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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GAS2L3-MED13L (FusionGDB2 ID:32488) |
Fusion Gene Summary for GAS2L3-MED13L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GAS2L3-MED13L | Fusion gene ID: 32488 | Hgene | Tgene | Gene symbol | GAS2L3 | MED13L | Gene ID | 283431 | 23389 |
| Gene name | growth arrest specific 2 like 3 | mediator complex subunit 13L | |
| Synonyms | G2L3 | MRFACD|PROSIT240|THRAP2|TRAP240L | |
| Cytomap | 12q23.1 | 12q24.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GAS2-like protein 3growth arrest-specific protein 2-like 3 | mediator of RNA polymerase II transcription subunit 13-likemediator complex subunit 13 likethyroid hormone receptor-associated protein 2thyroid hormone receptor-associated protein complex 240 kDa component-like | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | . | Q71F56 | |
| Ensembl transtripts involved in fusion gene | ENST00000266754, ENST00000539410, ENST00000547754, ENST00000537247, ENST00000547739, | ENST00000551197, ENST00000281928, | |
| Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 14 X 14 X 4=784 |
| # samples | 8 | 15 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/784*10)=-2.38589115361933 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GAS2L3 [Title/Abstract] AND MED13L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GAS2L3(100995531)-MED13L(116404048), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GAS2L3 | GO:0000226 | microtubule cytoskeleton organization | 21561867 |
| Hgene | GAS2L3 | GO:0030036 | actin cytoskeleton organization | 21561867 |
| Fusion gene breakpoints across GAS2L3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MED13L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-FD-A6TB-01A | GAS2L3 | chr12 | 100995531 | - | MED13L | chr12 | 116404048 | - |
| ChimerDB4 | BLCA | TCGA-FD-A6TB-01A | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
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Fusion Gene ORF analysis for GAS2L3-MED13L |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000266754 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| 5CDS-intron | ENST00000539410 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| 5CDS-intron | ENST00000547754 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| 5UTR-3CDS | ENST00000537247 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| 5UTR-intron | ENST00000537247 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| In-frame | ENST00000266754 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| In-frame | ENST00000539410 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| In-frame | ENST00000547754 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| intron-3CDS | ENST00000547739 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| intron-intron | ENST00000547739 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000266754 | GAS2L3 | chr12 | 100995531 | + | ENST00000281928 | MED13L | chr12 | 116404048 | - | 3534 | 436 | 133 | 843 | 236 |
| ENST00000547754 | GAS2L3 | chr12 | 100995531 | + | ENST00000281928 | MED13L | chr12 | 116404048 | - | 3627 | 529 | 226 | 936 | 236 |
| ENST00000539410 | GAS2L3 | chr12 | 100995531 | + | ENST00000281928 | MED13L | chr12 | 116404048 | - | 3787 | 689 | 386 | 1096 | 236 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000266754 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - | 0.001695077 | 0.99830496 |
| ENST00000547754 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - | 0.001781175 | 0.99821883 |
| ENST00000539410 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - | 0.001729413 | 0.9982705 |
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Fusion Genomic Features for GAS2L3-MED13L |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GAS2L3-MED13L |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:100995531/chr12:116404048) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MED13L |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000266754 | + | 4 | 9 | 208_281 | 101 | 695.0 | Domain | GAR |
| Hgene | GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000266754 | + | 4 | 9 | 48_168 | 101 | 695.0 | Domain | Calponin-homology (CH) |
| Hgene | GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000539410 | + | 4 | 9 | 208_281 | 101 | 695.0 | Domain | GAR |
| Hgene | GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000539410 | + | 4 | 9 | 48_168 | 101 | 695.0 | Domain | Calponin-homology (CH) |
| Hgene | GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000547754 | + | 5 | 10 | 208_281 | 101 | 695.0 | Domain | GAR |
| Hgene | GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000547754 | + | 5 | 10 | 48_168 | 101 | 695.0 | Domain | Calponin-homology (CH) |
| Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | 27 | 31 | 1566_1610 | 2075 | 2211.0 | Compositional bias | Note=Ser-rich | |
| Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | 27 | 31 | 1225_1229 | 2075 | 2211.0 | Motif | Note=LXXLL motif 2 | |
| Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | 27 | 31 | 669_673 | 2075 | 2211.0 | Motif | Note=LXXLL motif 1 | |
| Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | 27 | 31 | 1380_1401 | 2075 | 2211.0 | Region | Note=Leucine-zipper |
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Fusion Gene Sequence for GAS2L3-MED13L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >32488_32488_1_GAS2L3-MED13L_GAS2L3_chr12_100995531_ENST00000266754_MED13L_chr12_116404048_ENST00000281928_length(transcript)=3534nt_BP=436nt CAGGCGGCGGCGGCAGCGGCGGCGGTTGGTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGAC CCTCCTGCGCCTGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAG TCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCAC TTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGA TAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCG TCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCC CCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACA GACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTT GGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCTCAC TCAGTTGTACAATGCCATCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGTCCA AGGAACCTGCTACACTCTGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGGCAC ATGTCAATTCTGCAGTGTTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAGCCA GTGCGGTGGTGTGTGTAGCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTGTCC TTTTGCACAAGAGTCTGTGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGTATG GCCTGTGGGTTACCTGAACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGTCTC CCTAGTGTTCCCATCCAGATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATTTTG TTTATTTATTTTAATTTGTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCAATT CAGATCCACCATAGGATTCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAAAAG TAATATATTCAAAACCACCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTCATG AAGGATAACATTTTTATACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAACGGA AATATATTTTCTAGTGAATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAAGTG TTTGCTCATGAAATCAGTTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATTAAA TTAGTACTTGAAGTTGAGCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGACTC CTCATTCCTGGCCCAGAGGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTACTGG CCTCCCGGGAGCCACTGTGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGACTTC CATGTCCTGGTTATTAACAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTAAAA CATTATATTAAAAAAAAAGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCAGTT GAAGGGGGGGTTGACTTTCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGACTT TAAAAATATTGCAGTGCTATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAACTT GTATAAAATTATCTTGGTGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATTCAT CAGAACTTTGAATTTTTTTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAAAAA AAACACAAAAAATAAAAAACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAGTTT TTTAAGTTAAGAAAAGCTGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATGTAC TTCTGTGTGAAAAAGTCTGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTACAAG CCCTGGATTTGCTACAGAGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCATGGT TTGAACAAAAAAAGGGGAAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATGTAA AAGCTGTACATTTCTGGGAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGCAAA CAATTTGAAAGAATACAAAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGATAA AAAGAAACAATAATAAAAGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTTAGA >32488_32488_1_GAS2L3-MED13L_GAS2L3_chr12_100995531_ENST00000266754_MED13L_chr12_116404048_ENST00000281928_length(amino acids)=236AA_BP=101 MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP -------------------------------------------------------------- >32488_32488_2_GAS2L3-MED13L_GAS2L3_chr12_100995531_ENST00000539410_MED13L_chr12_116404048_ENST00000281928_length(transcript)=3787nt_BP=689nt ATGTGGAACTCCATTTTAATAGGAGCAGCTTCTTTGCTGCATTTTTAAAAAATGGTCTTGGAAGCTTCTTACTTCCGAGAAGTGGATCTT TGTTGCGGACAAAGGATTATTTATGCTAAAGGAAAATGTATTCCCCACTGAATTAGCTCGTGGGAAGCATAACAAGCTCATTAGGAATGC TCACTTGTACTTTGGCCTTTTGCTGTGGTGGAGAGAAGGGAAAATGACATCAAAAAGGACATTCTGTTGTCTTTTGCCTTCCTGCAAAGA AAATGTGTTATAATATTAGGCTTTTCAGTATGGTTTAGCTCAGGTTCAACTTTGGTACTAGAAGAAATGTTCCTGAAAGGAAAGTGAAAA GAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGA CTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAG AAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTAT GTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAG CACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCAT CGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGC CTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTC TGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCTCACTCAGTTGTACAATGCCA TCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGTCCAAGGAACCTGCTACACTC TGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGGCACATGTCAATTCTGCAGTG TTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAGCCAGTGCGGTGGTGTGTGTA GCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTGTCCTTTTGCACAAGAGTCTG TGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGTATGGCCTGTGGGTTACCTGA ACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGTCTCCCTAGTGTTCCCATCCA GATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATTTTGTTTATTTATTTTAATTT GTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCAATTCAGATCCACCATAGGAT TCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAAAAGTAATATATTCAAAACCA CCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTCATGAAGGATAACATTTTTAT ACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAACGGAAATATATTTTCTAGTGA ATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAAGTGTTTGCTCATGAAATCAG TTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATTAAATTAGTACTTGAAGTTGA GCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGACTCCTCATTCCTGGCCCAGA GGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTACTGGCCTCCCGGGAGCCACTG TGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGACTTCCATGTCCTGGTTATTAA CAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTAAAACATTATATTAAAAAAAA AGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCAGTTGAAGGGGGGGTTGACTT TCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGACTTTAAAAATATTGCAGTGC TATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAACTTGTATAAAATTATCTTGG TGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATTCATCAGAACTTTGAATTTTT TTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAAAAAAAACACAAAAAATAAAA AACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAGTTTTTTAAGTTAAGAAAAGC TGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATGTACTTCTGTGTGAAAAAGTC TGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTACAAGCCCTGGATTTGCTACAG AGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCATGGTTTGAACAAAAAAAGGGG AAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATGTAAAAGCTGTACATTTCTGG GAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGCAAACAATTTGAAAGAATACA AAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGATAAAAAGAAACAATAATAAA AGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTTAGAGGAATAAATTATTGAAT >32488_32488_2_GAS2L3-MED13L_GAS2L3_chr12_100995531_ENST00000539410_MED13L_chr12_116404048_ENST00000281928_length(amino acids)=236AA_BP=101 MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP -------------------------------------------------------------- >32488_32488_3_GAS2L3-MED13L_GAS2L3_chr12_100995531_ENST00000547754_MED13L_chr12_116404048_ENST00000281928_length(transcript)=3627nt_BP=529nt GTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGACCCTCCTGCGCCTGATCAGAACACTGAGG CTCAGAGAAGTTAACTACTCCAAAGTCATATAGCCAGTATTTTCTGGAGCTGTAATTCAAATCAGATGTGTTCAATACCTTCTACTACCC CATTGCTGTCTTTATGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCT AAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGC CACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACT TGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGA GCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCT TCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGC ACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGT TTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCT CACTCAGTTGTACAATGCCATCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGT CCAAGGAACCTGCTACACTCTGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGG CACATGTCAATTCTGCAGTGTTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAG CCAGTGCGGTGGTGTGTGTAGCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTG TCCTTTTGCACAAGAGTCTGTGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGT ATGGCCTGTGGGTTACCTGAACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGT CTCCCTAGTGTTCCCATCCAGATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATT TTGTTTATTTATTTTAATTTGTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCA ATTCAGATCCACCATAGGATTCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAA AAGTAATATATTCAAAACCACCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTC ATGAAGGATAACATTTTTATACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAAC GGAAATATATTTTCTAGTGAATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAA GTGTTTGCTCATGAAATCAGTTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATT AAATTAGTACTTGAAGTTGAGCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGA CTCCTCATTCCTGGCCCAGAGGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTAC TGGCCTCCCGGGAGCCACTGTGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGAC TTCCATGTCCTGGTTATTAACAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTA AAACATTATATTAAAAAAAAAGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCA GTTGAAGGGGGGGTTGACTTTCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGA CTTTAAAAATATTGCAGTGCTATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAA CTTGTATAAAATTATCTTGGTGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATT CATCAGAACTTTGAATTTTTTTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAA AAAAAACACAAAAAATAAAAAACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAG TTTTTTAAGTTAAGAAAAGCTGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATG TACTTCTGTGTGAAAAAGTCTGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTAC AAGCCCTGGATTTGCTACAGAGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCAT GGTTTGAACAAAAAAAGGGGAAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATG TAAAAGCTGTACATTTCTGGGAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGC AAACAATTTGAAAGAATACAAAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGA TAAAAAGAAACAATAATAAAAGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTT >32488_32488_3_GAS2L3-MED13L_GAS2L3_chr12_100995531_ENST00000547754_MED13L_chr12_116404048_ENST00000281928_length(amino acids)=236AA_BP=101 MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GAS2L3-MED13L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GAS2L3-MED13L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GAS2L3-MED13L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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