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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GALNS-ECI1 (FusionGDB2 ID:32204)

Fusion Gene Summary for GALNS-ECI1

Fusion gene summary

Fusion gene information	Fusion gene name: GALNS-ECI1
	Fusion gene ID: 32204
		Hgene	Tgene
	Gene symbol	GALNS	ECI1
	Gene ID	2588	1632
	Gene name	galactosamine (N-acetyl)-6-sulfatase	enoyl-CoA delta isomerase 1
	Synonyms	GALNAC6S\|GAS\|GalN6S\|MPS4A	DCI
	Cytomap	16q24.3	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	N-acetylgalactosamine-6-sulfataseN-acetylgalactosamine-6-sulfate sulfatasechondroitinasechondroitinsulfatasegalNAc6S sulfatasegalactosamine (N-acetyl)-6-sulfate sulfatasegalactose-6-sulfate sulfatase	enoyl-CoA delta isomerase 1, mitochondrial3,2 trans-enoyl-Coenzyme A isomerase3,2-trans-enoyl-CoA isomerase, mitochondrialD3,D2-enoyl-CoA isomeraseacetylene-allene isomerasedelta(3),Delta(2)-enoyl-CoA isomerasedodecenoyl-CoA delta isomerase (3,2 tra
	Modification date	20200313	20200313
	UniProtAcc	.	P42126
	Ensembl transtripts involved in fusion gene	ENST00000565364, ENST00000268695, ENST00000568311, ENST00000569433, ENST00000542788,	ENST00000301729, ENST00000562238, ENST00000570258,
Fusion gene scores	* DoF score	5 X 2 X 4=40	5 X 7 X 5=175
	# samples	5	6
	** MAII score	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/175*10)=-1.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GALNS [Title/Abstract] AND ECI1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GALNS(88923166)-ECI1(2293440), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GALNS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ECI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0184-01A	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-

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Fusion Gene ORF analysis for GALNS-ECI1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000565364	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
5UTR-3CDS	ENST00000565364	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
5UTR-3CDS	ENST00000565364	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000268695	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000268695	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000268695	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000568311	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000568311	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000568311	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000569433	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000569433	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
In-frame	ENST00000569433	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
intron-3CDS	ENST00000542788	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
intron-3CDS	ENST00000542788	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-
intron-3CDS	ENST00000542788	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000268695	GALNS	chr16	88923166	-	ENST00000301729	ECI1	chr16	2293440	-	1261	209	89	676	195
ENST00000268695	GALNS	chr16	88923166	-	ENST00000562238	ECI1	chr16	2293440	-	710	209	89	625	178
ENST00000268695	GALNS	chr16	88923166	-	ENST00000570258	ECI1	chr16	2293440	-	716	209	89	676	195
ENST00000568311	GALNS	chr16	88923166	-	ENST00000301729	ECI1	chr16	2293440	-	1265	213	93	680	195
ENST00000568311	GALNS	chr16	88923166	-	ENST00000562238	ECI1	chr16	2293440	-	714	213	93	629	178
ENST00000568311	GALNS	chr16	88923166	-	ENST00000570258	ECI1	chr16	2293440	-	720	213	93	680	195
ENST00000569433	GALNS	chr16	88923166	-	ENST00000301729	ECI1	chr16	2293440	-	1226	174	54	641	195
ENST00000569433	GALNS	chr16	88923166	-	ENST00000562238	ECI1	chr16	2293440	-	675	174	54	590	178
ENST00000569433	GALNS	chr16	88923166	-	ENST00000570258	ECI1	chr16	2293440	-	681	174	54	641	195

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000268695	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.002901194	0.9970988
ENST00000268695	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.001787838	0.9982122
ENST00000268695	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.001446204	0.9985538
ENST00000568311	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.002448101	0.99755186
ENST00000568311	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.001608024	0.9983919
ENST00000568311	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.001265611	0.9987344
ENST00000569433	ENST00000301729	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.002739627	0.99726033
ENST00000569433	ENST00000562238	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.002121561	0.99787843
ENST00000569433	ENST00000570258	GALNS	chr16	88923166	-	ECI1	chr16	2293440	-	0.001626685	0.99837327

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Fusion Genomic Features for GALNS-ECI1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GALNS-ECI1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:88923166/chr16:2293440)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ECI1 P42126
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. {ECO:0000269\|PubMed:7818490}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GALNS

chr16:88923166

chr16:2293440

ENST00000268695

27_379

523.0

Region

Note=Catalytic domain

Tgene

ECI1

chr16:88923166

chr16:2293440

ENST00000301729

106_110

147

303.0

Region

Substrate binding

Tgene

ECI1

chr16:88923166

chr16:2293440

ENST00000562238

106_110

147

286.0

Region

Substrate binding

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Fusion Gene Sequence for GALNS-ECI1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>32204_32204_1_GALNS-ECI1_GALNS_chr16_88923166_ENST00000268695_ECI1_chr16_2293440_ENST00000301729_length(transcript)=1261nt_BP=209nt
AGGCCCCGCCCCGCAGCCCAGCCGGAAGGGCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCCA
TGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAGCCCC
CCAACATCCTGCTCCTGCTCATGGACGACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTGGCGG
ACAACCCCAGGTACTGCATAGGACTCAATGAGACCCAGCTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACCATCG
GGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTGGTCC
CGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGA
TGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATCCAGA
AGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAAAAAGGCTAACGATTGGGCTGCCACAGGCTTACGGCCACACGTGCCCCTGTGG
GTCCCAGGGAGGTCTTAAACAAGGTATTTTTCAACTTAAAAGTACTGCCAGCGTTTCATTTTGCTGATGTTACGTAGAAGTTCCTGTTCC
TCATAGCCCAGTGGCCCAAGGCCCAGCCACACACAAACACACATGGGTGCCTGTGCCCGTCAGGCAAGGGGAGTTGGAGGGCAGCCTTTT
GACTTGGGATTGTGACTGGCAGGGGATGCCATTCTGGACCTGGTGAGGTTGCCACGGAGTGTCTCTGTTCCCAAGGCAGAATCGTAAGTC
AAGTCCCTGGTCATCCATTCTGGCCTTTGGACTGCCTGCTCTTAGGTGTAAGGCCAGGTGGTCTTGGCCCCCATGACCCACACAGAACTC
CCCAGGGAAAAGCCCTTTGGTCACTGCCCTTACTCATCAGGATGAAGAGCGCACAGTGAATCAGAGCAACTGGGGGATCCTGAGCCAGCG
GGAGTGGGACTCTGGAGGCAGCTGTGCTGCCAGGGATCCAAATGTCCCTTAAGAAGGATTTTGCAAGAACCAAACTCATCCAAACCCTTG

>32204_32204_1_GALNS-ECI1_GALNS_chr16_88923166_ENST00000268695_ECI1_chr16_2293440_ENST00000301729_length(amino acids)=195AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTI
GHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQ

--------------------------------------------------------------
>32204_32204_2_GALNS-ECI1_GALNS_chr16_88923166_ENST00000268695_ECI1_chr16_2293440_ENST00000562238_length(transcript)=710nt_BP=209nt
AGGCCCCGCCCCGCAGCCCAGCCGGAAGGGCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCCA
TGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAGCCCC
CCAACATCCTGCTCCTGCTCATGGACGACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTGGCGG
ACAACCCCAGGTTGAAAGACACCCTGGAGAACACCATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGG
CGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTGGTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGGATGG
CCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGC
AGAACTTCGTCAGCTTCATCTCCAAAGACTCCATCCAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAAAAAGGCTAACGAT

>32204_32204_2_GALNS-ECI1_GALNS_chr16_88923166_ENST00000268695_ECI1_chr16_2293440_ENST00000562238_length(amino acids)=178AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRLKDTLENTIGHRAAERALQLGLLFPP

--------------------------------------------------------------
>32204_32204_3_GALNS-ECI1_GALNS_chr16_88923166_ENST00000268695_ECI1_chr16_2293440_ENST00000570258_length(transcript)=716nt_BP=209nt
AGGCCCCGCCCCGCAGCCCAGCCGGAAGGGCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCCA
TGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAGCCCC
CCAACATCCTGCTCCTGCTCATGGACGACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTGGCGG
ACAACCCCAGGTACTGCATAGGACTCAATGAGACCCAGCTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACCATCG
GGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTGGTCC
CGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGA
TGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATCCAGA

>32204_32204_3_GALNS-ECI1_GALNS_chr16_88923166_ENST00000268695_ECI1_chr16_2293440_ENST00000570258_length(amino acids)=195AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTI
GHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQ

--------------------------------------------------------------
>32204_32204_4_GALNS-ECI1_GALNS_chr16_88923166_ENST00000568311_ECI1_chr16_2293440_ENST00000301729_length(transcript)=1265nt_BP=213nt
GTCCAGGCCCCGCCCCGCAGCCCAGCCGGAAGGGCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTT
GCCATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAG
CCCCCCAACATCCTGCTCCTGCTCATGGACGACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTG
GCGGACAACCCCAGGTACTGCATAGGACTCAATGAGACCCAGCTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACC
ATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTG
GTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCC
ATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATC
CAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAAAAAGGCTAACGATTGGGCTGCCACAGGCTTACGGCCACACGTGCCCCT
GTGGGTCCCAGGGAGGTCTTAAACAAGGTATTTTTCAACTTAAAAGTACTGCCAGCGTTTCATTTTGCTGATGTTACGTAGAAGTTCCTG
TTCCTCATAGCCCAGTGGCCCAAGGCCCAGCCACACACAAACACACATGGGTGCCTGTGCCCGTCAGGCAAGGGGAGTTGGAGGGCAGCC
TTTTGACTTGGGATTGTGACTGGCAGGGGATGCCATTCTGGACCTGGTGAGGTTGCCACGGAGTGTCTCTGTTCCCAAGGCAGAATCGTA
AGTCAAGTCCCTGGTCATCCATTCTGGCCTTTGGACTGCCTGCTCTTAGGTGTAAGGCCAGGTGGTCTTGGCCCCCATGACCCACACAGA
ACTCCCCAGGGAAAAGCCCTTTGGTCACTGCCCTTACTCATCAGGATGAAGAGCGCACAGTGAATCAGAGCAACTGGGGGATCCTGAGCC
AGCGGGAGTGGGACTCTGGAGGCAGCTGTGCTGCCAGGGATCCAAATGTCCCTTAAGAAGGATTTTGCAAGAACCAAACTCATCCAAACC

>32204_32204_4_GALNS-ECI1_GALNS_chr16_88923166_ENST00000568311_ECI1_chr16_2293440_ENST00000301729_length(amino acids)=195AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTI
GHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQ

--------------------------------------------------------------
>32204_32204_5_GALNS-ECI1_GALNS_chr16_88923166_ENST00000568311_ECI1_chr16_2293440_ENST00000562238_length(transcript)=714nt_BP=213nt
GTCCAGGCCCCGCCCCGCAGCCCAGCCGGAAGGGCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTT
GCCATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAG
CCCCCCAACATCCTGCTCCTGCTCATGGACGACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTG
GCGGACAACCCCAGGTTGAAAGACACCCTGGAGAACACCATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCG
CCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTGGTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGG
ATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGAC
GTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATCCAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAAAAAGGCTAA

>32204_32204_5_GALNS-ECI1_GALNS_chr16_88923166_ENST00000568311_ECI1_chr16_2293440_ENST00000562238_length(amino acids)=178AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRLKDTLENTIGHRAAERALQLGLLFPP

--------------------------------------------------------------
>32204_32204_6_GALNS-ECI1_GALNS_chr16_88923166_ENST00000568311_ECI1_chr16_2293440_ENST00000570258_length(transcript)=720nt_BP=213nt
GTCCAGGCCCCGCCCCGCAGCCCAGCCGGAAGGGCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTT
GCCATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAG
CCCCCCAACATCCTGCTCCTGCTCATGGACGACGGAGCCTGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTG
GCGGACAACCCCAGGTACTGCATAGGACTCAATGAGACCCAGCTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACC
ATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTG
GTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCC
ATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATC
CAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAAAAAGGCTAACGATTGGGCTGCCACAGGCTTACGGCCACACGTGCCCCT

>32204_32204_6_GALNS-ECI1_GALNS_chr16_88923166_ENST00000568311_ECI1_chr16_2293440_ENST00000570258_length(amino acids)=195AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTI
GHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQ

--------------------------------------------------------------
>32204_32204_7_GALNS-ECI1_GALNS_chr16_88923166_ENST00000569433_ECI1_chr16_2293440_ENST00000301729_length(transcript)=1226nt_BP=174nt
GGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCCATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAG
CTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAGCCCCCCAACATCCTGCTCCTGCTCATGGACGACGGAGCC
TGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTGGCGGACAACCCCAGGTACTGCATAGGACTCAATGAGACC
CAGCTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACCATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGG
CTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTGGTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCG
ATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAG
CGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATCCAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAA
GAAAAAGGCTAACGATTGGGCTGCCACAGGCTTACGGCCACACGTGCCCCTGTGGGTCCCAGGGAGGTCTTAAACAAGGTATTTTTCAAC
TTAAAAGTACTGCCAGCGTTTCATTTTGCTGATGTTACGTAGAAGTTCCTGTTCCTCATAGCCCAGTGGCCCAAGGCCCAGCCACACACA
AACACACATGGGTGCCTGTGCCCGTCAGGCAAGGGGAGTTGGAGGGCAGCCTTTTGACTTGGGATTGTGACTGGCAGGGGATGCCATTCT
GGACCTGGTGAGGTTGCCACGGAGTGTCTCTGTTCCCAAGGCAGAATCGTAAGTCAAGTCCCTGGTCATCCATTCTGGCCTTTGGACTGC
CTGCTCTTAGGTGTAAGGCCAGGTGGTCTTGGCCCCCATGACCCACACAGAACTCCCCAGGGAAAAGCCCTTTGGTCACTGCCCTTACTC
ATCAGGATGAAGAGCGCACAGTGAATCAGAGCAACTGGGGGATCCTGAGCCAGCGGGAGTGGGACTCTGGAGGCAGCTGTGCTGCCAGGG

>32204_32204_7_GALNS-ECI1_GALNS_chr16_88923166_ENST00000569433_ECI1_chr16_2293440_ENST00000301729_length(amino acids)=195AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTI
GHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQ

--------------------------------------------------------------
>32204_32204_8_GALNS-ECI1_GALNS_chr16_88923166_ENST00000569433_ECI1_chr16_2293440_ENST00000562238_length(transcript)=675nt_BP=174nt
GGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCCATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAG
CTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAGCCCCCCAACATCCTGCTCCTGCTCATGGACGACGGAGCC
TGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTGGCGGACAACCCCAGGTTGAAAGACACCCTGGAGAACACC
ATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGGCTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTG
GTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCGATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCC
ATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAGCGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATC
CAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAAGAAAAAGGCTAACGATTGGGCTGCCACAGGCTTACGGCCACACGTGCCCCT

>32204_32204_8_GALNS-ECI1_GALNS_chr16_88923166_ENST00000569433_ECI1_chr16_2293440_ENST00000562238_length(amino acids)=178AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRLKDTLENTIGHRAAERALQLGLLFPP

--------------------------------------------------------------
>32204_32204_9_GALNS-ECI1_GALNS_chr16_88923166_ENST00000569433_ECI1_chr16_2293440_ENST00000570258_length(transcript)=681nt_BP=174nt
GGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCCATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAG
CTGTTGCTGGTGCTCAGCGCCGCGGGGATGGGGGCCTCGGGCGCCCCGCAGCCCCCCAACATCCTGCTCCTGCTCATGGACGACGGAGCC
TGCCCCGCTGGAGGCTGCCTGGTGGCCCTGACCTGTGACTACCGCATCCTGGCGGACAACCCCAGGTACTGCATAGGACTCAATGAGACC
CAGCTGGGCATCATCGCCCCTTTCTGGTTGAAAGACACCCTGGAGAACACCATCGGGCACCGGGCGGCGGAGCGTGCCCTGCAGCTGGGG
CTGCTCTTCCCGCCGGCGGAGGCCCTGCAGGTGGGCATAGTGGACCAGGTGGTCCCGGAGGAGCAGGTGCAGAGCACTGCGCTGTCAGCG
ATAGCCCAGTGGATGGCCATTCCAGACCATGCTCGACAGCTGACCAAGGCCATGATGCGAAAGGCCACGGCCAGCCGCCTGGTCACGCAG
CGCGATGCGGACGTGCAGAACTTCGTCAGCTTCATCTCCAAAGACTCCATCCAGAAGTCCCTGCAGATGTACTTAGAGAGGCTCAAAGAA

>32204_32204_9_GALNS-ECI1_GALNS_chr16_88923166_ENST00000569433_ECI1_chr16_2293440_ENST00000570258_length(amino acids)=195AA_BP=40
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTI
GHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GALNS-ECI1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GALNS-ECI1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GALNS-ECI1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source