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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AJUBA-CEP192 (FusionGDB2 ID:3231)

Fusion Gene Summary for AJUBA-CEP192

check button Fusion gene summary
Fusion gene informationFusion gene name: AJUBA-CEP192
Fusion gene ID: 3231
HgeneTgene
Gene symbol

AJUBA

CEP192

Gene ID

84962

55125

Gene nameajuba LIM proteincentrosomal protein 192
SynonymsJUBPPP1R62
Cytomap

14q11.2

18p11.21

Type of geneprotein-codingprotein-coding
DescriptionLIM domain-containing protein ajubajub, ajuba homologcentrosomal protein of 192 kDa192 kDa centrosomal proteincentrosomal protein 192kDacep192/SPD-2protein phosphatase 1, regulatory subunit 62
Modification date2020031320200313
UniProtAcc

Q96IF1

Q8TEP8

Ensembl transtripts involved in fusion geneENST00000262713, ENST00000361265, 
ENST00000397388, 		ENST00000540847, 
ENST00000325971, ENST00000430049, 
ENST00000506447, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 4=64
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AJUBA [Title/Abstract] AND CEP192 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAJUBA(23445854)-CEP192(13087016), # samples:2
Anticipated loss of major functional domain due to fusion event.AJUBA-CEP192 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAJUBA

GO:0001666

response to hypoxia

22286099

HgeneAJUBA

GO:0031334

positive regulation of protein complex assembly

15870274

HgeneAJUBA

GO:0035331

negative regulation of hippo signaling

20303269

HgeneAJUBA

GO:1900037

regulation of cellular response to hypoxia

22286099

TgeneCEP192

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across AJUBA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP192 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W6-AA0S-01AAJUBAchr14

23445854

-CEP192chr18

13087016

+


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Fusion Gene ORF analysis for AJUBA-CEP192

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262713ENST00000540847AJUBAchr14

23445854

-CEP192chr18

13087016

+
5CDS-3UTRENST00000361265ENST00000540847AJUBAchr14

23445854

-CEP192chr18

13087016

+
5UTR-3CDSENST00000397388ENST00000325971AJUBAchr14

23445854

-CEP192chr18

13087016

+
5UTR-3CDSENST00000397388ENST00000430049AJUBAchr14

23445854

-CEP192chr18

13087016

+
5UTR-3CDSENST00000397388ENST00000506447AJUBAchr14

23445854

-CEP192chr18

13087016

+
5UTR-3UTRENST00000397388ENST00000540847AJUBAchr14

23445854

-CEP192chr18

13087016

+
Frame-shiftENST00000361265ENST00000325971AJUBAchr14

23445854

-CEP192chr18

13087016

+
Frame-shiftENST00000361265ENST00000430049AJUBAchr14

23445854

-CEP192chr18

13087016

+
Frame-shiftENST00000361265ENST00000506447AJUBAchr14

23445854

-CEP192chr18

13087016

+
In-frameENST00000262713ENST00000325971AJUBAchr14

23445854

-CEP192chr18

13087016

+
In-frameENST00000262713ENST00000430049AJUBAchr14

23445854

-CEP192chr18

13087016

+
In-frameENST00000262713ENST00000506447AJUBAchr14

23445854

-CEP192chr18

13087016

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262713AJUBAchr1423445854-ENST00000506447CEP192chr1813087016+3816155227735491090
ENST00000262713AJUBAchr1423445854-ENST00000325971CEP192chr1813087016+3828155227735491090
ENST00000262713AJUBAchr1423445854-ENST00000430049CEP192chr1813087016+3775155227735491090

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262713ENST00000506447AJUBAchr1423445854-CEP192chr1813087016+0.0003923330.99960774
ENST00000262713ENST00000325971AJUBAchr1423445854-CEP192chr1813087016+0.0003841920.9996158
ENST00000262713ENST00000430049AJUBAchr1423445854-CEP192chr1813087016+0.0004295070.9995704

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Fusion Genomic Features for AJUBA-CEP192


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AJUBAchr1423445853-CEP192chr1813087015+0.0021879980.99781203
AJUBAchr1423445853-CEP192chr1813087015+0.0021879980.99781203

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AJUBA-CEP192


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23445854/chr18:13087016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AJUBA

Q96IF1

CEP192

Q8TEP8

FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}.FUNCTION: Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804). {ECO:0000269|PubMed:17980596, ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:25042804}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAJUBAchr14:23445854chr18:13087016ENST00000262713-38280_288392539.0MotifNuclear localization signal
HgeneAJUBAchr14:23445854chr18:13087016ENST00000361265-39280_288392481.0MotifNuclear localization signal
HgeneAJUBAchr14:23445854chr18:13087016ENST00000262713-381_335392539.0RegionNote=PreLIM
HgeneAJUBAchr14:23445854chr18:13087016ENST00000361265-391_335392481.0RegionNote=PreLIM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAJUBAchr14:23445854chr18:13087016ENST00000262713-38336_397392539.0DomainLIM zinc-binding 1
HgeneAJUBAchr14:23445854chr18:13087016ENST00000262713-38401_461392539.0DomainLIM zinc-binding 2
HgeneAJUBAchr14:23445854chr18:13087016ENST00000262713-38462_530392539.0DomainLIM zinc-binding 3
HgeneAJUBAchr14:23445854chr18:13087016ENST00000361265-39336_397392481.0DomainLIM zinc-binding 1
HgeneAJUBAchr14:23445854chr18:13087016ENST00000361265-39401_461392481.0DomainLIM zinc-binding 2
HgeneAJUBAchr14:23445854chr18:13087016ENST00000361265-39462_530392481.0DomainLIM zinc-binding 3
HgeneAJUBAchr14:23445854chr18:13087016ENST00000397388-16336_3970122.0DomainLIM zinc-binding 1
HgeneAJUBAchr14:23445854chr18:13087016ENST00000397388-16401_4610122.0DomainLIM zinc-binding 2
HgeneAJUBAchr14:23445854chr18:13087016ENST00000397388-16462_5300122.0DomainLIM zinc-binding 3
HgeneAJUBAchr14:23445854chr18:13087016ENST00000397388-16280_2880122.0MotifNuclear localization signal
HgeneAJUBAchr14:23445854chr18:13087016ENST00000397388-161_3350122.0RegionNote=PreLIM


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Fusion Gene Sequence for AJUBA-CEP192


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3231_3231_1_AJUBA-CEP192_AJUBA_chr14_23445854_ENST00000262713_CEP192_chr18_13087016_ENST00000325971_length(transcript)=3828nt_BP=1552nt
AGATCCGGCCAGGCAGACAAAAGTTTGGGAGAGAAGTTCGGTCTGTGGCTAGCGTGAGAGCTAGGGGGGCGGGGGCCGGGGAGAGTGGGG
CAGTCGGGCGAGTCGACGCGTGAACAGATAGACCTGCGGACTGGACAGCCGCGGCCAGAGACCCTGCTAGCCCCGCTCAGCCCCAGATGC
GCGGGGGGACGCAGCCCCTCCCGCTGGGGGATGCTGTGGGATTCCTGGCGCAGGGCATCCAGGCCGCCCGCTAAGCCCCTGTGCCTCCCC
TGTGCCCCTGGGGAACCAGAGTCCGGCTGCAGGGAAAGAGAACCGGCCGCCGAGACGCCGCAGGGTGCCAGGCGGGGAGGGGGCGAGAGG
CCCCAGGCCCGAGGGCATGGAGCGGTTAGGAGAGAAAGCCAGTCGCCTGCTGGAGAAGTTCGGCCGCAGAAAGGGTGAATCTAGCCGGTC
TGGGTCTGACGGGACCCCCGGGCCGGGCAAGGGGCGCCTAAGTGGGTTGGGGGGACCTAGGAAGTCAGGGCCCCGAGGAGCTACTGGGGG
ACCTGGGGATGAGCCGTTGGAGCCGGCCCGGGAGCAAGGTTCCCTGGACGCTGAGCGAAATCAGCGCGGCTCCTTTGAGGCGCCGCGCTA
CGAAGGCTCTTTTCCCGCGGGGCCGCCGCCCACCCGGGCCTTGCCTCTACCTCAGTCGTTGCCCCCCGATTTTCGGCTGGAGCCCACGGC
CCCGGCCCTCAGCCCCCGCTCTAGCTTCGCCAGTAGCTCGGCCAGCGACGCGAGCAAGCCGTCCAGCCCCCGGGGCAGCCTGCTGCTGGA
CGGGGCGGGGGCTGGCGGAGCTGGAGGTAGCCGGCCCTGCAGCAATCGCACCAGCGGCATCAGCATGGGCTACGACCAGCGCCACGGGAG
CCCCTTGCCAGCGGGGCCGTGCCTGTTTGGCCCACCCCTGGCCGGAGCACCGGCAGGCTATTCTCCCGGAGGGGTCCCGTCCGCCTACCC
GGAGCTCCACGCCGCCCTGGACCGATTGTACGCTCAGCGGCCCGCGGGGTTCGGCTGCCAGGAAAGCCGCCACTCGTATCCCCCGGCCCT
GGGCAGCCCTGGAGCTCTAGCCGGGGCCGGAGTGGGAGCGGCGGGGCCCTTGGAGAGACGGGGGGCGCAACCCGGACGACACTCTGTGAC
CGGCTACGGGGACTGCGCCGTGGGCGCCCGGTACCAGGACGAGCTAACAGCTTTGCTTCGCCTGACGGTGGGCACCGGTGGGCGAGAAGC
CGGAGCCCGCGGAGAACCCTCGGGGATTGAGCCGTCGGGTCTGGAGGAGCCACCAGGTCCTTTCGTTCCGGAGGCCGCCCGGGCCCGGAT
GCGGGAGCCAGAGGCCAGGGAGGACTACTTCGGCACCTGTATCAAGTGCAACAAAGGCATCTATGGGCAGAGCAATGCCTGCCAGGCCCT
GGACAGCCTCTACCACACCCAGTGCTTTGTTTGCTGCTCTTGTGGGCGAACTTTGCGTTGCAAGGCTTTCTACAGTGTCAATGGCTCTGT
GTACTGTGAGGAAGATTATCTGATACCTTTGTCTGGATATGGAGGAACAAGCAATCTTATTTTGGAAGGCGTTAAAAAATTATCTGACAG
TTACATGGTAACAGTGAATGGCTTAGTACCTGGCAAAGAAAGTAAAATTGTTTTTTCTGTCCGCAACACTGGCTCCCGAGCAGCTTTTGT
TAAAGCAGTAGGTTTTAAGGATTCTCAGAAAAAAGTTTTGCTGGATCCTAAAGTATTGAGGATTTTTCCAGATAAATTTGTACTCAAGGA
AAGAACACAAGAAAATGTTACTTTAATATATAATCCATCAGACAGAGGAATCAATAATAAAACTGCAACAGAACTATCAACTGTATACTT
ATTTGGTGGAGATGAAATTTCAAGACAGCAGTATCGCAGGGCCCTGTTACATAAACCAGAGATGATAAAACAGATACTTCCAGAACATAG
TGTGCTTCAAAACATTAATTTTGTTGAAGCATTTCAAGATGAGCTATTAGTAACTGAAGTATATGATCTTCCCCAACGACCTAATGATGT
TCAGCTCTTTTATGGAAGCATGTGTAAAATTATACTTTCAGTAATTGGAGAATTCAGAGATTGCATTTCTAGCAGAGAATTCCTTCAGCC
TTCTTCCAAAGCTAGCTTGGAATCTACAAGCGACTTGGGAGCTTCTGGGAAACATGGTGGCAACGTCTCTTTGGATGTTTTACCAGTCAA
AGGTCCTCAGGGTTCTCCTCTTCTCTCACGGGCGGCTCGCCCGCCTCTGGATCAGCTGGCCTCCGAAGAGCCGTGGACTGTCCTACCCGA
GCACTTGATTCTGGTAGCTCCTTCTCCTTGTGACATGGCAAAAACTGGACGTTTCCAGATTGTGAATAACTCTGTGAGGTTACTGAGATT
TGAGCTGTGCTGGCCAGCGCATTGCCTCACAGTCACGCCGCAGCATGGATGTGTCGCGCCAGAGAGTAAACTACAAATTCTTGTGAGTCC
TAATTCCTCCTTATCCACAAAACAGTCAATGTTCCCGTGGAGTGGTTTGATCTATATACACTGTGACGATGGACAGAAGAAAATTGTGAA
AGTTCAAATTCGAGAAGATTTAACTCAAGTGGAACTTTTAACTCGTTTGACCTCCAAACCATTTGGAATTCTTTCCCCAGTATCTGAGCC
TTCAGTTAGTCATTTGGTCAAACCAATGACAAAACCGCCTTCCACAAAAGTTGAAATAAGAAACAAGAGTATTACTTTTCCTACAACAGA
ACCTGGTGAAACTTCAGAGAGCTGTCTAGAACTCGAGAATCATGGCACCACAGACGTGAAATGGCATCTGTCATCTTTAGCGCCACCTTA
TGTCAAGGGAGTTGATGAAAGTGGAGATGTTTTTAGAGCTACCTATGCAGCATTCAGATGTTCTCCTATTTCTGGTCTGCTGGAAAGCCA
TGGGATCCAAAAAGTCTCCATCACATTTTTGCCCAGAGGTAGGGGGGATTATGCCCAGTTTTGGGATGTTGAATGTCACCCTCTTAAGGA
GCCTCACATGAAACACACGTTGAGATTCCAACTCTCTGGACAAAGCATCGAAGCAGAAAATGAGCCTGAAAACGCATGCCTTTCCACGGA
TTCCCTCATTAAAATAGATCATTTAGTTAAGCCCCGAAGACAAGCTGTGTCAGAGGCTTCTGCTCGCATACCTGAGCAGCTTGATGTGAC
TGCTCGTGGAGTTTATGCCCCAGAGGATGTGTACAGGTTCCGGCCGACTAGTGTGGGGGAATCACGGACACTTAAAGTCAATCTGCGAAA
TAATTCTTTTATTACACACTCACTGAAGTTTTTGAGTCCCAGAGAGCCATTCTATGTCAAACATTCCAAGTACTCTTTGAGAGCCCAGCA
TTACATCAACATGCCCGTGCAGTTCAAACCGAAGTCCGCAGGCAAATTTGAAGCTTTGCTTGTCATTCAAACAGATGAAGGCAAGAGTAT
TGCTATTCGACTAATTGGTGAAGCTCTTGGAAAAAATTAACTAGAATACATTTTTGTGTAAAGTAAATTACATAAGTTGTATTTTGTTAA
CTTTATCTTTCTACACTACAATTATGCTTTTGTATATATATTTTGTATGATGGATATCTATAATTGTAGATTTTGTTTTTACAAGCTAAT
ACTGAAGACTCGACTGAAATATTATGTATCTAGCCCATAGTATTGTACTTAACTTTTACAGGTGAGAAGAGAGTTCTGTGTTTGCATTGA

>3231_3231_1_AJUBA-CEP192_AJUBA_chr14_23445854_ENST00000262713_CEP192_chr18_13087016_ENST00000325971_length(amino acids)=1090AA_BP=425
MGNQSPAAGKENRPPRRRRVPGGEGARGPRPEGMERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPG
DEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGA
GAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGS
PGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMRE
PEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLIPLSGYGGTSNLILEGVKKLSDSYM
VTVNGLVPGKESKIVFSVRNTGSRAAFVKAVGFKDSQKKVLLDPKVLRIFPDKFVLKERTQENVTLIYNPSDRGINNKTATELSTVYLFG
GDEISRQQYRRALLHKPEMIKQILPEHSVLQNINFVEAFQDELLVTEVYDLPQRPNDVQLFYGSMCKIILSVIGEFRDCISSREFLQPSS
KASLESTSDLGASGKHGGNVSLDVLPVKGPQGSPLLSRAARPPLDQLASEEPWTVLPEHLILVAPSPCDMAKTGRFQIVNNSVRLLRFEL
CWPAHCLTVTPQHGCVAPESKLQILVSPNSSLSTKQSMFPWSGLIYIHCDDGQKKIVKVQIREDLTQVELLTRLTSKPFGILSPVSEPSV
SHLVKPMTKPPSTKVEIRNKSITFPTTEPGETSESCLELENHGTTDVKWHLSSLAPPYVKGVDESGDVFRATYAAFRCSPISGLLESHGI
QKVSITFLPRGRGDYAQFWDVECHPLKEPHMKHTLRFQLSGQSIEAENEPENACLSTDSLIKIDHLVKPRRQAVSEASARIPEQLDVTAR
GVYAPEDVYRFRPTSVGESRTLKVNLRNNSFITHSLKFLSPREPFYVKHSKYSLRAQHYINMPVQFKPKSAGKFEALLVIQTDEGKSIAI

--------------------------------------------------------------
>3231_3231_2_AJUBA-CEP192_AJUBA_chr14_23445854_ENST00000262713_CEP192_chr18_13087016_ENST00000430049_length(transcript)=3775nt_BP=1552nt
AGATCCGGCCAGGCAGACAAAAGTTTGGGAGAGAAGTTCGGTCTGTGGCTAGCGTGAGAGCTAGGGGGGCGGGGGCCGGGGAGAGTGGGG
CAGTCGGGCGAGTCGACGCGTGAACAGATAGACCTGCGGACTGGACAGCCGCGGCCAGAGACCCTGCTAGCCCCGCTCAGCCCCAGATGC
GCGGGGGGACGCAGCCCCTCCCGCTGGGGGATGCTGTGGGATTCCTGGCGCAGGGCATCCAGGCCGCCCGCTAAGCCCCTGTGCCTCCCC
TGTGCCCCTGGGGAACCAGAGTCCGGCTGCAGGGAAAGAGAACCGGCCGCCGAGACGCCGCAGGGTGCCAGGCGGGGAGGGGGCGAGAGG
CCCCAGGCCCGAGGGCATGGAGCGGTTAGGAGAGAAAGCCAGTCGCCTGCTGGAGAAGTTCGGCCGCAGAAAGGGTGAATCTAGCCGGTC
TGGGTCTGACGGGACCCCCGGGCCGGGCAAGGGGCGCCTAAGTGGGTTGGGGGGACCTAGGAAGTCAGGGCCCCGAGGAGCTACTGGGGG
ACCTGGGGATGAGCCGTTGGAGCCGGCCCGGGAGCAAGGTTCCCTGGACGCTGAGCGAAATCAGCGCGGCTCCTTTGAGGCGCCGCGCTA
CGAAGGCTCTTTTCCCGCGGGGCCGCCGCCCACCCGGGCCTTGCCTCTACCTCAGTCGTTGCCCCCCGATTTTCGGCTGGAGCCCACGGC
CCCGGCCCTCAGCCCCCGCTCTAGCTTCGCCAGTAGCTCGGCCAGCGACGCGAGCAAGCCGTCCAGCCCCCGGGGCAGCCTGCTGCTGGA
CGGGGCGGGGGCTGGCGGAGCTGGAGGTAGCCGGCCCTGCAGCAATCGCACCAGCGGCATCAGCATGGGCTACGACCAGCGCCACGGGAG
CCCCTTGCCAGCGGGGCCGTGCCTGTTTGGCCCACCCCTGGCCGGAGCACCGGCAGGCTATTCTCCCGGAGGGGTCCCGTCCGCCTACCC
GGAGCTCCACGCCGCCCTGGACCGATTGTACGCTCAGCGGCCCGCGGGGTTCGGCTGCCAGGAAAGCCGCCACTCGTATCCCCCGGCCCT
GGGCAGCCCTGGAGCTCTAGCCGGGGCCGGAGTGGGAGCGGCGGGGCCCTTGGAGAGACGGGGGGCGCAACCCGGACGACACTCTGTGAC
CGGCTACGGGGACTGCGCCGTGGGCGCCCGGTACCAGGACGAGCTAACAGCTTTGCTTCGCCTGACGGTGGGCACCGGTGGGCGAGAAGC
CGGAGCCCGCGGAGAACCCTCGGGGATTGAGCCGTCGGGTCTGGAGGAGCCACCAGGTCCTTTCGTTCCGGAGGCCGCCCGGGCCCGGAT
GCGGGAGCCAGAGGCCAGGGAGGACTACTTCGGCACCTGTATCAAGTGCAACAAAGGCATCTATGGGCAGAGCAATGCCTGCCAGGCCCT
GGACAGCCTCTACCACACCCAGTGCTTTGTTTGCTGCTCTTGTGGGCGAACTTTGCGTTGCAAGGCTTTCTACAGTGTCAATGGCTCTGT
GTACTGTGAGGAAGATTATCTGATACCTTTGTCTGGATATGGAGGAACAAGCAATCTTATTTTGGAAGGCGTTAAAAAATTATCTGACAG
TTACATGGTAACAGTGAATGGCTTAGTACCTGGCAAAGAAAGTAAAATTGTTTTTTCTGTCCGCAACACTGGCTCCCGAGCAGCTTTTGT
TAAAGCAGTAGGTTTTAAGGATTCTCAGAAAAAAGTTTTGCTGGATCCTAAAGTATTGAGGATTTTTCCAGATAAATTTGTACTCAAGGA
AAGAACACAAGAAAATGTTACTTTAATATATAATCCATCAGACAGAGGAATCAATAATAAAACTGCAACAGAACTATCAACTGTATACTT
ATTTGGTGGAGATGAAATTTCAAGACAGCAGTATCGCAGGGCCCTGTTACATAAACCAGAGATGATAAAACAGATACTTCCAGAACATAG
TGTGCTTCAAAACATTAATTTTGTTGAAGCATTTCAAGATGAGCTATTAGTAACTGAAGTATATGATCTTCCCCAACGACCTAATGATGT
TCAGCTCTTTTATGGAAGCATGTGTAAAATTATACTTTCAGTAATTGGAGAATTCAGAGATTGCATTTCTAGCAGAGAATTCCTTCAGCC
TTCTTCCAAAGCTAGCTTGGAATCTACAAGCGACTTGGGAGCTTCTGGGAAACATGGTGGCAACGTCTCTTTGGATGTTTTACCAGTCAA
AGGTCCTCAGGGTTCTCCTCTTCTCTCACGGGCGGCTCGCCCGCCTCTGGATCAGCTGGCCTCCGAAGAGCCGTGGACTGTCCTACCCGA
GCACTTGATTCTGGTAGCTCCTTCTCCTTGTGACATGGCAAAAACTGGACGTTTCCAGATTGTGAATAACTCTGTGAGGTTACTGAGATT
TGAGCTGTGCTGGCCAGCGCATTGCCTCACAGTCACGCCGCAGCATGGATGTGTCGCGCCAGAGAGTAAACTACAAATTCTTGTGAGTCC
TAATTCCTCCTTATCCACAAAACAGTCAATGTTCCCGTGGAGTGGTTTGATCTATATACACTGTGACGATGGACAGAAGAAAATTGTGAA
AGTTCAAATTCGAGAAGATTTAACTCAAGTGGAACTTTTAACTCGTTTGACCTCCAAACCATTTGGAATTCTTTCCCCAGTATCTGAGCC
TTCAGTTAGTCATTTGGTCAAACCAATGACAAAACCGCCTTCCACAAAAGTTGAAATAAGAAACAAGAGTATTACTTTTCCTACAACAGA
ACCTGGTGAAACTTCAGAGAGCTGTCTAGAACTCGAGAATCATGGCACCACAGACGTGAAATGGCATCTGTCATCTTTAGCGCCACCTTA
TGTCAAGGGAGTTGATGAAAGTGGAGATGTTTTTAGAGCTACCTATGCAGCATTCAGATGTTCTCCTATTTCTGGTCTGCTGGAAAGCCA
TGGGATCCAAAAAGTCTCCATCACATTTTTGCCCAGAGGTAGGGGGGATTATGCCCAGTTTTGGGATGTTGAATGTCACCCTCTTAAGGA
GCCTCACATGAAACACACGTTGAGATTCCAACTCTCTGGACAAAGCATCGAAGCAGAAAATGAGCCTGAAAACGCATGCCTTTCCACGGA
TTCCCTCATTAAAATAGATCATTTAGTTAAGCCCCGAAGACAAGCTGTGTCAGAGGCTTCTGCTCGCATACCTGAGCAGCTTGATGTGAC
TGCTCGTGGAGTTTATGCCCCAGAGGATGTGTACAGGTTCCGGCCGACTAGTGTGGGGGAATCACGGACACTTAAAGTCAATCTGCGAAA
TAATTCTTTTATTACACACTCACTGAAGTTTTTGAGTCCCAGAGAGCCATTCTATGTCAAACATTCCAAGTACTCTTTGAGAGCCCAGCA
TTACATCAACATGCCCGTGCAGTTCAAACCGAAGTCCGCAGGCAAATTTGAAGCTTTGCTTGTCATTCAAACAGATGAAGGCAAGAGTAT
TGCTATTCGACTAATTGGTGAAGCTCTTGGAAAAAATTAACTAGAATACATTTTTGTGTAAAGTAAATTACATAAGTTGTATTTTGTTAA
CTTTATCTTTCTACACTACAATTATGCTTTTGTATATATATTTTGTATGATGGATATCTATAATTGTAGATTTTGTTTTTACAAGCTAAT

>3231_3231_2_AJUBA-CEP192_AJUBA_chr14_23445854_ENST00000262713_CEP192_chr18_13087016_ENST00000430049_length(amino acids)=1090AA_BP=425
MGNQSPAAGKENRPPRRRRVPGGEGARGPRPEGMERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPG
DEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGA
GAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGS
PGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMRE
PEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLIPLSGYGGTSNLILEGVKKLSDSYM
VTVNGLVPGKESKIVFSVRNTGSRAAFVKAVGFKDSQKKVLLDPKVLRIFPDKFVLKERTQENVTLIYNPSDRGINNKTATELSTVYLFG
GDEISRQQYRRALLHKPEMIKQILPEHSVLQNINFVEAFQDELLVTEVYDLPQRPNDVQLFYGSMCKIILSVIGEFRDCISSREFLQPSS
KASLESTSDLGASGKHGGNVSLDVLPVKGPQGSPLLSRAARPPLDQLASEEPWTVLPEHLILVAPSPCDMAKTGRFQIVNNSVRLLRFEL
CWPAHCLTVTPQHGCVAPESKLQILVSPNSSLSTKQSMFPWSGLIYIHCDDGQKKIVKVQIREDLTQVELLTRLTSKPFGILSPVSEPSV
SHLVKPMTKPPSTKVEIRNKSITFPTTEPGETSESCLELENHGTTDVKWHLSSLAPPYVKGVDESGDVFRATYAAFRCSPISGLLESHGI
QKVSITFLPRGRGDYAQFWDVECHPLKEPHMKHTLRFQLSGQSIEAENEPENACLSTDSLIKIDHLVKPRRQAVSEASARIPEQLDVTAR
GVYAPEDVYRFRPTSVGESRTLKVNLRNNSFITHSLKFLSPREPFYVKHSKYSLRAQHYINMPVQFKPKSAGKFEALLVIQTDEGKSIAI

--------------------------------------------------------------
>3231_3231_3_AJUBA-CEP192_AJUBA_chr14_23445854_ENST00000262713_CEP192_chr18_13087016_ENST00000506447_length(transcript)=3816nt_BP=1552nt
AGATCCGGCCAGGCAGACAAAAGTTTGGGAGAGAAGTTCGGTCTGTGGCTAGCGTGAGAGCTAGGGGGGCGGGGGCCGGGGAGAGTGGGG
CAGTCGGGCGAGTCGACGCGTGAACAGATAGACCTGCGGACTGGACAGCCGCGGCCAGAGACCCTGCTAGCCCCGCTCAGCCCCAGATGC
GCGGGGGGACGCAGCCCCTCCCGCTGGGGGATGCTGTGGGATTCCTGGCGCAGGGCATCCAGGCCGCCCGCTAAGCCCCTGTGCCTCCCC
TGTGCCCCTGGGGAACCAGAGTCCGGCTGCAGGGAAAGAGAACCGGCCGCCGAGACGCCGCAGGGTGCCAGGCGGGGAGGGGGCGAGAGG
CCCCAGGCCCGAGGGCATGGAGCGGTTAGGAGAGAAAGCCAGTCGCCTGCTGGAGAAGTTCGGCCGCAGAAAGGGTGAATCTAGCCGGTC
TGGGTCTGACGGGACCCCCGGGCCGGGCAAGGGGCGCCTAAGTGGGTTGGGGGGACCTAGGAAGTCAGGGCCCCGAGGAGCTACTGGGGG
ACCTGGGGATGAGCCGTTGGAGCCGGCCCGGGAGCAAGGTTCCCTGGACGCTGAGCGAAATCAGCGCGGCTCCTTTGAGGCGCCGCGCTA
CGAAGGCTCTTTTCCCGCGGGGCCGCCGCCCACCCGGGCCTTGCCTCTACCTCAGTCGTTGCCCCCCGATTTTCGGCTGGAGCCCACGGC
CCCGGCCCTCAGCCCCCGCTCTAGCTTCGCCAGTAGCTCGGCCAGCGACGCGAGCAAGCCGTCCAGCCCCCGGGGCAGCCTGCTGCTGGA
CGGGGCGGGGGCTGGCGGAGCTGGAGGTAGCCGGCCCTGCAGCAATCGCACCAGCGGCATCAGCATGGGCTACGACCAGCGCCACGGGAG
CCCCTTGCCAGCGGGGCCGTGCCTGTTTGGCCCACCCCTGGCCGGAGCACCGGCAGGCTATTCTCCCGGAGGGGTCCCGTCCGCCTACCC
GGAGCTCCACGCCGCCCTGGACCGATTGTACGCTCAGCGGCCCGCGGGGTTCGGCTGCCAGGAAAGCCGCCACTCGTATCCCCCGGCCCT
GGGCAGCCCTGGAGCTCTAGCCGGGGCCGGAGTGGGAGCGGCGGGGCCCTTGGAGAGACGGGGGGCGCAACCCGGACGACACTCTGTGAC
CGGCTACGGGGACTGCGCCGTGGGCGCCCGGTACCAGGACGAGCTAACAGCTTTGCTTCGCCTGACGGTGGGCACCGGTGGGCGAGAAGC
CGGAGCCCGCGGAGAACCCTCGGGGATTGAGCCGTCGGGTCTGGAGGAGCCACCAGGTCCTTTCGTTCCGGAGGCCGCCCGGGCCCGGAT
GCGGGAGCCAGAGGCCAGGGAGGACTACTTCGGCACCTGTATCAAGTGCAACAAAGGCATCTATGGGCAGAGCAATGCCTGCCAGGCCCT
GGACAGCCTCTACCACACCCAGTGCTTTGTTTGCTGCTCTTGTGGGCGAACTTTGCGTTGCAAGGCTTTCTACAGTGTCAATGGCTCTGT
GTACTGTGAGGAAGATTATCTGATACCTTTGTCTGGATATGGAGGAACAAGCAATCTTATTTTGGAAGGCGTTAAAAAATTATCTGACAG
TTACATGGTAACAGTGAATGGCTTAGTACCTGGCAAAGAAAGTAAAATTGTTTTTTCTGTCCGCAACACTGGCTCCCGAGCAGCTTTTGT
TAAAGCAGTAGGTTTTAAGGATTCTCAGAAAAAAGTTTTGCTGGATCCTAAAGTATTGAGGATTTTTCCAGATAAATTTGTACTCAAGGA
AAGAACACAAGAAAATGTTACTTTAATATATAATCCATCAGACAGAGGAATCAATAATAAAACTGCAACAGAACTATCAACTGTATACTT
ATTTGGTGGAGATGAAATTTCAAGACAGCAGTATCGCAGGGCCCTGTTACATAAACCAGAGATGATAAAACAGATACTTCCAGAACATAG
TGTGCTTCAAAACATTAATTTTGTTGAAGCATTTCAAGATGAGCTATTAGTAACTGAAGTATATGATCTTCCCCAACGACCTAATGATGT
TCAGCTCTTTTATGGAAGCATGTGTAAAATTATACTTTCAGTAATTGGAGAATTCAGAGATTGCATTTCTAGCAGAGAATTCCTTCAGCC
TTCTTCCAAAGCTAGCTTGGAATCTACAAGCGACTTGGGAGCTTCTGGGAAACATGGTGGCAACGTCTCTTTGGATGTTTTACCAGTCAA
AGGTCCTCAGGGTTCTCCTCTTCTCTCACGGGCGGCTCGCCCGCCTCTGGATCAGCTGGCCTCCGAAGAGCCGTGGACTGTCCTACCCGA
GCACTTGATTCTGGTAGCTCCTTCTCCTTGTGACATGGCAAAAACTGGACGTTTCCAGATTGTGAATAACTCTGTGAGGTTACTGAGATT
TGAGCTGTGCTGGCCAGCGCATTGCCTCACAGTCACGCCGCAGCATGGATGTGTCGCGCCAGAGAGTAAACTACAAATTCTTGTGAGTCC
TAATTCCTCCTTATCCACAAAACAGTCAATGTTCCCGTGGAGTGGTTTGATCTATATACACTGTGACGATGGACAGAAGAAAATTGTGAA
AGTTCAAATTCGAGAAGATTTAACTCAAGTGGAACTTTTAACTCGTTTGACCTCCAAACCATTTGGAATTCTTTCCCCAGTATCTGAGCC
TTCAGTTAGTCATTTGGTCAAACCAATGACAAAACCGCCTTCCACAAAAGTTGAAATAAGAAACAAGAGTATTACTTTTCCTACAACAGA
ACCTGGTGAAACTTCAGAGAGCTGTCTAGAACTCGAGAATCATGGCACCACAGACGTGAAATGGCATCTGTCATCTTTAGCGCCACCTTA
TGTCAAGGGAGTTGATGAAAGTGGAGATGTTTTTAGAGCTACCTATGCAGCATTCAGATGTTCTCCTATTTCTGGTCTGCTGGAAAGCCA
TGGGATCCAAAAAGTCTCCATCACATTTTTGCCCAGAGGTAGGGGGGATTATGCCCAGTTTTGGGATGTTGAATGTCACCCTCTTAAGGA
GCCTCACATGAAACACACGTTGAGATTCCAACTCTCTGGACAAAGCATCGAAGCAGAAAATGAGCCTGAAAACGCATGCCTTTCCACGGA
TTCCCTCATTAAAATAGATCATTTAGTTAAGCCCCGAAGACAAGCTGTGTCAGAGGCTTCTGCTCGCATACCTGAGCAGCTTGATGTGAC
TGCTCGTGGAGTTTATGCCCCAGAGGATGTGTACAGGTTCCGGCCGACTAGTGTGGGGGAATCACGGACACTTAAAGTCAATCTGCGAAA
TAATTCTTTTATTACACACTCACTGAAGTTTTTGAGTCCCAGAGAGCCATTCTATGTCAAACATTCCAAGTACTCTTTGAGAGCCCAGCA
TTACATCAACATGCCCGTGCAGTTCAAACCGAAGTCCGCAGGCAAATTTGAAGCTTTGCTTGTCATTCAAACAGATGAAGGCAAGAGTAT
TGCTATTCGACTAATTGGTGAAGCTCTTGGAAAAAATTAACTAGAATACATTTTTGTGTAAAGTAAATTACATAAGTTGTATTTTGTTAA
CTTTATCTTTCTACACTACAATTATGCTTTTGTATATATATTTTGTATGATGGATATCTATAATTGTAGATTTTGTTTTTACAAGCTAAT
ACTGAAGACTCGACTGAAATATTATGTATCTAGCCCATAGTATTGTACTTAACTTTTACAGGTGAGAAGAGAGTTCTGTGTTTGCATTGA

>3231_3231_3_AJUBA-CEP192_AJUBA_chr14_23445854_ENST00000262713_CEP192_chr18_13087016_ENST00000506447_length(amino acids)=1090AA_BP=425
MGNQSPAAGKENRPPRRRRVPGGEGARGPRPEGMERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPG
DEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGA
GAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGS
PGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMRE
PEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLIPLSGYGGTSNLILEGVKKLSDSYM
VTVNGLVPGKESKIVFSVRNTGSRAAFVKAVGFKDSQKKVLLDPKVLRIFPDKFVLKERTQENVTLIYNPSDRGINNKTATELSTVYLFG
GDEISRQQYRRALLHKPEMIKQILPEHSVLQNINFVEAFQDELLVTEVYDLPQRPNDVQLFYGSMCKIILSVIGEFRDCISSREFLQPSS
KASLESTSDLGASGKHGGNVSLDVLPVKGPQGSPLLSRAARPPLDQLASEEPWTVLPEHLILVAPSPCDMAKTGRFQIVNNSVRLLRFEL
CWPAHCLTVTPQHGCVAPESKLQILVSPNSSLSTKQSMFPWSGLIYIHCDDGQKKIVKVQIREDLTQVELLTRLTSKPFGILSPVSEPSV
SHLVKPMTKPPSTKVEIRNKSITFPTTEPGETSESCLELENHGTTDVKWHLSSLAPPYVKGVDESGDVFRATYAAFRCSPISGLLESHGI
QKVSITFLPRGRGDYAQFWDVECHPLKEPHMKHTLRFQLSGQSIEAENEPENACLSTDSLIKIDHLVKPRRQAVSEASARIPEQLDVTAR
GVYAPEDVYRFRPTSVGESRTLKVNLRNNSFITHSLKFLSPREPFYVKHSKYSLRAQHYINMPVQFKPKSAGKFEALLVIQTDEGKSIAI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AJUBA-CEP192


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AJUBA-CEP192


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AJUBA-CEP192


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource