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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCD3-EXOC4 (FusionGDB2 ID:326)

Fusion Gene Summary for ABCD3-EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCD3-EXOC4
Fusion gene ID: 326
HgeneTgene
Gene symbol

ABCD3

EXOC4

Gene ID

5825

60412

Gene nameATP binding cassette subfamily D member 3exocyst complex component 4
SynonymsABC43|CBAS5|PMP70|PXMP1|ZWS2SEC8|SEC8L1|Sec8p
Cytomap

1p21.3

7q33

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family D member 370 kDa peroxisomal membrane proteinATP-binding cassette, sub-family D (ALD), member 3Peroxisomal membrane protein-1 (70kD)dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))peroxisoexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020031320200320
UniProtAcc

P28288

Q96A65

Ensembl transtripts involved in fusion geneENST00000315713, ENST00000370214, 
ENST00000394233, ENST00000454898, 
ENST00000536817, ENST00000484213, 
ENST00000460346, ENST00000393161, 
ENST00000541309, ENST00000545148, 
ENST00000253861, ENST00000539845, 
Fusion gene scores* DoF score6 X 5 X 4=12035 X 25 X 10=8750
# samples 639
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCD3 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCD3(94884144)-EXOC4(133502077), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCD3

GO:0007031

peroxisome organization

9425230


check buttonFusion gene breakpoints across ABCD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA454805ABCD3chr1

94884144

+EXOC4chr7

133502077

+


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Fusion Gene ORF analysis for ABCD3-EXOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000315713ENST00000460346ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-3UTRENST00000370214ENST00000460346ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-3UTRENST00000394233ENST00000460346ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-3UTRENST00000454898ENST00000460346ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000315713ENST00000393161ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000315713ENST00000541309ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000315713ENST00000545148ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000370214ENST00000393161ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000370214ENST00000541309ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000370214ENST00000545148ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000394233ENST00000393161ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000394233ENST00000541309ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000394233ENST00000545148ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000454898ENST00000393161ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000454898ENST00000541309ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5CDS-intronENST00000454898ENST00000545148ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5UTR-3CDSENST00000536817ENST00000253861ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5UTR-3CDSENST00000536817ENST00000539845ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5UTR-3UTRENST00000536817ENST00000460346ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5UTR-intronENST00000536817ENST00000393161ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5UTR-intronENST00000536817ENST00000541309ABCD3chr1

94884144

+EXOC4chr7

133502077

+
5UTR-intronENST00000536817ENST00000545148ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000315713ENST00000253861ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000315713ENST00000539845ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000370214ENST00000253861ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000370214ENST00000539845ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000394233ENST00000253861ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000394233ENST00000539845ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000454898ENST00000253861ABCD3chr1

94884144

+EXOC4chr7

133502077

+
In-frameENST00000454898ENST00000539845ABCD3chr1

94884144

+EXOC4chr7

133502077

+
intron-3CDSENST00000484213ENST00000253861ABCD3chr1

94884144

+EXOC4chr7

133502077

+
intron-3CDSENST00000484213ENST00000539845ABCD3chr1

94884144

+EXOC4chr7

133502077

+
intron-3UTRENST00000484213ENST00000460346ABCD3chr1

94884144

+EXOC4chr7

133502077

+
intron-intronENST00000484213ENST00000393161ABCD3chr1

94884144

+EXOC4chr7

133502077

+
intron-intronENST00000484213ENST00000541309ABCD3chr1

94884144

+EXOC4chr7

133502077

+
intron-intronENST00000484213ENST00000545148ABCD3chr1

94884144

+EXOC4chr7

133502077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394233ABCD3chr194884144+ENST00000253861EXOC4chr7133502077+28542121021622506
ENST00000394233ABCD3chr194884144+ENST00000539845EXOC4chr7133502077+16822121021622506
ENST00000454898ABCD3chr194884144+ENST00000253861EXOC4chr7133502077+2818176661586506
ENST00000454898ABCD3chr194884144+ENST00000539845EXOC4chr7133502077+1646176661586506
ENST00000370214ABCD3chr194884144+ENST00000253861EXOC4chr7133502077+2776134241544506
ENST00000370214ABCD3chr194884144+ENST00000539845EXOC4chr7133502077+1604134241544506
ENST00000315713ABCD3chr194884144+ENST00000253861EXOC4chr7133502077+275211001520506
ENST00000315713ABCD3chr194884144+ENST00000539845EXOC4chr7133502077+158011001520506

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394233ENST00000253861ABCD3chr194884144+EXOC4chr7133502077+0.0006674190.9993326
ENST00000394233ENST00000539845ABCD3chr194884144+EXOC4chr7133502077+0.0016914590.99830854
ENST00000454898ENST00000253861ABCD3chr194884144+EXOC4chr7133502077+0.000647340.99935263
ENST00000454898ENST00000539845ABCD3chr194884144+EXOC4chr7133502077+0.0015601520.99843985
ENST00000370214ENST00000253861ABCD3chr194884144+EXOC4chr7133502077+0.0006611620.9993388
ENST00000370214ENST00000539845ABCD3chr194884144+EXOC4chr7133502077+0.0019614570.9980386
ENST00000315713ENST00000253861ABCD3chr194884144+EXOC4chr7133502077+0.0006376150.9993624
ENST00000315713ENST00000539845ABCD3chr194884144+EXOC4chr7133502077+0.001882380.9981177

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Fusion Genomic Features for ABCD3-EXOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCD3chr194884144+EXOC4chr7133502077+0.0002444770.99975556
ABCD3chr194884144+EXOC4chr7133502077+0.0002444770.99975556

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCD3-EXOC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94884144/chr7:133502077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCD3

P28288

EXOC4

Q96A65

FUNCTION: Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). {ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:25168382}.FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEXOC4chr1:94884144chr7:133502077ENST0000039316101032_1140474.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+19440_65936237.0DomainABC transporter
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+1985_37236237.0DomainABC transmembrane type-1
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+123440_65936660.0DomainABC transporter
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+12385_37236660.0DomainABC transmembrane type-1
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+119440_65936550.0DomainABC transporter
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+11985_37236550.0DomainABC transmembrane type-1
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+19473_48036237.0Nucleotide bindingATP
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+123473_48036660.0Nucleotide bindingATP
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+119473_48036550.0Nucleotide bindingATP
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+191_12436237.0RegionNote=Targeting to peroxisomes
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+1231_12436660.0RegionNote=Targeting to peroxisomes
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+1191_12436550.0RegionNote=Targeting to peroxisomes
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+19126_14636237.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+19224_24436237.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+19313_33336237.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+1984_10436237.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+123126_14636660.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+123224_24436660.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+123313_33336660.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+12384_10436660.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+119126_14636550.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+119224_24436550.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+119313_33336550.0TransmembraneHelical
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+11984_10436550.0TransmembraneHelical
TgeneEXOC4chr1:94884144chr7:133502077ENST0000025386191832_114504975.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ABCD3-EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>326_326_1_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000315713_EXOC4_chr7_133502077_ENST00000253861_length(transcript)=2752nt_BP=110nt
ATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTGCTCTGCCTGCTCCACAAGCGGCGC
CGCGCCCTCGGCCTGCACGGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTC
ACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTG
AAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACAGTTCAA
GACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACC
TGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTC
TTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCT
TTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAA
GCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCT
CCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAG
GATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAAC
TATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATG
AGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTAC
TTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGG
GAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTG
AAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGG
CTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTA
CTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAGTTTTCTCTACAG
TGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCGACAGTACAGAGT
GTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAATTGTTGGACTCTG
AAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAGTAGGCTGCTACC
TAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTATCCGTTTACAGTT
CAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTACAACAAACTTCCC
TAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCTGTATCTTGTACA
CAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTATGGAGGAATGAA
AGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCATCTCACTTGAAAC
ATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGACATTTCTCCTCT
GTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACTGGACCTCACCAT
GTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATCTTGAAAACTCGT
GGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTACCTGTTTGTACAA

>326_326_1_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000315713_EXOC4_chr7_133502077_ENST00000253861_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_2_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000315713_EXOC4_chr7_133502077_ENST00000539845_length(transcript)=1580nt_BP=110nt
ATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTGCTCTGCCTGCTCCACAAGCGGCGC
CGCGCCCTCGGCCTGCACGGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTC
ACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTG
AAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACAGTTCAA
GACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACC
TGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTC
TTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCT
TTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAA
GCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCT
CCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAG
GATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAAC
TATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATG
AGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTAC
TTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGG
GAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTG
AAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGG
CTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTA

>326_326_2_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000315713_EXOC4_chr7_133502077_ENST00000539845_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_3_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000370214_EXOC4_chr7_133502077_ENST00000253861_length(transcript)=2776nt_BP=134nt
CGGCTCGCTGGTACCGGCAGTGCCATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTG
CTCTGCCTGCTCCACAAGCGGCGCCGCGCCCTCGGCCTGCACGGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAA
CAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGA
GTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACA
ATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTG
AAGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCA
AAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAG
GAAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATC
CTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAAT
CTTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTC
AGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTT
ATCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGAT
ATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGC
ATCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAAT
TTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTG
AACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGG
GAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAG
ATAACTACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATA
TTCTGAGCTTAGTTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGC
TAAAGGAAGGCGACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAG
GTGGTATCAAATTGTTGGACTCTGAAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGG
AAAGTAGGAAAGTAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTC
TCCTGACCTTATCCGTTTACAGTTCAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCA
GCTGCTGTTTACAACAAACTTCCCTAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACA
GTTTTGTATGCTGTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACA
ATTAGACAACTATGGAGGAATGAAAGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAG
AGAACATTGCATCTCACTTGAAACATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGAT
GGGACAGAGTGACATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGT
TCCTGGCACACTGGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGA
CTGGGCCACATCTTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGG

>326_326_3_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000370214_EXOC4_chr7_133502077_ENST00000253861_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_4_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000370214_EXOC4_chr7_133502077_ENST00000539845_length(transcript)=1604nt_BP=134nt
CGGCTCGCTGGTACCGGCAGTGCCATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTG
CTCTGCCTGCTCCACAAGCGGCGCCGCGCCCTCGGCCTGCACGGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAA
CAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGA
GTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACA
ATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTG
AAGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCA
AAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAG
GAAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATC
CTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAAT
CTTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTC
AGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTT
ATCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGAT
ATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGC
ATCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAAT
TTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTG
AACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGG
GAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAG

>326_326_4_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000370214_EXOC4_chr7_133502077_ENST00000539845_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_5_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000394233_EXOC4_chr7_133502077_ENST00000253861_length(transcript)=2854nt_BP=212nt
CTCTGCTCTCCTCCCAGTCTCCCCCGCGCTGCGTGCAGTAAGGTAGCCGCCGCCGCCGCCGCCGCCGCGTCCCCTCGCCGGCTCGCTGGT
ACCGGCAGTGCCATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTGCTCTGCCTGCTC
CACAAGCGGCGCCGCGCCCTCGGCCTGCACGGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTT
CGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACA
TCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAG
AAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAG
TACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGAT
ATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTC
ATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTC
AGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCC
CAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCC
AAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCA
AAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATT
GAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAAT
GGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATC
ACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTG
GACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACC
CAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTT
TAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAG
TTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCG
ACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAAT
TGTTGGACTCTGAAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAG
TAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTAT
CCGTTTACAGTTCAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTAC
AACAAACTTCCCTAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCT
GTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTA
TGGAGGAATGAAAGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCAT
CTCACTTGAAACATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGA
CATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACT
GGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATC
TTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTAC

>326_326_5_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000394233_EXOC4_chr7_133502077_ENST00000253861_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_6_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000394233_EXOC4_chr7_133502077_ENST00000539845_length(transcript)=1682nt_BP=212nt
CTCTGCTCTCCTCCCAGTCTCCCCCGCGCTGCGTGCAGTAAGGTAGCCGCCGCCGCCGCCGCCGCCGCGTCCCCTCGCCGGCTCGCTGGT
ACCGGCAGTGCCATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTGCTCTGCCTGCTC
CACAAGCGGCGCCGCGCCCTCGGCCTGCACGGATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTT
CGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACA
TCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAG
AAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAG
TACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGAT
ATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTC
ATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTC
AGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCC
CAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCC
AAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCA
AAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATT
GAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAAT
GGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATC
ACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTG
GACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACC
CAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTT

>326_326_6_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000394233_EXOC4_chr7_133502077_ENST00000539845_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_7_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000454898_EXOC4_chr7_133502077_ENST00000253861_length(transcript)=2818nt_BP=176nt
AGTAAGGTAGCCGCCGCCGCCGCCGCCGCCGCGTCCCCTCGCCGGCTCGCTGGTACCGGCAGTGCCATGGCGGCCTTCAGCAAGTACTTG
ACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTGCTCTGCCTGCTCCACAAGCGGCGCCGCGCCCTCGGCCTGCACGGATTT
ATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTT
CTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACC
ATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGAC
TTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATT
GTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATG
AATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTT
ATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGC
CTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAAC
ACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTT
GTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAA
AGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAG
TTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGC
ATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGG
CAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATC
CACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATC
TGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCC
TCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAGTTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTG
TAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCGACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAA
TGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAATTGTTGGACTCTGAAAAACAAGTGGATGGATTACTAA
TATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAGTAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACC
ATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTATCCGTTTACAGTTCAATGAAATAAGTGTATGTGCATT
GCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTACAACAAACTTCCCTAACCAAAACAGAACCTCTAATTT
AGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCTGTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCC
ATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTATGGAGGAATGAAAGGCAATTCAAACATCTGCTTGAT
TCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCATCTCACTTGAAACATCCTTTGGGGGTAAATGATTCTT
AGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGACATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTC
TCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACTGGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTG
CTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATCTTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGG
GACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTACCTGTTTGTACAACTTTGGTCTTGATGGGAAAAATGG

>326_326_7_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000454898_EXOC4_chr7_133502077_ENST00000253861_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

--------------------------------------------------------------
>326_326_8_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000454898_EXOC4_chr7_133502077_ENST00000539845_length(transcript)=1646nt_BP=176nt
AGTAAGGTAGCCGCCGCCGCCGCCGCCGCCGCGTCCCCTCGCCGGCTCGCTGGTACCGGCAGTGCCATGGCGGCCTTCAGCAAGTACTTG
ACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCCTGCTGCTCTGCCTGCTCCACAAGCGGCGCCGCGCCCTCGGCCTGCACGGATTT
ATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTT
CTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACC
ATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGAC
TTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATT
GTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATG
AATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTT
ATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGC
CTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAAC
ACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTT
GTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAA
AGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAG
TTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGC
ATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGG
CAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATC
CACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATC
TGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCC

>326_326_8_ABCD3-EXOC4_ABCD3_chr1_94884144_ENST00000454898_EXOC4_chr7_133502077_ENST00000539845_length(amino acids)=506AA_BP=37
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPL
KILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRL
LKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLS
PAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAM
SASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV

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Fusion Gene PPI Analysis for ABCD3-EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneABCD3chr1:94884144chr7:133502077ENST00000315713+191_19936.666666666666664237.0PEX19
HgeneABCD3chr1:94884144chr7:133502077ENST00000370214+1231_19936.666666666666664660.0PEX19
HgeneABCD3chr1:94884144chr7:133502077ENST00000394233+1191_19936.666666666666664550.0PEX19


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCD3-EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCD3-EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource