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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GBE1-LONRF1 (FusionGDB2 ID:32708)

Fusion Gene Summary for GBE1-LONRF1

Fusion gene summary

Fusion gene information	Fusion gene name: GBE1-LONRF1
	Fusion gene ID: 32708
		Hgene	Tgene
	Gene symbol	GBE1	LONRF1
	Gene ID	2632	91694
	Gene name	1,4-alpha-glucan branching enzyme 1	LON peptidase N-terminal domain and ring finger 1
	Synonyms	APBD\|GBE\|GSD4	RNF191
	Cytomap	3p12.2	8p23.1
	Type of gene	protein-coding	protein-coding
	Description	1,4-alpha-glucan-branching enzymeamylo-(1,4 to 1,6) transglucosidaseamylo-(1,4 to 1,6) transglycosylasebrancher enzymeglucan (1,4-alpha-), branching enzyme 1glycogen branching enzyme	LON peptidase N-terminal domain and RING finger protein 1RING finger protein 191
	Modification date	20200313	20200327
	UniProtAcc	.	Q17RB8
	Ensembl transtripts involved in fusion gene	ENST00000429644, ENST00000489715, ENST00000477426,	ENST00000530693, ENST00000533751, ENST00000525024, ENST00000398246,
Fusion gene scores	* DoF score	11 X 11 X 8=968	3 X 3 X 2=18
	# samples	13	3
	** MAII score	log2(13/968*10)=-2.89649542424614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GBE1 [Title/Abstract] AND LONRF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GBE1(81754595)-LONRF1(12600791), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GBE1	GO:0005978	glycogen biosynthetic process	26199317

Fusion gene breakpoints across GBE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LONRF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-A01C-01A	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-

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Fusion Gene ORF analysis for GBE1-LONRF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000429644	ENST00000530693	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
5CDS-5UTR	ENST00000429644	ENST00000533751	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
5CDS-5UTR	ENST00000489715	ENST00000530693	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
5CDS-5UTR	ENST00000489715	ENST00000533751	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
5CDS-intron	ENST00000429644	ENST00000525024	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
5CDS-intron	ENST00000489715	ENST00000525024	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
In-frame	ENST00000429644	ENST00000398246	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
In-frame	ENST00000489715	ENST00000398246	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
intron-3CDS	ENST00000477426	ENST00000398246	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
intron-5UTR	ENST00000477426	ENST00000530693	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
intron-5UTR	ENST00000477426	ENST00000533751	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-
intron-intron	ENST00000477426	ENST00000525024	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000429644	GBE1	chr3	81754595	-	ENST00000398246	LONRF1	chr8	12600791	-	3760	957	632	2557	641
ENST00000489715	GBE1	chr3	81754595	-	ENST00000398246	LONRF1	chr8	12600791	-	3046	243	53	1843	596

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000429644	ENST00000398246	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-	0.000166766	0.9998332
ENST00000489715	ENST00000398246	GBE1	chr3	81754595	-	LONRF1	chr8	12600791	-	7.96E-05	0.99992037

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Fusion Genomic Features for GBE1-LONRF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GBE1-LONRF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:81754595/chr8:12600791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LONRF1 Q17RB8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GBE1

chr3:81754595

chr8:12600791

ENST00000429644

62_63

104

703.0

Region

Substrate binding

Hgene

GBE1

chr3:81754595

chr8:12600791

ENST00000429644

91_93

104

703.0

Region

Substrate binding

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

565_766

240

774.0

Domain

Lon N-terminal

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

565_766

417.0

Domain

Lon N-terminal

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

246_278

240

774.0

Repeat

Note=TPR 3

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

279_312

240

774.0

Repeat

Note=TPR 4

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

212_244

417.0

Repeat

Note=TPR 2

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

246_278

417.0

Repeat

Note=TPR 3

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

279_312

417.0

Repeat

Note=TPR 4

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

48_81

417.0

Repeat

Note=TPR 1

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

479_517

240

774.0

Zinc finger

RING-type 2

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

123_159

417.0

Zinc finger

RING-type 1

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000533751

479_517

417.0

Zinc finger

RING-type 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GBE1

chr3:81754595

chr8:12600791

ENST00000429644

118_121

104

703.0

Region

Substrate binding

Hgene

GBE1

chr3:81754595

chr8:12600791

ENST00000429644

333_336

104

703.0

Region

Substrate binding

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

212_244

240

774.0

Repeat

Note=TPR 2

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

48_81

240

774.0

Repeat

Note=TPR 1

Tgene

LONRF1

chr3:81754595

chr8:12600791

ENST00000398246

123_159

240

774.0

Zinc finger

RING-type 1

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Fusion Gene Sequence for GBE1-LONRF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>32708_32708_1_GBE1-LONRF1_GBE1_chr3_81754595_ENST00000429644_LONRF1_chr8_12600791_ENST00000398246_length(transcript)=3760nt_BP=957nt
AAACTTAGGAGAGTCCTGGTTGTAAGAGGTATTAACATTTTCAGCAGTAGTACTCTAGCTACACTTGACTGTTCCCCTCTCTGTGAATTT
ACATGATATGTTTGAAATACTGCCCCTCAAAAGTCTCAGAACTTTGAGAAATACGGTCCTTTCCAAAAAAACCCCTTATGTCCAATTTGA
AGGGGTCGCTGTCAGTGGGTGCTTAAGTGGGTAAAGAAAAGCCAAGAATATGTCAGGGTGAGGAAGGCCAAGGCTGAGCGAGGTCAGCTT
GGGACCCACCTCCTAGAATGACCTCCGCCAGCAGGAAAAAACCGTTAAGGGGAGGAAAGGGCAGGTCCCTGCGGCCTCCAGGTGCCAGCC
GCGTGAGTGGGCGGAGAGGCCTCGGTGCCTCCTACCCGCTCCGGACGTGCGTCCCGGCATCACCCCGGGATCCGCTCCTCCCCGCTGGCG
GGGGGAGAAAGGGCAGGAGGCCTTCCGTCCCGGCTATAAAGGGCCCCGGACCGCCGCGGCTCGCCTCGGCTTGCCTCGACACGCCTAGGC
GCCCTCCGGCTCCGCCCTAGCCGCCGCGTCCCAGCTAGAGCTCCAGCGCCCGCTCAGGCCCCACTCGACCTCTCGGGCCTCGGCTACTTG
GACTGCGGCGGAATATGGCGGCTCCGATGACTCCCGCGGCTCGGCCCGAGGACTACGAGGCGGCGCTCAATGCCGCCCTGGCTGACGTGC
CCGAACTGGCCAGACTCCTGGAGATCGACCCGTACTTGAAGCCCTACGCCGTGGACTTCCAGCGCAGGTATAAGCAGTTTAGCCAAATTT
TGAAGAACATTGGAGAAAATGAAGGTGGTATTGATAAGTTTTCCAGAGGCTATGAATCATTTGGCGTCCACAGATGTGCTGATGGTGGTT
TATACTGCAAAGAATGGGCCCCGGGAGCAGAAGGAGTTTTTCTTACTGGAGATTTTAAACCCAGTGACTTGATTGTAAAAATTTACAGAG
CGGAATCATATGCTGGTCTCCAAGAGTTTAAAGCAGCCATAGAAGATTTAAATGCAGTTCTTTTTCAACTTCCAGATTGGCCTGAGGTCT
ACTTCAGGAAAGGAAAAGTACTCTGCGATGCTGGTTTTTTAGGTGATGCCTTACAACTCTTTCTTCAGTGCTTAGCCCTTGATGAAGATT
TTGCACCTGCAAAGCTGCAAGTACAAAAGATTTTATGTGATTTATTATTACCTGAAAACTTAAAAGAAGGCCTGAAGGAATCTTCCTGGA
GTTCATTACCATGTACTAAAAACAGACCTTTTGATTTTCATTCAGTGATGGAAGAGTCTCAGTCTCTCAATGAACCTAGCCCAAAGCAGA
GTGAAGAAATACCAGAGGTCACTTCAGAGCCTGTCAAAGGAAGCTTAAACCGTGCTCAGTCAGCACAGTCTATAAATTCAACAGAAATGC
CTGCCAGAGAGGACTGTTTAAAAAGAGTGTCCTCAGAACCTGTTCTGTCAGTTCAAGAAAAAGGTGTTCTGCTGAAAAGAAAGTTGTCTC
TTTTAGAACAGGATGTGATTGTAAATGAAGATGGAAGAAATAAGCTGAAAAAACAAGGAGAAACTCCCAATGAAGTCTGTATGTTTTCCT
TAGCTTATGGTGATATTCCAGAAGAATTAATCGATGTCTCAGATTTCGAGTGTTCTCTCTGCATGAGGTTGTTTTTTGAGCCAGTAACAA
CCCCTTGCGGACATTCGTTCTGTAAGAATTGTCTTGAGCGTTGTTTAGATCATGCACCATATTGTCCTCTTTGCAAAGAAAGCTTAAAAG
AGTATCTAGCAGATAGGAGGTACTGTGTCACACAGCTGTTGGAAGAATTAATAGTGAAGTATCTGCCTGATGAACTGTCTGAGAGAAAAA
AAATATATGATGAAGAAACTGCTGAACTCTCACACTTGACCAAGAATGTTCCAATATTTGTTTGCACTATGGCCTACCCCACTGTGCCTT
GCCCTCTCCATGTATTTGAGCCAAGATACAGATTGATGATTCGAAGAAGTATACAGACTGGAACCAAACAGTTTGGCATGTGTGTCAGTG
ATACACAAAATAGTTTTGCAGATTATGGTTGTATGTTACAAATTAGAAACGTGCATTTCTTACCGGACGGAAGGTCTGTGGTTGATACAG
TTGGAGGAAAGCGGTTTAGGGTTTTAAAAAGAGGAATGAAAGATGGATATTGCACTGCCGACATTGAATATCTGGAAGATGTTAAGGTTG
AGAATGAAGATGAGATTAAGAATCTCAGAGAGCTTCATGATTTGGTTTACTCTCAAGCCTGCAGCTGGTTTCAGAATTTAAGAGACAGAT
TTCGAAGCCAAATTCTTCAGCATTTCGGATCAATGCCCGAGAGGGAGGAAAACCTTCAGGCAGCCCCTAATGGACCTGCATGGTGTTGGT
GGCTTCTTGCAGTTCTCCCTGTAGACCCACGATACCAGCTGTCGGTTTTGTCAATGAAGTCTTTGAAAGAACGGTTGACCAAGATACAGC
ATATACTGACCTATTTTTCTAGAGACCAATCTAAGTAACTAACTCTTTGGATCTCCCTTTAAAGTGACCCTAATCTGGCTGCATTGATGG
CCAGATTGTCTGCTGCCTTTGCACATCTAGTGCTGGTTTCAGAAATTTAATGAAACTTTTCTTTTTCCTTCGACCTCCTGAATCATGTGG
TTCTGCAAATGAATACCTTCAACTAGGATTTAGACCACTAAGAACTTGCACAGAAAAACACGCATTGAATGTGTGTCGAACCTCTACATT
GTGAAGTTGCACTATGTACCATACTCTAAAATGAAATAAGAACTCTTTATGTCTGTGAGAGAGTGTGTGTGTGTGTGTGCGTGCGTGTGT
GCTTGTGGGGGTTGGGTAGTGTGTGTGTATTTTCTCTGGCTTTAAAATTTTAAAACAAACAAACAAAAAAGCCATAGAGAGCAGAACTTG
CCGAGGGTCATTTATTGCCCAAGTTTACAAGAGTAGCGATACAAGTTTTTGCAAATTGAATTTGCCTCAGATATATCTGTCCTAATGCTT
ATATTTGCACAAGTATGTAAAATATCGTGTTGAGGATCATTCTTTGTTGGAAACACTGCTCTTGCTGAACTGTCTTGACCATTGACTATG
ACACAGTTTCTTATTTATGTAAATACTTGCATCACAGTGGCCGACAGGCATTGGATGCAGAACCTAGAGCCAGTTTTCAGGAACAATTGT
AAACCTGACATGGTACTGTGCATCTATTCATAAAACACTCAAAACTGTGAAAATATGGTTTACATTTAATTGTACATAAAGGTAAAGGGA
GAACTCAATTCAGTACCAGTTAGTTTGTACATTTTAGGGGGCTTTTCACATTAACTGCCCATTTGTGTAATTTATAGTTTGACATGATGT
GTTTGTTTTAAAAAAAAATGCATAGTATAAACCCATTAAGGATCTGGGAAAAGAGAAGAAGTTTAATATAGAACTAAGCTTTTAAAGTTT
GTTTTTGTTTTTAATTCTGGTCTCGGTGCAAATGTTAGTTATGCCTTATTCATATCACAGTTAGATCACCATGCTGCAACATGGTTTATA
TTCATGCTGCCCTAGAAACTTTTGTAATTATTTGTTGCAAATTTGTGACTGTCCTTATTAACTTTCTTTTATGTAAGTAATTTGTAAAAG

>32708_32708_1_GBE1-LONRF1_GBE1_chr3_81754595_ENST00000429644_LONRF1_chr8_12600791_ENST00000398246_length(amino acids)=641AA_BP=109
MRRNMAAPMTPAARPEDYEAALNAALADVPELARLLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGL
YCKEWAPGAEGVFLTGDFKPSDLIVKIYRAESYAGLQEFKAAIEDLNAVLFQLPDWPEVYFRKGKVLCDAGFLGDALQLFLQCLALDEDF
APAKLQVQKILCDLLLPENLKEGLKESSWSSLPCTKNRPFDFHSVMEESQSLNEPSPKQSEEIPEVTSEPVKGSLNRAQSAQSINSTEMP
AREDCLKRVSSEPVLSVQEKGVLLKRKLSLLEQDVIVNEDGRNKLKKQGETPNEVCMFSLAYGDIPEELIDVSDFECSLCMRLFFEPVTT
PCGHSFCKNCLERCLDHAPYCPLCKESLKEYLADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPC
PLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVE
NEDEIKNLRELHDLVYSQACSWFQNLRDRFRSQILQHFGSMPEREENLQAAPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQH

--------------------------------------------------------------
>32708_32708_2_GBE1-LONRF1_GBE1_chr3_81754595_ENST00000489715_LONRF1_chr8_12600791_ENST00000398246_length(transcript)=3046nt_BP=243nt
AATTTCACTTGGATTCGGCCCAGATTAACAGCTGTTTCTAACTTCGTTGTCCCATGAATCTTGCTAAAGTGAGGTATAAGCAGTTTAGCC
AAATTTTGAAGAACATTGGAGAAAATGAAGGTGGTATTGATAAGTTTTCCAGAGGCTATGAATCATTTGGCGTCCACAGATGTGCTGATG
GTGGTTTATACTGCAAAGAATGGGCCCCGGGAGCAGAAGGAGTTTTTCTTACTGGAGATTTTAAACCCAGTGACTTGATTGTAAAAATTT
ACAGAGCGGAATCATATGCTGGTCTCCAAGAGTTTAAAGCAGCCATAGAAGATTTAAATGCAGTTCTTTTTCAACTTCCAGATTGGCCTG
AGGTCTACTTCAGGAAAGGAAAAGTACTCTGCGATGCTGGTTTTTTAGGTGATGCCTTACAACTCTTTCTTCAGTGCTTAGCCCTTGATG
AAGATTTTGCACCTGCAAAGCTGCAAGTACAAAAGATTTTATGTGATTTATTATTACCTGAAAACTTAAAAGAAGGCCTGAAGGAATCTT
CCTGGAGTTCATTACCATGTACTAAAAACAGACCTTTTGATTTTCATTCAGTGATGGAAGAGTCTCAGTCTCTCAATGAACCTAGCCCAA
AGCAGAGTGAAGAAATACCAGAGGTCACTTCAGAGCCTGTCAAAGGAAGCTTAAACCGTGCTCAGTCAGCACAGTCTATAAATTCAACAG
AAATGCCTGCCAGAGAGGACTGTTTAAAAAGAGTGTCCTCAGAACCTGTTCTGTCAGTTCAAGAAAAAGGTGTTCTGCTGAAAAGAAAGT
TGTCTCTTTTAGAACAGGATGTGATTGTAAATGAAGATGGAAGAAATAAGCTGAAAAAACAAGGAGAAACTCCCAATGAAGTCTGTATGT
TTTCCTTAGCTTATGGTGATATTCCAGAAGAATTAATCGATGTCTCAGATTTCGAGTGTTCTCTCTGCATGAGGTTGTTTTTTGAGCCAG
TAACAACCCCTTGCGGACATTCGTTCTGTAAGAATTGTCTTGAGCGTTGTTTAGATCATGCACCATATTGTCCTCTTTGCAAAGAAAGCT
TAAAAGAGTATCTAGCAGATAGGAGGTACTGTGTCACACAGCTGTTGGAAGAATTAATAGTGAAGTATCTGCCTGATGAACTGTCTGAGA
GAAAAAAAATATATGATGAAGAAACTGCTGAACTCTCACACTTGACCAAGAATGTTCCAATATTTGTTTGCACTATGGCCTACCCCACTG
TGCCTTGCCCTCTCCATGTATTTGAGCCAAGATACAGATTGATGATTCGAAGAAGTATACAGACTGGAACCAAACAGTTTGGCATGTGTG
TCAGTGATACACAAAATAGTTTTGCAGATTATGGTTGTATGTTACAAATTAGAAACGTGCATTTCTTACCGGACGGAAGGTCTGTGGTTG
ATACAGTTGGAGGAAAGCGGTTTAGGGTTTTAAAAAGAGGAATGAAAGATGGATATTGCACTGCCGACATTGAATATCTGGAAGATGTTA
AGGTTGAGAATGAAGATGAGATTAAGAATCTCAGAGAGCTTCATGATTTGGTTTACTCTCAAGCCTGCAGCTGGTTTCAGAATTTAAGAG
ACAGATTTCGAAGCCAAATTCTTCAGCATTTCGGATCAATGCCCGAGAGGGAGGAAAACCTTCAGGCAGCCCCTAATGGACCTGCATGGT
GTTGGTGGCTTCTTGCAGTTCTCCCTGTAGACCCACGATACCAGCTGTCGGTTTTGTCAATGAAGTCTTTGAAAGAACGGTTGACCAAGA
TACAGCATATACTGACCTATTTTTCTAGAGACCAATCTAAGTAACTAACTCTTTGGATCTCCCTTTAAAGTGACCCTAATCTGGCTGCAT
TGATGGCCAGATTGTCTGCTGCCTTTGCACATCTAGTGCTGGTTTCAGAAATTTAATGAAACTTTTCTTTTTCCTTCGACCTCCTGAATC
ATGTGGTTCTGCAAATGAATACCTTCAACTAGGATTTAGACCACTAAGAACTTGCACAGAAAAACACGCATTGAATGTGTGTCGAACCTC
TACATTGTGAAGTTGCACTATGTACCATACTCTAAAATGAAATAAGAACTCTTTATGTCTGTGAGAGAGTGTGTGTGTGTGTGTGCGTGC
GTGTGTGCTTGTGGGGGTTGGGTAGTGTGTGTGTATTTTCTCTGGCTTTAAAATTTTAAAACAAACAAACAAAAAAGCCATAGAGAGCAG
AACTTGCCGAGGGTCATTTATTGCCCAAGTTTACAAGAGTAGCGATACAAGTTTTTGCAAATTGAATTTGCCTCAGATATATCTGTCCTA
ATGCTTATATTTGCACAAGTATGTAAAATATCGTGTTGAGGATCATTCTTTGTTGGAAACACTGCTCTTGCTGAACTGTCTTGACCATTG
ACTATGACACAGTTTCTTATTTATGTAAATACTTGCATCACAGTGGCCGACAGGCATTGGATGCAGAACCTAGAGCCAGTTTTCAGGAAC
AATTGTAAACCTGACATGGTACTGTGCATCTATTCATAAAACACTCAAAACTGTGAAAATATGGTTTACATTTAATTGTACATAAAGGTA
AAGGGAGAACTCAATTCAGTACCAGTTAGTTTGTACATTTTAGGGGGCTTTTCACATTAACTGCCCATTTGTGTAATTTATAGTTTGACA
TGATGTGTTTGTTTTAAAAAAAAATGCATAGTATAAACCCATTAAGGATCTGGGAAAAGAGAAGAAGTTTAATATAGAACTAAGCTTTTA
AAGTTTGTTTTTGTTTTTAATTCTGGTCTCGGTGCAAATGTTAGTTATGCCTTATTCATATCACAGTTAGATCACCATGCTGCAACATGG
TTTATATTCATGCTGCCCTAGAAACTTTTGTAATTATTTGTTGCAAATTTGTGACTGTCCTTATTAACTTTCTTTTATGTAAGTAATTTG

>32708_32708_2_GBE1-LONRF1_GBE1_chr3_81754595_ENST00000489715_LONRF1_chr8_12600791_ENST00000398246_length(amino acids)=596AA_BP=64
MNLAKVRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEGVFLTGDFKPSDLIVKIYRAESYAGLQEFKAAIED
LNAVLFQLPDWPEVYFRKGKVLCDAGFLGDALQLFLQCLALDEDFAPAKLQVQKILCDLLLPENLKEGLKESSWSSLPCTKNRPFDFHSV
MEESQSLNEPSPKQSEEIPEVTSEPVKGSLNRAQSAQSINSTEMPAREDCLKRVSSEPVLSVQEKGVLLKRKLSLLEQDVIVNEDGRNKL
KKQGETPNEVCMFSLAYGDIPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKEYLADRRYCVTQLLEE
LIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIR
NVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRELHDLVYSQACSWFQNLRDRFRSQILQHFGSMPERE

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Fusion Gene PPI Analysis for GBE1-LONRF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GBE1-LONRF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GBE1-LONRF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source