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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AK5-LY6E (FusionGDB2 ID:3247)

Fusion Gene Summary for AK5-LY6E

check button Fusion gene summary
Fusion gene informationFusion gene name: AK5-LY6E
Fusion gene ID: 3247
HgeneTgene
Gene symbol

AK5

LY6E

Gene ID

26289

4061

Gene nameadenylate kinase 5lymphocyte antigen 6 family member E
SynonymsAK6RIG-E|RIGE|SCA-2|SCA2|TSA-1
Cytomap

1p31.1

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6lymphocyte antigen 6Ely-6Elymphocyte antigen 6 complex, locus Eretinoic acid induced gene Eretinoic acid-induced gene E proteinstem cell antigen 2thymic shared antigen 1
Modification date2020031320200313
UniProtAcc.

Q16553

Ensembl transtripts involved in fusion geneENST00000317704, ENST00000344720, 
ENST00000354567, ENST00000478255, 
ENST00000292494, ENST00000429120, 
ENST00000517503, ENST00000519546, 
ENST00000519611, ENST00000519615, 
ENST00000520466, ENST00000520531, 
ENST00000521003, ENST00000521182, 
ENST00000521699, ENST00000522024, 
ENST00000522528, ENST00000522971, 
ENST00000523847, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 5 X 2=40
# samples 55
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AK5 [Title/Abstract] AND LY6E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAK5(77842117)-LY6E(144103826), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAK5

GO:0006165

nucleoside diphosphate phosphorylation

23416111

HgeneAK5

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check buttonFusion gene breakpoints across AK5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LY6E (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA533732AK5chr1

77842117

-LY6Echr8

144103826

-


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Fusion Gene ORF analysis for AK5-LY6E

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000317704ENST00000292494AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000429120AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000517503AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000519546AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000519611AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000519615AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000520466AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000520531AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000521003AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000521182AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000521699AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000522024AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000522528AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000522971AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000317704ENST00000523847AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000292494AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000429120AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000517503AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000519546AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000519611AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000519615AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000520466AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000520531AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000521003AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000521182AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000521699AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000522024AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000522528AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000522971AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000344720ENST00000523847AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000292494AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000429120AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000517503AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000519546AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000519611AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000519615AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000520466AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000520531AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000521003AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000521182AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000521699AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000522024AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000522528AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000522971AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000354567ENST00000523847AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000292494AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000429120AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000517503AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000519546AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000519611AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000519615AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000520466AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000520531AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000521003AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000521182AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000521699AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000522024AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000522528AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000522971AK5chr1

77842117

-LY6Echr8

144103826

-
intron-intronENST00000478255ENST00000523847AK5chr1

77842117

-LY6Echr8

144103826

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AK5-LY6E


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AK5-LY6E


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:77842117/:144103826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LY6E

Q16553

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). {ECO:0000250|UniProtKB:Q64253, ECO:0000269|PubMed:32641482}.; FUNCTION: (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477). {ECO:0000269|PubMed:28130445, ECO:0000269|PubMed:29610346, ECO:0000269|PubMed:30190477}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AK5-LY6E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AK5-LY6E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AK5-LY6E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AK5-LY6E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource