTGGCCACTGGT
AGTCATGTGGCCCCACCTGGATGCAGAGGAGGCCAGGATGTGCAGTCTCCACATAGTGGCTTCCCAGCAACAACTTTTGACTTAGATGGG
GGGTATGTATTATGGTGAGAGGTTAGCCTTCCTGGCACATCTTCCCTTAAAACTTCTAACTTGCCCCTCCTAGTCCAAGTCACCTCTCAG
ATGAAGTCTTTTTTGACCCCCTTTCAGCCACTGGGTCCCTTAGTGCTGTGTATGTGACTGCTGTAGCATTCCACTGCACCTGCTGCATAC
AGCTTACATTGGAGATGTGTATGTCAAACGCATTTTTCTTTATTGCAAAGAGAGTCTATTATAGAAGGAAAGAAGTGGAGGCCTGCTGTG
TGGATCCCTTCTTCTTCCTAGCTTTCAGTTTCCTTATCTGCAAAGTGGAAGGTCAGACCAGATGATGCTCTGGTACTCCACAGTGCTCAC
CTGTATCACTGCAGGGCTTTCTGCACTGAAAGTGGAAGCAGAAGGCTAATGGGTCACATTGTGTAAAGGTCTCTGGTGCTCAAAGTTTCT
AGGCAAAGAAGTGAAAATTTGGAATTTTGTCTACATCCTATTAATGCTGTGTTCCTCAAAAGGGAATTGGCTTGTGTAGTTTCCTACCAT
ATCATATTTTATTAAATTAGAGGGGCCCTGACTTTTAAAACCCACTGGCTTTCTGAAGTGTTTTCCAGTGAATGACTCATTCAGCCAGTG
CTTGTTGCATTTATGTTAGCTACCAGGTGCCAAGTGTGCAGACACAATACAGAGCCTTCAGGCTCTCGACAGGCAAGAGAACACCTGTAA
ATAGATGGTCCCGACATTGAGAGGCAGCATGGTAGAGTGGGCAGACCTTGTGCTCTGGACTCAGGTTCAAAGTTCAGATGAAGCTCAATG
GCCTCTTAGTTGGAGCTTAGAACCAGTATGCCCAAAGTGCTGGGTCTGCAGGAAGTACCCAGTCGATGGTAGGCTGCACAGAATTCTGAT
CTCTACCTTGAGCCATGCTGAGCCACAAGTTGGTCTCCTTGGGAGGTGCCATCTCTCATCTGTCCCTCCCCCAGCCATGAAAGCCCATTC
CCCTATGCTGGCTTTCAGAGGCTGTCGTTAACTTACTGCCCAGAGCCTCGTAGTTTTCTTCCCCTGCCCTGATGGTTGGGTGTTTTTCCT
TTAAATTCTCTCAGCCTTACACTCACAGAAGCCAACTTTCCACAGGACTGAAGACAAAGTGTTTCATTTAGCTGTTACTGATAGACACCT
TTACAAAGGTTACTAATGTCCCAGCCTTTTTAAGGAGACACACTCATTCATCCCCTACTATGTGCTGGCAGCTTTACCTTTGTCATTTCA
TCCTCATGGCCACCCTGGAGGTGGCATTGTGTAACCTCATCTTGCACATTCGGGAAACGGATGCTTAGGAGAGGGAAGCAGCTTGCCAGT
TAAACAGCCCAGAAGGAGCAGATCTGGGGTCAGAACCGGACCTGGTGGGCTTGCAAGCCTGTGCCTTTTCCACTAACTCCTATAGACTCC
TGGAGCTAGAAGCACTTGTGATTCTTGTTTTAATTTACTGATGGCTTCAGGGGTTAACAGTAGGCCTAGAATTGTTTGCCTCTGAAATTC
ATGGCCCCTGACGTTATGTGCTTTGAGGTTTTGTGCCTGCTTTTTGCTGTGGTCCTGTTTTTTTCATAACAATATACTGGTATAGCTTCC
ACTCAGGTAAGTTTGATTGAACAATGATACACAGCTGCACCGGGGGGTCACCTTTTCACAAATGTAGACCTCCATGAACTCATTGGATGA
CCCTGGACAGAGCGGGGCTATTCCCATTTTGCAGACAGGACAGCAGAGGCTCCAGACAATGCCTTTCCTTTCTTTTTCACTGGACTCAAG
TGTCCAAGGCTTTTCATCCTAGGAAGTTTGTGTGCTGGTTCACAAGAGGTCCCTGGCACCCTTTCTGGGGATGTTTGGATGCGGCTGGTA
GGCAGGGAAGAGAAAGGGCACCCCAGCGGGGGCATGTGTGGAGGCAGCACGGAACATGTAGGTTATAGATCGTCAGGGAGGAGGGGTCAG
TTGGGTGCTTGTTTTTCTGATTTTTGGTCCTTGATCACCCCCTTCCCTTCCCACACGTGTCCCCAGCCTGCCTGTGGCTGTTCCCCCCAC
AAGAAGCACCTCCCTTGCTTGGCAACCTTCACCAGCATTTCCCAAAAGTATGCTCCTGGGAACCCTAGTTCCACAGGATAATAGGTTTTT
CATAAAGAAACGTAGGGTGTGTATGTGAAAGTGGGGTGAGGTTCCCTGGTTGAGTAGGTTTGGCAGACACTAAAGCGAGCTACACGATCA
TCTTTGCTACAGGCCTCTCACAACCTTCAGCATGCCAGCATGGGTCAGGCCTCTTCACAGGGCCAAGAAACTCATAGCATCTCCCACATT
ACTCTCATCACTTCTCCAAGGTGCTTTTGCAAGACTGGAATTCCTTGGACACCATTGGAGAAGCCCCGCTTTTTCTGGAACAGCGGCAAC
CAAGAGGCCTTGCAGCCCTGGAAGTGGGTCAGGGCCCTTGGTGGTCACCTTTTTCTCCCCAGCAGCTCTGCAGAGGTGGCCTGCTTGGCA
GTGGGACATCAGGGGACCGGTCCTGCTTTGAGATGGCAGGGTCCCTGTTCTGAGAGCTCTCCAGCCTGAGGGCATTGAGCTGAGGCTCCA
CCCTGAGCTCTCCTGCAGGGTGGAGGGCATTGTTTCCCAGCACCCAGGCAGTGTCTTGCTGGTGTGTCGTGAGTGCTGGATGTCCAAGTC
CCTGCTGGCCACGGAGGGCTCCTGCCTCTCTTCTTCAGCGCCACAAAATTACATGGAGGCCAGCTGGTTTTGTGAGGAGATTGTTTATTT
TTTAATTCTTTTGTTTACCGAACGTTTACTGAGCATCTACCCTGTGCCAGCCCTACTCGTACGCTCTGTCTCCAAAGATGAAAAAGGACT
TCTCTGCCCTCAAGGGAACCCCACAGTATCTTAGAGGAGACAATCATGTCGGTGAGATGGTGTGGTGATGAAGCCTGCTGGGTATACAGC
TCAGGGAAAGTCATCGATGATGGCTCAGGCTCAGCCTGGGCACGCCCCAGAGGAGAGAGATGGAGTGGGGCCTCAAAGGGCAGGTTTAGG
CAGAAAAGAAAAAGGGCATTCCAGCTGGGGCATGTGCAAAGGCAGCACGTAATGTGTAAGTTCTAGATCGTCAGGGAGGAAGGGTCAGTT
GGGTGCCTGTTTTTCTGTTTTTAGTCCTTTAAAATGAGTAGAAGCAACCTGTTACCCTGGAAAGAGCACTGGACATAGACCTAGTGCTGC
GTGATGTTGAGCACGTTTCTTCTTCCCTTTGAGTCCCAGTTTCCCTTTTGGTTACAGGGGGATAGTAGCCCCCAGGGATCATGTGAAAGT
GAGAAAGCCCTTTTCACACTGTGGAGCGGTGCAGATGTGGGAAACCTCAAAGATGGTTGCCCATTTTAAATCCTTTCATCTCTCATCTCT
CTTTCTTCTCTCCCTTCTGCCCTGACGTAGCCATGGTTGGGTGGGTGAGGCCAGAAGAAACTGCCTCCGGCAAGAGGTAGCAGCCGCTCA
GGTGGCTCTGCTGGCATCGGAGCCCACAGAAGTGAGGAGTGGCCGATGGACCTGCCCTCCAAATGTGCCTGACTCTGGGTCTTGCTGTCA
CTGGATTTCCTGGCATGGCAGACAGAAAGAAAGATAGTTTGACCAAGTCGTAGAAGCTGATCCAGCGGGTAAAAAGGGGGCAGGGAACTC
GTCCCTTTTATTCTTGCCTCAGAGCTGCCTGAAGACATGGGCCAGGCCGGAGGCTGGACAACTTTGGATAACGCTGACCTGTACTTCCAA
GTAAATGCCTCCTGAAGAGCCCGGGACCCTTCCTGGGAGAATTCTGCAGCCAGAATGAAGGTGCCATCAGCAGGAGGCACTGTGAAGCAC
CATCCTGTCGCTGTCCTTGTCCATTCCTAGCAAGTTAATCGTGTCTTGTTAACCAGCAGTTCCTGTTCAACGTGTAAAGAGACCTGATGT

>32069_32069_1_GABBR2-ANKS6_GABBR2_chr9_101304155_ENST00000259455_ANKS6_chr9_101498905_ENST00000353234_length(amino acids)=244AA_BP=11
MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRN
ESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN

--------------------------------------------------------------
>32069_32069_2_GABBR2-ANKS6_GABBR2_chr9_101304155_ENST00000259455_ANKS6_chr9_101498905_ENST00000375018_length(transcript)=5705nt_BP=1090nt
GCCGCCCCTGAGCAGCCTCGCCTTCGCCTCCCGCGTTTCCTGCCGTCCGCCCTCCCCCGGCCGAGCTCCAGGGGCTGCCGCCTAGCAGCT
CCCGGCGGGAGAGCGGTTCAGAGCGCGCACGGGGGCGGGCGGAGGCGGCCCGGTGCGGGGCGGCCGCGCTGGAGAGAGGCGCGCGCGGAG
ACGCCGGCCCCCCTCTCCGCGTTTGCTCGCTTGCTCCCCGCCTCCCGCACTCCGCTCGCTCCCACCCCTTCCCGGCGTGATTGATCCGTC
ACGGGCGCCGCCGCTGCCGCCGCCGCCGCCGCGGCCGTTCTGAGCCGAGCCGGAACCCTAGCCCGAGACGGAGCCGGGGCCCGGGCCGGC
GCCATTGCGCGGGCGCCGCGGGAAGACCTTGGCGCGGGGCGGCGGGCCGGGCCAGGCCATGCGGGCCGAGTGAGCCGGCGCCCGCAGCCC
GCGGCGCGGCATGGCTTCCCCGCGGAGCTCCGGGCAGCCCGGGCCGCCGCCGCCGCCGCCACCGCCGCCCGCGCGCCTGCTACTGCTACT
GCTGCTGCCGCTGCTGCTGCCTCTGGCGCCCGGGGCCTGGGGCTGGGCGCGGGGCGCCCCCCGGCCGCCGCCCAGCAGCCCGCCGCTCTC
CATCATGGGCCTCATGCCGCTCACCAAGGAGGTGGCCAAGGGCAGCATCGGGCGCGGTGTGCTCCCCGCCGTGGAACTGGCCATCGAGCA
GATCCGCAACGAGTCACTCCTGCGCCCCTACTTCCTCGACCTGCGGCTCTATGACACGGAGTGCGACAACGCAAAAGGGTTGAAAGCCTT
CTACGATGCAATAAAATACGGGCCTAACCACTTGATGGTGTTTGGAGGCGTCTGTCCATCCGTCACATCCATCATTGCAGAGTCCCTCCA
AGGCTGGAATCTGGTGCAGCTTTCTTTTGCTGCAACCACGCCTGTTCTAGCCGATAAGAAAAAATACCCTTATTTCTTTCGGACCGTCCC
ATCAGACAATGCGGTGAATCCAGCCATTCTGAAGTTGCTCAAGCACTACCAGTGGAAGCGCGTGGGCACGCTGACGCAAGACGTTCAGAG
GTTCTCTGAGGGACGCGAGAGACAAATTTTACAGGAAACCATTCACAACTTTCACTCTTCCTTTGAGAGCAGTGCCAGCAACACCAGGGC
CCCTGGCAACAGCCCCTGTGCGTGATCCTCCTTCCCGCAGCCACCAGCGTGAGCTCTCTGAATCCCGGGACCCCTTCACGTGGCCACAGC
CCCAGCCCTGCCCCCGTCACACTGCTGTGCCTTAGTCATGTTGTTCCCTTTGCTCGGGATGCCCACTTCACGTCGACGGCATTCATTGGT
AGTACTTCTTGCTGCAACAAACTTCAACACACAGAGACAGATTCCCATGTAACAGTCCAGTGGGGGTGCTTCTGCTTGGCAGGTTGGTTC
ACACAGTGATGCAGGGACTCAGCTCCTTTCATCCTGTGCTCTGCCCTCCCCGGGAGCCTCAGAGTTTGCTTCTGGCTGGCGGCAAGGGAA
AGGGACGATGGAGAAGGCACGGCTGCTTCTTACCTGCCTTGCTCTTAACTGACACACATCACTCCTGCTCACGTCCTCTTGGCCACTGGT
AGTCATGTGGCCCCACCTGGATGCAGAGGAGGCCAGGATGTGCAGTCTCCACATAGTGGCTTCCCAGCAACAACTTTTGACTTAGATGGG
GGGTATGTATTATGGTGAGAGGTTAGCCTTCCTGGCACATCTTCCCTTAAAACTTCTAACTTGCCCCTCCTAGTCCAAGTCACCTCTCAG
ATGAAGTCTTTTTTGACCCCCTTTCAGCCACTGGGTCCCTTAGTGCTGTGTATGTGACTGCTGTAGCATTCCACTGCACCTGCTGCATAC
AGCTTACATTGGAGATGTGTATGTCAAACGCATTTTTCTTTATTGCAAAGAGAGTCTATTATAGAAGGAAAGAAGTGGAGGCCTGCTGTG
TGGATCCCTTCTTCTTCCTAGCTTTCAGTTTCCTTATCTGCAAAGTGGAAGGTCAGACCAGATGATGCTCTGGTACTCCACAGTGCTCAC
CTGTATCACTGCAGGGCTTTCTGCACTGAAAGTGGAAGCAGAAGGCTAATGGGTCACATTGTGTAAAGGTCTCTGGTGCTCAAAGTTTCT
AGGCAAAGAAGTGAAAATTTGGAATTTTGTCTACATCCTATTAATGCTGTGTTCCTCAAAAGGGAATTGGCTTGTGTAGTTTCCTACCAT
ATCATATTTTATTAAATTAGAGGGGCCCTGACTTTTAAAACCCACTGGCTTTCTGAAGTGTTTTCCAGTGAATGACTCATTCAGCCAGTG
CTTGTTGCATTTATGTTAGCTACCAGGTGCCAAGTGTGCAGACACAATACAGAGCCTTCAGGCTCTCGACAGGCAAGAGAACACCTGTAA
ATAGATGGTCCCGACATTGAGAGGCAGCATGGTAGAGTGGGCAGACCTTGTGCTCTGGACTCAGGTTCAAAGTTCAGATGAAGCTCAATG
GCCTCTTAGTTGGAGCTTAGAACCAGTATGCCCAAAGTGCTGGGTCTGCAGGAAGTACCCAGTCGATGGTAGGCTGCACAGAATTCTGAT
CTCTACCTTGAGCCATGCTGAGCCACAAGTTGGTCTCCTTGGGAGGTGCCATCTCTCATCTGTCCCTCCCCCAGCCATGAAAGCCCATTC
CCCTATGCTGGCTTTCAGAGGCTGTCGTTAACTTACTGCCCAGAGCCTCGTAGTTTTCTTCCCCTGCCCTGATGGTTGGGTGTTTTTCCT
TTAAATTCTCTCAGCCTTACACTCACAGAAGCCAACTTTCCACAGGACTGAAGACAAAGTGTTTCATTTAGCTGTTACTGATAGACACCT
TTACAAAGGTTACTAATGTCCCAGCCTTTTTAAGGAGACACACTCATTCATCCCCTACTATGTGCTGGCAGCTTTACCTTTGTCATTTCA
TCCTCATGGCCACCCTGGAGGTGGCATTGTGTAACCTCATCTTGCACATTCGGGAAACGGATGCTTAGGAGAGGGAAGCAGCTTGCCAGT
TAAACAGCCCAGAAGGAGCAGATCTGGGGTCAGAACCGGACCTGGTGGGCTTGCAAGCCTGTGCCTTTTCCACTAACTCCTATAGACTCC
TGGAGCTAGAAGCACTTGTGATTCTTGTTTTAATTTACTGATGGCTTCAGGGGTTAACAGTAGGCCTAGAATTGTTTGCCTCTGAAATTC
ATGGCCCCTGACGTTATGTGCTTTGAGGTTTTGTGCCTGCTTTTTGCTGTGGTCCTGTTTTTTTCATAACAATATACTGGTATAGCTTCC
ACTCAGGTAAGTTTGATTGAACAATGATACACAGCTGCACCGGGGGGTCACCTTTTCACAAATGTAGACCTCCATGAACTCATTGGATGA
CCCTGGACAGAGCGGGGCTATTCCCATTTTGCAGACAGGACAGCAGAGGCTCCAGACAATGCCTTTCCTTTCTTTTTCACTGGACTCAAG
TGTCCAAGGCTTTTCATCCTAGGAAGTTTGTGTGCTGGTTCACAAGAGGTCCCTGGCACCCTTTCTGGGGATGTTTGGATGCGGCTGGTA
GGCAGGGAAGAGAAAGGGCACCCCAGCGGGGGCATGTGTGGAGGCAGCACGGAACATGTAGGTTATAGATCGTCAGGGAGGAGGGGTCAG
TTGGGTGCTTGTTTTTCTGATTTTTGGTCCTTGATCACCCCCTTCCCTTCCCACACGTGTCCCCAGCCTGCCTGTGGCTGTTCCCCCCAC
AAGAAGCACCTCCCTTGCTTGGCAACCTTCACCAGCATTTCCCAAAAGTATGCTCCTGGGAACCCTAGTTCCACAGGATAATAGGTTTTT
CATAAAGAAACGTAGGGTGTGTATGTGAAAGTGGGGTGAGGTTCCCTGGTTGAGTAGGTTTGGCAGACACTAAAGCGAGCTACACGATCA
TCTTTGCTACAGGCCTCTCACAACCTTCAGCATGCCAGCATGGGTCAGGCCTCTTCACAGGGCCAAGAAACTCATAGCATCTCCCACATT
ACTCTCATCACTTCTCCAAGGTGCTTTTGCAAGACTGGAATTCCTTGGACACCATTGGAGAAGCCCCGCTTTTTCTGGAACAGCGGCAAC
CAAGAGGCCTTGCAGCCCTGGAAGTGGGTCAGGGCCCTTGGTGGTCACCTTTTTCTCCCCAGCAGCTCTGCAGAGGTGGCCTGCTTGGCA
GTGGGACATCAGGGGACCGGTCCTGCTTTGAGATGGCAGGGTCCCTGTTCTGAGAGCTCTCCAGCCTGAGGGCATTGAGCTGAGGCTCCA
CCCTGAGCTCTCCTGCAGGGTGGAGGGCATTGTTTCCCAGCACCCAGGCAGTGTCTTGCTGGTGTGTCGTGAGTGCTGGATGTCCAAGTC
CCTGCTGGCCACGGAGGGCTCCTGCCTCTCTTCTTCAGCGCCACAAAATTACATGGAGGCCAGCTGGTTTTGTGAGGAGATTGTTTATTT
TTTAATTCTTTTGTTTACCGAACGTTTACTGAGCATCTACCCTGTGCCAGCCCTACTCGTACGCTCTGTCTCCAAAGATGAAAAAGGACT
TCTCTGCCCTCAAGGGAACCCCACAGTATCTTAGAGGAGACAATCATGTCGGTGAGATGGTGTGGTGATGAAGCCTGCTGGGTATACAGC
TCAGGGAAAGTCATCGATGATGGCTCAGGCTCAGCCTGGGCACGCCCCAGAGGAGAGAGATGGAGTGGGGCCTCAAAGGGCAGGTTTAGG
CAGAAAAGAAAAAGGGCATTCCAGCTGGGGCATGTGCAAAGGCAGCACGTAATGTGTAAGTTCTAGATCGTCAGGGAGGAAGGGTCAGTT
GGGTGCCTGTTTTTCTGTTTTTAGTCCTTTAAAATGAGTAGAAGCAACCTGTTACCCTGGAAAGAGCACTGGACATAGACCTAGTGCTGC
GTGATGTTGAGCACGTTTCTTCTTCCCTTTGAGTCCCAGTTTCCCTTTTGGTTACAGGGGGATAGTAGCCCCCAGGGATCATGTGAAAGT
GAGAAAGCCCTTTTCACACTGTGGAGCGGTGCAGATGTGGGAAACCTCAAAGATGGTTGCCCATTTTAAATCCTTTCATCTCTCATCTCT
CTTTCTTCTCTCCCTTCTGCCCTGACGTAGCCATGGTTGGGTGGGTGAGGCCAGAAGAAACTGCCTCCGGCAAGAGGTAGCAGCCGCTCA
GGTGGCTCTGCTGGCATCGGAGCCCACAGAAGTGAGGAGTGGCCGATGGACCTGCCCTCCAAATGTGCCTGACTCTGGGTCTTGCTGTCA
CTGGATTTCCTGGCATGGCAGACAGAAAGAAAGATAGTTTGACCAAGTCGTAGAAGCTGATCCAGCGGGTAAAAAGGGGGCAGGGAACTC
GTCCCTTTTATTCTTGCCTCAGAGCTGCCTGAAGACATGGGCCAGGCCGGAGGCTGGACAACTTTGGATAACGCTGACCTGTACTTCCAA
GTAAATGCCTCCTGAAGAGCCCGGGACCCTTCCTGGGAGAATTCTGCAGCCAGAATGAAGGTGCCATCAGCAGGAGGCACTGTGAAGCAC
CATCCTGTCGCTGTCCTTGTCCATTCCTAGCAAGTTAATCGTGTCTTGTTAACCAGCAGTTCCTGTTCAACGTGTAAAGAGACCTGATGT

>32069_32069_2_GABBR2-ANKS6_GABBR2_chr9_101304155_ENST00000259455_ANKS6_chr9_101498905_ENST00000375018_length(amino acids)=244AA_BP=11
MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRN
ESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN

--------------------------------------------------------------
>32069_32069_3_GABBR2-ANKS6_GABBR2_chr9_101304155_ENST00000259455_ANKS6_chr9_101498905_ENST00000375019_length(transcript)=1745nt_BP=1090nt
GCCGCCCCTGAGCAGCCTCGCCTTCGCCTCCCGCGTTTCCTGCCGTCCGCCCTCCCCCGGCCGAGCTCCAGGGGCTGCCGCCTAGCAGCT
CCCGGCGGGAGAGCGGTTCAGAGCGCGCACGGGGGCGGGCGGAGGCGGCCCGGTGCGGGGCGGCCGCGCTGGAGAGAGGCGCGCGCGGAG
ACGCCGGCCCCCCTCTCCGCGTTTGCTCGCTTGCTCCCCGCCTCCCGCACTCCGCTCGCTCCCACCCCTTCCCGGCGTGATTGATCCGTC
ACGGGCGCCGCCGCTGCCGCCGCCGCCGCCGCGGCCGTTCTGAGCCGAGCCGGAACCCTAGCCCGAGACGGAGCCGGGGCCCGGGCCGGC
GCCATTGCGCGGGCGCCGCGGGAAGACCTTGGCGCGGGGCGGCGGGCCGGGCCAGGCCATGCGGGCCGAGTGAGCCGGCGCCCGCAGCCC
GCGGCGCGGCATGGCTTCCCCGCGGAGCTCCGGGCAGCCCGGGCCGCCGCCGCCGCCGCCACCGCCGCCCGCGCGCCTGCTACTGCTACT
GCTGCTGCCGCTGCTGCTGCCTCTGGCGCCCGGGGCCTGGGGCTGGGCGCGGGGCGCCCCCCGGCCGCCGCCCAGCAGCCCGCCGCTCTC
CATCATGGGCCTCATGCCGCTCACCAAGGAGGTGGCCAAGGGCAGCATCGGGCGCGGTGTGCTCCCCGCCGTGGAACTGGCCATCGAGCA
GATCCGCAACGAGTCACTCCTGCGCCCCTACTTCCTCGACCTGCGGCTCTATGACACGGAGTGCGACAACGCAAAAGGGTTGAAAGCCTT
CTACGATGCAATAAAATACGGGCCTAACCACTTGATGGTGTTTGGAGGCGTCTGTCCATCCGTCACATCCATCATTGCAGAGTCCCTCCA
AGGCTGGAATCTGGTGCAGCTTTCTTTTGCTGCAACCACGCCTGTTCTAGCCGATAAGAAAAAATACCCTTATTTCTTTCGGACCGTCCC
ATCAGACAATGCGGTGAATCCAGCCATTCTGAAGTTGCTCAAGCACTACCAGTGGAAGCGCGTGGGCACGCTGACGCAAGACGTTCAGAG
GTTCTCTGAGGGACGCGAGAGACAAATTTTACAGGAAACCATTCACAACTTTCACTCTTCCTTTGAGAGCAGTGCCAGCAACACCAGGGC
CCCTGGCAACAGCCCCTCCATGGTTGGGTGGGTGAGGCCAGAAGAAACTGCCTCCGGCAAGAGGTAGCAGCCGCTCAGGTGGCTCTGCTG
GCATCGGAGCCCACAGAAGTGAGGAGTGGCCGATGGACCTGCCCTCCAAATGTGCCTGACTCTGGGTCTTGCTGTCACTGGATTTCCTGG
CATGGCAGACAGAAAGAAAGATAGTTTGACCAAGTCGTAGAAGCTGATCCAGCGGGTAAAAAGGGGGCAGGGAACTCGTCCCTTTTATTC
TTGCCTCAGAGCTGCCTGAAGACATGGGCCAGGCCGGAGGCTGGACAACTTTGGATAACGCTGACCTGTACTTCCAAGTAAATGCCTCCT
GAAGAGCCCGGGACCCTTCCTGGGAGAATTCTGCAGCCAGAATGAAGGTGCCATCAGCAGGAGGCACTGTGAAGCACCATCCTGTCGCTG
TCCTTGTCCATTCCTAGCAAGTTAATCGTGTCTTGTTAACCAGCAGTTCCTGTTCAACGTGTAAAGAGACCTGATGTTTTCCCTAATAAA

>32069_32069_3_GABBR2-ANKS6_GABBR2_chr9_101304155_ENST00000259455_ANKS6_chr9_101498905_ENST00000375019_length(amino acids)=258AA_BP=11
MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRN
ESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GABBR2-ANKS6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GABBR2-ANKS6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GABBR2-ANKS6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source