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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GAS6-NOC4L (FusionGDB2 ID:32546)

Fusion Gene Summary for GAS6-NOC4L

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS6-NOC4L
Fusion gene ID: 32546
HgeneTgene
Gene symbol

GAS6

NOC4L

Gene ID

2621

79050

Gene namegrowth arrest specific 6nucleolar complex associated 4 homolog
SynonymsAXLLG|AXSFNET49|NOC4|UTP19
Cytomap

13q34

12q24.33

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factornucleolar complex protein 4 homologNOC4 protein homologNOC4-like proteinnucleolar complex-associated protein 4-like protein
Modification date2020031320200313
UniProtAcc

Q14393

Q9BVI4

Ensembl transtripts involved in fusion geneENST00000327773, ENST00000357389, 
ENST00000476291, ENST00000355761, 
ENST00000418959, ENST00000450766, 
ENST00000538784, ENST00000535343, 
ENST00000330579, 
Fusion gene scores* DoF score21 X 12 X 12=302436 X 4 X 20=2880
# samples 2941
** MAII scorelog2(29/3024*10)=-3.38233333420614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/2880*10)=-2.81237299682423
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAS6 [Title/Abstract] AND NOC4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGAS6(114566548)-NOC4L(132635526), # samples:1
Anticipated loss of major functional domain due to fusion event.GAS6-NOC4L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAS6

GO:0001934

positive regulation of protein phosphorylation

7854420|16723520|20103767

HgeneGAS6

GO:0006468

protein phosphorylation

16359517

HgeneGAS6

GO:0006909

phagocytosis

21501828

HgeneGAS6

GO:0007165

signal transduction

7854420|18680538

HgeneGAS6

GO:0010628

positive regulation of gene expression

19657094

HgeneGAS6

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

19657094

HgeneGAS6

GO:0018105

peptidyl-serine phosphorylation

18680538|20103767

HgeneGAS6

GO:0019064

fusion of virus membrane with host plasma membrane

21501828

HgeneGAS6

GO:0019079

viral genome replication

21501828

HgeneGAS6

GO:0032689

negative regulation of interferon-gamma production

18840707

HgeneGAS6

GO:0032715

negative regulation of interleukin-6 production

19657094

HgeneGAS6

GO:0032720

negative regulation of tumor necrosis factor production

19657094|20103767

HgeneGAS6

GO:0032825

positive regulation of natural killer cell differentiation

18840707

HgeneGAS6

GO:0033138

positive regulation of peptidyl-serine phosphorylation

16723520

HgeneGAS6

GO:0035457

cellular response to interferon-alpha

19657094

HgeneGAS6

GO:0035690

cellular response to drug

16359517

HgeneGAS6

GO:0035754

B cell chemotaxis

19922767

HgeneGAS6

GO:0043066

negative regulation of apoptotic process

19922767

HgeneGAS6

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

16723520

HgeneGAS6

GO:0043277

apoptotic cell clearance

21501828

HgeneGAS6

GO:0043433

negative regulation of DNA-binding transcription factor activity

18680538

HgeneGAS6

GO:0043491

protein kinase B signaling

16723520|20103767

HgeneGAS6

GO:0045860

positive regulation of protein kinase activity

7854420

HgeneGAS6

GO:0045892

negative regulation of transcription, DNA-templated

18680538

HgeneGAS6

GO:0046718

viral entry into host cell

21501828

HgeneGAS6

GO:0046813

receptor-mediated virion attachment to host cell

21501828

HgeneGAS6

GO:0046827

positive regulation of protein export from nucleus

18680538

HgeneGAS6

GO:0048146

positive regulation of fibroblast proliferation

7854420|15184064

HgeneGAS6

GO:0050711

negative regulation of interleukin-1 secretion

20103767

HgeneGAS6

GO:0050766

positive regulation of phagocytosis

18395422

HgeneGAS6

GO:0051897

positive regulation of protein kinase B signaling

16359517|16723520|18680538

HgeneGAS6

GO:0061098

positive regulation of protein tyrosine kinase activity

20103767

HgeneGAS6

GO:0070168

negative regulation of biomineral tissue development

20048160

HgeneGAS6

GO:0070374

positive regulation of ERK1 and ERK2 cascade

15184064

HgeneGAS6

GO:0070588

calcium ion transmembrane transport

18395422

HgeneGAS6

GO:0071307

cellular response to vitamin K

16359517

HgeneGAS6

GO:0072659

protein localization to plasma membrane

16359517

HgeneGAS6

GO:0097241

hematopoietic stem cell migration to bone marrow

19922767

HgeneGAS6

GO:1900142

negative regulation of oligodendrocyte apoptotic process

16723520

HgeneGAS6

GO:1900165

negative regulation of interleukin-6 secretion

20103767

HgeneGAS6

GO:2000270

negative regulation of fibroblast apoptotic process

16359517

HgeneGAS6

GO:2000352

negative regulation of endothelial cell apoptotic process

16359517|18680538|18760998

HgeneGAS6

GO:2000510

positive regulation of dendritic cell chemotaxis

19657094

HgeneGAS6

GO:2000669

negative regulation of dendritic cell apoptotic process

19657094


check buttonFusion gene breakpoints across GAS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NOC4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KO-8415-01AGAS6chr13

114566548

-NOC4Lchr12

132635526

+


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Fusion Gene ORF analysis for GAS6-NOC4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000327773ENST00000538784GAS6chr13

114566548

-NOC4Lchr12

132635526

+
5CDS-5UTRENST00000357389ENST00000538784GAS6chr13

114566548

-NOC4Lchr12

132635526

+
5CDS-intronENST00000327773ENST00000535343GAS6chr13

114566548

-NOC4Lchr12

132635526

+
5CDS-intronENST00000357389ENST00000535343GAS6chr13

114566548

-NOC4Lchr12

132635526

+
5UTR-3CDSENST00000476291ENST00000330579GAS6chr13

114566548

-NOC4Lchr12

132635526

+
5UTR-5UTRENST00000476291ENST00000538784GAS6chr13

114566548

-NOC4Lchr12

132635526

+
5UTR-intronENST00000476291ENST00000535343GAS6chr13

114566548

-NOC4Lchr12

132635526

+
Frame-shiftENST00000327773ENST00000330579GAS6chr13

114566548

-NOC4Lchr12

132635526

+
Frame-shiftENST00000357389ENST00000330579GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-3CDSENST00000355761ENST00000330579GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-3CDSENST00000418959ENST00000330579GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-3CDSENST00000450766ENST00000330579GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-5UTRENST00000355761ENST00000538784GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-5UTRENST00000418959ENST00000538784GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-5UTRENST00000450766ENST00000538784GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-intronENST00000355761ENST00000535343GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-intronENST00000418959ENST00000535343GAS6chr13

114566548

-NOC4Lchr12

132635526

+
intron-intronENST00000450766ENST00000535343GAS6chr13

114566548

-NOC4Lchr12

132635526

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GAS6-NOC4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GAS6chr13114566547-NOC4Lchr12132635525+0.0001366790.99986327
GAS6chr13114566547-NOC4Lchr12132635525+0.0001366790.99986327

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GAS6-NOC4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:114566548/:132635526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS6

Q14393

NOC4L

Q9BVI4

FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GAS6-NOC4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GAS6-NOC4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GAS6-NOC4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GAS6-NOC4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource