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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GALK2-FGF7 (FusionGDB2 ID:32191)

Fusion Gene Summary for GALK2-FGF7

check button Fusion gene summary
Fusion gene informationFusion gene name: GALK2-FGF7
Fusion gene ID: 32191
HgeneTgene
Gene symbol

GALK2

FGF7

Gene ID

2585

2252

Gene namegalactokinase 2fibroblast growth factor 7
SynonymsGK2HBGF-7|KGF
Cytomap

15q21.1-q21.2

15q21.2

Type of geneprotein-codingprotein-coding
DescriptionN-acetylgalactosamine kinasegalNAc kinasefibroblast growth factor 7FGF-7heparin-binding growth factor 7keratinocyte growth factor
Modification date2020031320200313
UniProtAcc

Q01415

P21781

Ensembl transtripts involved in fusion geneENST00000543495, ENST00000327171, 
ENST00000396509, ENST00000544523, 
ENST00000559454, ENST00000560031, 
ENST00000561014, 		ENST00000267843, 
ENST00000560704, ENST00000560270, 
Fusion gene scores* DoF score8 X 9 X 6=4326 X 4 X 6=144
# samples 97
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GALK2 [Title/Abstract] AND FGF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGALK2(49612002)-FGF7(49775348), # samples:4
Anticipated loss of major functional domain due to fusion event.GALK2-FGF7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGF7

GO:0010463

mesenchymal cell proliferation

11023837

TgeneFGF7

GO:0010838

positive regulation of keratinocyte proliferation

17449030

TgeneFGF7

GO:0031532

actin cytoskeleton reorganization

17449030

TgeneFGF7

GO:0034394

protein localization to cell surface

17449030

TgeneFGF7

GO:0050679

positive regulation of epithelial cell proliferation

11493558|15690149

TgeneFGF7

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17449030

TgeneFGF7

GO:0050918

positive chemotaxis

17449030

TgeneFGF7

GO:0051549

positive regulation of keratinocyte migration

17449030

TgeneFGF7

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

9740653

TgeneFGF7

GO:0061033

secretion by lung epithelial cell involved in lung growth

10541313


check buttonFusion gene breakpoints across GALK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FGF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-02-2485-01AGALK2chr15

49612002

+FGF7chr15

49775348

+
ChimerDB4KICHTCGA-KL-8336-01AGALK2chr15

49612002

+FGF7chr15

49775348

+
ChimerDB4PCPGTCGA-QR-A6GO-01AGALK2chr15

49612002

+FGF7chr15

49775348

+
ChimerDB4PRADTCGA-YJ-A8SWGALK2chr15

49612002

+FGF7chr15

49775348

+
ChimerDB4UCECTCGA-B5-A0K9-01AGALK2chr15

49620327

+FGF7chr15

49775348

+


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Fusion Gene ORF analysis for GALK2-FGF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000543495ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
3UTR-3CDSENST00000543495ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
3UTR-3UTRENST00000543495ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
3UTR-3UTRENST00000543495ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
3UTR-intronENST00000543495ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
3UTR-intronENST00000543495ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-3UTRENST00000327171ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-3UTRENST00000327171ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-3UTRENST00000396509ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-3UTRENST00000396509ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-3UTRENST00000544523ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-3UTRENST00000544523ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-3UTRENST00000559454ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-3UTRENST00000559454ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-3UTRENST00000560031ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-3UTRENST00000560031ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-intronENST00000327171ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-intronENST00000327171ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-intronENST00000396509ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-intronENST00000396509ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-intronENST00000544523ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-intronENST00000544523ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-intronENST00000559454ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-intronENST00000559454ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+
5CDS-intronENST00000560031ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
5CDS-intronENST00000560031ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+
Frame-shiftENST00000327171ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
Frame-shiftENST00000327171ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
Frame-shiftENST00000396509ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
Frame-shiftENST00000544523ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
Frame-shiftENST00000544523ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
Frame-shiftENST00000559454ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
Frame-shiftENST00000559454ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
Frame-shiftENST00000560031ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
Frame-shiftENST00000560031ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
In-frameENST00000396509ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
intron-3CDSENST00000561014ENST00000267843GALK2chr15

49612002

+FGF7chr15

49775348

+
intron-3CDSENST00000561014ENST00000267843GALK2chr15

49620327

+FGF7chr15

49775348

+
intron-3UTRENST00000561014ENST00000560704GALK2chr15

49612002

+FGF7chr15

49775348

+
intron-3UTRENST00000561014ENST00000560704GALK2chr15

49620327

+FGF7chr15

49775348

+
intron-intronENST00000561014ENST00000560270GALK2chr15

49612002

+FGF7chr15

49775348

+
intron-intronENST00000561014ENST00000560270GALK2chr15

49620327

+FGF7chr15

49775348

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396509GALK2chr1549620327+ENST00000267843FGF7chr1549775348+62251655631292409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396509ENST00000267843GALK2chr1549620327+FGF7chr1549775348+0.0002335720.9997664

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Fusion Genomic Features for GALK2-FGF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GALK2chr1549612002+FGF7chr1549775347+1.40E-050.99998593
GALK2chr1549612002+FGF7chr1549775347+1.40E-050.99998593

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GALK2-FGF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:49612002/chr15:49775348)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALK2

Q01415

FGF7

P21781

FUNCTION: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. {ECO:0000269|PubMed:16006554}.FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGALK2chr15:49620327chr15:49775348ENST00000327171+110139_1490448.0Nucleotide bindingATP
HgeneGALK2chr15:49620327chr15:49775348ENST00000560031+110139_1490459.0Nucleotide bindingATP
HgeneGALK2chr15:49620327chr15:49775348ENST00000327171+110187_1900448.0RegionNote=Substrate binding
HgeneGALK2chr15:49620327chr15:49775348ENST00000327171+11049_520448.0RegionNote=Substrate binding
HgeneGALK2chr15:49620327chr15:49775348ENST00000560031+110187_1900459.0RegionNote=Substrate binding
HgeneGALK2chr15:49620327chr15:49775348ENST00000560031+11049_520459.0RegionNote=Substrate binding


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Fusion Gene Sequence for GALK2-FGF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32191_32191_1_GALK2-FGF7_GALK2_chr15_49620327_ENST00000396509_FGF7_chr15_49775348_ENST00000267843_length(transcript)=6225nt_BP=1655nt
AGGGCGGGAGCTGTTTATCTCCCGGAAGAAAACGGCTCCTGTCACAGAAGTCTCGTGATTGCTCTGGGAGCTTTGCTTAGACACTTGAAA
CTACAGGAGAAAGAAGGATCTAGCGAAATATGGCTACAGAGAGCCCTGCTACGCGTCGGGTCCAGGTTACTGAAGCTAAAGGAGATGTTT
AACTCCAAGTTTGGATCTATTCCCAAGTTTTATGTTCGAGCACCAGGAAGAGTCAACATAATAGGAGAGCATATAGATTATTGTGGATAT
TCTGTTCTTCCTATGGCTGTAGAACAAGATGTGCTAATAGCTGTAGAACCTGTGAAAACGTACGCTCTCCAACTGGCCAATACAAATCCC
TTGTATCCGGACTTCAGTACTAGTGCTAATAACATCCAGATTGATAAAACCAAGCCTTTGTGGCACAACTATTTCTTATGTGGACTTAAA
GGAATTCAGGAACACTTTGGTCTTAGTAACCTGACTGGAATGAACTGCCTGGTAGATGGAAATATCCCACCAAGTTCTGGCCTCTCCAGC
TCCAGTGCTTTGGTCTGTTGTGCTGGCTTGGTGACGCTCACAGTGCTGGGAAGGAATCTATCCAAGGTGGAACTTGCAGAAATCTGTGCC
AAGAGTGAGCGTTACATTGGCACTGAAGGAGGAGGCATGGACCAGTCTATATCATTTCTTGCAGAAGAAGGAACTGCCAAGTTGATAGAA
TTTAGTCCTCTGAGGGCAACCGATGTAAAACTCCCAAGTGGAGCAGTGTTTGTGATTGCCAACAGTTGTGTGGAGATGAATAAGGCAGCA
ACTTCCCATTTCAATATCAGGGTGATGGAGTGTCGGCTGGCTGCGAAGCTCCTGGCTAAATACAAAAGCTTGCAATGGGACAAAGTACTG
AGGCTGGAGGAGGTGCAGGCTAAACTAGGGATTAGTCTAGAAGAAATGCTGTTGGTCACAGAAGATGCCCTTCATCCTGAACCCTATAAC
CCTGAGGAGATCTGCAGGTGTCTGGGAATTAGCCTGGAGGAACTCCGAACCCAAATCCTGAGTCCAAACACTCAAGATGTGCTCATCTTC
AAACTCTATCAGCGGGCAAAGCATGTGTACAGCGAGGCTGCGCGAGTGCTCCAGTTTAAGAAGATATGTGAAGAAGCACCTGAAAACATG
GTCCAGCTGCTGGGAGAGTTGATGAACCAGAGCCACATGAGCTGCCGGGACATGTATGAGTGCAGCTGCCCCGAGCTGGATCAGCTGGTG
GACATCTGTCGGTGGGGCTTTGGTTTTGCTTGAGGCCTGAAAAAATGTAAAAAGTCTGAGAGAAACTACTTAGGGCACTTAGGAATTGGC
AGGACTTTCTGTGCCACAGTAAATTAATCTTCCTTCTGTTTTGTATTATGATGAACGGTTGCTATTATATCAAGATATATTTTCAAAGAA
ATGGTTGAAAGCTCTCTATGCTTCATAATGATTCTTTTTCCATCTTAAAATATGGTTTTACTATTAAGAGCCAAGATCATGCTTGGACAG
ATCTTTTAAGAATAACTTACTGAGATTTATTGATTTGAAGATTTTAAAGATGAATGGTAAAACACACTCTTAATACTGATTACATGGATT
GGACTTGAATTAAATATATTGTTACAATTAAACTGATATCATGGAAATCAGGACAGTGGCAGTTGGAATTGTGGCAATCAAAGGGGTGGA
AAGTGAATTCTATCTTGCAATGAACAAGGAAGGAAAACTCTATGCAAAGAAAGAATGCAATGAAGATTGTAACTTCAAAGAACTAATTCT
GGAAAACCATTACAACACATATGCATCAGCTAAATGGACACACAACGGAGGGGAAATGTTTGTTGCCTTAAATCAAAAGGGGATTCCTGT
AAGAGGAAAAAAAACGAAGAAAGAACAAAAAACAGCCCACTTTCTTCCTATGGCAATAACTTAATTGCATATGGTATATAAAGAACCAGT
TCCAGCAGGGAGATTTCTTTAAGTGGACTGTTTTCTTTCTTCTCAAAATTTTCTTTCCTTTTATTTTTTAGTAATCAAGAAAGGCTGGAA
AACTACTGAAAAACTGATCAAGCTGGACTTGTGCATTTATGTTTGTTTTAAGACACTGCATTAAAGAAAGATTTGAAAAGTATACACAAA
AATCAGATTTAGTAACTAAAGGTTGTAAAAAATTGTAAAACTGGTTGTACAATCATGATGTTAGTAACAGTAATTTTTTTCTTAAATTAA
TTTACCCTTAAGAGTATGTTAGATTTGATTATCTGATAATGATTATTTAAATATTCCTATCTGCTTATAAAATGGCTGCTATAATAATAA
TAATACAGATGTTGTTATATAAGGTATATCAGACCTACAGGCTTCTGGCAGGATTTGTCAGATAATCAAGCCACACTAACTATGGAAAAT
GAGCAGCATTTTAAATGCTTTCTAGTGAAAAATTATAATCTACTTAAACTCTAATCAGAAAAAAAATTCTCAAAAAAACTATTATGAAAG
TCAATAAAATAGATAATTTAACAAAAGTACAGGATTAGAACATGCTTATACCTATAAATAAGAACAAAATTTCTAATGCTGCTCAAGTGG
AAAGGGTATTGCTAAAAGGATGTTTCCAAAAATCTTGTATATAAGATAGCAACAGTGATTGATGATAATACTGTACTTCATCTTACTTGC
CACAAAATAACATTTTATAAATCCTCAAAGTAAAATTGAGAAATCTTTAAGTTTTTTTCAAGTAACATAATCTATCTTTGTATAATTCAT
ATTTGGGAATATGGCTTTTAATAATGTTCTTCCCACAAATAATCATGCTTTTTTCCTATGGTTACAGCATTAAACTCTATTTTAAGTTGT
TTTTGAACTTTATTGTTTTGTTATTTAAGTTTATGTTATTTATAAAAAAAAAACCTTAATAAGCTGTATCTGTTTCATATGCTTTTAATT
TTAAAGGAATAACAAAACTGTCTGGCTCAACGGCAAGTTTCCCTCCCTTTTCTGACTGACACTAAGTCTAGCACACAGCACTTGGGCCAG
CAAATCCTGGAAGGCAGACAAAAATAAGAGCCTGAAGCAATGCTTACAATAGATGTCTCACACAGAACAATACAAATATGTAAAAAATCT
TTCACCACATATTCTTGCCAATTAATTGGATCATATAAGTAAAATCATTACAAATATAAGTATTTACAGGATTTTAAAGTTAGAATATAT
TTGAATGCATGGGTAGAAAATATCATATTTTAAAACTATGTATATTTAAATTTAGTAATTTTCTAATCTCTAGAAATCTCTGCTGTTCAA
AAGGTGGCAGCACTGAAAGTTGTTTTCCTGTTAGATGGCAAGAGCACAATGCCCAAAATAGAAGATGCAGTTAAGAATAAGGGGCCCTGA
ATGTCATGAAGGCTTGAGGTCAGCCTACAGATAACAGGATTATTACAAGGATGAATTTCCACTTCAAAAGTCTTTCATTGGCAGATCTTG
GTAGCACTTTATATGTTCACCAATGGGAGGTCAATATTTATCTAATTTAAAAGGTATGCTAACCACTGTGGTTTTAATTTCAAAATATTT
GTCATTCAAGTCCCTTTACATAAATAGTATTTGGTAATACATTTATAGATGAGAGTTATATGAAAAGGCTAGGTCAACAAAAACAATAGA
TTCATTTAATTTTCCTGTGGTTGACCTATACGACCAGGATGTAGAAAACTAGAAAGAACTGCCCTTCCTCAGATATACTCTTGGGAGAGA
GCATGAATGGTATTCTGAACTATCACCTGATTCAAGGACTTTGCTAGCTAGGTTTTGAGGTCAGGCTTCAGTAACTGTAGTCTTGTGAGC
ATATTGAGGGCAGAGGAGGACTTAGTTTTTCATATGTGTTTCCTTAGTGCCTAGCAGACTATCTGTTCATAATCAGTTTTCAGTGTGAAT
TCACTGAATGTTTATAGACAAAAGAAAATACACACTAAAACTAATCTTCATTTTAAAAGGGTAAAACATGACTATACAGAAATTTAAATA
GAAATAGTGTATATACATATAAAATACAAGCTATGTTAGGACCAAATGCTCTTTGTCTATGGAGTTATACTTCCATCAAATTACATAGCA
ATGCTGAATTAGGCAAAACCAACATTTAGTGGTAAATCCATTCCTGGTAGTATAAGTCACCTAAAAAAGACTTCTAGAAATATGTACTTT
AATTATTTGTTTTTCTCCTATTTTTAAATTTATTATGCAAATTTTAGAAAATAAAATTTGCTCTAGTTACACACCTTTAGAATTCTAGAA
TATTAAAACTGTAAGGGGCCTCCATCCCTCTTACTCATTTGTAGTCTAGGAAATTGAGATTTTGATACACCTAAGGTCACGCAGCTGGGT
AGATATACAGCTGTCACAAGAGTCTAGATCAGTTAGCACATGCTTTCTACTCTTCGATTATTAGTATTATTAGCTAATGGTCTTTGGCAT
GTTTTTGTTTTTTATTTCTGTTGAGATATAGCCTTTACATTTGTACACAAATGTGACTATGTCTTGGCAATGCACTTCATACACAATGAC
TAATCTATACTGTGATGATTTGACTCAAAAGGAGAAAAGAAATTATGTAGTTTTCAATTCTGATTCCTATTCACCTTTTGTTTATGAATG
GAAAGCTTTGTGCAAAATATACATATAAGCAGAGTAAGCCTTTTAAAAATGTTCTTTGAAAGATAAAATTAAATACATGAGTTTCTAACA
ATTAGAAAAGAAAAAATTAAAACATGAAATGATAACAAAAGTAAACAAAAGATACTTTCAAAGCAGTGAACAAAACATTTTGACATAAGC
CATAATATAAATTATAATATAAAAAATAAAAACCATAGTATAAATTGTCAGCCTTTGAGTTGGCTACAAATTCAATTTAATGACAGAAGA
GAAGGGATGCTGGAGGTAAATTCTTAGGGTTTCTATCTCATAGAGTTTGCTCTTCTGGTTCTCTAGACTGCCAAAGAACATAAAGATGTG
CGAGGGGACCTAGCTGTAGTAAAAGCAATCCTATAACAAGAAAAACTCTAAAACAGTGCCCCTTACGATTTTCTACTGAAATTTCTCTAA
TAGTAGAGGTGTAAAATAAGAAGTTAGAGAATAATGCAAAGGGGGCCCACCACAGACGGAACATTTCTTTTCTCTTAAGACTCATGTGAT
TTTTGCATCTTACTCCATAATATATTTGTGGTTGCGTTAATATGACAATGTCTGCAATTAAACACCAGTAAGCAAAATTGATACATCAGA
ATGACTTGCAGGGCTTATCATGCAGTTTGGTTTACATCCCTACTCCACTGCCATTTACTTGAGCGTGAATGAGACACAAAAGATTATTTG
CCTCCCATAATCCAACTTTACACATAAATAACACAAGGCTAAAGAAAACCAGAACTCAAATTCACCACGCATAGGAGTGATAACAAAAAT
ATTTAACAGTCAGTATGGGTGATTACTGGCCAATCAGAATACATCACTGATACATCGAAATGGATGCAGGCCACTATGACTAACTTGTGG
GTATCATTTCTATGATCACCCTAAAACAGAGTTGGGAAAATATCTATTAACTGGTCTCTCTGGTTTGAATTCTCAATATGTATCTTAATA
TGAAATAGCTCATTAAAACTTCATGTGTAACTATTTCAGCATTGTTGTCAGCTACTCTTTATTCCACTTCTGTACAGTATTTATTCAACC
AAGCTGCTGCTTTCAATGAAGGTCACTTGTTCCTTCAGGGACACATATACTCCCACCTATCCTTTAATTTTGAATGGTTTGTCAGGAAAA
TTTACTTTCTCTTGAGTTGAAAAACTTGACAGGAAGCAAGAAATAATACAGTCCTAGCCTCTTTCCAATAACATCTGATTTCTCCATTCT
CAAACTACACTTCTCAAGGAACCAGATATTTACTCTCATCTGGGAAGATGCCTCTTATGTTTTCCTTTTACTTCCTGGTTATCATGTGGT
TGCATTTTCCAAGTTCTTATCATTGAATTTATGAGAGCCTATCAAAATTTATTTTCTTTCATTTATATTCTAATAATTGAAATGTGAGAT
GAAAATAACATTTCACTTATGAAAAACCCTTCTCTTGATGAATCCTTCCATGTGTTAGTTATCTATTGCTGTGTAACAAATTAAAACTTA

>32191_32191_1_GALK2-FGF7_GALK2_chr15_49620327_ENST00000396509_FGF7_chr15_49775348_ENST00000267843_length(amino acids)=409AA_BP=
MGALLRHLKLQEKEGSSEIWLQRALLRVGSRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY
ALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQEHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLS
KVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKY
KSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEICRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GALK2-FGF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GALK2-FGF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GALK2-FGF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource