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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GAK-PLEKHG2 (FusionGDB2 ID:32177)

Fusion Gene Summary for GAK-PLEKHG2

check button Fusion gene summary
Fusion gene informationFusion gene name: GAK-PLEKHG2
Fusion gene ID: 32177
HgeneTgene
Gene symbol

GAK

PLEKHG2

Gene ID

2580

64857

Gene namecyclin G associated kinasepleckstrin homology and RhoGEF domain containing G2
SynonymsDNAJ26|DNAJC26ARHGEF42|CLG|CTB-60E11.4|LDAMD
Cytomap

4p16.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptioncyclin-G-associated kinaseauxilin-2pleckstrin homology domain-containing family G member 2PH domain-containing family G member 2common-site lymphoma/leukemia guanine nucleotide exchange factorpleckstrin homology domain containing, family G (with RhoGef domain) member 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314167, ENST00000511163, 
ENST00000509566, 		ENST00000378550, 
ENST00000409794, ENST00000409797, 
ENST00000425673, ENST00000458508, 
Fusion gene scores* DoF score16 X 17 X 8=21765 X 5 X 3=75
# samples 185
** MAII scorelog2(18/2176*10)=-3.59560974492067
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAK [Title/Abstract] AND PLEKHG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGAK(891821)-PLEKHG2(39912755), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAK

GO:0010977

negative regulation of neuron projection development

24510904


check buttonFusion gene breakpoints across GAK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLEKHG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-HU-A4GC-11AGAKchr4

891821

-PLEKHG2chr19

39912755

+


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Fusion Gene ORF analysis for GAK-PLEKHG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314167ENST00000378550GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000314167ENST00000409794GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000314167ENST00000409797GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000314167ENST00000425673GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000314167ENST00000458508GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000511163ENST00000378550GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000511163ENST00000409794GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000511163ENST00000409797GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000511163ENST00000425673GAKchr4

891821

-PLEKHG2chr19

39912755

+
In-frameENST00000511163ENST00000458508GAKchr4

891821

-PLEKHG2chr19

39912755

+
intron-3CDSENST00000509566ENST00000378550GAKchr4

891821

-PLEKHG2chr19

39912755

+
intron-3CDSENST00000509566ENST00000409794GAKchr4

891821

-PLEKHG2chr19

39912755

+
intron-3CDSENST00000509566ENST00000409797GAKchr4

891821

-PLEKHG2chr19

39912755

+
intron-3CDSENST00000509566ENST00000425673GAKchr4

891821

-PLEKHG2chr19

39912755

+
intron-3CDSENST00000509566ENST00000458508GAKchr4

891821

-PLEKHG2chr19

39912755

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314167GAKchr4891821-ENST00000409794PLEKHG2chr1939912755+364076211134191102
ENST00000314167GAKchr4891821-ENST00000378550PLEKHG2chr1939912755+993762111992293
ENST00000314167GAKchr4891821-ENST00000425673PLEKHG2chr1939912755+654076211134191102
ENST00000314167GAKchr4891821-ENST00000458508PLEKHG2chr1939912755+320876211131491012
ENST00000314167GAKchr4891821-ENST00000409797PLEKHG2chr1939912755+1215762111992293
ENST00000511163GAKchr4891821-ENST00000409794PLEKHG2chr1939912755+347860018632571023
ENST00000511163GAKchr4891821-ENST00000378550PLEKHG2chr1939912755+831600186830214
ENST00000511163GAKchr4891821-ENST00000425673PLEKHG2chr1939912755+637860018632571023
ENST00000511163GAKchr4891821-ENST00000458508PLEKHG2chr1939912755+30466001862987933
ENST00000511163GAKchr4891821-ENST00000409797PLEKHG2chr1939912755+1053600186830214

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314167ENST00000409794GAKchr4891821-PLEKHG2chr1939912755+0.00485150.9951485
ENST00000314167ENST00000378550GAKchr4891821-PLEKHG2chr1939912755+0.0067509140.99324906
ENST00000314167ENST00000425673GAKchr4891821-PLEKHG2chr1939912755+0.0022872140.99771273
ENST00000314167ENST00000458508GAKchr4891821-PLEKHG2chr1939912755+0.0053780320.994622
ENST00000314167ENST00000409797GAKchr4891821-PLEKHG2chr1939912755+0.0047533010.9952467
ENST00000511163ENST00000409794GAKchr4891821-PLEKHG2chr1939912755+0.0058760140.994124
ENST00000511163ENST00000378550GAKchr4891821-PLEKHG2chr1939912755+0.0124414770.9875585
ENST00000511163ENST00000425673GAKchr4891821-PLEKHG2chr1939912755+0.0029495610.9970504
ENST00000511163ENST00000458508GAKchr4891821-PLEKHG2chr1939912755+0.0068408970.9931591
ENST00000511163ENST00000409797GAKchr4891821-PLEKHG2chr1939912755+0.0078146690.9921853

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Fusion Genomic Features for GAK-PLEKHG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GAKchr4891820-PLEKHG2chr1939912754+5.27E-060.99999475
GAKchr4891820-PLEKHG2chr1939912754+5.27E-060.99999475

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GAK-PLEKHG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:891821/chr19:39912755)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLEKHG2chr4:891821chr19:39912755ENST0000037855015181067_1184501578.0Compositional biasNote=Pro-rich
TgenePLEKHG2chr4:891821chr19:39912755ENST0000037855015181319_1328501578.0Compositional biasNote=Poly-Pro
TgenePLEKHG2chr4:891821chr19:39912755ENST0000037855015181344_1347501578.0Compositional biasNote=Poly-Gly
TgenePLEKHG2chr4:891821chr19:39912755ENST000003785501518593_600501578.0Compositional biasNote=Poly-Glu
TgenePLEKHG2chr4:891821chr19:39912755ENST0000040979415191067_11845011387.0Compositional biasNote=Pro-rich
TgenePLEKHG2chr4:891821chr19:39912755ENST0000040979415191319_13285011387.0Compositional biasNote=Poly-Pro
TgenePLEKHG2chr4:891821chr19:39912755ENST0000040979415191344_13475011387.0Compositional biasNote=Poly-Gly
TgenePLEKHG2chr4:891821chr19:39912755ENST000004097941519593_6005011387.0Compositional biasNote=Poly-Glu
TgenePLEKHG2chr4:891821chr19:39912755ENST0000040979715181067_1184501578.0Compositional biasNote=Pro-rich
TgenePLEKHG2chr4:891821chr19:39912755ENST0000040979715181319_1328501578.0Compositional biasNote=Poly-Pro
TgenePLEKHG2chr4:891821chr19:39912755ENST0000040979715181344_1347501578.0Compositional biasNote=Poly-Gly
TgenePLEKHG2chr4:891821chr19:39912755ENST000004097971518593_600501578.0Compositional biasNote=Poly-Glu
TgenePLEKHG2chr4:891821chr19:39912755ENST0000042567313171067_11844721358.0Compositional biasNote=Pro-rich
TgenePLEKHG2chr4:891821chr19:39912755ENST0000042567313171319_13284721358.0Compositional biasNote=Poly-Pro
TgenePLEKHG2chr4:891821chr19:39912755ENST0000042567313171344_13474721358.0Compositional biasNote=Poly-Gly
TgenePLEKHG2chr4:891821chr19:39912755ENST000004256731317593_6004721358.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAKchr4:891821chr19:39912755ENST00000314167-628347_3502171312.0Compositional biasNote=Poly-Pro
HgeneGAKchr4:891821chr19:39912755ENST00000314167-6281247_13112171312.0DomainJ
HgeneGAKchr4:891821chr19:39912755ENST00000314167-628399_5662171312.0DomainPhosphatase tensin-type
HgeneGAKchr4:891821chr19:39912755ENST00000314167-62840_3142171312.0DomainProtein kinase
HgeneGAKchr4:891821chr19:39912755ENST00000314167-628572_7102171312.0DomainC2 tensin-type
TgenePLEKHG2chr4:891821chr19:39912755ENST000003785501518102_283501578.0DomainDH
TgenePLEKHG2chr4:891821chr19:39912755ENST000003785501518313_411501578.0DomainPH
TgenePLEKHG2chr4:891821chr19:39912755ENST000004097941519102_2835011387.0DomainDH
TgenePLEKHG2chr4:891821chr19:39912755ENST000004097941519313_4115011387.0DomainPH
TgenePLEKHG2chr4:891821chr19:39912755ENST000004097971518102_283501578.0DomainDH
TgenePLEKHG2chr4:891821chr19:39912755ENST000004097971518313_411501578.0DomainPH
TgenePLEKHG2chr4:891821chr19:39912755ENST000004256731317102_2834721358.0DomainDH
TgenePLEKHG2chr4:891821chr19:39912755ENST000004256731317313_4114721358.0DomainPH


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Fusion Gene Sequence for GAK-PLEKHG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32177_32177_1_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000378550_length(transcript)=993nt_BP=762nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTT
TCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGAC
CTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGAC
TACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCTCCAGAATCTCAGCCACCA
GTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCAATCACTGAAGAAATCCTG
GAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGATGCCCCCTTCCACATG

>32177_32177_1_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000378550_length(amino acids)=293AA_BP=217
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRG

--------------------------------------------------------------
>32177_32177_2_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000409794_length(transcript)=3640nt_BP=762nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTT
TCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGAC
CTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGAC
TACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCTCCAGAATCTCAGCCACCA
GTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCAATCACTGAAGAAATCCTG
GAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGCCGTCCACCCATGACATTCCCAAGTTCCCCGGAGACTCCCAGGTGCCTGGCGAC
AGCGAAACCCTCACATTCCAAGCCCTGCCCAGCCGGGACTCTTCAGAAGAGGAGGAGGAGGAAGAGGAAGGGCTGGAGATGGATGAACGG
GGGCCTTCCCCACTCCACGTCCTGGAAGGGCTCGAAAGTTCCATTGCAGCTGAAATGCCCAGCATTCCCTGCCTTACCAAAATTCCTGAC
GTGCCCAACCTTCCTGAAATTCCCAGCCGCTGTGAAATTCCCGAAGGTTCTCGCCTTCCTAGTCTCTCTGACATTTCCGATGTTTTTGAG
ATGCCCTGCCTTCCAGCCATACCTAGTGTCCCCAACACCCCCAGTCTGTCTAGCACTCCCACCCTCTCCTGTGACTCCTGGCTCCAAGGG
CCTCTGCAGGAACCAGCTGAGGCTCCAGCCACCAGGAGAGAACTGTTTTCTGGGAGCAATCCTGGGAAACTGGGAGAGCCGCCTTCAGGA
GGCAAGGCAGGGCCAGAGGAGGATGAAGAAGGGGTATCATTCACAGACTTCCAGCCCCAGGATGTCACCCAACATCAGGGATTCCCAGAT
GAGCTGGCATTCCGCTCTTGCTCAGAAATCCGGAGCGCCTGGCAGGCATTGGAACAGGGACAGCTGGCCCGGCCAGGCTTCCCAGAGCCA
CTGCTGATCCTGGAGGATTCGGATCTGGGTGGAGACAGCGGGAGCGGGAAGGCAGGAGCCCCGAGTTCAGAAAGGACGGCGTCCCGAGTG
CGAGAGCTGGCCCGGCTTTACAGCGAGCGGATCCAGCAGATGCAGCGGGCGGAGACTCGGGCATCAGCCAATGCCCCGCGCCGCCGGCCT
CGGGTTCTGGCCCAACCCCAGCCATCCCCCTGTCTGCCCCAGGAGCAGGCAGAGCCAGGGCTCCTGCCTGCCTTTGGACACGTGCTGGTA
TGTGAGCTGGCCTTCCCACTGACATGTGCCCAGGAGTCTGTCCCCCTGGGTCCTGCTGTCTGGGTTCAAGCTGCCATACCTTTGTCAAAG
CAGGGAGGCAGCCCGGATGGCCAGGGTCTACATGTTTCCAATTTGCCTAAGCAAGACCTTCCGGGCATCCACGTTTCAGCTGCTACCCTT
TTGCCTGAGCAAGGAGGTTCCCGGCATGTCCAGGCTCCAGCCGCCACACCTTTGCCCAAGCAAGAAGGCCCCCTGCACCTCCAGGTGCCG
GCTCTTACAACTTTCTCTGATCAAGGCCACCCAGAAATCCAAGTTCCAGCCACCACTCCTTTGCCTGAGCATAGAAGTCACATGGTTATA
CCAGCTCCATCCACCGCCTTTTGTCCTGAGCAGGGACACTGTGCGGACATCCACGTTCCCACCACTCCAGCTTTGCCCAAGGAGATTTGT
TCTGATTTCACAGTTTCAGTCACCACCCCTGTGCCCAAGCAAGAAGGTCACCTAGACAGCGAGAGCCCAACCAATATCCCACTGACAAAG
CAAGGAGGTTCCAGGGATGTTCAGGGCCCAGACCCTGTCTGCAGTCAACCCATCCAGCCTTTGTCTTGGCATGGAAGCAGCCTGGATCCC
CAGGGCCCAGGCGACACCCTACCACCCTTGCCATGTCACCTCCCAGACCTTCAGATTCCAGGTACCTCACCTTTGCCTGCACATGGAAGC
CACCTGGACCATCGGATCCCAGCCAACGCCCCACTGTCTTTGTCCCAGGAGCTCCCAGACACTCAGGTTCCAGCTACCACACCTTTGCCC
CTGCCACAAGTCCTCACAGACATCTGGGTCCAAGCCCTCCCAACTTCACCCAAGCAGGGAAGCCTCCCAGACATCCAGGGTCCAGCGGCT
GCACCTCCACTTCCGGAGCCAAGCCTTACAGATACACAGGTCCAAAAACTCACACCTTCGTTGGAGCAGAAGAGCCTCATAGATGCCCAT
GTTCCAGCTGCCACACCTTTACCTGAGAGAGGAGGCTCTCTAGACATTCAGGGCCTCTCACCCACCCCAGTTCAGACCACCATGGTTTTG
TCCAAACCAGGAGGCTCCTTAGCCTCTCACGTTGCCAGGTTGGAGTCTTCAGACTTGACGCCACCTCATAGTCCCCCACCTTCCAGCCGT
CAGCTCCTGGGCCCCAATGCAGCTGCCCTCTCCAGATACCTGGCAGCCTCATATATCAGCCAGAGCCTGGCTCGGCGGCAGGGGCCTGGG
GGAGGGGCCCCCGCAGCCTCCCGGGGCTCCTGGTCCTCTGCTCCCACGTCACGGGCATCTTCGCCGCCCCCCCAGCCCCAGCCACCACCT
CCCCCAGCCAGGCGGCTCAGCTATGCCACGACGGTTAACATCCACGTGGGCGGGGGTGGGCGGCTGCGGCCAGCCAAGGCCCAGGTCCGG
TTGAACCACCCTGCTCTCTTGGCCTCCACACAGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGATGCCCCCTTCCACATGTGA
GCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAAGTCCAGACACTGAACGCA
GGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGATCCACAGGGATGGGGAAGGGAG

>32177_32177_2_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000409794_length(amino acids)=1102AA_BP=217
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRG
LRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEI
PSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEE
DEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLY
SERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAIPLSKQGGSPDG
QGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAF
CPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGSSLDPQGPGDTL
PPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEP
SLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPPPSSRQLLGPNA
AALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALL

--------------------------------------------------------------
>32177_32177_3_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000409797_length(transcript)=1215nt_BP=762nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTT
TCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGAC
CTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGAC
TACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCTCCAGAATCTCAGCCACCA
GTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCAATCACTGAAGAAATCCTG
GAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGATGCCCCCTTCCACATG
TGAGCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAAGTCCAGACACTGAAC
GCAGGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGATCCACAGGGATGGGGAAGG

>32177_32177_3_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000409797_length(amino acids)=293AA_BP=217
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRG

--------------------------------------------------------------
>32177_32177_4_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000425673_length(transcript)=6540nt_BP=762nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTT
TCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGAC
CTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGAC
TACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCTCCAGAATCTCAGCCACCA
GTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCAATCACTGAAGAAATCCTG
GAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGCCGTCCACCCATGACATTCCCAAGTTCCCCGGAGACTCCCAGGTGCCTGGCGAC
AGCGAAACCCTCACATTCCAAGCCCTGCCCAGCCGGGACTCTTCAGAAGAGGAGGAGGAGGAAGAGGAAGGGCTGGAGATGGATGAACGG
GGGCCTTCCCCACTCCACGTCCTGGAAGGGCTCGAAAGTTCCATTGCAGCTGAAATGCCCAGCATTCCCTGCCTTACCAAAATTCCTGAC
GTGCCCAACCTTCCTGAAATTCCCAGCCGCTGTGAAATTCCCGAAGGTTCTCGCCTTCCTAGTCTCTCTGACATTTCCGATGTTTTTGAG
ATGCCCTGCCTTCCAGCCATACCTAGTGTCCCCAACACCCCCAGTCTGTCTAGCACTCCCACCCTCTCCTGTGACTCCTGGCTCCAAGGG
CCTCTGCAGGAACCAGCTGAGGCTCCAGCCACCAGGAGAGAACTGTTTTCTGGGAGCAATCCTGGGAAACTGGGAGAGCCGCCTTCAGGA
GGCAAGGCAGGGCCAGAGGAGGATGAAGAAGGGGTATCATTCACAGACTTCCAGCCCCAGGATGTCACCCAACATCAGGGATTCCCAGAT
GAGCTGGCATTCCGCTCTTGCTCAGAAATCCGGAGCGCCTGGCAGGCATTGGAACAGGGACAGCTGGCCCGGCCAGGCTTCCCAGAGCCA
CTGCTGATCCTGGAGGATTCGGATCTGGGTGGAGACAGCGGGAGCGGGAAGGCAGGAGCCCCGAGTTCAGAAAGGACGGCGTCCCGAGTG
CGAGAGCTGGCCCGGCTTTACAGCGAGCGGATCCAGCAGATGCAGCGGGCGGAGACTCGGGCATCAGCCAATGCCCCGCGCCGCCGGCCT
CGGGTTCTGGCCCAACCCCAGCCATCCCCCTGTCTGCCCCAGGAGCAGGCAGAGCCAGGGCTCCTGCCTGCCTTTGGACACGTGCTGGTA
TGTGAGCTGGCCTTCCCACTGACATGTGCCCAGGAGTCTGTCCCCCTGGGTCCTGCTGTCTGGGTTCAAGCTGCCATACCTTTGTCAAAG
CAGGGAGGCAGCCCGGATGGCCAGGGTCTACATGTTTCCAATTTGCCTAAGCAAGACCTTCCGGGCATCCACGTTTCAGCTGCTACCCTT
TTGCCTGAGCAAGGAGGTTCCCGGCATGTCCAGGCTCCAGCCGCCACACCTTTGCCCAAGCAAGAAGGCCCCCTGCACCTCCAGGTGCCG
GCTCTTACAACTTTCTCTGATCAAGGCCACCCAGAAATCCAAGTTCCAGCCACCACTCCTTTGCCTGAGCATAGAAGTCACATGGTTATA
CCAGCTCCATCCACCGCCTTTTGTCCTGAGCAGGGACACTGTGCGGACATCCACGTTCCCACCACTCCAGCTTTGCCCAAGGAGATTTGT
TCTGATTTCACAGTTTCAGTCACCACCCCTGTGCCCAAGCAAGAAGGTCACCTAGACAGCGAGAGCCCAACCAATATCCCACTGACAAAG
CAAGGAGGTTCCAGGGATGTTCAGGGCCCAGACCCTGTCTGCAGTCAACCCATCCAGCCTTTGTCTTGGCATGGAAGCAGCCTGGATCCC
CAGGGCCCAGGCGACACCCTACCACCCTTGCCATGTCACCTCCCAGACCTTCAGATTCCAGGTACCTCACCTTTGCCTGCACATGGAAGC
CACCTGGACCATCGGATCCCAGCCAACGCCCCACTGTCTTTGTCCCAGGAGCTCCCAGACACTCAGGTTCCAGCTACCACACCTTTGCCC
CTGCCACAAGTCCTCACAGACATCTGGGTCCAAGCCCTCCCAACTTCACCCAAGCAGGGAAGCCTCCCAGACATCCAGGGTCCAGCGGCT
GCACCTCCACTTCCGGAGCCAAGCCTTACAGATACACAGGTCCAAAAACTCACACCTTCGTTGGAGCAGAAGAGCCTCATAGATGCCCAT
GTTCCAGCTGCCACACCTTTACCTGAGAGAGGAGGCTCTCTAGACATTCAGGGCCTCTCACCCACCCCAGTTCAGACCACCATGGTTTTG
TCCAAACCAGGAGGCTCCTTAGCCTCTCACGTTGCCAGGTTGGAGTCTTCAGACTTGACGCCACCTCATAGTCCCCCACCTTCCAGCCGT
CAGCTCCTGGGCCCCAATGCAGCTGCCCTCTCCAGATACCTGGCAGCCTCATATATCAGCCAGAGCCTGGCTCGGCGGCAGGGGCCTGGG
GGAGGGGCCCCCGCAGCCTCCCGGGGCTCCTGGTCCTCTGCTCCCACGTCACGGGCATCTTCGCCGCCCCCCCAGCCCCAGCCACCACCT
CCCCCAGCCAGGCGGCTCAGCTATGCCACGACGGTTAACATCCACGTGGGCGGGGGTGGGCGGCTGCGGCCAGCCAAGGCCCAGGTCCGG
TTGAACCACCCTGCTCTCTTGGCCTCCACACAGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGATGCCCCCTTCCACATGTGA
GCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAAGTCCAGACACTGAACGCA
GGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGATCCACAGGGATGGGGAAGGGAG
GAATGTCATTAATGTTTTGTTAATACTGATTCTTTCATGCAATGATGTGTATTTTCCCATTCTGGAGGCTGTGGGAGATGACAAGACAAT
GAATGGGAAGGTCTGACACAGAACAAATCAGCGGTTCTGAAAGCTTGGGGAATCTCAGACTCCTTTGAGAATTATTGGAAAATGGACCCA
CTATAACTTGGCGTGTGTGTGAACTGCTTGATGCCCATCCAGGAAAGCCAAGTTAAGAAGCTTTGCTTCAAGTAGACACTAGAAATCCAT
TCCCTTGGCAATTTATACAGTTCACGTCTCCCACCATCCGTTCATCTCACCCACCCTGCCATCTCTCCACCTATCCATCTGGCTATTGCT
CCATCTAGCTTTCCCGCTCCATCTACCCATCTTCCAATCCATCATCTCACGTATCTGCCTTGCTTATCCAACTGTCTGCCTTATTCACCC
ACCCATCCCTTTATCATTCTAACCCCATCTGGCATTCCATCCCTCCATTTATCCATCTTCCCACTTACCCATCTTCTCCATCCAGCACTC
CGTTCATCAGTCCGTCTCTCCCTCCATATTTCCATCTGTCCATTCATCCACTCATTTTGCCATCCATACATATTCACCCAGCCATCTCCC
AATCCATCGACATACCCCATCCCTCCCTCACTGGACTCTCCGGGGTCTTAGTACTATGATACTTCAGAGACAATTCCATGCTGATACGGG
GGAGATCAATTTTGGGGCTCTGGGATAAGTCTGTCCCACATCTGTCTGATTTCCCTTGGCATCCTTCCCGTCAGTTCCTCTTGAATATCC
CAGTTCTTGTACCCACTCACATACCTCAGATCCCTTCACTCCTCCCCGCAGTTTGCAGCCTCTACAATTCATCCACATGCTCCCTCCCCC
AGCAAAATAATTCAGGTCGTGGAGACAAAAGGCTTTTATGTTAGGTTCTGTCTGCCCCCTTGTTCCAGCAGTGGTATGCCCAGTGAGAGG
CACAATTTAAACGGTTTCTTTGGTGATGATATTAGCTACTTTCATCAAATACTTAGCCTCTTGTGCTTTAGCACATTATTTATGTAAGCT
CCCCTAGGATTCTCTGAAGCACCCTGGTGTCCTGGCTGTGAATTCAAGTCCCATCTTTACTTATTTGGTGTGGGTCCTCCCTCTGAGCCG
GTTTTCTCATCTACAAAATGAAGACAACAGTACTTCCCTCCTGGGATCATTGAAAGATTTAGGGAGCATATCCTTCCACTTCCCAAACAT
ATTTGAACCTCTGACTTGCTTAGGAGCATCATTCAAATCACAGATCCCCCAGTATCTAGTCCCAACCTATTGAATCAGGATCCCCAGGGA
AGGAGGAGCTTGGGAATCTGATTTTTTTTTTTTTTTTTAGATAAAGTCTCACTCTGTCACCCAGGCTTGAGTGCAGTGGCAAAATCTTGG
CTCATTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCATGCCTCAGCTTCCCGACATAGCTGGGATTATAGGCGTGCACCACCATGCC
CAGCTAATTTTTCGTTGTTGTTGTTGTTGTTTTGTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTACAGTGGCACGATCTT
GGCTCACTGCAAGCTCCGCTTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACCACAGGTGCCCGCCACCACGC
CCGGCTAATTTTTTTGGTATTTTTAGTAGAGACGGGGTTTTACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCTCCCG
CCTCGGCCTCCCAAAGTGCTGGCATTACAGGCGTGAGCCATCATTCCTGGCTGGGAATCCGAATTTTTTTTTTTTTTTAGACGGAGTTTC
GCTCTTGTTGCCCAGGCTGGAGTTCAATAGCATGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCTAG
CTGGGATTGCAGGCGCCCACGACCACGCCCAGCTAATTTTTGTATTTTGTAGTAGAGACGGGATTTCGCCATATTGGCCAGGCCATAGTG
GTCTTGGACTCCTGACCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGTTGGGTTTACAGGCGTGAGCTACCATACCCTGCCCAGGA
ATCTGAATTTTTAGCAATCAGTTAGCAGCAAATAAGCTGAGATTTCCTGGGTACTAAGCACATACTATGAGCATTACAGCCGCTTTATAT
AAGCTCGTTCACTGTCCTCATTACATTCCTAATATGCAAGTGAGCATGTTTTTTAATCCTCAGTCTAGAGGTGAGGAAACTGAGGCAGGC
ACAGAGAGGCTAAGGGATTTGCCTAGTCGCACAGCTAGGAAGGTGCAGCACTGAGACTCGAATCCACACAGCTTGGCTTAAGTCTACCAT
TAAATTTGCCTGTCCTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAACACTTCGTGAGGCCAAGGCAGGTGGATCACTTGAAGTGAG
GAGTTCGAGACCACACCAGCCTGGCCAACATGGTGAAATCCCGTCTTTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGTGCC
GGTAATCCTAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAACCGAGATTGCGCCACTAGA
CTCCAGCCTGGGAGACGAGCAAAACTGTCTCAAAAAAATAAAATGAAATACATAAATAAATGTGCCTATCCTGTGCCGGGTGCTGTTCTT
GCCAGTGGGGATACATGAGAGAACACTGCCTTGCCCGCATGAGGCTTGTGGCCTGGTACTGTGCACACCTCAGGGGATTCTGATAATTAG

>32177_32177_4_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000425673_length(amino acids)=1102AA_BP=217
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRG
LRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEI
PSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEE
DEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLY
SERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAIPLSKQGGSPDG
QGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAF
CPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGSSLDPQGPGDTL
PPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEP
SLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPPPSSRQLLGPNA
AALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALL

--------------------------------------------------------------
>32177_32177_5_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000458508_length(transcript)=3208nt_BP=762nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGGCAGCTGGTGGAATTTTTGAAGAAAATGGAATCTCGAGGCCCCCTT
TCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCGCCCATCATCCACAGGGAC
CTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACCATCTCGCACTACCCTGAC
TACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCTCCAGAATCTCAGCCACCA
GTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCAATCACTGAAGAAATCCTG
GAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGCCGTCCACCCATGACATTCCCAAGTTCCCCGGAGACTCCCAGGTGCCTGGCGAC
AGCGAAACCCTCACATTCCAAGCCCTGCCCAGCCGGGACTCTTCAGAAGAGGAGGAGGAGGAAGAGGAAGGGCTGGAGATGGATGAACGG
GGGCCTTCCCCACTCCACGTCCTGGAAGGGCTCGAAAGTTCCATTGCAGCTGAAATGCCCAGCATTCCCTGCCTTACCAAAATTCCTGAC
GTGCCCAACCTTCCTGAAATTCCCAGCCGCTGTGAAATTCCCGAAGGTTCTCGCCTTCCTAGTCTCTCTGACATTTCCGATGTTTTTGAG
ATGCCCTGCCTTCCAGCCATACCTAGTGTCCCCAACACCCCCAGTCTGTCTAGCACTCCCACCCTCTCCTGTGACTCCTGGCTCCAAGGG
CCTCTGCAGGAACCAGCTGAGGCTCCAGCCACCAGGAGAGAACTGTTTTCTGGGAGCAATCCTGGGAAACTGGGAGAGCCGCCTTCAGGA
GGCAAGGCAGGGCCAGAGGAGGATGAAGAAGGGGTATCATTCACAGACTTCCAGCCCCAGGATGTCACCCAACATCAGGGATTCCCAGAT
GAGCTGGCATTCCGCTCTTGCTCAGAAATCCGGAGCGCCTGGCAGGCATTGGAACAGGGACAGCTGGCCCGGCCAGGCTTCCCAGAGCCA
CTGCTGATCCTGGAGGATTCGGATCTGGGTGGAGACAGCGGGAGCGGGAAGGCAGGAGCCCCGAGTTCAGAAAGGACGGCGTCCCGAGTG
CGAGAGCTGGCCCGGCTTTACAGCGAGCGGATCCAGCAGATGCAGCGGGCGGAGACTCGGGCATCAGCCAATGCCCCGCGCCGCCGGCCT
CGGGTTCTGGCCCAACCCCAGCCATCCCCCTGTCTGCCCCAGGAGCAGGCAGAGCCAGGGCTCCTGCCTGCCTTTGGACACGTGCTGGTA
TGTGAGCTGGCCTTCCCACTGACATGTGCCCAGGAGTCTGTCCCCCTGGGTCCTGCTGTCTGGGTTCAAGCTGCCATACCTTTGTCAAAG
CAGGGAGGCAGCCCGGATGGCCAGGGTCTACATGTTTCCAATTTGCCTAAGCAAGACCTTCCGGGCATCCACGTTTCAGCTGCTACCCTT
TTGCCTGAGCAAGGAGGTTCCCGGCATGTCCAGGCTCCAGCCGCCACACCTTTGCCCAAGCAAGAAGGCCCCCTGCACCTCCAGGTGCCG
GCTCTTACAACTTTCTCTGATCAAGGCCACCCAGAAATCCAAGTTCCAGCCACCACTCCTTTGCCTGAGCATAGAAGTCACATGGTTATA
CCAGCTCCATCCACCGCCTTTTGTCCTGAGCAGGGACACTGTGCGGACATCCACGTTCCCACCACTCCAGCTTTGCCCAAGGAGATTTGT
TCTGATTTCACAGTTTCAGTCACCACCCCTGTGCCCAAGCAAGAAGGTCACCTAGACAGCGAGAGCCCAACCAATATCCCACTGACAAAG
CAAGGAGGTTCCAGGGATGTTCAGGGCCCAGACCCTGTCTGCAGTCAACCCATCCAGCCTTTGTCTTGGCATGGAAGCAGCCTGGATCCC
CAGGGCCCAGGCGACACCCTACCACCCTTGCCATGTCACCTCCCAGACCTTCAGATTCCAGGTACCTCACCTTTGCCTGCACATGGAAGC
CACCTGGACCATCGGATCCCAGCCAACGCCCCACTGTCTTTGTCCCAGGAGCTCCCAGACACTCAGGTTCCAGCTACCACACCTTTGCCC
CTGCCACAAGTCCTCACAGACATCTGGGTCCAAGCCCTCCCAACTTCACCCAAGCAGGGAAGCCTCCCAGACATCCAGGGTCCAGCGGCT
GCACCTCCACTTCCGGAGCCAAGCCTTACAGATACACAGGTCCAAAAACTCACACCTTCGTTGGAGCAGAAGAGCCTCATAGATGCCCAT
GTTCCAGCTGCCACACCTTTACCTGAGAGAGGAGGCTCTCTAGACATTCAGGGCCTCTCACCCACCCCAGTTCAGACCACCATGGTTTTG
TCCAAACCAGGAGGCTCCTTAGCCTCTCACGTTGCCAGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGATGCCCCCTTCCACA
TGTGAGCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAAGTCCAGACACTGA

>32177_32177_5_GAK-PLEKHG2_GAK_chr4_891821_ENST00000314167_PLEKHG2_chr19_39912755_ENST00000458508_length(amino acids)=1012AA_BP=217
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRG
LRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEI
PSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEE
DEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLY
SERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAIPLSKQGGSPDG
QGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAF
CPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGSSLDPQGPGDTL
PPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEP
SLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARNLWAFTGPRGLLMPPSTCEPGHEA

--------------------------------------------------------------
>32177_32177_6_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000378550_length(transcript)=831nt_BP=600nt
AGGGGACGGGGCTAGGCCGGGTCGCCGCCTGACGCGACGCGTCCTCACGGGCGCCTACGTCACGGCGTCGAGGCGGAAGATGGTGCACCT
CCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCGGGGTGCGGCGCAGCC
ACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTC
GTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATG
GAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCG
CCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACC
ATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCT
CCAGAATCTCAGCCACCAGTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCA
ATCACTGAAGAAATCCTGGAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCT

>32177_32177_6_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000378550_length(amino acids)=214AA_BP=138
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPI
IHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSIT

--------------------------------------------------------------
>32177_32177_7_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000409794_length(transcript)=3478nt_BP=600nt
AGGGGACGGGGCTAGGCCGGGTCGCCGCCTGACGCGACGCGTCCTCACGGGCGCCTACGTCACGGCGTCGAGGCGGAAGATGGTGCACCT
CCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCGGGGTGCGGCGCAGCC
ACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTC
GTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATG
GAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCG
CCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACC
ATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCT
CCAGAATCTCAGCCACCAGTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCA
ATCACTGAAGAAATCCTGGAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGCCGTCCACCCATGACATTCCCAAGTTCCCCGGAGAC
TCCCAGGTGCCTGGCGACAGCGAAACCCTCACATTCCAAGCCCTGCCCAGCCGGGACTCTTCAGAAGAGGAGGAGGAGGAAGAGGAAGGG
CTGGAGATGGATGAACGGGGGCCTTCCCCACTCCACGTCCTGGAAGGGCTCGAAAGTTCCATTGCAGCTGAAATGCCCAGCATTCCCTGC
CTTACCAAAATTCCTGACGTGCCCAACCTTCCTGAAATTCCCAGCCGCTGTGAAATTCCCGAAGGTTCTCGCCTTCCTAGTCTCTCTGAC
ATTTCCGATGTTTTTGAGATGCCCTGCCTTCCAGCCATACCTAGTGTCCCCAACACCCCCAGTCTGTCTAGCACTCCCACCCTCTCCTGT
GACTCCTGGCTCCAAGGGCCTCTGCAGGAACCAGCTGAGGCTCCAGCCACCAGGAGAGAACTGTTTTCTGGGAGCAATCCTGGGAAACTG
GGAGAGCCGCCTTCAGGAGGCAAGGCAGGGCCAGAGGAGGATGAAGAAGGGGTATCATTCACAGACTTCCAGCCCCAGGATGTCACCCAA
CATCAGGGATTCCCAGATGAGCTGGCATTCCGCTCTTGCTCAGAAATCCGGAGCGCCTGGCAGGCATTGGAACAGGGACAGCTGGCCCGG
CCAGGCTTCCCAGAGCCACTGCTGATCCTGGAGGATTCGGATCTGGGTGGAGACAGCGGGAGCGGGAAGGCAGGAGCCCCGAGTTCAGAA
AGGACGGCGTCCCGAGTGCGAGAGCTGGCCCGGCTTTACAGCGAGCGGATCCAGCAGATGCAGCGGGCGGAGACTCGGGCATCAGCCAAT
GCCCCGCGCCGCCGGCCTCGGGTTCTGGCCCAACCCCAGCCATCCCCCTGTCTGCCCCAGGAGCAGGCAGAGCCAGGGCTCCTGCCTGCC
TTTGGACACGTGCTGGTATGTGAGCTGGCCTTCCCACTGACATGTGCCCAGGAGTCTGTCCCCCTGGGTCCTGCTGTCTGGGTTCAAGCT
GCCATACCTTTGTCAAAGCAGGGAGGCAGCCCGGATGGCCAGGGTCTACATGTTTCCAATTTGCCTAAGCAAGACCTTCCGGGCATCCAC
GTTTCAGCTGCTACCCTTTTGCCTGAGCAAGGAGGTTCCCGGCATGTCCAGGCTCCAGCCGCCACACCTTTGCCCAAGCAAGAAGGCCCC
CTGCACCTCCAGGTGCCGGCTCTTACAACTTTCTCTGATCAAGGCCACCCAGAAATCCAAGTTCCAGCCACCACTCCTTTGCCTGAGCAT
AGAAGTCACATGGTTATACCAGCTCCATCCACCGCCTTTTGTCCTGAGCAGGGACACTGTGCGGACATCCACGTTCCCACCACTCCAGCT
TTGCCCAAGGAGATTTGTTCTGATTTCACAGTTTCAGTCACCACCCCTGTGCCCAAGCAAGAAGGTCACCTAGACAGCGAGAGCCCAACC
AATATCCCACTGACAAAGCAAGGAGGTTCCAGGGATGTTCAGGGCCCAGACCCTGTCTGCAGTCAACCCATCCAGCCTTTGTCTTGGCAT
GGAAGCAGCCTGGATCCCCAGGGCCCAGGCGACACCCTACCACCCTTGCCATGTCACCTCCCAGACCTTCAGATTCCAGGTACCTCACCT
TTGCCTGCACATGGAAGCCACCTGGACCATCGGATCCCAGCCAACGCCCCACTGTCTTTGTCCCAGGAGCTCCCAGACACTCAGGTTCCA
GCTACCACACCTTTGCCCCTGCCACAAGTCCTCACAGACATCTGGGTCCAAGCCCTCCCAACTTCACCCAAGCAGGGAAGCCTCCCAGAC
ATCCAGGGTCCAGCGGCTGCACCTCCACTTCCGGAGCCAAGCCTTACAGATACACAGGTCCAAAAACTCACACCTTCGTTGGAGCAGAAG
AGCCTCATAGATGCCCATGTTCCAGCTGCCACACCTTTACCTGAGAGAGGAGGCTCTCTAGACATTCAGGGCCTCTCACCCACCCCAGTT
CAGACCACCATGGTTTTGTCCAAACCAGGAGGCTCCTTAGCCTCTCACGTTGCCAGGTTGGAGTCTTCAGACTTGACGCCACCTCATAGT
CCCCCACCTTCCAGCCGTCAGCTCCTGGGCCCCAATGCAGCTGCCCTCTCCAGATACCTGGCAGCCTCATATATCAGCCAGAGCCTGGCT
CGGCGGCAGGGGCCTGGGGGAGGGGCCCCCGCAGCCTCCCGGGGCTCCTGGTCCTCTGCTCCCACGTCACGGGCATCTTCGCCGCCCCCC
CAGCCCCAGCCACCACCTCCCCCAGCCAGGCGGCTCAGCTATGCCACGACGGTTAACATCCACGTGGGCGGGGGTGGGCGGCTGCGGCCA
GCCAAGGCCCAGGTCCGGTTGAACCACCCTGCTCTCTTGGCCTCCACACAGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGAT
GCCCCCTTCCACATGTGAGCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAA
GTCCAGACACTGAACGCAGGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGATCCA

>32177_32177_7_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000409794_length(amino acids)=1023AA_BP=138
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPI
IHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSIT
EEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLT
KIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGE
PPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERT
ASRVRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAI
PLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRS
HMVIPAPSTAFCPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGS
SLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQ
GPAAAPPLPEPSLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPP
PSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAK

--------------------------------------------------------------
>32177_32177_8_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000409797_length(transcript)=1053nt_BP=600nt
AGGGGACGGGGCTAGGCCGGGTCGCCGCCTGACGCGACGCGTCCTCACGGGCGCCTACGTCACGGCGTCGAGGCGGAAGATGGTGCACCT
CCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCGGGGTGCGGCGCAGCC
ACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTC
GTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATG
GAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCG
CCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACC
ATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCT
CCAGAATCTCAGCCACCAGTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCA
ATCACTGAAGAAATCCTGGAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCT
GATGCCCCCTTCCACATGTGAGCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTG
GAAGTCCAGACACTGAACGCAGGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGAT

>32177_32177_8_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000409797_length(amino acids)=214AA_BP=138
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPI
IHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSIT

--------------------------------------------------------------
>32177_32177_9_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000425673_length(transcript)=6378nt_BP=600nt
AGGGGACGGGGCTAGGCCGGGTCGCCGCCTGACGCGACGCGTCCTCACGGGCGCCTACGTCACGGCGTCGAGGCGGAAGATGGTGCACCT
CCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCGGGGTGCGGCGCAGCC
ACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTC
GTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATG
GAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCG
CCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACC
ATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCT
CCAGAATCTCAGCCACCAGTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCA
ATCACTGAAGAAATCCTGGAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGCCGTCCACCCATGACATTCCCAAGTTCCCCGGAGAC
TCCCAGGTGCCTGGCGACAGCGAAACCCTCACATTCCAAGCCCTGCCCAGCCGGGACTCTTCAGAAGAGGAGGAGGAGGAAGAGGAAGGG
CTGGAGATGGATGAACGGGGGCCTTCCCCACTCCACGTCCTGGAAGGGCTCGAAAGTTCCATTGCAGCTGAAATGCCCAGCATTCCCTGC
CTTACCAAAATTCCTGACGTGCCCAACCTTCCTGAAATTCCCAGCCGCTGTGAAATTCCCGAAGGTTCTCGCCTTCCTAGTCTCTCTGAC
ATTTCCGATGTTTTTGAGATGCCCTGCCTTCCAGCCATACCTAGTGTCCCCAACACCCCCAGTCTGTCTAGCACTCCCACCCTCTCCTGT
GACTCCTGGCTCCAAGGGCCTCTGCAGGAACCAGCTGAGGCTCCAGCCACCAGGAGAGAACTGTTTTCTGGGAGCAATCCTGGGAAACTG
GGAGAGCCGCCTTCAGGAGGCAAGGCAGGGCCAGAGGAGGATGAAGAAGGGGTATCATTCACAGACTTCCAGCCCCAGGATGTCACCCAA
CATCAGGGATTCCCAGATGAGCTGGCATTCCGCTCTTGCTCAGAAATCCGGAGCGCCTGGCAGGCATTGGAACAGGGACAGCTGGCCCGG
CCAGGCTTCCCAGAGCCACTGCTGATCCTGGAGGATTCGGATCTGGGTGGAGACAGCGGGAGCGGGAAGGCAGGAGCCCCGAGTTCAGAA
AGGACGGCGTCCCGAGTGCGAGAGCTGGCCCGGCTTTACAGCGAGCGGATCCAGCAGATGCAGCGGGCGGAGACTCGGGCATCAGCCAAT
GCCCCGCGCCGCCGGCCTCGGGTTCTGGCCCAACCCCAGCCATCCCCCTGTCTGCCCCAGGAGCAGGCAGAGCCAGGGCTCCTGCCTGCC
TTTGGACACGTGCTGGTATGTGAGCTGGCCTTCCCACTGACATGTGCCCAGGAGTCTGTCCCCCTGGGTCCTGCTGTCTGGGTTCAAGCT
GCCATACCTTTGTCAAAGCAGGGAGGCAGCCCGGATGGCCAGGGTCTACATGTTTCCAATTTGCCTAAGCAAGACCTTCCGGGCATCCAC
GTTTCAGCTGCTACCCTTTTGCCTGAGCAAGGAGGTTCCCGGCATGTCCAGGCTCCAGCCGCCACACCTTTGCCCAAGCAAGAAGGCCCC
CTGCACCTCCAGGTGCCGGCTCTTACAACTTTCTCTGATCAAGGCCACCCAGAAATCCAAGTTCCAGCCACCACTCCTTTGCCTGAGCAT
AGAAGTCACATGGTTATACCAGCTCCATCCACCGCCTTTTGTCCTGAGCAGGGACACTGTGCGGACATCCACGTTCCCACCACTCCAGCT
TTGCCCAAGGAGATTTGTTCTGATTTCACAGTTTCAGTCACCACCCCTGTGCCCAAGCAAGAAGGTCACCTAGACAGCGAGAGCCCAACC
AATATCCCACTGACAAAGCAAGGAGGTTCCAGGGATGTTCAGGGCCCAGACCCTGTCTGCAGTCAACCCATCCAGCCTTTGTCTTGGCAT
GGAAGCAGCCTGGATCCCCAGGGCCCAGGCGACACCCTACCACCCTTGCCATGTCACCTCCCAGACCTTCAGATTCCAGGTACCTCACCT
TTGCCTGCACATGGAAGCCACCTGGACCATCGGATCCCAGCCAACGCCCCACTGTCTTTGTCCCAGGAGCTCCCAGACACTCAGGTTCCA
GCTACCACACCTTTGCCCCTGCCACAAGTCCTCACAGACATCTGGGTCCAAGCCCTCCCAACTTCACCCAAGCAGGGAAGCCTCCCAGAC
ATCCAGGGTCCAGCGGCTGCACCTCCACTTCCGGAGCCAAGCCTTACAGATACACAGGTCCAAAAACTCACACCTTCGTTGGAGCAGAAG
AGCCTCATAGATGCCCATGTTCCAGCTGCCACACCTTTACCTGAGAGAGGAGGCTCTCTAGACATTCAGGGCCTCTCACCCACCCCAGTT
CAGACCACCATGGTTTTGTCCAAACCAGGAGGCTCCTTAGCCTCTCACGTTGCCAGGTTGGAGTCTTCAGACTTGACGCCACCTCATAGT
CCCCCACCTTCCAGCCGTCAGCTCCTGGGCCCCAATGCAGCTGCCCTCTCCAGATACCTGGCAGCCTCATATATCAGCCAGAGCCTGGCT
CGGCGGCAGGGGCCTGGGGGAGGGGCCCCCGCAGCCTCCCGGGGCTCCTGGTCCTCTGCTCCCACGTCACGGGCATCTTCGCCGCCCCCC
CAGCCCCAGCCACCACCTCCCCCAGCCAGGCGGCTCAGCTATGCCACGACGGTTAACATCCACGTGGGCGGGGGTGGGCGGCTGCGGCCA
GCCAAGGCCCAGGTCCGGTTGAACCACCCTGCTCTCTTGGCCTCCACACAGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTCCTGAT
GCCCCCTTCCACATGTGAGCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAA
GTCCAGACACTGAACGCAGGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGATCCA
CAGGGATGGGGAAGGGAGGAATGTCATTAATGTTTTGTTAATACTGATTCTTTCATGCAATGATGTGTATTTTCCCATTCTGGAGGCTGT
GGGAGATGACAAGACAATGAATGGGAAGGTCTGACACAGAACAAATCAGCGGTTCTGAAAGCTTGGGGAATCTCAGACTCCTTTGAGAAT
TATTGGAAAATGGACCCACTATAACTTGGCGTGTGTGTGAACTGCTTGATGCCCATCCAGGAAAGCCAAGTTAAGAAGCTTTGCTTCAAG
TAGACACTAGAAATCCATTCCCTTGGCAATTTATACAGTTCACGTCTCCCACCATCCGTTCATCTCACCCACCCTGCCATCTCTCCACCT
ATCCATCTGGCTATTGCTCCATCTAGCTTTCCCGCTCCATCTACCCATCTTCCAATCCATCATCTCACGTATCTGCCTTGCTTATCCAAC
TGTCTGCCTTATTCACCCACCCATCCCTTTATCATTCTAACCCCATCTGGCATTCCATCCCTCCATTTATCCATCTTCCCACTTACCCAT
CTTCTCCATCCAGCACTCCGTTCATCAGTCCGTCTCTCCCTCCATATTTCCATCTGTCCATTCATCCACTCATTTTGCCATCCATACATA
TTCACCCAGCCATCTCCCAATCCATCGACATACCCCATCCCTCCCTCACTGGACTCTCCGGGGTCTTAGTACTATGATACTTCAGAGACA
ATTCCATGCTGATACGGGGGAGATCAATTTTGGGGCTCTGGGATAAGTCTGTCCCACATCTGTCTGATTTCCCTTGGCATCCTTCCCGTC
AGTTCCTCTTGAATATCCCAGTTCTTGTACCCACTCACATACCTCAGATCCCTTCACTCCTCCCCGCAGTTTGCAGCCTCTACAATTCAT
CCACATGCTCCCTCCCCCAGCAAAATAATTCAGGTCGTGGAGACAAAAGGCTTTTATGTTAGGTTCTGTCTGCCCCCTTGTTCCAGCAGT
GGTATGCCCAGTGAGAGGCACAATTTAAACGGTTTCTTTGGTGATGATATTAGCTACTTTCATCAAATACTTAGCCTCTTGTGCTTTAGC
ACATTATTTATGTAAGCTCCCCTAGGATTCTCTGAAGCACCCTGGTGTCCTGGCTGTGAATTCAAGTCCCATCTTTACTTATTTGGTGTG
GGTCCTCCCTCTGAGCCGGTTTTCTCATCTACAAAATGAAGACAACAGTACTTCCCTCCTGGGATCATTGAAAGATTTAGGGAGCATATC
CTTCCACTTCCCAAACATATTTGAACCTCTGACTTGCTTAGGAGCATCATTCAAATCACAGATCCCCCAGTATCTAGTCCCAACCTATTG
AATCAGGATCCCCAGGGAAGGAGGAGCTTGGGAATCTGATTTTTTTTTTTTTTTTTAGATAAAGTCTCACTCTGTCACCCAGGCTTGAGT
GCAGTGGCAAAATCTTGGCTCATTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCATGCCTCAGCTTCCCGACATAGCTGGGATTATA
GGCGTGCACCACCATGCCCAGCTAATTTTTCGTTGTTGTTGTTGTTGTTTTGTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGA
GTACAGTGGCACGATCTTGGCTCACTGCAAGCTCCGCTTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACCAC
AGGTGCCCGCCACCACGCCCGGCTAATTTTTTTGGTATTTTTAGTAGAGACGGGGTTTTACCATGTTAGCCAGGATGGTCTCGATCTCCT
GACCTCGTGATCCTCCCGCCTCGGCCTCCCAAAGTGCTGGCATTACAGGCGTGAGCCATCATTCCTGGCTGGGAATCCGAATTTTTTTTT
TTTTTTAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTTCAATAGCATGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAG
TGATTCTCCTGCCTCTAGCTGGGATTGCAGGCGCCCACGACCACGCCCAGCTAATTTTTGTATTTTGTAGTAGAGACGGGATTTCGCCAT
ATTGGCCAGGCCATAGTGGTCTTGGACTCCTGACCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGTTGGGTTTACAGGCGTGAGCT
ACCATACCCTGCCCAGGAATCTGAATTTTTAGCAATCAGTTAGCAGCAAATAAGCTGAGATTTCCTGGGTACTAAGCACATACTATGAGC
ATTACAGCCGCTTTATATAAGCTCGTTCACTGTCCTCATTACATTCCTAATATGCAAGTGAGCATGTTTTTTAATCCTCAGTCTAGAGGT
GAGGAAACTGAGGCAGGCACAGAGAGGCTAAGGGATTTGCCTAGTCGCACAGCTAGGAAGGTGCAGCACTGAGACTCGAATCCACACAGC
TTGGCTTAAGTCTACCATTAAATTTGCCTGTCCTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAACACTTCGTGAGGCCAAGGCAGG
TGGATCACTTGAAGTGAGGAGTTCGAGACCACACCAGCCTGGCCAACATGGTGAAATCCCGTCTTTACTAAAAATACAAAAAATTAGCTG
GGCGTGGTGGTGGGTGCCGGTAATCCTAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAAC
CGAGATTGCGCCACTAGACTCCAGCCTGGGAGACGAGCAAAACTGTCTCAAAAAAATAAAATGAAATACATAAATAAATGTGCCTATCCT
GTGCCGGGTGCTGTTCTTGCCAGTGGGGATACATGAGAGAACACTGCCTTGCCCGCATGAGGCTTGTGGCCTGGTACTGTGCACACCTCA

>32177_32177_9_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000425673_length(amino acids)=1023AA_BP=138
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPI
IHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSIT
EEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLT
KIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGE
PPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERT
ASRVRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAI
PLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRS
HMVIPAPSTAFCPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGS
SLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQ
GPAAAPPLPEPSLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPP
PSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAK

--------------------------------------------------------------
>32177_32177_10_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000458508_length(transcript)=3046nt_BP=600nt
AGGGGACGGGGCTAGGCCGGGTCGCCGCCTGACGCGACGCGTCCTCACGGGCGCCTACGTCACGGCGTCGAGGCGGAAGATGGTGCACCT
CCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCGGGGTGCGGCGCAGCC
ACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGCGACCAGAGTGACTTC
GTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGGCAGCTGGTGGAATTTTTGAAGAAAATG
GAATCTCGAGGCCCCCTTTCGTGCGACACGGTTCTGAAGATCTTCTACCAGACGTGCCGCGCCGTGCAGCACATGCACCGGCAGAAGCCG
CCCATCATCCACAGGGACCTCAAGGTTGAGAACTTGTTGCTTAGTAACCAAGGGACCATTAAGCTGTGTGACTTTGGCAGTGCCACGACC
ATCTCGCACTACCCTGACTACAGCTGGAGCGCCCAGAGGCGAGCCCTGGTGGAGGAAGAGCACGCTGGCAGCGAAGGGGAACTCTACCCT
CCAGAATCTCAGCCACCAGTTTCAGGCTCTGCACCCCCTGAGGACCTGGAGGATGCTGGACCCCCAACACTGGACCCCTCTGGGACCTCA
ATCACTGAAGAAATCCTGGAACTGCTGAATCAGCGAGGCCTTCGAGATCCAGGGCCGTCCACCCATGACATTCCCAAGTTCCCCGGAGAC
TCCCAGGTGCCTGGCGACAGCGAAACCCTCACATTCCAAGCCCTGCCCAGCCGGGACTCTTCAGAAGAGGAGGAGGAGGAAGAGGAAGGG
CTGGAGATGGATGAACGGGGGCCTTCCCCACTCCACGTCCTGGAAGGGCTCGAAAGTTCCATTGCAGCTGAAATGCCCAGCATTCCCTGC
CTTACCAAAATTCCTGACGTGCCCAACCTTCCTGAAATTCCCAGCCGCTGTGAAATTCCCGAAGGTTCTCGCCTTCCTAGTCTCTCTGAC
ATTTCCGATGTTTTTGAGATGCCCTGCCTTCCAGCCATACCTAGTGTCCCCAACACCCCCAGTCTGTCTAGCACTCCCACCCTCTCCTGT
GACTCCTGGCTCCAAGGGCCTCTGCAGGAACCAGCTGAGGCTCCAGCCACCAGGAGAGAACTGTTTTCTGGGAGCAATCCTGGGAAACTG
GGAGAGCCGCCTTCAGGAGGCAAGGCAGGGCCAGAGGAGGATGAAGAAGGGGTATCATTCACAGACTTCCAGCCCCAGGATGTCACCCAA
CATCAGGGATTCCCAGATGAGCTGGCATTCCGCTCTTGCTCAGAAATCCGGAGCGCCTGGCAGGCATTGGAACAGGGACAGCTGGCCCGG
CCAGGCTTCCCAGAGCCACTGCTGATCCTGGAGGATTCGGATCTGGGTGGAGACAGCGGGAGCGGGAAGGCAGGAGCCCCGAGTTCAGAA
AGGACGGCGTCCCGAGTGCGAGAGCTGGCCCGGCTTTACAGCGAGCGGATCCAGCAGATGCAGCGGGCGGAGACTCGGGCATCAGCCAAT
GCCCCGCGCCGCCGGCCTCGGGTTCTGGCCCAACCCCAGCCATCCCCCTGTCTGCCCCAGGAGCAGGCAGAGCCAGGGCTCCTGCCTGCC
TTTGGACACGTGCTGGTATGTGAGCTGGCCTTCCCACTGACATGTGCCCAGGAGTCTGTCCCCCTGGGTCCTGCTGTCTGGGTTCAAGCT
GCCATACCTTTGTCAAAGCAGGGAGGCAGCCCGGATGGCCAGGGTCTACATGTTTCCAATTTGCCTAAGCAAGACCTTCCGGGCATCCAC
GTTTCAGCTGCTACCCTTTTGCCTGAGCAAGGAGGTTCCCGGCATGTCCAGGCTCCAGCCGCCACACCTTTGCCCAAGCAAGAAGGCCCC
CTGCACCTCCAGGTGCCGGCTCTTACAACTTTCTCTGATCAAGGCCACCCAGAAATCCAAGTTCCAGCCACCACTCCTTTGCCTGAGCAT
AGAAGTCACATGGTTATACCAGCTCCATCCACCGCCTTTTGTCCTGAGCAGGGACACTGTGCGGACATCCACGTTCCCACCACTCCAGCT
TTGCCCAAGGAGATTTGTTCTGATTTCACAGTTTCAGTCACCACCCCTGTGCCCAAGCAAGAAGGTCACCTAGACAGCGAGAGCCCAACC
AATATCCCACTGACAAAGCAAGGAGGTTCCAGGGATGTTCAGGGCCCAGACCCTGTCTGCAGTCAACCCATCCAGCCTTTGTCTTGGCAT
GGAAGCAGCCTGGATCCCCAGGGCCCAGGCGACACCCTACCACCCTTGCCATGTCACCTCCCAGACCTTCAGATTCCAGGTACCTCACCT
TTGCCTGCACATGGAAGCCACCTGGACCATCGGATCCCAGCCAACGCCCCACTGTCTTTGTCCCAGGAGCTCCCAGACACTCAGGTTCCA
GCTACCACACCTTTGCCCCTGCCACAAGTCCTCACAGACATCTGGGTCCAAGCCCTCCCAACTTCACCCAAGCAGGGAAGCCTCCCAGAC
ATCCAGGGTCCAGCGGCTGCACCTCCACTTCCGGAGCCAAGCCTTACAGATACACAGGTCCAAAAACTCACACCTTCGTTGGAGCAGAAG
AGCCTCATAGATGCCCATGTTCCAGCTGCCACACCTTTACCTGAGAGAGGAGGCTCTCTAGACATTCAGGGCCTCTCACCCACCCCAGTT
CAGACCACCATGGTTTTGTCCAAACCAGGAGGCTCCTTAGCCTCTCACGTTGCCAGGAATCTATGGGCCTTCACAGGGCCCAGGGGGCTC
CTGATGCCCCCTTCCACATGTGAGCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACC

>32177_32177_10_GAK-PLEKHG2_GAK_chr4_891821_ENST00000511163_PLEKHG2_chr19_39912755_ENST00000458508_length(amino acids)=933AA_BP=138
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPI
IHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSIT
EEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLT
KIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGE
PPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERT
ASRVRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAI
PLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRS
HMVIPAPSTAFCPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGS
SLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQ
GPAAAPPLPEPSLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARNLWAFTGPRGLLM

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Fusion Gene PPI Analysis for GAK-PLEKHG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GAK-PLEKHG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GAK-PLEKHG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource