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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GALNT11-PTPRN2 (FusionGDB2 ID:32231)

Fusion Gene Summary for GALNT11-PTPRN2

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNT11-PTPRN2
Fusion gene ID: 32231
HgeneTgene
Gene symbol

GALNT11

PTPRN2

Gene ID

63917

5799

Gene namepolypeptide N-acetylgalactosaminyltransferase 11protein tyrosine phosphatase receptor type N2
SynonymsGALNAC-T11|GALNACT11IA-2beta|IAR|ICAAR|PTPRP|R-PTP-N2
Cytomap

7q36.1|7q36.1

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionpolypeptide N-acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)polypeptide GalNAc transferase 11pp-GaNTase 11preceptor-type tyrosine-protein phosphatase N2IAR/receptor-like protein-tyrosine phosphataseislet cell autoantigen-related proteinphogrinprotein tyrosine phosphatase receptor piprotein tyrosine phosphatase, receptor type, N polypeptide 2tyrosine phos
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000482812, ENST00000452146, 
ENST00000430044, ENST00000320311, 
ENST00000415421, ENST00000422997, 
ENST00000434507, 		ENST00000389413, 
ENST00000409483, ENST00000389416, 
ENST00000389418, ENST00000404321, 
Fusion gene scores* DoF score14 X 8 X 9=100816 X 17 X 9=2448
# samples 1624
** MAII scorelog2(16/1008*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2448*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GALNT11 [Title/Abstract] AND PTPRN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGALNT11(151722969)-PTPRN2(158282477), # samples:3
PTPRN2(157959623)-GALNT11(151797883), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGALNT11

GO:0018243

protein O-linked glycosylation via threonine

24226769


check buttonFusion gene breakpoints across GALNT11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C4-01AGALNT11chr7

151722969

-PTPRN2chr7

158282477

-
ChimerDB4SARCTCGA-X6-A8C4-01AGALNT11chr7

151722969

+PTPRN2chr7

158282477

-


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Fusion Gene ORF analysis for GALNT11-PTPRN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482812ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
3UTR-3CDSENST00000482812ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
3UTR-intronENST00000482812ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
3UTR-intronENST00000482812ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
3UTR-intronENST00000482812ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5CDS-intronENST00000452146ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5CDS-intronENST00000452146ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5CDS-intronENST00000452146ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5UTR-3CDSENST00000430044ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5UTR-3CDSENST00000430044ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5UTR-intronENST00000430044ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5UTR-intronENST00000430044ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
5UTR-intronENST00000430044ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
In-frameENST00000452146ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
In-frameENST00000452146ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000320311ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000320311ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000415421ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000415421ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000422997ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000422997ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000434507ENST00000389413GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-3CDSENST00000434507ENST00000409483GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000320311ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000320311ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000320311ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000415421ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000415421ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000415421ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000422997ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000422997ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000422997ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000434507ENST00000389416GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000434507ENST00000389418GALNT11chr7

151722969

+PTPRN2chr7

158282477

-
intron-intronENST00000434507ENST00000404321GALNT11chr7

151722969

+PTPRN2chr7

158282477

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000452146GALNT11chr7151722969+ENST00000389413PTPRN2chr7158282477-464113472982991
ENST00000452146GALNT11chr7151722969+ENST00000409483PTPRN2chr7158282477-461413472955982

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000452146ENST00000389413GALNT11chr7151722969+PTPRN2chr7158282477-0.0022789180.997721
ENST00000452146ENST00000409483GALNT11chr7151722969+PTPRN2chr7158282477-0.0025900650.99741

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Fusion Genomic Features for GALNT11-PTPRN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GALNT11-PTPRN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151722969/chr7:158282477)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389413022745_100537987.0DomainTyrosine-protein phosphatase
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389416022745_10050999.0DomainTyrosine-protein phosphatase
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389418023745_1005371016.0DomainTyrosine-protein phosphatase
TgenePTPRN2chr7:151722969chr7:158282477ENST00000404321023745_1005601039.0DomainTyrosine-protein phosphatase
TgenePTPRN2chr7:151722969chr7:158282477ENST000003894130221004_101037987.0MotifLeucine-based sorting signal
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389413022666_67537987.0MotifTyrosine-based internalization motif
TgenePTPRN2chr7:151722969chr7:158282477ENST000003894160221004_10100999.0MotifLeucine-based sorting signal
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389416022666_6750999.0MotifTyrosine-based internalization motif
TgenePTPRN2chr7:151722969chr7:158282477ENST000003894180231004_1010371016.0MotifLeucine-based sorting signal
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389418023666_675371016.0MotifTyrosine-based internalization motif
TgenePTPRN2chr7:151722969chr7:158282477ENST000004043210231004_1010601039.0MotifLeucine-based sorting signal
TgenePTPRN2chr7:151722969chr7:158282477ENST00000404321023666_675601039.0MotifTyrosine-based internalization motif
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389413022945_95137987.0RegionSubstrate binding
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389416022945_9510999.0RegionSubstrate binding
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389418023945_951371016.0RegionSubstrate binding
TgenePTPRN2chr7:151722969chr7:158282477ENST00000404321023945_951601039.0RegionSubstrate binding
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389413022637_101537987.0Topological domainCytoplasmic
TgenePTPRN2chr7:151722969chr7:158282477ENST0000038941602222_6150999.0Topological domainExtracellular
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389416022637_10150999.0Topological domainCytoplasmic
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389418023637_1015371016.0Topological domainCytoplasmic
TgenePTPRN2chr7:151722969chr7:158282477ENST00000404321023637_1015601039.0Topological domainCytoplasmic
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389413022616_63637987.0TransmembraneHelical
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389416022616_6360999.0TransmembraneHelical
TgenePTPRN2chr7:151722969chr7:158282477ENST00000389418023616_636371016.0TransmembraneHelical
TgenePTPRN2chr7:151722969chr7:158282477ENST00000404321023616_636601039.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGALNT11chr7:151722969chr7:158282477ENST00000320311+112476_6070609.0DomainRicin B-type lectin
HgeneGALNT11chr7:151722969chr7:158282477ENST00000415421+15476_6070203.0DomainRicin B-type lectin
HgeneGALNT11chr7:151722969chr7:158282477ENST00000430044+112476_6070609.0DomainRicin B-type lectin
HgeneGALNT11chr7:151722969chr7:158282477ENST00000434507+114476_6070609.0DomainRicin B-type lectin
HgeneGALNT11chr7:151722969chr7:158282477ENST00000320311+112150_2610609.0RegionNote=Catalytic subdomain A
HgeneGALNT11chr7:151722969chr7:158282477ENST00000320311+112319_3810609.0RegionNote=Catalytic subdomain B
HgeneGALNT11chr7:151722969chr7:158282477ENST00000415421+15150_2610203.0RegionNote=Catalytic subdomain A
HgeneGALNT11chr7:151722969chr7:158282477ENST00000415421+15319_3810203.0RegionNote=Catalytic subdomain B
HgeneGALNT11chr7:151722969chr7:158282477ENST00000430044+112150_2610609.0RegionNote=Catalytic subdomain A
HgeneGALNT11chr7:151722969chr7:158282477ENST00000430044+112319_3810609.0RegionNote=Catalytic subdomain B
HgeneGALNT11chr7:151722969chr7:158282477ENST00000434507+114150_2610609.0RegionNote=Catalytic subdomain A
HgeneGALNT11chr7:151722969chr7:158282477ENST00000434507+114319_3810609.0RegionNote=Catalytic subdomain B
HgeneGALNT11chr7:151722969chr7:158282477ENST00000320311+1121_60609.0Topological domainCytoplasmic
HgeneGALNT11chr7:151722969chr7:158282477ENST00000320311+11230_6080609.0Topological domainLumenal
HgeneGALNT11chr7:151722969chr7:158282477ENST00000415421+151_60203.0Topological domainCytoplasmic
HgeneGALNT11chr7:151722969chr7:158282477ENST00000415421+1530_6080203.0Topological domainLumenal
HgeneGALNT11chr7:151722969chr7:158282477ENST00000430044+1121_60609.0Topological domainCytoplasmic
HgeneGALNT11chr7:151722969chr7:158282477ENST00000430044+11230_6080609.0Topological domainLumenal
HgeneGALNT11chr7:151722969chr7:158282477ENST00000434507+1141_60609.0Topological domainCytoplasmic
HgeneGALNT11chr7:151722969chr7:158282477ENST00000434507+11430_6080609.0Topological domainLumenal
HgeneGALNT11chr7:151722969chr7:158282477ENST00000320311+1127_290609.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneGALNT11chr7:151722969chr7:158282477ENST00000415421+157_290203.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneGALNT11chr7:151722969chr7:158282477ENST00000430044+1127_290609.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneGALNT11chr7:151722969chr7:158282477ENST00000434507+1147_290609.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePTPRN2chr7:151722969chr7:158282477ENST0000038941302222_61537987.0Topological domainExtracellular
TgenePTPRN2chr7:151722969chr7:158282477ENST0000038941802322_615371016.0Topological domainExtracellular
TgenePTPRN2chr7:151722969chr7:158282477ENST0000040432102322_615601039.0Topological domainExtracellular


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Fusion Gene Sequence for GALNT11-PTPRN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32231_32231_1_GALNT11-PTPRN2_GALNT11_chr7_151722969_ENST00000452146_PTPRN2_chr7_158282477_ENST00000389413_length(transcript)=4641nt_BP=134nt
GCGACGCCTGGCTGCTGGGCCCCGGGGCAGTTCAGCCCGCGCCGCTCCTGCGGGTCGGACTGGGGCTGTGGCGGGAGAGAAGATGCCGCA
GCCCGAGTCCCAGAAGGCGGCGATCCTGGGCTGCGGGCAAGGCGGCTGCCTGCTCGAGGAGGGCCTCTGCGGAGCGTCCGAGGCCTGTGT
GAACGATGGAGTGTTTGGAAGGTGCCAGAAGGTTCCGGCAATGGACTTTTACCGCTACGAGGTGTCGCCCGTGGCCCTGCAGCGCCTGCG
CGTGGCGTTGCAGAAGCTTTCCGGCACAGGTTTCACGTGGCAGGATGACTATACTCAGTATGTGATGGACCAGGAACTTGCAGACCTCCC
GAAAACCTACCTGAGGCGTCCTGAAGCATCCAGCCCAGCCAGGCCCTCAAAACACAGCGTTGGCAGCGAGAGGAGGTACAGTCGGGAGGG
CGGTGCTGCCCTGGCCAACGCCCTCCGACGCCACCTGCCCTTCCTGGAGGCCCTGTCCCAGGCCCCAGCCTCAGACGTGCTCGCCAGGAC
CCATACGGCGCAGGACAGACCCCCCGCTGAGGGTGATGACCGCTTCTCCGAGAGCATCCTGACCTATGTGGCCCACACGTCTGCGCTGAC
CTACCCTCCCGGGTCCCGGACCCAGCTCCGCGAGGACCTCCTGCCGCGGACCCTCGGCCAGCTCCAGCCAGATGAGCTCAGCCCTAAGGT
GGACAGTGGTGTGGACAGACACCATCTGATGGCGGCCCTCAGTGCCTATGCTGCCCAGAGGCCCCCAGCTCCCCCCGGGGAGGGCAGCCT
GGAGCCACAGTACCTTCTGCGTGCACCCTCAAGAATGCCCAGGCCTTTGCTGGCACCAGCCGCCCCCCAGAAGTGGCCTTCACCTCTGGG
AGATTCCGAAGACCCCTCCAGCACAGGCGATGGAGCACGGATTCATACCCTCCTGAAGGACCTGCAGAGGCAGCCGGCTGAGGTGAGGGG
CCTGAGTGGCCTGGAGCTGGACGGCATGGCTGAGCTGATGGCTGGCCTGATGCAAGGCGTGGACCATGGAGTAGCTCGAGGCAGCCCTGG
GAGAGCGGCCCTGGGAGAGTCTGGAGAACAGGCGGATGGCCCCAAGGCCACCCTCCGTGGAGACAGCTTTCCAGATGACGGAGTGCAGGA
CGACGATGATAGACTTTACCAAGAGGTCCATCGTCTGAGTGCCACACTCGGGGGCCTCCTGCAGGACCACGGGTCTCGACTCTTACCTGG
AGCCCTCCCCTTTGCAAGGCCCCTCGACATGGAGAGGAAGAAGTCCGAGCACCCTGAGTCTTCCCTGTCTTCAGAAGAGGAGACTGCCGG
AGTGGAGAACGTCAAGAGCCAGACGTATTCCAAAGATCTGCTGGGGCAGCAGCCGCATTCGGAGCCCGGGGCCGCTGCGTTTGGGGAGCT
CCAAAACCAGATGCCTGGGCCCTCGAAGGAGGAGCAGAGCCTTCCAGCGGGTGCTCAGGAGGCCCTCAGCGACGGCCTGCAATTGGAGGT
CCAGCCTTCCGAGGAAGAGGCGCGGGGCTACATCGTGACAGACAGAGAGGTTCTCGGACCAGCAGTGACCTTCAAAGTGAGCGCCAATGT
CCAAAACGTGACCACTGAGGATGTGGAGAAGGCCACAGTTGACAACAAAGACAAACTGGAGGAAACCTCTGGACTGAAAATTCTTCAAAC
CGGAGTCGGGTCGAAAAGCAAACTCAAGTTCCTGCCTCCTCAGGCGGAGCAAGAAGACTCCACCAAGTTCATCGCGCTCACCCTGGTCTC
CCTCGCCTGCATCCTGGGCGTCCTCCTGGCCTCTGGCCTCATCTACTGCCTCCGCCATAGCTCTCAGCACAGGCTGAAGGAGAAGCTCTC
GGGACTAGGGGGCGACCCAGGTGCAGATGCCACTGCCGCCTACCAGGAGCTGTGCCGCCAGCGTATGGCCACGCGGCCACCAGACCGACC
TGAGGGCCCGCACACGTCACGCATCAGCAGCGTCTCATCCCAGTTCAGCGACGGGCCGATCCCCAGCCCCTCCGCACGCAGCAGCGCCTC
ATCCTGGTCCGAGGAGCCTGTGCAGTCCAACATGGACATCTCCACCGGCCACATGATCCTGTCCTACATGGAGGACCACCTGAAGAACAA
GAACCGGCTGGAGAAGGAGTGGGAAGCGCTGTGCGCCTACCAGGCGGAGCCCAACAGCTCGTTCGTGGCCCAGAGGGAGGAGAACGTGCC
CAAGAACCGCTCCCTGGCCGTGCTGACCTATGACCACTCCCGGGTCCTGCTGAAGGCGGAGAACAGCCACAGCCACTCAGACTACATCAA
CGCTAGCCCCATCATGGATCACGACCCGAGGAACCCCGCGTACATCGCCACCCAGGGACCGCTGCCCGCCACCGTGGCTGACTTTTGGCA
GATGGTGTGGGAGAGCGGCTGCGTGGTGATCGTCATGCTGACACCCCTCGCGGAGAACGGCGTCCGGCAGTGCTACCACTACTGGCCGGA
TGAAGGCTCCAATCTCTACCACATCTATGAGGTGAACCTGGTCTCCGAGCACATCTGGTGTGAGGACTTCCTGGTGAGGAGCTTCTATCT
GAAGAACCTGCAGACCAACGAGACGCGCACCGTGACGCAGTTCCACTTCCTGAGTTGGTATGACCGAGGAGTCCCTTCCTCCTCAAGGTC
CCTCCTGGACTTCCGCAGAAAAGTAAACAAGTGCTACAGGGGCCGTTCTTGTCCAATAATTGTTCATTGCAGTGACGGTGCAGGCCGGAG
CGGCACCTACGTCCTGATCGACATGGTTCTCAACAAGATGGCCAAAGGTGCTAAAGAGATTGATATCGCAGCGACCCTGGAGCACTTGAG
GGACCAGAGACCCGGCATGGTCCAGACGAAGGAGCAGTTTGAGTTCGCGCTGACAGCCGTGGCTGAGGAGGTGAACGCCATCCTCAAGGC
CCTTCCCCAGTGAGCGGCAGCCTCAGGGGCCTCAGGGGAGCCCCCACCCCACGGATGTTGTCAGGAATCATGATCTGACTTTAATTGTGT
GTCTTCTATTATAACTGCATAGTAATAGGGCCCTTAGCTCTCCCGTAGTCAGCGCAGTTTAGCAGTTAAAAGTGTATTTTTGTTTAATCA
AACAATAATAAAGAGAGATTTGTGGAAAAATCCAGTTACGGGTGGAGGGGAATCGGTTCATCAATTTTCACTTGCTTAAAAAAAATACTT
TTTCTTAAAGCACCCGTTCACCTTCTTGGTTGAAGTTGTGTTAACAATGCAGTAGCCAGCACGTTCGAGGCGGTTTCCAGGAAGAGTGTG
CTTGTCATCTGCCACTTTCGGGAGGGTGGATCCACTGTGCAGGAGTGGCCGGGGAAGCTGGCAGCACTCAGTGAGGCCGCCCGGCACACA
AGGCACGTTTGGCATTTCTCTTTGAGAGAGTTTATCATTGGGAGAAGCCGCAGGGACAGAACTGAACGTCCTGCAGCTTCGGGGCAAGTG
AGACAATCACAGCTCCTCGCTGCGTCTCCATCAACACTGCGCCGGGTACCATGGACGGCCCCGTCAGCCACACCTGTCAGCCCAAGCAGA
GTGATTCAGGGGCTCCCCGGGGGCAGACACCTGTGCACCCCATGAGTAGTGCCCACTTGAGGCTGGCACTCCCCTGACCTCACCTTTGCA
AAGTTACAGATGCACCCCAACATTGAGATGTGTTTTTAATGTTAAAATATTGATTTCTACGTTATGAAAACAGATGCCCCCGTGAATGCT
TACCTGTGAGATAACCACAACCAGGAAGAACAAATCTGGGCATTGAGCAAGCTATGAGGGTCCCCGGGAGCACACGAACCCTGCCAGGCC
CCCGCTGGCTCCTCCAGGCACGTCCCGGACCTGTGGGGCCCCAGAGAGGGGACATTTCCCTCCTGGGAGAGAAGGAGATCAGGGCAACTC
GGAGAGGGCTGCGAGCATTTCCCTCCCGGGAGAGGAGATCAGGGCGACCTGCACGCACTGCGTAGAGCCTGGAAGGGAAGTGAGAAACCA
GCCGACCGGCCCTGCCCCTCTTCCCGGGATCACTTAATGAACCACGTGTTTTGACATCATGTAAACCTAAGCACGTAGAGATGATTCGGA
TTTGACAAAATAACATTTGAGTATCCGATTCGCCATCACCCCCTACCCCAGAAATAGGACAATTCACTTCATTGACCAAGATGATCACAT
GGAAGGCGGCACAGAGGCAGCTGTGTGGGCTGCAGATTTCCTGTGTGGGGTTCAGCGTAGAAAACGCACCTCCATCCCGCCCTTCCCACA
GCATTCCTCCATCTTAGATAGATGGTACTCTCCAAAGGCCCTACCAGAGGGAACACGGCCTACTGAGCGGACAGAATGATGCCAAAATAT
TGCTTATGTCTCTACATGGTATTGTAATGAATATCTGCTTTAATATAGCTATCATTTCTTTTCCAAAATTACTTCTCTCTATCTGGAATT
TAATTAATCGAAATGAATTTATCTGAATATAGGAAGCATATGCCTACTTGTAATTTCTAACTCCTTATGTTTGAAGAGAAACCTCCGGTG

>32231_32231_1_GALNT11-PTPRN2_GALNT11_chr7_151722969_ENST00000452146_PTPRN2_chr7_158282477_ENST00000389413_length(amino acids)=991AA_BP=26
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGCLLEEGLCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVA
LQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHT
AQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEP
QYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRA
ALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVE
NVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDREVLGPAVTFKVSANVQN
VTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGL
GGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNR
LEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMV
WESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL
DFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALP

--------------------------------------------------------------
>32231_32231_2_GALNT11-PTPRN2_GALNT11_chr7_151722969_ENST00000452146_PTPRN2_chr7_158282477_ENST00000409483_length(transcript)=4614nt_BP=134nt
GCGACGCCTGGCTGCTGGGCCCCGGGGCAGTTCAGCCCGCGCCGCTCCTGCGGGTCGGACTGGGGCTGTGGCGGGAGAGAAGATGCCGCA
GCCCGAGTCCCAGAAGGCGGCGATCCTGGGCTGCGGGCAAGGCGGCTGCCTGCTCGAGGAGGGCCTCTGCGGAGCGTCCGAGGCCTGTGT
GAACGGTTTCACGTGGCAGGATGACTATACTCAGTATGTGATGGACCAGGAACTTGCAGACCTCCCGAAAACCTACCTGAGGCGTCCTGA
AGCATCCAGCCCAGCCAGGCCCTCAAAACACAGCGTTGGCAGCGAGAGGAGGTACAGTCGGGAGGGCGGTGCTGCCCTGGCCAACGCCCT
CCGACGCCACCTGCCCTTCCTGGAGGCCCTGTCCCAGGCCCCAGCCTCAGACGTGCTCGCCAGGACCCATACGGCGCAGGACAGACCCCC
CGCTGAGGGTGATGACCGCTTCTCCGAGAGCATCCTGACCTATGTGGCCCACACGTCTGCGCTGACCTACCCTCCCGGGTCCCGGACCCA
GCTCCGCGAGGACCTCCTGCCGCGGACCCTCGGCCAGCTCCAGCCAGATGAGCTCAGCCCTAAGGTGGACAGTGGTGTGGACAGACACCA
TCTGATGGCGGCCCTCAGTGCCTATGCTGCCCAGAGGCCCCCAGCTCCCCCCGGGGAGGGCAGCCTGGAGCCACAGTACCTTCTGCGTGC
ACCCTCAAGAATGCCCAGGCCTTTGCTGGCACCAGCCGCCCCCCAGAAGTGGCCTTCACCTCTGGGAGATTCCGAAGACCCCTCCAGCAC
AGGCGATGGAGCACGGATTCATACCCTCCTGAAGGACCTGCAGAGGCAGCCGGCTGAGGTGAGGGGCCTGAGTGGCCTGGAGCTGGACGG
CATGGCTGAGCTGATGGCTGGCCTGATGCAAGGCGTGGACCATGGAGTAGCTCGAGGCAGCCCTGGGAGAGCGGCCCTGGGAGAGTCTGG
AGAACAGGCGGATGGCCCCAAGGCCACCCTCCGTGGAGACAGCTTTCCAGATGACGGAGTGCAGGACGACGATGATAGACTTTACCAAGA
GGTCCATCGTCTGAGTGCCACACTCGGGGGCCTCCTGCAGGACCACGGGTCTCGACTCTTACCTGGAGCCCTCCCCTTTGCAAGGCCCCT
CGACATGGAGAGGAAGAAGTCCGAGCACCCTGAGTCTTCCCTGTCTTCAGAAGAGGAGACTGCCGGAGTGGAGAACGTCAAGAGCCAGAC
GTATTCCAAAGATCTGCTGGGGCAGCAGCCGCATTCGGAGCCCGGGGCCGCTGCGTTTGGGGAGCTCCAAAACCAGATGCCTGGGCCCTC
GAAGGAGGAGCAGAGCCTTCCAGCGGGTGCTCAGGAGGCCCTCAGCGACGGCCTGCAATTGGAGGTCCAGCCTTCCGAGGAAGAGGCGCG
GGGCTACATCGTGACAGACAGAGACCCCCTGCGCCCCGAGGAAGGAAGGCGGCTGGTGGAGGACGTCGCCCGCCTCCTGCAGGTGCCCAG
CAGTGCGTTCGCTGACGTGGAGGTTCTCGGACCAGCAGTGACCTTCAAAGTGAGCGCCAATGTCCAAAACGTGACCACTGAGGATGTGGA
GAAGGCCACAGTTGACAACAAAGACAAACTGGAGGAAACCTCTGGACTGAAAATTCTTCAAACCGGAGTCGGGTCGAAAAGCAAACTCAA
GTTCCTGCCTCCTCAGGCGGAGCAAGAAGACTCCACCAAGTTCATCGCGCTCACCCTGGTCTCCCTCGCCTGCATCCTGGGCGTCCTCCT
GGCCTCTGGCCTCATCTACTGCCTCCGCCATAGCTCTCAGCACAGGCTGAAGGAGAAGCTCTCGGGACTAGGGGGCGACCCAGGTGCAGA
TGCCACTGCCGCCTACCAGGAGCTGTGCCGCCAGCGTATGGCCACGCGGCCACCAGACCGACCTGAGGGCCCGCACACGTCACGCATCAG
CAGCGTCTCATCCCAGTTCAGCGACGGGCCGATCCCCAGCCCCTCCGCACGCAGCAGCGCCTCATCCTGGTCCGAGGAGCCTGTGCAGTC
CAACATGGACATCTCCACCGGCCACATGATCCTGTCCTACATGGAGGACCACCTGAAGAACAAGAACCGGCTGGAGAAGGAGTGGGAAGC
GCTGTGCGCCTACCAGGCGGAGCCCAACAGCTCGTTCGTGGCCCAGAGGGAGGAGAACGTGCCCAAGAACCGCTCCCTGGCCGTGCTGAC
CTATGACCACTCCCGGGTCCTGCTGAAGGCGGAGAACAGCCACAGCCACTCAGACTACATCAACGCTAGCCCCATCATGGATCACGACCC
GAGGAACCCCGCGTACATCGCCACCCAGGGACCGCTGCCCGCCACCGTGGCTGACTTTTGGCAGATGGTGTGGGAGAGCGGCTGCGTGGT
GATCGTCATGCTGACACCCCTCGCGGAGAACGGCGTCCGGCAGTGCTACCACTACTGGCCGGATGAAGGCTCCAATCTCTACCACATCTA
TGAGGTGAACCTGGTCTCCGAGCACATCTGGTGTGAGGACTTCCTGGTGAGGAGCTTCTATCTGAAGAACCTGCAGACCAACGAGACGCG
CACCGTGACGCAGTTCCACTTCCTGAGTTGGTATGACCGAGGAGTCCCTTCCTCCTCAAGGTCCCTCCTGGACTTCCGCAGAAAAGTAAA
CAAGTGCTACAGGGGCCGTTCTTGTCCAATAATTGTTCATTGCAGTGACGGTGCAGGCCGGAGCGGCACCTACGTCCTGATCGACATGGT
TCTCAACAAGATGGCCAAAGGTGCTAAAGAGATTGATATCGCAGCGACCCTGGAGCACTTGAGGGACCAGAGACCCGGCATGGTCCAGAC
GAAGGAGCAGTTTGAGTTCGCGCTGACAGCCGTGGCTGAGGAGGTGAACGCCATCCTCAAGGCCCTTCCCCAGTGAGCGGCAGCCTCAGG
GGCCTCAGGGGAGCCCCCACCCCACGGATGTTGTCAGGAATCATGATCTGACTTTAATTGTGTGTCTTCTATTATAACTGCATAGTAATA
GGGCCCTTAGCTCTCCCGTAGTCAGCGCAGTTTAGCAGTTAAAAGTGTATTTTTGTTTAATCAAACAATAATAAAGAGAGATTTGTGGAA
AAATCCAGTTACGGGTGGAGGGGAATCGGTTCATCAATTTTCACTTGCTTAAAAAAAATACTTTTTCTTAAAGCACCCGTTCACCTTCTT
GGTTGAAGTTGTGTTAACAATGCAGTAGCCAGCACGTTCGAGGCGGTTTCCAGGAAGAGTGTGCTTGTCATCTGCCACTTTCGGGAGGGT
GGATCCACTGTGCAGGAGTGGCCGGGGAAGCTGGCAGCACTCAGTGAGGCCGCCCGGCACACAAGGCACGTTTGGCATTTCTCTTTGAGA
GAGTTTATCATTGGGAGAAGCCGCAGGGACAGAACTGAACGTCCTGCAGCTTCGGGGCAAGTGAGACAATCACAGCTCCTCGCTGCGTCT
CCATCAACACTGCGCCGGGTACCATGGACGGCCCCGTCAGCCACACCTGTCAGCCCAAGCAGAGTGATTCAGGGGCTCCCCGGGGGCAGA
CACCTGTGCACCCCATGAGTAGTGCCCACTTGAGGCTGGCACTCCCCTGACCTCACCTTTGCAAAGTTACAGATGCACCCCAACATTGAG
ATGTGTTTTTAATGTTAAAATATTGATTTCTACGTTATGAAAACAGATGCCCCCGTGAATGCTTACCTGTGAGATAACCACAACCAGGAA
GAACAAATCTGGGCATTGAGCAAGCTATGAGGGTCCCCGGGAGCACACGAACCCTGCCAGGCCCCCGCTGGCTCCTCCAGGCACGTCCCG
GACCTGTGGGGCCCCAGAGAGGGGACATTTCCCTCCTGGGAGAGAAGGAGATCAGGGCAACTCGGAGAGGGCTGCGAGCATTTCCCTCCC
GGGAGAGGAGATCAGGGCGACCTGCACGCACTGCGTAGAGCCTGGAAGGGAAGTGAGAAACCAGCCGACCGGCCCTGCCCCTCTTCCCGG
GATCACTTAATGAACCACGTGTTTTGACATCATGTAAACCTAAGCACGTAGAGATGATTCGGATTTGACAAAATAACATTTGAGTATCCG
ATTCGCCATCACCCCCTACCCCAGAAATAGGACAATTCACTTCATTGACCAAGATGATCACATGGAAGGCGGCACAGAGGCAGCTGTGTG
GGCTGCAGATTTCCTGTGTGGGGTTCAGCGTAGAAAACGCACCTCCATCCCGCCCTTCCCACAGCATTCCTCCATCTTAGATAGATGGTA
CTCTCCAAAGGCCCTACCAGAGGGAACACGGCCTACTGAGCGGACAGAATGATGCCAAAATATTGCTTATGTCTCTACATGGTATTGTAA
TGAATATCTGCTTTAATATAGCTATCATTTCTTTTCCAAAATTACTTCTCTCTATCTGGAATTTAATTAATCGAAATGAATTTATCTGAA
TATAGGAAGCATATGCCTACTTGTAATTTCTAACTCCTTATGTTTGAAGAGAAACCTCCGGTGTGAGATATACAAATATATTTAATTGTG

>32231_32231_2_GALNT11-PTPRN2_GALNT11_chr7_151722969_ENST00000452146_PTPRN2_chr7_158282477_ENST00000409483_length(amino acids)=982AA_BP=26
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGCLLEEGLCGASEACVNGFTWQDDYTQYVMDQELADLPKTYLRRPEAS
SPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRTQLR
EDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGD
GARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVH
RLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKE
EQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEKA
TVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADAT
AAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALC
AYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIV
MLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GALNT11-PTPRN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GALNT11-PTPRN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GALNT11-PTPRN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource