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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GANAB-EEF1D (FusionGDB2 ID:32337)

Fusion Gene Summary for GANAB-EEF1D

check button Fusion gene summary
Fusion gene informationFusion gene name: GANAB-EEF1D
Fusion gene ID: 32337
HgeneTgene
Gene symbol

GANAB

EEF1D

Gene ID

23193

1936

Gene nameglucosidase II alpha subuniteukaryotic translation elongation factor 1 delta
SynonymsG2AN|GIIA|GLUII|PKD3EF-1D|EF1D|FP1047
Cytomap

11q12.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionneutral alpha-glucosidase ABalpha-glucosidase 2elongation factor 1-deltaEF-1-deltaantigen NY-CO-4eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Modification date2020031320200313
UniProtAcc

Q14697

Q658K8

Ensembl transtripts involved in fusion geneENST00000346178, ENST00000356638, 
ENST00000534779, ENST00000540933, 
ENST00000534422, 		ENST00000317198, 
ENST00000395119, ENST00000419152, 
ENST00000423316, ENST00000442189, 
ENST00000524624, ENST00000526838, 
ENST00000528610, ENST00000529272, 
ENST00000531621, ENST00000532400, 
ENST00000532741, ENST00000531770, 
Fusion gene scores* DoF score11 X 15 X 7=115536 X 16 X 12=6912
# samples 1938
** MAII scorelog2(19/1155*10)=-2.60382152797247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(38/6912*10)=-4.18503189383252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GANAB [Title/Abstract] AND EEF1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGANAB(62414033)-EEF1D(144669022), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGANAB

GO:0006491

N-glycan processing

10929008

TgeneEEF1D

GO:0071479

cellular response to ionizing radiation

8168075


check buttonFusion gene breakpoints across GANAB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EEF1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A487GANABchr11

62414033

-EEF1Dchr8

144669022

-


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Fusion Gene ORF analysis for GANAB-EEF1D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000346178ENST00000317198GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000395119GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000419152GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000423316GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000442189GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000524624GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000526838GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000528610GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000529272GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000531621GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000532400GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000346178ENST00000532741GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000317198GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000395119GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000419152GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000423316GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000442189GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000524624GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000526838GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000528610GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000529272GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000531621GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000532400GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000356638ENST00000532741GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000317198GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000395119GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000419152GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000423316GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000442189GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000524624GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000526838GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000528610GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000529272GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000531621GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000532400GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-5UTRENST00000534779ENST00000532741GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-intronENST00000346178ENST00000531770GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-intronENST00000356638ENST00000531770GANABchr11

62414033

-EEF1Dchr8

144669022

-
5CDS-intronENST00000534779ENST00000531770GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000317198GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000395119GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000419152GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000423316GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000442189GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000524624GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000526838GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000528610GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000529272GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000531621GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000532400GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-5UTRENST00000540933ENST00000532741GANABchr11

62414033

-EEF1Dchr8

144669022

-
5UTR-intronENST00000540933ENST00000531770GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000317198GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000395119GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000419152GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000423316GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000442189GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000524624GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000526838GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000528610GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000529272GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000531621GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000532400GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-5UTRENST00000534422ENST00000532741GANABchr11

62414033

-EEF1Dchr8

144669022

-
intron-intronENST00000534422ENST00000531770GANABchr11

62414033

-EEF1Dchr8

144669022

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GANAB-EEF1D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GANAB-EEF1D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:62414033/:144669022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GANAB

Q14697

EEF1D

Q658K8

FUNCTION: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GANAB-EEF1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GANAB-EEF1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GANAB-EEF1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GANAB-EEF1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource