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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AIMP2-EIF2AK1 (FusionGDB2 ID:3220)

Fusion Gene Summary for AIMP2-EIF2AK1

check button Fusion gene summary
Fusion gene informationFusion gene name: AIMP2-EIF2AK1
Fusion gene ID: 3220
HgeneTgene
Gene symbol

AIMP2

EIF2AK1

Gene ID

7965

27102

Gene nameaminoacyl tRNA synthetase complex interacting multifunctional protein 2eukaryotic translation initiation factor 2 alpha kinase 1
SynonymsHLD17|JTV-1|JTV1|P38HCR|HRI
Cytomap

7p22.1

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionaminoacyl tRNA synthase complex-interacting multifunctional protein 2ARS-interacting multi-functional protein 2multisynthase complex auxiliary component p38multisynthetase complex auxiliary component p38protein JTV-1eukaryotic translation initiation factor 2-alpha kinase 1heme regulated initiation factor 2 alpha kinaseheme sensitive initiation factor 2a kinaseheme-controlled repressorheme-regulated eukaryotic initiation factor eIF-2-alpha kinaseheme-regulated in
Modification date2020032720200313
UniProtAcc

Q13155

Q9BQI3

Ensembl transtripts involved in fusion geneENST00000223029, ENST00000395236, 
ENST00000400479, 		ENST00000199389, 
ENST00000495565, ENST00000536084, 
Fusion gene scores* DoF score2 X 26 X 7=3647 X 32 X 9=2016
# samples 2127
** MAII scorelog2(21/364*10)=-0.793549122532573
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2016*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AIMP2 [Title/Abstract] AND EIF2AK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAIMP2(6063342)-EIF2AK1(6064102), # samples:1
AIMP2(6062392)-EIF2AK1(6063655), # samples:1
AIMP2(6063282)-EIF2AK1(6064169), # samples:1
AIMP2(6063376)-EIF2AK1(6064098), # samples:1
AIMP2(6063167)-EIF2AK1(6063690), # samples:1
AIMP2(6063465)-EIF2AK1(6064000), # samples:1
AIMP2(6063382)-EIF2AK1(6064216), # samples:1
AIMP2(6062777)-EIF2AK1(6064078), # samples:1
AIMP2(6062843)-EIF2AK1(6063794), # samples:1
AIMP2(6063015)-EIF2AK1(6063594), # samples:1
AIMP2(6063019)-EIF2AK1(6063525), # samples:1
AIMP2(6063101)-EIF2AK1(6064147), # samples:1
AIMP2(6063222)-EIF2AK1(6063698), # samples:1
AIMP2(6063267)-EIF2AK1(6063974), # samples:1
AIMP2(6057587)-EIF2AK1(6063849), # samples:1
AIMP2(6063233)-EIF2AK1(6064142), # samples:1
AIMP2(6062773)-EIF2AK1(6063699), # samples:1
AIMP2(6062863)-EIF2AK1(6063606), # samples:1
AIMP2(6063287)-EIF2AK1(6064162), # samples:1
AIMP2(6063022)-EIF2AK1(6063468), # samples:1
AIMP2(6063440)-EIF2AK1(6063978), # samples:1
AIMP2(6063290)-EIF2AK1(6064368), # samples:1
AIMP2(6062821)-EIF2AK1(6064320), # samples:1
AIMP2(6057675)-EIF2AK1(6064431), # samples:1
AIMP2(6063282)-EIF2AK1(6064405), # samples:1
AIMP2(6063141)-EIF2AK1(6062541), # samples:1
EIF2AK1(6062934)-AIMP2(6063143), # samples:1
Anticipated loss of major functional domain due to fusion event.AIMP2-EIF2AK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AIMP2-EIF2AK1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
AIMP2-EIF2AK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AIMP2-EIF2AK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF2AK1

GO:1990641

response to iron ion starvation

11036079


check buttonFusion gene breakpoints across AIMP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF2AK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BAIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
ChimerDB4BRCATCGA-BH-A1FE-01AAIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
ChimerDB4LUADTCGA-64-5774-01AAIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
ChimerDB4LUSCTCGA-43-3394-11AAIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
ChimerDB4OVTCGA-09-1667-01CAIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
ChimerDB4OVTCGA-09-1667-01CAIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
ChimerDB4OVTCGA-13-1481-01AAIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
ChimerDB4OVTCGA-13-1492-01AAIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
ChimerDB4OVTCGA-23-1024-01AAIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
ChimerDB4OVTCGA-24-1549-01AAIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
ChimerDB4OVTCGA-59-2352-01AAIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
ChimerDB4OVTCGA-61-1743-01AAIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
ChimerDB4PRADTCGA-EJ-7123-01AAIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
ChimerDB4STADTCGA-2H-A9GK-01A2AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
ChimerDB4STADTCGA-JY-A6FH-01A6AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
ChimerDB4STADTCGA-JY-A6FH-01A6AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
ChimerDB4STADTCGA-JY-A6FH-01A6AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
ChimerDB4STADTCGA-L5-A8NH-01A8AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
ChimerDB4STADTCGA-LN-A5U5-01A3AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
ChimerDB4STADTCGA-R6-A8WC-01A6AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
ChimerDB4STADTCGA-R6-A8WC-01A6AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
ChimerDB4STADTCGA-R6-A8WC-01A6AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
ChimerDB4STADTCGA-V5-AASX-11A8AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
ChimerDB4STADTCGA-VR-A8EX-01A1AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
ChimerDB4STADTCGA-VR-A8EX-01A1AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
ChiTaRS5.0N/AW25934AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-


Top

Fusion Gene ORF analysis for AIMP2-EIF2AK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000223029ENST00000199389AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
3UTR-3UTRENST00000223029ENST00000199389AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
3UTR-3UTRENST00000223029ENST00000199389AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
3UTR-3UTRENST00000223029ENST00000199389AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
3UTR-3UTRENST00000395236ENST00000199389AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
3UTR-intronENST00000223029ENST00000495565AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
3UTR-intronENST00000223029ENST00000495565AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
3UTR-intronENST00000223029ENST00000495565AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
3UTR-intronENST00000223029ENST00000495565AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
3UTR-intronENST00000223029ENST00000536084AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
3UTR-intronENST00000223029ENST00000536084AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
3UTR-intronENST00000223029ENST00000536084AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
3UTR-intronENST00000223029ENST00000536084AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
3UTR-intronENST00000395236ENST00000495565AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
3UTR-intronENST00000395236ENST00000536084AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-3UTRENST00000223029ENST00000199389AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-3UTRENST00000223029ENST00000536084AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-3UTRENST00000223029ENST00000536084AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-3UTRENST00000223029ENST00000536084AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-3UTRENST00000223029ENST00000536084AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-3UTRENST00000223029ENST00000536084AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
5CDS-3UTRENST00000395236ENST00000199389AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-3UTRENST00000395236ENST00000536084AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-3UTRENST00000395236ENST00000536084AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-3UTRENST00000395236ENST00000536084AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-3UTRENST00000395236ENST00000536084AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-3UTRENST00000395236ENST00000536084AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-3UTRENST00000400479ENST00000199389AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-3UTRENST00000400479ENST00000536084AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-3UTRENST00000400479ENST00000536084AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-3UTRENST00000400479ENST00000536084AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-3UTRENST00000400479ENST00000536084AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-3UTRENST00000400479ENST00000536084AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-intronENST00000223029ENST00000495565AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
5CDS-intronENST00000223029ENST00000536084AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
5CDS-intronENST00000395236ENST00000495565AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
5CDS-intronENST00000395236ENST00000536084AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063022

+EIF2AK1chr7

6063468

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063222

-EIF2AK1chr7

6063698

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063015

+EIF2AK1chr7

6063594

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063019

+EIF2AK1chr7

6063525

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063167

-EIF2AK1chr7

6063690

-
5CDS-intronENST00000400479ENST00000495565AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6063287

+EIF2AK1chr7

6064162

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6063233

-EIF2AK1chr7

6064142

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6063267

-EIF2AK1chr7

6063974

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6057587

-EIF2AK1chr7

6063849

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6063101

-EIF2AK1chr7

6064147

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6063282

+EIF2AK1chr7

6064169

-
5CDS-intronENST00000400479ENST00000536084AIMP2chr7

6063141

+EIF2AK1chr7

6062541

-
Frame-shiftENST00000223029ENST00000199389AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
Frame-shiftENST00000223029ENST00000536084AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
Frame-shiftENST00000223029ENST00000536084AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
Frame-shiftENST00000223029ENST00000536084AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
Frame-shiftENST00000395236ENST00000199389AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
Frame-shiftENST00000395236ENST00000536084AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
Frame-shiftENST00000395236ENST00000536084AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
Frame-shiftENST00000395236ENST00000536084AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
Frame-shiftENST00000400479ENST00000199389AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
Frame-shiftENST00000400479ENST00000199389AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
Frame-shiftENST00000400479ENST00000199389AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
Frame-shiftENST00000400479ENST00000536084AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
Frame-shiftENST00000400479ENST00000536084AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
Frame-shiftENST00000400479ENST00000536084AIMP2chr7

6057675

+EIF2AK1chr7

6064431

-
In-frameENST00000223029ENST00000199389AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
In-frameENST00000223029ENST00000199389AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
In-frameENST00000395236ENST00000199389AIMP2chr7

6063282

-EIF2AK1chr7

6064405

-
In-frameENST00000395236ENST00000199389AIMP2chr7

6063290

-EIF2AK1chr7

6064368

-
intron-3CDSENST00000223029ENST00000199389AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-3CDSENST00000395236ENST00000199389AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-3CDSENST00000400479ENST00000199389AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-3UTRENST00000223029ENST00000199389AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-3UTRENST00000223029ENST00000199389AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-3UTRENST00000223029ENST00000199389AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-3UTRENST00000223029ENST00000199389AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-3UTRENST00000223029ENST00000199389AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-3UTRENST00000223029ENST00000536084AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-3UTRENST00000223029ENST00000536084AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-3UTRENST00000223029ENST00000536084AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-3UTRENST00000395236ENST00000199389AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-3UTRENST00000395236ENST00000536084AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-3UTRENST00000395236ENST00000536084AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-3UTRENST00000395236ENST00000536084AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-3UTRENST00000400479ENST00000199389AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
intron-3UTRENST00000400479ENST00000536084AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-3UTRENST00000400479ENST00000536084AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-3UTRENST00000400479ENST00000536084AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-intronENST00000223029ENST00000495565AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-intronENST00000223029ENST00000495565AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-intronENST00000223029ENST00000495565AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-intronENST00000223029ENST00000495565AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-intronENST00000223029ENST00000495565AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-intronENST00000223029ENST00000495565AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-intronENST00000223029ENST00000536084AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-intronENST00000223029ENST00000536084AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-intronENST00000223029ENST00000536084AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-intronENST00000395236ENST00000495565AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-intronENST00000395236ENST00000536084AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
intron-intronENST00000395236ENST00000536084AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-intronENST00000395236ENST00000536084AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
intron-intronENST00000395236ENST00000536084AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-intronENST00000395236ENST00000536084AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6062773

+EIF2AK1chr7

6063699

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6062863

+EIF2AK1chr7

6063606

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6062392

+EIF2AK1chr7

6063655

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-intronENST00000400479ENST00000495565AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6063440

-EIF2AK1chr7

6063978

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6062821

-EIF2AK1chr7

6064320

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6063376

+EIF2AK1chr7

6064098

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6063465

-EIF2AK1chr7

6064000

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6063342

-EIF2AK1chr7

6064102

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6062843

+EIF2AK1chr7

6063794

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6062777

+EIF2AK1chr7

6064078

-
intron-intronENST00000400479ENST00000536084AIMP2chr7

6063382

+EIF2AK1chr7

6064216

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AIMP2-EIF2AK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AIMP2-EIF2AK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6063342/chr7:6064102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AIMP2

Q13155

EIF2AK1

Q9BQI3

FUNCTION: Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}.FUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes (By similarity). May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF2AK1chr7:6063282chr7:6064405ENST00000199389015167_5830631.0DomainProtein kinase
TgeneEIF2AK1chr7:6063290chr7:6064368ENST00000199389015167_5830631.0DomainProtein kinase
TgeneEIF2AK1chr7:6063282chr7:6064405ENST00000199389015173_1810631.0Nucleotide bindingATP
TgeneEIF2AK1chr7:6063290chr7:6064368ENST00000199389015173_1810631.0Nucleotide bindingATP
TgeneEIF2AK1chr7:6063282chr7:6064405ENST00000199389015410_4150631.0RepeatNote=HRM 1
TgeneEIF2AK1chr7:6063282chr7:6064405ENST00000199389015552_5570631.0RepeatNote=HRM 2
TgeneEIF2AK1chr7:6063290chr7:6064368ENST00000199389015410_4150631.0RepeatNote=HRM 1
TgeneEIF2AK1chr7:6063290chr7:6064368ENST00000199389015552_5570631.0RepeatNote=HRM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAIMP2chr7:6063282chr7:6064405ENST00000223029-14220_3170321.0DomainNote=GST C-terminal
HgeneAIMP2chr7:6063290chr7:6064368ENST00000223029-14220_3170321.0DomainNote=GST C-terminal


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Fusion Gene Sequence for AIMP2-EIF2AK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AIMP2-EIF2AK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAIMP2chr7:6063282chr7:6064405ENST00000223029-1482_1620321.0PRKN
HgeneAIMP2chr7:6063290chr7:6064368ENST00000223029-1482_1620321.0PRKN
HgeneAIMP2chr7:6063282chr7:6064405ENST00000223029-14162_2250321.0TP53
HgeneAIMP2chr7:6063290chr7:6064368ENST00000223029-14162_2250321.0TP53


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AIMP2-EIF2AK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AIMP2-EIF2AK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource