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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GAS6-GTPBP4 (FusionGDB2 ID:32533)

Fusion Gene Summary for GAS6-GTPBP4

Fusion gene summary

Fusion gene information	Fusion gene name: GAS6-GTPBP4
	Fusion gene ID: 32533
		Hgene	Tgene
	Gene symbol	GAS6	GTPBP4
	Gene ID	2621	23560
	Gene name	growth arrest specific 6	GTP binding protein 4
	Synonyms	AXLLG\|AXSF	CRFG\|NGB\|NOG1
	Cytomap	13q34	10p15.3
	Type of gene	protein-coding	protein-coding
	Description	growth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factor	nucleolar GTP-binding protein 1G protein-binding protein CRFGGTP-binding protein NGBchronic renal failure gene protein
	Modification date	20200313	20200313
	UniProtAcc	Q14393	Q9BZE4
	Ensembl transtripts involved in fusion gene	ENST00000327773, ENST00000357389, ENST00000476291, ENST00000355761, ENST00000418959, ENST00000450766,	ENST00000491635, ENST00000538293, ENST00000545048, ENST00000360803,
Fusion gene scores	* DoF score	21 X 12 X 12=3024	5 X 5 X 2=50
	# samples	29	5
	** MAII score	log2(29/3024*10)=-3.38233333420614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/50*10)=0
Context	PubMed: GAS6 [Title/Abstract] AND GTPBP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GAS6(114566547)-GTPBP4(1060186), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GAS6	GO:0001934	positive regulation of protein phosphorylation	7854420\|16723520\|20103767
Hgene	GAS6	GO:0006468	protein phosphorylation	16359517
Hgene	GAS6	GO:0006909	phagocytosis	21501828
Hgene	GAS6	GO:0007165	signal transduction	7854420\|18680538
Hgene	GAS6	GO:0010628	positive regulation of gene expression	19657094
Hgene	GAS6	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	19657094
Hgene	GAS6	GO:0018105	peptidyl-serine phosphorylation	18680538\|20103767
Hgene	GAS6	GO:0019064	fusion of virus membrane with host plasma membrane	21501828
Hgene	GAS6	GO:0019079	viral genome replication	21501828
Hgene	GAS6	GO:0032689	negative regulation of interferon-gamma production	18840707
Hgene	GAS6	GO:0032715	negative regulation of interleukin-6 production	19657094
Hgene	GAS6	GO:0032720	negative regulation of tumor necrosis factor production	19657094\|20103767
Hgene	GAS6	GO:0032825	positive regulation of natural killer cell differentiation	18840707
Hgene	GAS6	GO:0033138	positive regulation of peptidyl-serine phosphorylation	16723520
Hgene	GAS6	GO:0035457	cellular response to interferon-alpha	19657094
Hgene	GAS6	GO:0035690	cellular response to drug	16359517
Hgene	GAS6	GO:0035754	B cell chemotaxis	19922767
Hgene	GAS6	GO:0043066	negative regulation of apoptotic process	19922767
Hgene	GAS6	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	16723520
Hgene	GAS6	GO:0043277	apoptotic cell clearance	21501828
Hgene	GAS6	GO:0043433	negative regulation of DNA-binding transcription factor activity	18680538
Hgene	GAS6	GO:0043491	protein kinase B signaling	16723520\|20103767
Hgene	GAS6	GO:0045860	positive regulation of protein kinase activity	7854420
Hgene	GAS6	GO:0045892	negative regulation of transcription, DNA-templated	18680538
Hgene	GAS6	GO:0046718	viral entry into host cell	21501828
Hgene	GAS6	GO:0046813	receptor-mediated virion attachment to host cell	21501828
Hgene	GAS6	GO:0046827	positive regulation of protein export from nucleus	18680538
Hgene	GAS6	GO:0048146	positive regulation of fibroblast proliferation	7854420\|15184064
Hgene	GAS6	GO:0050711	negative regulation of interleukin-1 secretion	20103767
Hgene	GAS6	GO:0050766	positive regulation of phagocytosis	18395422
Hgene	GAS6	GO:0051897	positive regulation of protein kinase B signaling	16359517\|16723520\|18680538
Hgene	GAS6	GO:0061098	positive regulation of protein tyrosine kinase activity	20103767
Hgene	GAS6	GO:0070168	negative regulation of biomineral tissue development	20048160
Hgene	GAS6	GO:0070374	positive regulation of ERK1 and ERK2 cascade	15184064
Hgene	GAS6	GO:0070588	calcium ion transmembrane transport	18395422
Hgene	GAS6	GO:0071307	cellular response to vitamin K	16359517
Hgene	GAS6	GO:0072659	protein localization to plasma membrane	16359517
Hgene	GAS6	GO:0097241	hematopoietic stem cell migration to bone marrow	19922767
Hgene	GAS6	GO:1900142	negative regulation of oligodendrocyte apoptotic process	16723520
Hgene	GAS6	GO:1900165	negative regulation of interleukin-6 secretion	20103767
Hgene	GAS6	GO:2000270	negative regulation of fibroblast apoptotic process	16359517
Hgene	GAS6	GO:2000352	negative regulation of endothelial cell apoptotic process	16359517\|18680538\|18760998
Hgene	GAS6	GO:2000510	positive regulation of dendritic cell chemotaxis	19657094
Hgene	GAS6	GO:2000669	negative regulation of dendritic cell apoptotic process	19657094
Tgene	GTPBP4	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	17210637
Tgene	GTPBP4	GO:0022408	negative regulation of cell-cell adhesion	17210637
Tgene	GTPBP4	GO:0030336	negative regulation of cell migration	17210637
Tgene	GTPBP4	GO:0031397	negative regulation of protein ubiquitination	17210637
Tgene	GTPBP4	GO:0050821	protein stabilization	17210637

Fusion gene breakpoints across GAS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GTPBP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-6706	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+

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Fusion Gene ORF analysis for GAS6-GTPBP4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000327773	ENST00000491635	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5CDS-intron	ENST00000327773	ENST00000538293	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5CDS-intron	ENST00000327773	ENST00000545048	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5CDS-intron	ENST00000357389	ENST00000491635	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5CDS-intron	ENST00000357389	ENST00000538293	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5CDS-intron	ENST00000357389	ENST00000545048	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5UTR-3CDS	ENST00000476291	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5UTR-intron	ENST00000476291	ENST00000491635	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5UTR-intron	ENST00000476291	ENST00000538293	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
5UTR-intron	ENST00000476291	ENST00000545048	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
In-frame	ENST00000327773	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
In-frame	ENST00000357389	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-3CDS	ENST00000355761	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-3CDS	ENST00000418959	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-3CDS	ENST00000450766	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000355761	ENST00000491635	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000355761	ENST00000538293	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000355761	ENST00000545048	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000418959	ENST00000491635	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000418959	ENST00000538293	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000418959	ENST00000545048	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000450766	ENST00000491635	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000450766	ENST00000538293	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+
intron-intron	ENST00000450766	ENST00000545048	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000357389

GAS6

chr13

114566547

ENST00000360803

GTPBP4

chr10

1060186

3480

408

842

262

ENST00000327773

GAS6

chr13

114566547

ENST00000360803

GTPBP4

chr10

1060186

3474

402

836

262

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357389	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+	0.00140883	0.9985911
ENST00000327773	ENST00000360803	GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+	0.001368202	0.9986318

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Fusion Genomic Features for GAS6-GTPBP4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+	1.69E-07	0.9999999
GAS6	chr13	114566547	-	GTPBP4	chr10	1060186	+	1.69E-07	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GAS6-GTPBP4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:114566547/chr10:1060186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GAS6 Q14393	GTPBP4 Q9BZE4
FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269\|PubMed:12364394, ECO:0000269\|PubMed:18840707}.; FUNCTION: (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). {ECO:0000269\|PubMed:17005688, ECO:0000269\|PubMed:21501828, ECO:0000269\|PubMed:23084921}.	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

116_154

679.0

Domain

EGF-like 1%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

156_196

679.0

Domain

EGF-like 2%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

197_237

679.0

Domain

EGF-like 3%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

238_278

679.0

Domain

EGF-like 4%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

298_470

679.0

Domain

Laminin G-like 1

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

477_670

679.0

Domain

Laminin G-like 2

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000327773

53_94

679.0

Domain

Gla

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

116_154

625.0

Domain

EGF-like 1%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

156_196

625.0

Domain

EGF-like 2%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

197_237

625.0

Domain

EGF-like 3%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

238_278

625.0

Domain

EGF-like 4%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

298_470

625.0

Domain

Laminin G-like 1

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

477_670

625.0

Domain

Laminin G-like 2

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000355761

53_94

625.0

Domain

Gla

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

116_154

380.0

Domain

EGF-like 1%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

156_196

380.0

Domain

EGF-like 2%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

197_237

380.0

Domain

EGF-like 3%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

238_278

380.0

Domain

EGF-like 4%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

298_470

380.0

Domain

Laminin G-like 1

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

477_670

380.0

Domain

Laminin G-like 2

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000418959

53_94

380.0

Domain

Gla

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

116_154

406.0

Domain

EGF-like 1%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

156_196

406.0

Domain

EGF-like 2%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

197_237

406.0

Domain

EGF-like 3%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

238_278

406.0

Domain

EGF-like 4%3B calcium-binding

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

298_470

406.0

Domain

Laminin G-like 1

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

477_670

406.0

Domain

Laminin G-like 2

Hgene

GAS6

chr13:114566547

chr10:1060186

ENST00000450766

53_94

406.0

Domain

Gla

Tgene

GTPBP4

chr13:114566547

chr10:1060186

ENST00000360803

169_340

514

635.0

Domain

OBG-type G

Tgene

GTPBP4

chr13:114566547

chr10:1060186

ENST00000360803

175_182

514

635.0

Nucleotide binding

GTP

Tgene

GTPBP4

chr13:114566547

chr10:1060186

ENST00000360803

221_225

514

635.0

Nucleotide binding

GTP

Tgene

GTPBP4

chr13:114566547

chr10:1060186

ENST00000360803

289_292

514

635.0

Nucleotide binding

GTP

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Fusion Gene Sequence for GAS6-GTPBP4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>32533_32533_1_GAS6-GTPBP4_GAS6_chr13_114566547_ENST00000327773_GTPBP4_chr10_1060186_ENST00000360803_length(transcript)=3474nt_BP=402nt
GCTTGAGGTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCGATGTGACCTTCAGGGCCGCCAGGACGGGATGACCGGAGCCTCCGCCCCGCG
GCGCCCGCGGCTCGCCTCGGCCTCCCGGGCGCTCTGACCGCGCGTCCCCGGCCCGCCATGGCCCCTTCGCTCTCGCCCGGGCCCGCCGCC
CTGCGCCGCGCGCCGCAGCTGCTGCTGCTGCTGCTGGCCGCGGAGTGCGCGCTTGCCGCGCTGTTGCCGGCGCGCGAGGCCACGCAGTTC
CTGCGGCCCAGGCAGCGCCGCGCCTTTCAGGTCTTCGAGGAGGCCAAGCAGGGCCACCTGGAGAGGGAGTGCGTGGAGGAGCTGTGCAGC
CGCGAGGAGGCGCGGGAGGTGTTCGAGAACGACCCCGAGACGGTTCAGAGGACAGTTTTGGAGAAGGAGATGCGTAGTCTTGGTGTTGAC
ATGGACGATAAAGACGATGCCCATTACGCAGTCCAGGCAAGAAGATCCCGGAGCATCACTAGGAAAAGAAAGCGGGAAGACTCTGCTCCC
CCGTCCTCTGTGGCCCGGAGTGGGAGTTGCTCTCGAACTCCACGTGACGTTTCTGGTCTTAGGGATGTCAAGATGGTGAAGAAAGCCAAG
ACTATGATGAAGAATGCTCAGAAGAAGATGAATCGGTTGGGGAAGAAAGGGGAGGCGGATAGACACGTGTTTGATATGAAGCCCAAGCAC
TTGCTGTCTGGGAAGAGGAAAGCTGGTAAAAAGGACAGGAGATAGTATCCGTTTGGTTGGCGTGGCTTCGCTAGAGTGTTGCTGTTTATT
TCCTGGTTTGGCACAGTATGGTTTCATGAAATTGGAGCTCTGTATAAACTGAAAAAGACAAAATAAGTAAAGCACTTGTTGCTTTGCTGA
AAACTATGGTTAACCCTATATAGGTGTGGGAAATTTTTGTCACTGCATAATATTACAAATATTTTGAGTAGACAGTGTTTCCACATTTAA
TGGAGTATCAGTTGCTTCAGATTTTCAGAACTGGGAAGATTTACTGGTTTAACTAGGTTGTTTTTGATGGAGAAAAACCTTATTTTCTTT
TGTAAGAGCTGGGAGCAAACACGTTTATGAGTGTGTCGGAATCCCGTGCTTAAAATACGCTCTTAAATTATTTTCTAGTCTTATTTTACA
ATGTCTCATTGTAGTCTGTCTTCAACTATTTTATCCAAAATAAACCTCCAGAAGAAAGTAGTTTTCATTTACTTAGCTCATGTTTTGGTT
TAGTTATAGTCGCTATGGATTTGGCCAAATAAAAAGGCAAACAACATGACATTTCTATTTTGTTTTAAAGCAAAAATACTTTTGGGGGAG
TAAAATGTTGCTGGAGGCATTAGGCAATTAAATATGGGCATTCTCCTATTTCTGTGGCCCGTCCCTGAAGTTACATGTTCAGTAAAACAC
AAAAACACCGCCAATGCCACCTCAAAAGCACCTGCTGGGGAGCGTTGGGGTGAAGAGCTGTGGGGTCGGAGGGACCTGCCCAGGGGTCCG
TGTGCTCCTGGAGCTCCAAAGACACACAGGGGTCCAAGAGCCACCACGGATAAGTTATCAAGTCACACAATCAACATTATAGCTGAGGAA
AGGACTTTAGTTAATCACACTTCTGGATTACATGTGGCAATTTTAAAAATTTACCAGGGCTGGGCTGGGCGCAGGGGCTCAAGCCTGTAG
TTCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCAGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACT
AAAAATACAAAAATTAGCCATGCGTGGTGGTGGGCATCTGTAATCCTAGCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAGCCCAGA
GGCGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGAGAGACTCCGTGTGAAAAAAAAAAAAAAAATAC
CAGGTCTGGTTTTTGAAATTCTTTCTCCGTATTAAACACCAAAACTTAACATATAGTTTACTTTGTGTTAAACAACAACAGTATGGCCGG
GCGCGGCAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAAC
ACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAACTACTTGGGAGGCTGAGG
CAGGAGAATGGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGTCGACAGCGAGACTCCAT
CTCAAAAAAAAAAAAAAAATACCAGGTCTGGTTTTTGAAATTCTTTCTCCGTATTAAACACCAAAACTTAACATATAGTTTACTTTGTGT
TAAACAACAACAGTATGTTTTAAAGCAAGTATGTCTTTATTTGTAAGCATATTACTGAAACGATCAAATGAACAGAAGTGGATAAACGTC
GAGTCACTTGGCTGAGACCATACGCATCTTCCGTACTGCTTGTATTAGGATGCAAGATTGAATGTGTCTTTTTTTTAAAAATGCAGCCTT
GTGTTGCACTCTGAAATAAGTGATTTAAAAAGAAAAACATGATACAGAGATCCCATCCTGACCTTGGAGGCTTGGATAAAGCTGTGGGGA
GACAGCCTCATGGTCCAGCCAGGCTAGTCCGCCTGCTTCAGGACTCTCAAGATCTCCCCAAGACTTTCAGGATCAGCTGCTGTTAATCAA
ACAAGTGCTTATAAAATGGAAATTGGGACAAAGGAAATGTTAAATTTCCTCCCTGCAACCAGGCAGATGAGAAATATGGAAATAAGGAAA
AGGGAAAATGAAGATATGACAAAGTTGATGAAAAGGTTGAAATAGTGATTTATACATGATGGGCAATCAAGTGCCCCTTTTGCCCTGTTT
TTTGGAGAGGGTGTATCATTGCCTCAATGGTGCGTCTGCCTGCACTGAGGGCATTACACATGGCTGACTCGACCTCCCTGCCTCTCACAC
TCTGTGTATTTTGTGAAGCTCCACAAACGGGGTCACGTCATCCAGGTGAGGCCACCACCGGTACAGAAACCTCTCGGCAATGGTTCTTAG
CCAGGGGGTGACTTTGACTTCACCCCTCGCCTCCCTCTCCAGCAGCTCCCACAGCTCCTCCTGGGACAGGTAGAGGATGCTTTTCGTTTC
ACTGGGATCCGGGTTCAGAGTGACGTTTTTCCTCACAAGCAGAAGGTAACAAATTTCATGCTCTCCCCAAATTCTGTCTGATTTTGCCTT
GTGGTGATAGATTGTCATGAACACAATGTCCTCTGGAGAAATCTATTGACAGAAATTGGTGCAGTGTTAACAACGCTAATGTAAAACACA

>32533_32533_1_GAS6-GTPBP4_GAS6_chr13_114566547_ENST00000327773_GTPBP4_chr10_1060186_ENST00000360803_length(amino acids)=262AA_BP=0
MKPYCAKPGNKQQHSSEATPTKRILSPVLFTSFPLPRQQVLGLHIKHVSIRLPFLPQPIHLLLSILHHSLGFLHHLDIPKTRNVTWSSRA
TPTPGHRGRGSRVFPLSFPSDAPGSSCLDCVMGIVFIVHVNTKTTHLLLQNCPLNRLGVVLEHLPRLLAAAQLLHALPLQVALLGLLEDL

--------------------------------------------------------------
>32533_32533_2_GAS6-GTPBP4_GAS6_chr13_114566547_ENST00000357389_GTPBP4_chr10_1060186_ENST00000360803_length(transcript)=3480nt_BP=408nt
CCGAGCGCTTGAGGTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCGATGTGACCTTCAGGGCCGCCAGGACGGGATGACCGGAGCCTCCGC
CCCGCGGCGCCCGCGGCTCGCCTCGGCCTCCCGGGCGCTCTGACCGCGCGTCCCCGGCCCGCCATGGCCCCTTCGCTCTCGCCCGGGCCC
GCCGCCCTGCGCCGCGCGCCGCAGCTGCTGCTGCTGCTGCTGGCCGCGGAGTGCGCGCTTGCCGCGCTGTTGCCGGCGCGCGAGGCCACG
CAGTTCCTGCGGCCCAGGCAGCGCCGCGCCTTTCAGGTCTTCGAGGAGGCCAAGCAGGGCCACCTGGAGAGGGAGTGCGTGGAGGAGCTG
TGCAGCCGCGAGGAGGCGCGGGAGGTGTTCGAGAACGACCCCGAGACGGTTCAGAGGACAGTTTTGGAGAAGGAGATGCGTAGTCTTGGT
GTTGACATGGACGATAAAGACGATGCCCATTACGCAGTCCAGGCAAGAAGATCCCGGAGCATCACTAGGAAAAGAAAGCGGGAAGACTCT
GCTCCCCCGTCCTCTGTGGCCCGGAGTGGGAGTTGCTCTCGAACTCCACGTGACGTTTCTGGTCTTAGGGATGTCAAGATGGTGAAGAAA
GCCAAGACTATGATGAAGAATGCTCAGAAGAAGATGAATCGGTTGGGGAAGAAAGGGGAGGCGGATAGACACGTGTTTGATATGAAGCCC
AAGCACTTGCTGTCTGGGAAGAGGAAAGCTGGTAAAAAGGACAGGAGATAGTATCCGTTTGGTTGGCGTGGCTTCGCTAGAGTGTTGCTG
TTTATTTCCTGGTTTGGCACAGTATGGTTTCATGAAATTGGAGCTCTGTATAAACTGAAAAAGACAAAATAAGTAAAGCACTTGTTGCTT
TGCTGAAAACTATGGTTAACCCTATATAGGTGTGGGAAATTTTTGTCACTGCATAATATTACAAATATTTTGAGTAGACAGTGTTTCCAC
ATTTAATGGAGTATCAGTTGCTTCAGATTTTCAGAACTGGGAAGATTTACTGGTTTAACTAGGTTGTTTTTGATGGAGAAAAACCTTATT
TTCTTTTGTAAGAGCTGGGAGCAAACACGTTTATGAGTGTGTCGGAATCCCGTGCTTAAAATACGCTCTTAAATTATTTTCTAGTCTTAT
TTTACAATGTCTCATTGTAGTCTGTCTTCAACTATTTTATCCAAAATAAACCTCCAGAAGAAAGTAGTTTTCATTTACTTAGCTCATGTT
TTGGTTTAGTTATAGTCGCTATGGATTTGGCCAAATAAAAAGGCAAACAACATGACATTTCTATTTTGTTTTAAAGCAAAAATACTTTTG
GGGGAGTAAAATGTTGCTGGAGGCATTAGGCAATTAAATATGGGCATTCTCCTATTTCTGTGGCCCGTCCCTGAAGTTACATGTTCAGTA
AAACACAAAAACACCGCCAATGCCACCTCAAAAGCACCTGCTGGGGAGCGTTGGGGTGAAGAGCTGTGGGGTCGGAGGGACCTGCCCAGG
GGTCCGTGTGCTCCTGGAGCTCCAAAGACACACAGGGGTCCAAGAGCCACCACGGATAAGTTATCAAGTCACACAATCAACATTATAGCT
GAGGAAAGGACTTTAGTTAATCACACTTCTGGATTACATGTGGCAATTTTAAAAATTTACCAGGGCTGGGCTGGGCGCAGGGGCTCAAGC
CTGTAGTTCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCAGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATC
TCTACTAAAAATACAAAAATTAGCCATGCGTGGTGGTGGGCATCTGTAATCCTAGCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAG
CCCAGAGGCGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGAGAGACTCCGTGTGAAAAAAAAAAAAA
AAATACCAGGTCTGGTTTTTGAAATTCTTTCTCCGTATTAAACACCAAAACTTAACATATAGTTTACTTTGTGTTAAACAACAACAGTAT
GGCCGGGCGCGGCAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTG
GCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAACTACTTGGGAGG
CTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGTCGACAGCGAGA
CTCCATCTCAAAAAAAAAAAAAAAATACCAGGTCTGGTTTTTGAAATTCTTTCTCCGTATTAAACACCAAAACTTAACATATAGTTTACT
TTGTGTTAAACAACAACAGTATGTTTTAAAGCAAGTATGTCTTTATTTGTAAGCATATTACTGAAACGATCAAATGAACAGAAGTGGATA
AACGTCGAGTCACTTGGCTGAGACCATACGCATCTTCCGTACTGCTTGTATTAGGATGCAAGATTGAATGTGTCTTTTTTTTAAAAATGC
AGCCTTGTGTTGCACTCTGAAATAAGTGATTTAAAAAGAAAAACATGATACAGAGATCCCATCCTGACCTTGGAGGCTTGGATAAAGCTG
TGGGGAGACAGCCTCATGGTCCAGCCAGGCTAGTCCGCCTGCTTCAGGACTCTCAAGATCTCCCCAAGACTTTCAGGATCAGCTGCTGTT
AATCAAACAAGTGCTTATAAAATGGAAATTGGGACAAAGGAAATGTTAAATTTCCTCCCTGCAACCAGGCAGATGAGAAATATGGAAATA
AGGAAAAGGGAAAATGAAGATATGACAAAGTTGATGAAAAGGTTGAAATAGTGATTTATACATGATGGGCAATCAAGTGCCCCTTTTGCC
CTGTTTTTTGGAGAGGGTGTATCATTGCCTCAATGGTGCGTCTGCCTGCACTGAGGGCATTACACATGGCTGACTCGACCTCCCTGCCTC
TCACACTCTGTGTATTTTGTGAAGCTCCACAAACGGGGTCACGTCATCCAGGTGAGGCCACCACCGGTACAGAAACCTCTCGGCAATGGT
TCTTAGCCAGGGGGTGACTTTGACTTCACCCCTCGCCTCCCTCTCCAGCAGCTCCCACAGCTCCTCCTGGGACAGGTAGAGGATGCTTTT
CGTTTCACTGGGATCCGGGTTCAGAGTGACGTTTTTCCTCACAAGCAGAAGGTAACAAATTTCATGCTCTCCCCAAATTCTGTCTGATTT
TGCCTTGTGGTGATAGATTGTCATGAACACAATGTCCTCTGGAGAAATCTATTGACAGAAATTGGTGCAGTGTTAACAACGCTAATGTAA

>32533_32533_2_GAS6-GTPBP4_GAS6_chr13_114566547_ENST00000357389_GTPBP4_chr10_1060186_ENST00000360803_length(amino acids)=262AA_BP=0
MKPYCAKPGNKQQHSSEATPTKRILSPVLFTSFPLPRQQVLGLHIKHVSIRLPFLPQPIHLLLSILHHSLGFLHHLDIPKTRNVTWSSRA
TPTPGHRGRGSRVFPLSFPSDAPGSSCLDCVMGIVFIVHVNTKTTHLLLQNCPLNRLGVVLEHLPRLLAAAQLLHALPLQVALLGLLEDL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GAS6-GTPBP4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GAS6-GTPBP4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GAS6-GTPBP4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source