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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GATA4-TRIB1 (FusionGDB2 ID:32588)

Fusion Gene Summary for GATA4-TRIB1

Fusion gene summary

Fusion gene information	Fusion gene name: GATA4-TRIB1
	Fusion gene ID: 32588
		Hgene	Tgene
	Gene symbol	GATA4	TRIB1
	Gene ID	2626	10221
	Gene name	GATA binding protein 4	tribbles pseudokinase 1
	Synonyms	ASD2\|TACHD\|TOF\|VSD1	C8FW\|GIG-2\|GIG2\|SKIP1\|TRB-1\|TRB1
	Cytomap	8p23.1	8q24.13
	Type of gene	protein-coding	protein-coding
	Description	transcription factor GATA-4GATA-binding factor 4	tribbles homolog 1G-protein-coupled receptor induced proteinG-protein-coupled receptor-induced gene 2 proteinG-protein-coupled receptor-induced protein 2phosphoprotein regulated by mitogenic pathwaystribbles-like protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000335135, ENST00000532059, ENST00000528712,	ENST00000519576, ENST00000521778, ENST00000520847, ENST00000311922,
Fusion gene scores	* DoF score	3 X 3 X 3=27	4 X 4 X 3=48
	# samples	4	6
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GATA4 [Title/Abstract] AND TRIB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GATA4(11566437)-TRIB1(126448247), # samples:2
Anticipated loss of major functional domain due to fusion event.	GATA4-TRIB1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GATA4-TRIB1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. GATA4-TRIB1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. GATA4-TRIB1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. GATA4-TRIB1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GATA4	GO:0045893	positive regulation of transcription, DNA-templated	24000169
Hgene	GATA4	GO:0045944	positive regulation of transcription by RNA polymerase II	21330551\|29325903
Hgene	GATA4	GO:0060575	intestinal epithelial cell differentiation	9566909
Tgene	TRIB1	GO:0043405	regulation of MAP kinase activity	15299019

Fusion gene breakpoints across GATA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OJ-01A	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
ChimerDB4	ESCA	TCGA-L5-A4OJ	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+

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Fusion Gene ORF analysis for GATA4-TRIB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000335135	ENST00000519576	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
5CDS-5UTR	ENST00000335135	ENST00000519576	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
5CDS-5UTR	ENST00000532059	ENST00000519576	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
5CDS-5UTR	ENST00000532059	ENST00000519576	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
5CDS-intron	ENST00000335135	ENST00000521778	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
5CDS-intron	ENST00000335135	ENST00000521778	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
5CDS-intron	ENST00000532059	ENST00000521778	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
5CDS-intron	ENST00000532059	ENST00000521778	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
Frame-shift	ENST00000335135	ENST00000520847	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
Frame-shift	ENST00000335135	ENST00000520847	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
Frame-shift	ENST00000532059	ENST00000520847	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
Frame-shift	ENST00000532059	ENST00000520847	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
In-frame	ENST00000335135	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
In-frame	ENST00000335135	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
In-frame	ENST00000532059	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
In-frame	ENST00000532059	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
intron-3CDS	ENST00000528712	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
intron-3CDS	ENST00000528712	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
intron-3CDS	ENST00000528712	ENST00000520847	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
intron-3CDS	ENST00000528712	ENST00000520847	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
intron-5UTR	ENST00000528712	ENST00000519576	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
intron-5UTR	ENST00000528712	ENST00000519576	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+
intron-intron	ENST00000528712	ENST00000521778	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+
intron-intron	ENST00000528712	ENST00000521778	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000335135

GATA4

chr8

11566437

ENST00000311922

TRIB1

chr8

126448248

3574

1174

473

1639

388

ENST00000532059

GATA4

chr8

11566437

ENST00000311922

TRIB1

chr8

126448248

3096

696

1161

375

ENST00000335135

GATA4

chr8

11566437

ENST00000311922

TRIB1

chr8

126448247

3574

1174

473

1639

388

ENST00000532059

GATA4

chr8

11566437

ENST00000311922

TRIB1

chr8

126448247

3096

696

1161

375

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000335135	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+	0.4947469	0.5052531
ENST00000532059	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448248	+	0.46004254	0.5399574
ENST00000335135	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+	0.4947469	0.5052531
ENST00000532059	ENST00000311922	GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+	0.46004254	0.5399574

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Fusion Genomic Features for GATA4-TRIB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+	2.01E-06	0.999998
GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+	2.01E-06	0.999998
GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+	2.01E-06	0.999998
GATA4	chr8	11566437	+	TRIB1	chr8	126448247	+	2.01E-06	0.999998

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GATA4-TRIB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11566437/chr8:126448247)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GATA4

chr8:11566437

chr8:126448247

ENST00000335135

118_126

205

443.0

Compositional bias

Note=Poly-Ala

Hgene

GATA4

chr8:11566437

chr8:126448247

ENST00000335135

174_181

205

443.0

Compositional bias

Note=Poly-Ala

Hgene

GATA4

chr8:11566437

chr8:126448248

ENST00000335135

118_126

205

443.0

Compositional bias

Note=Poly-Ala

Hgene

GATA4

chr8:11566437

chr8:126448248

ENST00000335135

174_181

205

443.0

Compositional bias

Note=Poly-Ala

Tgene

TRIB1

chr8:11566437

chr8:126448247

ENST00000311922

355_360

217

373.0

Motif

COP1-binding

Tgene

TRIB1

chr8:11566437

chr8:126448248

ENST00000311922

355_360

217

373.0

Motif

COP1-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GATA4

chr8:11566437

chr8:126448247

ENST00000335135

276_280

205

443.0

Compositional bias

Note=Poly-Thr

Hgene

GATA4

chr8:11566437

chr8:126448248

ENST00000335135

276_280

205

443.0

Compositional bias

Note=Poly-Thr

Hgene

GATA4

chr8:11566437

chr8:126448247

ENST00000335135

217_241

205

443.0

Zinc finger

GATA-type 1

Hgene

GATA4

chr8:11566437

chr8:126448247

ENST00000335135

271_295

205

443.0

Zinc finger

GATA-type 2

Hgene

GATA4

chr8:11566437

chr8:126448248

ENST00000335135

217_241

205

443.0

Zinc finger

GATA-type 1

Hgene

GATA4

chr8:11566437

chr8:126448248

ENST00000335135

271_295

205

443.0

Zinc finger

GATA-type 2

Tgene

TRIB1

chr8:11566437

chr8:126448247

ENST00000311922

1_338

217

373.0

Domain

Protein kinase

Tgene

TRIB1

chr8:11566437

chr8:126448248

ENST00000311922

1_338

217

373.0

Domain

Protein kinase

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Fusion Gene Sequence for GATA4-TRIB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>32588_32588_1_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000335135_TRIB1_chr8_126448247_ENST00000311922_length(transcript)=3574nt_BP=1174nt
GGACTTGGAGGCGGCCGGCGCAGGGGCCGCGAGAGGCTTCGTCGCCGCTGCAGCTCCGGGGGCTCCCAGGGGAGCGTGCGCGGAACCTCC
AGGCCCAGCAGGACCCCGGCTGCGGCGAGGAGGAAGGAGCCAGCCTAGCAGCTTCTGCGCCTGTGGCCGCGGGTGTCCTGGAGGCCTCTC
GGTGTGACGAGTGGGGGACCCGAAGGCTCGTGCGCCACCTCCAGGCCTGGACGCTGCCCTCCGTCTTCTGCCCCCAATAGGTGCGCCGGA
CCTTCAGGCCCTGGGGTGAATTCAGCTGCTCCTACATCAGCTTCCGGAACCACCAAAAATTCAAATTGGGATTTTCCGGAGTAAACAAGA
GCCTAGAGCCCTTTGCTCAATGCTGGATTTAATACGTATATATTTTTAAGCGAGTTGGTTTTTTCCCCTTTGATTTTTGATCTTCGCGAC
AGTTCCTCCCACGCATATTATCGTTGTTGCCGTCGTTTTCTCTCCCCGCGTGGCTCCTTGACCTGCGAGGGAGAGAGAGGACACCGAAGC
CGGGAGCTCGCAGGGACCATGTATCAGAGCTTGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCGGGCGGCCCCGGC
GCCTTCATGCACGGCGCGGGCGCCGCGTCCTCGCCAGTCTACGTGCCCACACCGCGGGTGCCCTCCTCCGTGCTGGGCCTGTCCTACCTC
CAGGGCGGAGGCGCGGGCTCTGCGTCCGGAGGCGCCTCGGGCGGCAGCTCCGGTGGGGCCGCGTCTGGTGCGGGGCCCGGGACCCAGCAG
GGCAGCCCGGGATGGAGCCAGGCGGGAGCCGACGGAGCCGCTTACACCCCGCCGCCGGTGTCGCCGCGCTTCTCCTTCCCGGGGACCACC
GGGTCCCTGGCGGCCGCCGCCGCCGCTGCCGCGGCCCGGGAAGCTGCGGCCTACAGCAGTGGCGGCGGAGCGGCGGGTGCGGGCCTGGCG
GGCCGCGAGCAGTACGGGCGCGCCGGCTTCGCGGGCTCCTACTCCAGCCCCTACCCGGCTTACATGGCCGACGTGGGCGCGTCCTGGGCC
GCAGCCGCCGCCGCCTCCGCCGGCCCCTTCGACAGCCCGGTCCTGCACAGCCTGCCCGGCCGGGCCAACCCGGCCGCCCGACACCCCAAT
CTCGAACCCAGCTTAGACTAGAAAGTCTAGAAGACACACACATAATGAAGGGGGAAGATGATGCTTTGTCAGACAAACATGGCTGCCCAG
CCTACGTGAGCCCTGAGATCCTCAACACCACTGGGACCTACTCCGGAAAGGCTGCGGACGTTTGGAGCCTGGGGGTGATGCTCTACACCC
TTCTGGTTGGACGATACCCCTTCCATGACTCAGACCCCAGTGCCCTTTTCTCCAAAATTCGGCGTGGACAGTTCTGCATTCCTGAGCACA
TTTCCCCCAAAGCCAGGTGCCTCATTCGCAGCCTCTTGAGACGGGAGCCCTCCGAGAGACTCACTGCCCCCGAGATCCTACTGCACCCCT
GGTTTGAGTCCGTCTTGGAACCCGGGTACATCGACTCAGAAATAGGAACTTCAGACCAGATTGTTCCAGAGTACCAGGAGGACAGTGACA
TTAGTTCCTTCTTCTGCTAATCCCCAAAACCTCAGAAACCTCATAATTCTTAACACCTGGCATTTCCATTTCTAAAGATGGACAGGCCCT
TTGGCGTGGTACCAACCAGATAATGACTGCATCAGGATGAAAGCTGCTGAACTCGGCATGGCGCCTCCTCTTCTCTGTTGGGATGAGTGA
CTTTATTGATTTGAGCAGCATATGCTGTGATTGGCTGCCCTGCAAATTTGTTTCCCTTAAGGAACCCTCACCAACTATCTCTGCTGGATT
TGGGAGTTCCGCATCTTTTGTGGAGGGCAGAGTATGGACATCTTACACCCGGTGGTCAAGTGTGTAATAAACTTGAGCATTCGAATGGGA
GAAAAAGCAAATCGCACAATGACATATTTTGAGTAATAACCGTATTTTTCACAGGGTGACAAATTGGGCCAATAAATCTGCCATCTTTGA
ACTCATCTTTGGTGGCTAGACTGCTACGGCAGCTTCTCTGATGGGAAAGTTCCTTTTTTGGCTTAACACTCACCCTTTCTTCACACTCAC
ATTTACCAATGACTCTGCTCCGTTTTTGGAGCAGACTGTTTTAAGTTGCTCAGGAGCCTGATGGAACCATGAACCGAGACTCTTCTCTGT
TTCCTGCCAAGACCTCATCTGCACTAATGCCTTCTCCCTGACCTTGACACTTCCCCCTTTAGCTATAAAAGCACTTACCAGCCGAACGTG
GAACAGTATCACAAAAGATTCCATCTCCCAACGATTTCAGAACTCTGAGCTCAGAGAGACTCCAGATTTTAAAAAATAATTTGAGTGCTT
GGAAACTATTAGCTTTTTAAGTTCCTTCCAAATATGTTAGTACCTACCCTTTACTTTTTCCCCAAGACCATCTCAGGGTGGAGCATTCTG
TCTAAGAGAAGAAAGATAAGGAGGCTCCCACCCACCTCTCCCAAGAGCAGACATTAAACATCTTTGTGCTTTGAAGAGAGTGAATTTTGG
ATAGTCTTGTGATTCTCAGACTAACTTCCAGAATTATACTTTAACCCCTCCCAGATATGGTCCGCCTTTGGCATTGTGTGTACATCTGCA
GTTTTGCATGGTGGGTTGTTAATATTTCAAATGTGTGGTTTATGAATACGTCTGTATAATCGGCTTCTGGAGTGAAACAGCAAACCCCAA
ATCTTCAAAGTTGGAAGGAACTTTAAAAATCATCCGGTCCAATCTCTTTCCTCTTTCTGCCACCTCCCAAGGCAGAAATCCCCTCTTCAG
CTTCTTTTGTAGGTGGGAATCCAGCCTCTGTTAGATATGTCCAGAGATGGAAACTCACTCCCCTACAAAAGATGGAGCTTAATGGAGAAA
TTGCAACTTTCATTAAAAAACAAATTCAGATGAAATATCAGTAACTGTCTTGGACAGTGCTGAAATCAGGTGGTTAAACGGGTAAACAAA
ATATACTGTATTTTGAGAAATGGCACAAAAACAGGCAGTCATCTTTAAGGGCTATGCCTAGGCAAACTACTAACATGCATTGTGAGAATG
CCGTGTATACCTCACGTACTGTGTACTTTGTACATATATTTTACCTTTTATACCTATGTTCGATTTTGTTTTGTTTTGTTTTGTTCTGGC
TTTGAGGCTTGTTTTGTTGTCTGTGTCTGTCTGAATAACCTGCGTGTCTAAAACCACGTGAAATGTGAATGATTATTGGCAATATTACCT
TGACAGAATCATGGGACTTTGAGAAGAGGGAGGACAGAGGCCTCTGTCGCACTAACGCTCTCGTGGTTGCTCGACTGTTGTATCTGTGAT
ACATTATCCGACTAAGGACTCTGGGCTGGCAGGGCCTTCTGCCGGGAAAGCTAGAAACACTAGGTTCTTCCTGTACATACGTGTATATAT

>32588_32588_1_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000335135_TRIB1_chr8_126448247_ENST00000311922_length(amino acids)=388AA_BP=233
MLPSFSLPAWLLDLRGRERTPKPGARRDHVSELGHGRQPRAAPRCLRGGRPRRLHARRGRRVLASLRAHTAGALLRAGPVLPPGRRRGLC
VRRRLGRQLRWGRVWCGARDPAGQPGMEPGGSRRSRLHPAAGVAALLLPGDHRVPGGRRRRCRGPGSCGLQQWRRSGGCGPGGPRAVRAR
RLRGLLLQPLPGLHGRRGRVLGRSRRRLRRPLRQPGPAQPARPGQPGRPTPQSRTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEIL
NTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP

--------------------------------------------------------------
>32588_32588_2_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000335135_TRIB1_chr8_126448248_ENST00000311922_length(transcript)=3574nt_BP=1174nt
GGACTTGGAGGCGGCCGGCGCAGGGGCCGCGAGAGGCTTCGTCGCCGCTGCAGCTCCGGGGGCTCCCAGGGGAGCGTGCGCGGAACCTCC
AGGCCCAGCAGGACCCCGGCTGCGGCGAGGAGGAAGGAGCCAGCCTAGCAGCTTCTGCGCCTGTGGCCGCGGGTGTCCTGGAGGCCTCTC
GGTGTGACGAGTGGGGGACCCGAAGGCTCGTGCGCCACCTCCAGGCCTGGACGCTGCCCTCCGTCTTCTGCCCCCAATAGGTGCGCCGGA
CCTTCAGGCCCTGGGGTGAATTCAGCTGCTCCTACATCAGCTTCCGGAACCACCAAAAATTCAAATTGGGATTTTCCGGAGTAAACAAGA
GCCTAGAGCCCTTTGCTCAATGCTGGATTTAATACGTATATATTTTTAAGCGAGTTGGTTTTTTCCCCTTTGATTTTTGATCTTCGCGAC
AGTTCCTCCCACGCATATTATCGTTGTTGCCGTCGTTTTCTCTCCCCGCGTGGCTCCTTGACCTGCGAGGGAGAGAGAGGACACCGAAGC
CGGGAGCTCGCAGGGACCATGTATCAGAGCTTGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCGGGCGGCCCCGGC
GCCTTCATGCACGGCGCGGGCGCCGCGTCCTCGCCAGTCTACGTGCCCACACCGCGGGTGCCCTCCTCCGTGCTGGGCCTGTCCTACCTC
CAGGGCGGAGGCGCGGGCTCTGCGTCCGGAGGCGCCTCGGGCGGCAGCTCCGGTGGGGCCGCGTCTGGTGCGGGGCCCGGGACCCAGCAG
GGCAGCCCGGGATGGAGCCAGGCGGGAGCCGACGGAGCCGCTTACACCCCGCCGCCGGTGTCGCCGCGCTTCTCCTTCCCGGGGACCACC
GGGTCCCTGGCGGCCGCCGCCGCCGCTGCCGCGGCCCGGGAAGCTGCGGCCTACAGCAGTGGCGGCGGAGCGGCGGGTGCGGGCCTGGCG
GGCCGCGAGCAGTACGGGCGCGCCGGCTTCGCGGGCTCCTACTCCAGCCCCTACCCGGCTTACATGGCCGACGTGGGCGCGTCCTGGGCC
GCAGCCGCCGCCGCCTCCGCCGGCCCCTTCGACAGCCCGGTCCTGCACAGCCTGCCCGGCCGGGCCAACCCGGCCGCCCGACACCCCAAT
CTCGAACCCAGCTTAGACTAGAAAGTCTAGAAGACACACACATAATGAAGGGGGAAGATGATGCTTTGTCAGACAAACATGGCTGCCCAG
CCTACGTGAGCCCTGAGATCCTCAACACCACTGGGACCTACTCCGGAAAGGCTGCGGACGTTTGGAGCCTGGGGGTGATGCTCTACACCC
TTCTGGTTGGACGATACCCCTTCCATGACTCAGACCCCAGTGCCCTTTTCTCCAAAATTCGGCGTGGACAGTTCTGCATTCCTGAGCACA
TTTCCCCCAAAGCCAGGTGCCTCATTCGCAGCCTCTTGAGACGGGAGCCCTCCGAGAGACTCACTGCCCCCGAGATCCTACTGCACCCCT
GGTTTGAGTCCGTCTTGGAACCCGGGTACATCGACTCAGAAATAGGAACTTCAGACCAGATTGTTCCAGAGTACCAGGAGGACAGTGACA
TTAGTTCCTTCTTCTGCTAATCCCCAAAACCTCAGAAACCTCATAATTCTTAACACCTGGCATTTCCATTTCTAAAGATGGACAGGCCCT
TTGGCGTGGTACCAACCAGATAATGACTGCATCAGGATGAAAGCTGCTGAACTCGGCATGGCGCCTCCTCTTCTCTGTTGGGATGAGTGA
CTTTATTGATTTGAGCAGCATATGCTGTGATTGGCTGCCCTGCAAATTTGTTTCCCTTAAGGAACCCTCACCAACTATCTCTGCTGGATT
TGGGAGTTCCGCATCTTTTGTGGAGGGCAGAGTATGGACATCTTACACCCGGTGGTCAAGTGTGTAATAAACTTGAGCATTCGAATGGGA
GAAAAAGCAAATCGCACAATGACATATTTTGAGTAATAACCGTATTTTTCACAGGGTGACAAATTGGGCCAATAAATCTGCCATCTTTGA
ACTCATCTTTGGTGGCTAGACTGCTACGGCAGCTTCTCTGATGGGAAAGTTCCTTTTTTGGCTTAACACTCACCCTTTCTTCACACTCAC
ATTTACCAATGACTCTGCTCCGTTTTTGGAGCAGACTGTTTTAAGTTGCTCAGGAGCCTGATGGAACCATGAACCGAGACTCTTCTCTGT
TTCCTGCCAAGACCTCATCTGCACTAATGCCTTCTCCCTGACCTTGACACTTCCCCCTTTAGCTATAAAAGCACTTACCAGCCGAACGTG
GAACAGTATCACAAAAGATTCCATCTCCCAACGATTTCAGAACTCTGAGCTCAGAGAGACTCCAGATTTTAAAAAATAATTTGAGTGCTT
GGAAACTATTAGCTTTTTAAGTTCCTTCCAAATATGTTAGTACCTACCCTTTACTTTTTCCCCAAGACCATCTCAGGGTGGAGCATTCTG
TCTAAGAGAAGAAAGATAAGGAGGCTCCCACCCACCTCTCCCAAGAGCAGACATTAAACATCTTTGTGCTTTGAAGAGAGTGAATTTTGG
ATAGTCTTGTGATTCTCAGACTAACTTCCAGAATTATACTTTAACCCCTCCCAGATATGGTCCGCCTTTGGCATTGTGTGTACATCTGCA
GTTTTGCATGGTGGGTTGTTAATATTTCAAATGTGTGGTTTATGAATACGTCTGTATAATCGGCTTCTGGAGTGAAACAGCAAACCCCAA
ATCTTCAAAGTTGGAAGGAACTTTAAAAATCATCCGGTCCAATCTCTTTCCTCTTTCTGCCACCTCCCAAGGCAGAAATCCCCTCTTCAG
CTTCTTTTGTAGGTGGGAATCCAGCCTCTGTTAGATATGTCCAGAGATGGAAACTCACTCCCCTACAAAAGATGGAGCTTAATGGAGAAA
TTGCAACTTTCATTAAAAAACAAATTCAGATGAAATATCAGTAACTGTCTTGGACAGTGCTGAAATCAGGTGGTTAAACGGGTAAACAAA
ATATACTGTATTTTGAGAAATGGCACAAAAACAGGCAGTCATCTTTAAGGGCTATGCCTAGGCAAACTACTAACATGCATTGTGAGAATG
CCGTGTATACCTCACGTACTGTGTACTTTGTACATATATTTTACCTTTTATACCTATGTTCGATTTTGTTTTGTTTTGTTTTGTTCTGGC
TTTGAGGCTTGTTTTGTTGTCTGTGTCTGTCTGAATAACCTGCGTGTCTAAAACCACGTGAAATGTGAATGATTATTGGCAATATTACCT
TGACAGAATCATGGGACTTTGAGAAGAGGGAGGACAGAGGCCTCTGTCGCACTAACGCTCTCGTGGTTGCTCGACTGTTGTATCTGTGAT
ACATTATCCGACTAAGGACTCTGGGCTGGCAGGGCCTTCTGCCGGGAAAGCTAGAAACACTAGGTTCTTCCTGTACATACGTGTATATAT

>32588_32588_2_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000335135_TRIB1_chr8_126448248_ENST00000311922_length(amino acids)=388AA_BP=233
MLPSFSLPAWLLDLRGRERTPKPGARRDHVSELGHGRQPRAAPRCLRGGRPRRLHARRGRRVLASLRAHTAGALLRAGPVLPPGRRRGLC
VRRRLGRQLRWGRVWCGARDPAGQPGMEPGGSRRSRLHPAAGVAALLLPGDHRVPGGRRRRCRGPGSCGLQQWRRSGGCGPGGPRAVRAR
RLRGLLLQPLPGLHGRRGRVLGRSRRRLRRPLRQPGPAQPARPGQPGRPTPQSRTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEIL
NTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP

--------------------------------------------------------------
>32588_32588_3_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000532059_TRIB1_chr8_126448247_ENST00000311922_length(transcript)=3096nt_BP=696nt
GCCGTCGTTTTCTCTCCCCGCGTGGCTCCTTGACCTGCGAGGGAGAGAGAGGACACCGAAGCCGGGAGCTCGCAGGGACCATGTATCAGA
GCTTGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCGGGCGGCCCCGGCGCCTTCATGCACGGCGCGGGCGCCGCGT
CCTCGCCAGTCTACGTGCCCACACCGCGGGTGCCCTCCTCCGTGCTGGGCCTGTCCTACCTCCAGGGCGGAGGCGCGGGCTCTGCGTCCG
GAGGCGCCTCGGGCGGCAGCTCCGGTGGGGCCGCGTCTGGTGCGGGGCCCGGGACCCAGCAGGGCAGCCCGGGATGGAGCCAGGCGGGAG
CCGACGGAGCCGCTTACACCCCGCCGCCGGTGTCGCCGCGCTTCTCCTTCCCGGGGACCACCGGGTCCCTGGCGGCCGCCGCCGCCGCTG
CCGCGGCCCGGGAAGCTGCGGCCTACAGCAGTGGCGGCGGAGCGGCGGGTGCGGGCCTGGCGGGCCGCGAGCAGTACGGGCGCGCCGGCT
TCGCGGGCTCCTACTCCAGCCCCTACCCGGCTTACATGGCCGACGTGGGCGCGTCCTGGGCCGCAGCCGCCGCCGCCTCCGCCGGCCCCT
TCGACAGCCCGGTCCTGCACAGCCTGCCCGGCCGGGCCAACCCGGCCGCCCGACACCCCAATCTCGAACCCAGCTTAGACTAGAAAGTCT
AGAAGACACACACATAATGAAGGGGGAAGATGATGCTTTGTCAGACAAACATGGCTGCCCAGCCTACGTGAGCCCTGAGATCCTCAACAC
CACTGGGACCTACTCCGGAAAGGCTGCGGACGTTTGGAGCCTGGGGGTGATGCTCTACACCCTTCTGGTTGGACGATACCCCTTCCATGA
CTCAGACCCCAGTGCCCTTTTCTCCAAAATTCGGCGTGGACAGTTCTGCATTCCTGAGCACATTTCCCCCAAAGCCAGGTGCCTCATTCG
CAGCCTCTTGAGACGGGAGCCCTCCGAGAGACTCACTGCCCCCGAGATCCTACTGCACCCCTGGTTTGAGTCCGTCTTGGAACCCGGGTA
CATCGACTCAGAAATAGGAACTTCAGACCAGATTGTTCCAGAGTACCAGGAGGACAGTGACATTAGTTCCTTCTTCTGCTAATCCCCAAA
ACCTCAGAAACCTCATAATTCTTAACACCTGGCATTTCCATTTCTAAAGATGGACAGGCCCTTTGGCGTGGTACCAACCAGATAATGACT
GCATCAGGATGAAAGCTGCTGAACTCGGCATGGCGCCTCCTCTTCTCTGTTGGGATGAGTGACTTTATTGATTTGAGCAGCATATGCTGT
GATTGGCTGCCCTGCAAATTTGTTTCCCTTAAGGAACCCTCACCAACTATCTCTGCTGGATTTGGGAGTTCCGCATCTTTTGTGGAGGGC
AGAGTATGGACATCTTACACCCGGTGGTCAAGTGTGTAATAAACTTGAGCATTCGAATGGGAGAAAAAGCAAATCGCACAATGACATATT
TTGAGTAATAACCGTATTTTTCACAGGGTGACAAATTGGGCCAATAAATCTGCCATCTTTGAACTCATCTTTGGTGGCTAGACTGCTACG
GCAGCTTCTCTGATGGGAAAGTTCCTTTTTTGGCTTAACACTCACCCTTTCTTCACACTCACATTTACCAATGACTCTGCTCCGTTTTTG
GAGCAGACTGTTTTAAGTTGCTCAGGAGCCTGATGGAACCATGAACCGAGACTCTTCTCTGTTTCCTGCCAAGACCTCATCTGCACTAAT
GCCTTCTCCCTGACCTTGACACTTCCCCCTTTAGCTATAAAAGCACTTACCAGCCGAACGTGGAACAGTATCACAAAAGATTCCATCTCC
CAACGATTTCAGAACTCTGAGCTCAGAGAGACTCCAGATTTTAAAAAATAATTTGAGTGCTTGGAAACTATTAGCTTTTTAAGTTCCTTC
CAAATATGTTAGTACCTACCCTTTACTTTTTCCCCAAGACCATCTCAGGGTGGAGCATTCTGTCTAAGAGAAGAAAGATAAGGAGGCTCC
CACCCACCTCTCCCAAGAGCAGACATTAAACATCTTTGTGCTTTGAAGAGAGTGAATTTTGGATAGTCTTGTGATTCTCAGACTAACTTC
CAGAATTATACTTTAACCCCTCCCAGATATGGTCCGCCTTTGGCATTGTGTGTACATCTGCAGTTTTGCATGGTGGGTTGTTAATATTTC
AAATGTGTGGTTTATGAATACGTCTGTATAATCGGCTTCTGGAGTGAAACAGCAAACCCCAAATCTTCAAAGTTGGAAGGAACTTTAAAA
ATCATCCGGTCCAATCTCTTTCCTCTTTCTGCCACCTCCCAAGGCAGAAATCCCCTCTTCAGCTTCTTTTGTAGGTGGGAATCCAGCCTC
TGTTAGATATGTCCAGAGATGGAAACTCACTCCCCTACAAAAGATGGAGCTTAATGGAGAAATTGCAACTTTCATTAAAAAACAAATTCA
GATGAAATATCAGTAACTGTCTTGGACAGTGCTGAAATCAGGTGGTTAAACGGGTAAACAAAATATACTGTATTTTGAGAAATGGCACAA
AAACAGGCAGTCATCTTTAAGGGCTATGCCTAGGCAAACTACTAACATGCATTGTGAGAATGCCGTGTATACCTCACGTACTGTGTACTT
TGTACATATATTTTACCTTTTATACCTATGTTCGATTTTGTTTTGTTTTGTTTTGTTCTGGCTTTGAGGCTTGTTTTGTTGTCTGTGTCT
GTCTGAATAACCTGCGTGTCTAAAACCACGTGAAATGTGAATGATTATTGGCAATATTACCTTGACAGAATCATGGGACTTTGAGAAGAG
GGAGGACAGAGGCCTCTGTCGCACTAACGCTCTCGTGGTTGCTCGACTGTTGTATCTGTGATACATTATCCGACTAAGGACTCTGGGCTG
GCAGGGCCTTCTGCCGGGAAAGCTAGAAACACTAGGTTCTTCCTGTACATACGTGTATATATGTGAACAGTGAGATGGCCGTTTCTGACT

>32588_32588_3_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000532059_TRIB1_chr8_126448247_ENST00000311922_length(amino acids)=375AA_BP=220
MRGRERTPKPGARRDHVSELGHGRQPRAAPRCLRGGRPRRLHARRGRRVLASLRAHTAGALLRAGPVLPPGRRRGLCVRRRLGRQLRWGR
VWCGARDPAGQPGMEPGGSRRSRLHPAAGVAALLLPGDHRVPGGRRRRCRGPGSCGLQQWRRSGGCGPGGPRAVRARRLRGLLLQPLPGL
HGRRGRVLGRSRRRLRRPLRQPGPAQPARPGQPGRPTPQSRTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADV
WSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQI

--------------------------------------------------------------
>32588_32588_4_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000532059_TRIB1_chr8_126448248_ENST00000311922_length(transcript)=3096nt_BP=696nt
GCCGTCGTTTTCTCTCCCCGCGTGGCTCCTTGACCTGCGAGGGAGAGAGAGGACACCGAAGCCGGGAGCTCGCAGGGACCATGTATCAGA
GCTTGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCGGGCGGCCCCGGCGCCTTCATGCACGGCGCGGGCGCCGCGT
CCTCGCCAGTCTACGTGCCCACACCGCGGGTGCCCTCCTCCGTGCTGGGCCTGTCCTACCTCCAGGGCGGAGGCGCGGGCTCTGCGTCCG
GAGGCGCCTCGGGCGGCAGCTCCGGTGGGGCCGCGTCTGGTGCGGGGCCCGGGACCCAGCAGGGCAGCCCGGGATGGAGCCAGGCGGGAG
CCGACGGAGCCGCTTACACCCCGCCGCCGGTGTCGCCGCGCTTCTCCTTCCCGGGGACCACCGGGTCCCTGGCGGCCGCCGCCGCCGCTG
CCGCGGCCCGGGAAGCTGCGGCCTACAGCAGTGGCGGCGGAGCGGCGGGTGCGGGCCTGGCGGGCCGCGAGCAGTACGGGCGCGCCGGCT
TCGCGGGCTCCTACTCCAGCCCCTACCCGGCTTACATGGCCGACGTGGGCGCGTCCTGGGCCGCAGCCGCCGCCGCCTCCGCCGGCCCCT
TCGACAGCCCGGTCCTGCACAGCCTGCCCGGCCGGGCCAACCCGGCCGCCCGACACCCCAATCTCGAACCCAGCTTAGACTAGAAAGTCT
AGAAGACACACACATAATGAAGGGGGAAGATGATGCTTTGTCAGACAAACATGGCTGCCCAGCCTACGTGAGCCCTGAGATCCTCAACAC
CACTGGGACCTACTCCGGAAAGGCTGCGGACGTTTGGAGCCTGGGGGTGATGCTCTACACCCTTCTGGTTGGACGATACCCCTTCCATGA
CTCAGACCCCAGTGCCCTTTTCTCCAAAATTCGGCGTGGACAGTTCTGCATTCCTGAGCACATTTCCCCCAAAGCCAGGTGCCTCATTCG
CAGCCTCTTGAGACGGGAGCCCTCCGAGAGACTCACTGCCCCCGAGATCCTACTGCACCCCTGGTTTGAGTCCGTCTTGGAACCCGGGTA
CATCGACTCAGAAATAGGAACTTCAGACCAGATTGTTCCAGAGTACCAGGAGGACAGTGACATTAGTTCCTTCTTCTGCTAATCCCCAAA
ACCTCAGAAACCTCATAATTCTTAACACCTGGCATTTCCATTTCTAAAGATGGACAGGCCCTTTGGCGTGGTACCAACCAGATAATGACT
GCATCAGGATGAAAGCTGCTGAACTCGGCATGGCGCCTCCTCTTCTCTGTTGGGATGAGTGACTTTATTGATTTGAGCAGCATATGCTGT
GATTGGCTGCCCTGCAAATTTGTTTCCCTTAAGGAACCCTCACCAACTATCTCTGCTGGATTTGGGAGTTCCGCATCTTTTGTGGAGGGC
AGAGTATGGACATCTTACACCCGGTGGTCAAGTGTGTAATAAACTTGAGCATTCGAATGGGAGAAAAAGCAAATCGCACAATGACATATT
TTGAGTAATAACCGTATTTTTCACAGGGTGACAAATTGGGCCAATAAATCTGCCATCTTTGAACTCATCTTTGGTGGCTAGACTGCTACG
GCAGCTTCTCTGATGGGAAAGTTCCTTTTTTGGCTTAACACTCACCCTTTCTTCACACTCACATTTACCAATGACTCTGCTCCGTTTTTG
GAGCAGACTGTTTTAAGTTGCTCAGGAGCCTGATGGAACCATGAACCGAGACTCTTCTCTGTTTCCTGCCAAGACCTCATCTGCACTAAT
GCCTTCTCCCTGACCTTGACACTTCCCCCTTTAGCTATAAAAGCACTTACCAGCCGAACGTGGAACAGTATCACAAAAGATTCCATCTCC
CAACGATTTCAGAACTCTGAGCTCAGAGAGACTCCAGATTTTAAAAAATAATTTGAGTGCTTGGAAACTATTAGCTTTTTAAGTTCCTTC
CAAATATGTTAGTACCTACCCTTTACTTTTTCCCCAAGACCATCTCAGGGTGGAGCATTCTGTCTAAGAGAAGAAAGATAAGGAGGCTCC
CACCCACCTCTCCCAAGAGCAGACATTAAACATCTTTGTGCTTTGAAGAGAGTGAATTTTGGATAGTCTTGTGATTCTCAGACTAACTTC
CAGAATTATACTTTAACCCCTCCCAGATATGGTCCGCCTTTGGCATTGTGTGTACATCTGCAGTTTTGCATGGTGGGTTGTTAATATTTC
AAATGTGTGGTTTATGAATACGTCTGTATAATCGGCTTCTGGAGTGAAACAGCAAACCCCAAATCTTCAAAGTTGGAAGGAACTTTAAAA
ATCATCCGGTCCAATCTCTTTCCTCTTTCTGCCACCTCCCAAGGCAGAAATCCCCTCTTCAGCTTCTTTTGTAGGTGGGAATCCAGCCTC
TGTTAGATATGTCCAGAGATGGAAACTCACTCCCCTACAAAAGATGGAGCTTAATGGAGAAATTGCAACTTTCATTAAAAAACAAATTCA
GATGAAATATCAGTAACTGTCTTGGACAGTGCTGAAATCAGGTGGTTAAACGGGTAAACAAAATATACTGTATTTTGAGAAATGGCACAA
AAACAGGCAGTCATCTTTAAGGGCTATGCCTAGGCAAACTACTAACATGCATTGTGAGAATGCCGTGTATACCTCACGTACTGTGTACTT
TGTACATATATTTTACCTTTTATACCTATGTTCGATTTTGTTTTGTTTTGTTTTGTTCTGGCTTTGAGGCTTGTTTTGTTGTCTGTGTCT
GTCTGAATAACCTGCGTGTCTAAAACCACGTGAAATGTGAATGATTATTGGCAATATTACCTTGACAGAATCATGGGACTTTGAGAAGAG
GGAGGACAGAGGCCTCTGTCGCACTAACGCTCTCGTGGTTGCTCGACTGTTGTATCTGTGATACATTATCCGACTAAGGACTCTGGGCTG
GCAGGGCCTTCTGCCGGGAAAGCTAGAAACACTAGGTTCTTCCTGTACATACGTGTATATATGTGAACAGTGAGATGGCCGTTTCTGACT

>32588_32588_4_GATA4-TRIB1_GATA4_chr8_11566437_ENST00000532059_TRIB1_chr8_126448248_ENST00000311922_length(amino acids)=375AA_BP=220
MRGRERTPKPGARRDHVSELGHGRQPRAAPRCLRGGRPRRLHARRGRRVLASLRAHTAGALLRAGPVLPPGRRRGLCVRRRLGRQLRWGR
VWCGARDPAGQPGMEPGGSRRSRLHPAAGVAALLLPGDHRVPGGRRRRCRGPGSCGLQQWRRSGGCGPGGPRAVRARRLRGLLLQPLPGL
HGRRGRVLGRSRRRLRRPLRQPGPAQPARPGQPGRPTPQSRTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADV
WSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GATA4-TRIB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GATA4-TRIB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GATA4-TRIB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source