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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GAREM-PTPRM (FusionGDB2 ID:32446)

Fusion Gene Summary for GAREM-PTPRM

check button Fusion gene summary
Fusion gene informationFusion gene name: GAREM-PTPRM
Fusion gene ID: 32446
HgeneTgene
Gene symbol

GAREM

PTPRM

Gene ID

64762

5797

Gene nameGRB2 associated regulator of MAPK1 subtype 1protein tyrosine phosphatase receptor type M
SynonymsC18orf11|FAM59A|GAREM|Gm944PTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu
Cytomap

18q12.1

18p11.23

Type of geneprotein-codingprotein-coding
DescriptionGRB2-associated and regulator of MAPK protein 1GRB2 associated regulator of MAPK1 1GRB2 associated, regulator of MAPK1GRB2-associated and regulator of MAPK1Grb2-associated and regulator of Erk/MAPKfamily with sequence similarity 59, member Aprotein receptor-type tyrosine-protein phosphatase muprotein tyrosine phosphatase muprotein tyrosine phosphatase, receptor type, mu polypeptide
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269209, ENST00000399218, 
ENST00000578619, 		ENST00000444013, 
ENST00000578571, ENST00000332175, 
ENST00000400053, ENST00000400060, 
ENST00000580170, 
Fusion gene scores* DoF score3 X 2 X 3=1820 X 18 X 6=2160
# samples 321
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(21/2160*10)=-3.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAREM [Title/Abstract] AND PTPRM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGAREM(29972858)-PTPRM(7888104), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAREM

GO:0007173

epidermal growth factor receptor signaling pathway

19509291

HgeneGAREM

GO:0008284

positive regulation of cell proliferation

19509291

HgeneGAREM

GO:0071364

cellular response to epidermal growth factor stimulus

19509291

TgenePTPRM

GO:0006470

protein dephosphorylation

8393854|10809770

TgenePTPRM

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

8393854

TgenePTPRM

GO:0007165

signal transduction

15080886

TgenePTPRM

GO:0031175

neuron projection development

16380380

TgenePTPRM

GO:0031290

retinal ganglion cell axon guidance

15080886

TgenePTPRM

GO:0042493

response to drug

18566238


check buttonFusion gene breakpoints across GAREM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2GB-06AGAREMchr18

29972858

-PTPRMchr18

7888104

+


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Fusion Gene ORF analysis for GAREM-PTPRM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000269209ENST00000444013GAREMchr18

29972858

-PTPRMchr18

7888104

+
5CDS-intronENST00000269209ENST00000578571GAREMchr18

29972858

-PTPRMchr18

7888104

+
5CDS-intronENST00000399218ENST00000444013GAREMchr18

29972858

-PTPRMchr18

7888104

+
5CDS-intronENST00000399218ENST00000578571GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000269209ENST00000332175GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000269209ENST00000400053GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000269209ENST00000400060GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000269209ENST00000580170GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000399218ENST00000332175GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000399218ENST00000400053GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000399218ENST00000400060GAREMchr18

29972858

-PTPRMchr18

7888104

+
In-frameENST00000399218ENST00000580170GAREMchr18

29972858

-PTPRMchr18

7888104

+
intron-3CDSENST00000578619ENST00000332175GAREMchr18

29972858

-PTPRMchr18

7888104

+
intron-3CDSENST00000578619ENST00000400053GAREMchr18

29972858

-PTPRMchr18

7888104

+
intron-3CDSENST00000578619ENST00000400060GAREMchr18

29972858

-PTPRMchr18

7888104

+
intron-3CDSENST00000578619ENST00000580170GAREMchr18

29972858

-PTPRMchr18

7888104

+
intron-intronENST00000578619ENST00000444013GAREMchr18

29972858

-PTPRMchr18

7888104

+
intron-intronENST00000578619ENST00000578571GAREMchr18

29972858

-PTPRMchr18

7888104

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399218GAREMchr1829972858-ENST00000580170PTPRMchr187888104+50263185645191487
ENST00000399218GAREMchr1829972858-ENST00000332175PTPRMchr187888104+51803185644801474
ENST00000399218GAREMchr1829972858-ENST00000400060PTPRMchr187888104+45233185645221489
ENST00000399218GAREMchr1829972858-ENST00000400053PTPRMchr187888104+51753185644801474
ENST00000269209GAREMchr1829972858-ENST00000580170PTPRMchr187888104+4974266444671487
ENST00000269209GAREMchr1829972858-ENST00000332175PTPRMchr187888104+5128266444281474
ENST00000269209GAREMchr1829972858-ENST00000400060PTPRMchr187888104+4471266444701489
ENST00000269209GAREMchr1829972858-ENST00000400053PTPRMchr187888104+5123266444281474

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399218ENST00000580170GAREMchr1829972858-PTPRMchr187888104+0.0005932650.9994067
ENST00000399218ENST00000332175GAREMchr1829972858-PTPRMchr187888104+0.00063590.9993641
ENST00000399218ENST00000400060GAREMchr1829972858-PTPRMchr187888104+0.0008261360.9991738
ENST00000399218ENST00000400053GAREMchr1829972858-PTPRMchr187888104+0.0006270190.999373
ENST00000269209ENST00000580170GAREMchr1829972858-PTPRMchr187888104+0.0005863160.9994137
ENST00000269209ENST00000332175GAREMchr1829972858-PTPRMchr187888104+0.0006286010.99937147
ENST00000269209ENST00000400060GAREMchr1829972858-PTPRMchr187888104+0.0008152520.9991848
ENST00000269209ENST00000400053GAREMchr1829972858-PTPRMchr187888104+0.0006197980.99938023

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Fusion Genomic Features for GAREM-PTPRM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GAREMchr1829972857-PTPRMchr187888103+0.0001163440.99988365
GAREMchr1829972857-PTPRMchr187888103+0.0001163440.99988365

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GAREM-PTPRM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:29972858/chr18:7888104)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRMchr18:29972858chr18:7888104ENST000003321751311186_1448651453.0DomainTyrosine-protein phosphatase 2
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131186_277651453.0DomainNote=Ig-like C2-type
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131284_379651453.0DomainFibronectin type-III 1
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131382_480651453.0DomainFibronectin type-III 2
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131482_587651453.0DomainFibronectin type-III 3
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131589_671651453.0DomainFibronectin type-III 4
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131900_1154651453.0DomainTyrosine-protein phosphatase 1
TgenePTPRMchr18:29972858chr18:7888104ENST000005801701331186_1448651466.0DomainTyrosine-protein phosphatase 2
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133186_277651466.0DomainNote=Ig-like C2-type
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133284_379651466.0DomainFibronectin type-III 1
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133382_480651466.0DomainFibronectin type-III 2
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133482_587651466.0DomainFibronectin type-III 3
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133589_671651466.0DomainFibronectin type-III 4
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133900_1154651466.0DomainTyrosine-protein phosphatase 1
TgenePTPRMchr18:29972858chr18:7888104ENST000003321751311095_1101651453.0RegionSubstrate binding
TgenePTPRMchr18:29972858chr18:7888104ENST000005801701331095_1101651466.0RegionSubstrate binding
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131765_1452651453.0Topological domainCytoplasmic
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133765_1452651466.0Topological domainCytoplasmic
TgenePTPRMchr18:29972858chr18:7888104ENST00000332175131743_764651453.0TransmembraneHelical
TgenePTPRMchr18:29972858chr18:7888104ENST00000580170133743_764651466.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAREMchr18:29972858chr18:7888104ENST00000269209-26512_56687877.0Compositional biasNote=Pro-rich
HgeneGAREMchr18:29972858chr18:7888104ENST00000399218-26512_56687876.0Compositional biasNote=Pro-rich
HgeneGAREMchr18:29972858chr18:7888104ENST00000269209-26811_87687877.0DomainNote=SAM
HgeneGAREMchr18:29972858chr18:7888104ENST00000399218-26811_87687876.0DomainNote=SAM
HgeneGAREMchr18:29972858chr18:7888104ENST00000269209-2612_32087877.0RegionNote=CABIT
HgeneGAREMchr18:29972858chr18:7888104ENST00000399218-2612_32087876.0RegionNote=CABIT
TgenePTPRMchr18:29972858chr18:7888104ENST0000033217513122_184651453.0DomainMAM
TgenePTPRMchr18:29972858chr18:7888104ENST0000058017013322_184651466.0DomainMAM
TgenePTPRMchr18:29972858chr18:7888104ENST0000033217513121_742651453.0Topological domainExtracellular
TgenePTPRMchr18:29972858chr18:7888104ENST0000058017013321_742651466.0Topological domainExtracellular


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Fusion Gene Sequence for GAREM-PTPRM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32446_32446_1_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000332175_length(transcript)=5128nt_BP=266nt
GAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCAAGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCAC
TTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAGAGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCG
CCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGGGTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTC
TTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCAT
CGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAA
TCCTATCTGGAATATATCTGGAGACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGT
GATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCA
CTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAG
GCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGT
TGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGT
AGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCAT
CAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAG
CTATAAAATTGGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGG
TCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCAC
TATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGA
ACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACTCACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGT
GAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCAC
TGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGA
GATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCA
TTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAA
CCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCAT
GCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGAC
AGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGC
AGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAG
CTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCC
GAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATT
TCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGAT
GGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAG
ATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGATGAAACCCACAC
AATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCA
CCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTT
CTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCA
TTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCAATCA
TTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGT
GACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAAT
AGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCA
CTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAG
TGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAG
GGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTAT
CCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACT
GGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCAT
CGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGG
GGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACAC
AGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACA
GTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGAT
ATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACAC
ACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGT
GCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGT
CTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGGA
ATACTTGAATTCTGGCTGATGGTGTAAACAGCTCTGCAAACAATCCCTTTCATACCACAAAGCCAAGACGTTCCATGGTATTTGTGCAAA
AGAGATGAAGACTTCTCAATATGCTTATTTTGCTTTGCATAATTGGCTCTTTTTAAGAGCCCAAGAAAGTGTTTCTAAAATTGCTTGCAC
TGCCCAATCCCAGTAATGCTGCTGCCTGACAGAAACACACACACAGCCACAGTTGCCAAATCCCGTACTCCTTGCCACCGGCTTCCTAGA
GCAGCGTAGACAGCTGGTAAACTGAAGAGCACAACTATATTCTTATGAAGGAATTTGTACCTTTGGGGTATTATTTTGTGGCCCGTGACC
CTCGTTATTGTTACAGCTGAGTGTATGTTTTTGTTCTGTGGAGAATGCTATCTGGCATTATGGTAATATATTATTTTAGGTAATATTTGT
ACTTTAACATGTTGCATAATATATGCTTATGTAGCTTTCCAGGACTAACAGATAAATGTGTAATGAACAAAGATATGTTGTATGAGTCGT
CGTTTCTGTCAGATTTGTATTGTTTCCAAGGGAAAAGCTTGGGGGAGGACTCAGTTCACAAAATGCAAAACTCAACGATCAGATTCACGG

>32446_32446_1_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000332175_length(amino acids)=1474AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHP
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY
IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHF
TGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
DAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE
SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIF
RIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVF

--------------------------------------------------------------
>32446_32446_2_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000400053_length(transcript)=5123nt_BP=266nt
GAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCAAGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCAC
TTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAGAGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCG
CCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGGGTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTC
TTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCAT
CGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAA
TCCTATCTGGAATATATCTGGAGACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGT
GATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCA
CTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAG
GCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGT
TGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGT
AGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCAT
CAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAG
CTATAAAATTGGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGG
TCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCAC
TATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGA
ACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACTCACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGT
GAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCAC
TGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGA
GATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCA
TTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAA
CCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCAT
GCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGAC
AGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGC
AGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAG
CTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCC
GAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATT
TCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGAT
GGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAG
ATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGATGAAACCCACAC
AATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCA
CCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTT
CTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCA
TTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCAATCA
TTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGT
GACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAAT
AGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCA
CTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAG
TGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAG
GGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTAT
CCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACT
GGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCAT
CGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGG
GGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACAC
AGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACA
GTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGAT
ATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACAC
ACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGT
GCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGT
CTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGGA
ATACTTGAATTCTGGCTGATGGTGTAAACAGCTCTGCAAACAATCCCTTTCATACCACAAAGCCAAGACGTTCCATGGTATTTGTGCAAA
AGAGATGAAGACTTCTCAATATGCTTATTTTGCTTTGCATAATTGGCTCTTTTTAAGAGCCCAAGAAAGTGTTTCTAAAATTGCTTGCAC
TGCCCAATCCCAGTAATGCTGCTGCCTGACAGAAACACACACACAGCCACAGTTGCCAAATCCCGTACTCCTTGCCACCGGCTTCCTAGA
GCAGCGTAGACAGCTGGTAAACTGAAGAGCACAACTATATTCTTATGAAGGAATTTGTACCTTTGGGGTATTATTTTGTGGCCCGTGACC
CTCGTTATTGTTACAGCTGAGTGTATGTTTTTGTTCTGTGGAGAATGCTATCTGGCATTATGGTAATATATTATTTTAGGTAATATTTGT
ACTTTAACATGTTGCATAATATATGCTTATGTAGCTTTCCAGGACTAACAGATAAATGTGTAATGAACAAAGATATGTTGTATGAGTCGT
CGTTTCTGTCAGATTTGTATTGTTTCCAAGGGAAAAGCTTGGGGGAGGACTCAGTTCACAAAATGCAAAACTCAACGATCAGATTCACGG

>32446_32446_2_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000400053_length(amino acids)=1474AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHP
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY
IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHF
TGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
DAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE
SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIF
RIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVF

--------------------------------------------------------------
>32446_32446_3_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000400060_length(transcript)=4471nt_BP=266nt
GAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCAAGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCAC
TTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAGAGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCG
CCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGGGTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTC
TTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCAT
CGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAA
TCCTATCTGGAATATATCTGGAGACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGT
GATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCA
CTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAG
GCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGT
TGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGT
AGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCAT
CAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAG
CTATAAAATTGGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGG
TCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCAC
TATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGA
ACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACTCACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGT
GAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCAC
TGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGA
GATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCA
TTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAA
CCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCAT
GCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGAC
AGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGC
AGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAG
CTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCC
GAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATT
TCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGAT
GGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAG
ATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGACCCATTTGTGCC
AACTGCAATTTTAGACTTTTCTCTAAACAATGAAACCCACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAA
GCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAA
GTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAA
CAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCATTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTA
TATCAATGGCAATTATATCGATGGTTATCATCGACCCAATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTG
GAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGTGACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCC
AGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGA
AAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCT
GCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGG
CTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACG
GAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCC
TGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACTGGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCT
AAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCT
GCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACAGCTATAAACA
GCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGT
AGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGA
ATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGT
GCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAA
GTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAG
CATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGA

>32446_32446_3_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000400060_length(amino acids)=1489AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILDFSLNNETHTMASDTSSLVQSHTYKKR
EPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYI
NGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEK
RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR
VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILP
PDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEF
VSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISI

--------------------------------------------------------------
>32446_32446_4_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000580170_length(transcript)=4974nt_BP=266nt
GAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCAAGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCAC
TTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAGAGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCG
CCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGGGTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTC
TTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCAT
CGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAA
TCCTATCTGGAATATATCTGGAGACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGT
GATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCA
CTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAG
GCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGT
TGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGT
AGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCAT
CAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAG
CTATAAAATTGGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGG
TCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCAC
TATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGA
ACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACTCACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGT
GAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCAC
TGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGA
GATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCA
TTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAA
CCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCAT
GCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGAC
AGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGC
AGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAG
CTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCC
GAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATT
TCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGAT
GGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAG
ATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGACCCATTTGTGCC
AACTGCAATTTTAGTGCCAATAAATGATGAAACCCACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAAGCG
AGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTG
TGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAACAG
AATGAAGAACAGATACGGGAATATCATTGCATACGATCATTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATAT
CAATGGCAATTATATCGATGGTTATCATCGACCCAATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTGGAG
GATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGTGACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGA
TGACACAGAGATATATAAAGACATTAAAGTTACCCTAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGAAAA
GAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCT
GGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGGCTG
TTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAG
GGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCCTGC
TTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACTGGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAA
CATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCTGCC
CCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCC
TTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGTAGT
TATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATT
TGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGTGCA
GCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTG
GCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAGCAT
CGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCT
CCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGGAATACTTGAATTCTGGCTGATGGTGTAAACAGCTCTGCAAACAATCCCTTTC
ATACCACAAAGCCAAGACGTTCCATGGTATTTGTGCAAAAGAGATGAAGACTTCTCAATATGCTTATTTTGCTTTGCATAATTGGCTCTT
TTTAAGAGCCCAAGAAAGTGTTTCTAAAATTGCTTGCACTGCCCAATCCCAGTAATGCTGCTGCCTGACAGAAACACACACACAGCCACA
GTTGCCAAATCCCGTACTCCTTGCCACCGGCTTCCTAGAGCAGCGTAGACAGCTGGTAAACTGAAGAGCACAACTATATTCTTATGAAGG
AATTTGTACCTTTGGGGTATTATTTTGTGGCCCGTGACCCTCGTTATTGTTACAGCTGAGTGTATGTTTTTGTTCTGTGGAGAATGCTAT
CTGGCATTATGGTAATATATTATTTTAGGTAATATTTGTACTTTAACATGTTGCATAATATATGCTTATGTAGCTTTCCAGGACTAACAG

>32446_32446_4_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000269209_PTPRM_chr18_7888104_ENST00000580170_length(amino acids)=1487AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKRE
PADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYIN
GNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKR
GVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV
NMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPP
DRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFV
SADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIV

--------------------------------------------------------------
>32446_32446_5_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000332175_length(transcript)=5180nt_BP=318nt
GCGGGTGGTGCCGGTGGCGGCGGCGGGGGAGCGCGGGACAGGAGGCTTCGGGGAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCA
AGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCACTTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAG
AGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCGCCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGG
GTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTCTTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGC
AGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTC
CTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACAT
GGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATC
TCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCC
AGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTC
TGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCT
GCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGC
TCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGT
ACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACCCAGATACAGAATATG
AGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCA
TGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTT
GCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACT
CACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAA
GCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATAT
TTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAA
TAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACT
CCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAG
CTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTG
TCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCC
AGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTG
ATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATG
GGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATA
CAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGG
CCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCA
CAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAA
ATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGATGAAACCCACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATA
CTTACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCA
CACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGA
AAGATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCATTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAA
ACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCAATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCT
ATGACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGTGACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCA
AATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACAT
TTGCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATG
CCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAG
GGAGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGC
TGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACA
CCTCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACTGGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAAT
TCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCA
TGGACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACA
GCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACT
GCACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCA
TCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGAT
ATCGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCC
AGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCT
GCGCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCA
ACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGGAATACTTGAATTCTGGCTGATGGTGTAAACAGCTCTGCA
AACAATCCCTTTCATACCACAAAGCCAAGACGTTCCATGGTATTTGTGCAAAAGAGATGAAGACTTCTCAATATGCTTATTTTGCTTTGC
ATAATTGGCTCTTTTTAAGAGCCCAAGAAAGTGTTTCTAAAATTGCTTGCACTGCCCAATCCCAGTAATGCTGCTGCCTGACAGAAACAC
ACACACAGCCACAGTTGCCAAATCCCGTACTCCTTGCCACCGGCTTCCTAGAGCAGCGTAGACAGCTGGTAAACTGAAGAGCACAACTAT
ATTCTTATGAAGGAATTTGTACCTTTGGGGTATTATTTTGTGGCCCGTGACCCTCGTTATTGTTACAGCTGAGTGTATGTTTTTGTTCTG
TGGAGAATGCTATCTGGCATTATGGTAATATATTATTTTAGGTAATATTTGTACTTTAACATGTTGCATAATATATGCTTATGTAGCTTT
CCAGGACTAACAGATAAATGTGTAATGAACAAAGATATGTTGTATGAGTCGTCGTTTCTGTCAGATTTGTATTGTTTCCAAGGGAAAAGC
TTGGGGGAGGACTCAGTTCACAAAATGCAAAACTCAACGATCAGATTCACGGACCCAGAGCTTTTCCATGTGTTTATATTGTAAATATTT

>32446_32446_5_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000332175_length(amino acids)=1474AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHP
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY
IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHF
TGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
DAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE
SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIF
RIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVF

--------------------------------------------------------------
>32446_32446_6_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000400053_length(transcript)=5175nt_BP=318nt
GCGGGTGGTGCCGGTGGCGGCGGCGGGGGAGCGCGGGACAGGAGGCTTCGGGGAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCA
AGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCACTTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAG
AGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCGCCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGG
GTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTCTTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGC
AGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTC
CTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACAT
GGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATC
TCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCC
AGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTC
TGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCT
GCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGC
TCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGT
ACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACCCAGATACAGAATATG
AGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCA
TGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTT
GCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACT
CACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAA
GCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATAT
TTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAA
TAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACT
CCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAG
CTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTG
TCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCC
AGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTG
ATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATG
GGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATA
CAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGG
CCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCA
CAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAA
ATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGATGAAACCCACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATA
CTTACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCA
CACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGA
AAGATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCATTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAA
ACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCAATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCT
ATGACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGTGACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCA
AATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACAT
TTGCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATG
CCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAG
GGAGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGC
TGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACA
CCTCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACTGGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAAT
TCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCA
TGGACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACA
GCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACT
GCACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCA
TCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGAT
ATCGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCC
AGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCT
GCGCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCA
ACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGGAATACTTGAATTCTGGCTGATGGTGTAAACAGCTCTGCA
AACAATCCCTTTCATACCACAAAGCCAAGACGTTCCATGGTATTTGTGCAAAAGAGATGAAGACTTCTCAATATGCTTATTTTGCTTTGC
ATAATTGGCTCTTTTTAAGAGCCCAAGAAAGTGTTTCTAAAATTGCTTGCACTGCCCAATCCCAGTAATGCTGCTGCCTGACAGAAACAC
ACACACAGCCACAGTTGCCAAATCCCGTACTCCTTGCCACCGGCTTCCTAGAGCAGCGTAGACAGCTGGTAAACTGAAGAGCACAACTAT
ATTCTTATGAAGGAATTTGTACCTTTGGGGTATTATTTTGTGGCCCGTGACCCTCGTTATTGTTACAGCTGAGTGTATGTTTTTGTTCTG
TGGAGAATGCTATCTGGCATTATGGTAATATATTATTTTAGGTAATATTTGTACTTTAACATGTTGCATAATATATGCTTATGTAGCTTT
CCAGGACTAACAGATAAATGTGTAATGAACAAAGATATGTTGTATGAGTCGTCGTTTCTGTCAGATTTGTATTGTTTCCAAGGGAAAAGC
TTGGGGGAGGACTCAGTTCACAAAATGCAAAACTCAACGATCAGATTCACGGACCCAGAGCTTTTCCATGTGTTTATATTGTAAATATTT

>32446_32446_6_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000400053_length(amino acids)=1474AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHP
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY
IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHF
TGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
DAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE
SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIF
RIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVF

--------------------------------------------------------------
>32446_32446_7_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000400060_length(transcript)=4523nt_BP=318nt
GCGGGTGGTGCCGGTGGCGGCGGCGGGGGAGCGCGGGACAGGAGGCTTCGGGGAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCA
AGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCACTTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAG
AGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCGCCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGG
GTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTCTTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGC
AGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTC
CTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACAT
GGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATC
TCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCC
AGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTC
TGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCT
GCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGC
TCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGT
ACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACCCAGATACAGAATATG
AGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCA
TGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTT
GCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACT
CACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAA
GCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATAT
TTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAA
TAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACT
CCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAG
CTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTG
TCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCC
AGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTG
ATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATG
GGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATA
CAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGG
CCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCA
CAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAA
ATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGACCCATTTGTGCCAACTGCAATTTTAGACTTTTCTCTAAACAATGAAACCC
ACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGC
TCCACCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGA
GCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACG
ATCATTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCA
ATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCA
TGGTGACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCC
TAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGT
TTCACTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGC
CCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCG
AAAGGGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGT
TTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACA
AACTGGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCA
GCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCG
ATGGGGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAA
ACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTC
CACAGTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCA
GGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGG
ACACACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGG
TTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGG
ATGTCTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCC

>32446_32446_7_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000400060_length(amino acids)=1489AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILDFSLNNETHTMASDTSSLVQSHTYKKR
EPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYI
NGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEK
RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR
VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILP
PDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEF
VSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISI

--------------------------------------------------------------
>32446_32446_8_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000580170_length(transcript)=5026nt_BP=318nt
GCGGGTGGTGCCGGTGGCGGCGGCGGGGGAGCGCGGGACAGGAGGCTTCGGGGAAGATGGACCCGGCGCCCTCGCTGGGCTGCAGCCTCA
AGGATGTGAAGTGGAGCTCGGTGGCCGTGCCGCTCGACCTCCTGGTCAGCACTTACCGGCTGCCCCAGATCGCGCGCCTGGACAACGGAG
AGTGCGTAGAAGGGCTGCGGGAAAATGACTATCTGCTGATTCATTCCTGCCGCCAGTGGACCACCATCACTGCCCACAGCTTGGAGGAGG
GTCACTATGTCATTGGGCCAAAGATAGAGATTCCGGTACATTATGCAGGTTCTTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGC
AGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTC
CTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACAT
GGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATC
TCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCC
AGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTC
TGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCT
GCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGC
TCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGT
ACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACCCAGATACAGAATATG
AGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCA
TGCGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGGGAGCCATTTGGATATAATGTAACTCGTT
GCCACAGTTATAATCTCACTGTCCACTACTGTTACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACT
CACACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATCCTCATGAACCCAGAGGGCCGGAAGGAAA
GCCAAGAACTCATAGTGCAGACAGATGAAGACCTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATAT
TTCTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTACAAAGCAGTCAGTTCCTTTGACCCAGAAA
TAGATTTATCCAATCAGAGTGGAAGAGTTTCAAAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACT
CCTTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACCACCAAAATATCAGCACCCTCTATGCCAG
CTTATGAACTTGAGACACCTTTGAATCAAACTGACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTG
TCTATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTAAAGTGCTACCCAGTGCCAATTCACTTCC
AGAATGCTTCTCTGCTGAACTCACAGTACTACTTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTG
ATAATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATTTATTTCCAAGCTGCTAGTAGAGCCAATG
GGGAAACCAAAATAGACTGTGTCCAAGTGGCCACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATA
CAGTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTTGTGTTGGTAATGAAGAAAAGGAAACTGG
CCAAGAAGCGGAAAGAGACCATGAGCAGCACCCGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCA
CAAACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCTTCACCATCGTCCTTCACAATGAAAACAA
ATACACTGAGCACATCGGTGCCTAATTCCTATTACCCAGACCCATTTGTGCCAACTGCAATTTTAGTGCCAATAAATGATGAAACCCACA
CAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCC
ACCCCGCCATCCGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCT
TCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATC
ATTCCCGAGTGAGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCAATC
ATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGG
TGACCAATCTTGTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAA
TAGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTC
ACTTCACTGGCTGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCA
GTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAA
GGGAAGGGGTCGTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTA
TCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAAC
TGGATCCACAGACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCA
TCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATG
GGGAGAGCAGCAACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACA
CAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCAC
AGTACTGGCCAGAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGA
TATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACA
CACCAGTGTCTAAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTG
TGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATG
TCTTTCACGCTGTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGG
AATACTTGAATTCTGGCTGATGGTGTAAACAGCTCTGCAAACAATCCCTTTCATACCACAAAGCCAAGACGTTCCATGGTATTTGTGCAA
AAGAGATGAAGACTTCTCAATATGCTTATTTTGCTTTGCATAATTGGCTCTTTTTAAGAGCCCAAGAAAGTGTTTCTAAAATTGCTTGCA
CTGCCCAATCCCAGTAATGCTGCTGCCTGACAGAAACACACACACAGCCACAGTTGCCAAATCCCGTACTCCTTGCCACCGGCTTCCTAG
AGCAGCGTAGACAGCTGGTAAACTGAAGAGCACAACTATATTCTTATGAAGGAATTTGTACCTTTGGGGTATTATTTTGTGGCCCGTGAC
CCTCGTTATTGTTACAGCTGAGTGTATGTTTTTGTTCTGTGGAGAATGCTATCTGGCATTATGGTAATATATTATTTTAGGTAATATTTG

>32446_32446_8_GAREM-PTPRM_GAREM_chr18_29972858_ENST00000399218_PTPRM_chr18_7888104_ENST00000580170_length(amino acids)=1487AA_BP=86
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGSF
MLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVI
FEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV
NTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSY
KIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ
VREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEI
TYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML
KPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSY
RIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMV
NSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKRE
PADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYIN
GNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKR
GVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV
NMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPP
DRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFV
SADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GAREM-PTPRM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GAREM-PTPRM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GAREM-PTPRM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource