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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GCLC-FAM204A (FusionGDB2 ID:32763)

Fusion Gene Summary for GCLC-FAM204A

Fusion gene summary

Fusion gene information	Fusion gene name: GCLC-FAM204A
	Fusion gene ID: 32763
		Hgene	Tgene
	Gene symbol	GCLC	FAM204A
	Gene ID	2729	63877
	Gene name	glutamate-cysteine ligase catalytic subunit	family with sequence similarity 204 member A
	Synonyms	GCL\|GCS\|GLCL\|GLCLC	C10orf84\|bA319I23.1
	Cytomap	6p12.1	10q26.11
	Type of gene	protein-coding	protein-coding
	Description	glutamate--cysteine ligase catalytic subunitGCS heavy chaingamma-ECSgamma-glutamylcysteine synthetase	protein FAM204A
	Modification date	20200313	20200313
	UniProtAcc	P48506	Q9H8W3
	Ensembl transtripts involved in fusion gene	ENST00000229416, ENST00000514004,	ENST00000369172, ENST00000469758, ENST00000369183,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 3 X 3=27
	# samples	2	3
	** MAII score	log2(2/8*10)=1.32192809488736	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GCLC [Title/Abstract] AND FAM204A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GCLC(53409293)-FAM204A(120085755), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GCLC	GO:0006534	cysteine metabolic process	2294991
Hgene	GCLC	GO:0006536	glutamate metabolic process	2294991\|12663448
Hgene	GCLC	GO:0006750	glutathione biosynthetic process	8104187\|10395918
Hgene	GCLC	GO:0006979	response to oxidative stress	10395918\|11972604
Hgene	GCLC	GO:0009408	response to heat	8104187
Hgene	GCLC	GO:0009725	response to hormone	8104187
Hgene	GCLC	GO:0043066	negative regulation of apoptotic process	10439045
Hgene	GCLC	GO:0045454	cell redox homeostasis	10439045
Hgene	GCLC	GO:0045892	negative regulation of transcription, DNA-templated	10439045

Fusion gene breakpoints across GCLC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM204A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-V5-A7RC	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-

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Fusion Gene ORF analysis for GCLC-FAM204A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000229416	ENST00000369172	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-
5CDS-5UTR	ENST00000229416	ENST00000469758	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-
5CDS-5UTR	ENST00000514004	ENST00000369172	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-
5CDS-5UTR	ENST00000514004	ENST00000469758	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-
In-frame	ENST00000229416	ENST00000369183	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-
In-frame	ENST00000514004	ENST00000369183	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000229416	GCLC	chr6	53409293	-	ENST00000369183	FAM204A	chr10	120085755	-	5851	634	84	632	182
ENST00000514004	GCLC	chr6	53409293	-	ENST00000369183	FAM204A	chr10	120085755	-	5755	538	474	1	158

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000229416	ENST00000369183	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-	0.010655336	0.98934466
ENST00000514004	ENST00000369183	GCLC	chr6	53409293	-	FAM204A	chr10	120085755	-	0.010558421	0.9894415

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Fusion Genomic Features for GCLC-FAM204A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GCLC-FAM204A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:53409293/chr10:120085755)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GCLC P48506	FAM204A Q9H8W3

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FAM204A

chr6:53409293

chr10:120085755

ENST00000369172

144_164

151

234.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

FAM204A

chr6:53409293

chr10:120085755

ENST00000369183

144_164

151

234.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for GCLC-FAM204A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>32763_32763_1_GCLC-FAM204A_GCLC_chr6_53409293_ENST00000229416_FAM204A_chr10_120085755_ENST00000369183_length(transcript)=5851nt_BP=634nt
ATAAAACCTGGAGCGCAGGATCGCGCCCAGGAGCGGCGAGCTAGCGGACGCAAAGACTGGGCATGCTCCGCGGCGGCGCAGGTTTTGGTC
ACAAGTAGGAAGAAGCCAGTGCACCAGACCGGCAAAGAGAAGCGGGAGCCGCCGCGGCAGCGCGGCCGTGGGGTCCGCCGCCGCCGCATC
GGAGCGGGAGGAGGAGCAGCGGGGAGGGCGAGGCCGCCGGGCCGAGAGCCGTCCCGCCTGCTCTCGGTCTTCTGCCTTCGCCTCCGCGCG
GTGCGTCGGACCCAGGGTCTGTCACCTGGGCGCCAGGGGCCGCCGCCGGGGAGCCGGAGCGGGCAGGACCCTCCCTCCGCCGACTGCGGC
CCGAGAGCGCCCCCGCGGGGTGGAGCGGCAGCCGCCTTCTGCGGGCGGCTGAGTGTCCGTCTCGCGCCCGGAGCGGGCGACCGCCGTCAG
CCCGGAGGAGGAGGAGGAGGAGGAGGGGGCGGCCATGGGGCTGCTGTCCCAGGGCTCGCCGCTGAGCTGGGAGGAAACCAAGCGCCATGC
CGACCACGTGCGGCGGCACGGGATCCTCCAGTTCCTGCACATCTACCACGCCGTCAAGGACCGGCACAAGGACGTTCTCAAGTGGGGCGA
TGAGTCAGGCCTTGAAAAGAGGATAGACCAGGCTGTGGAGGAGTGGAATATTGAGAAGGCTGAGGAACTCAGCAACCAGCTAGCTACTCG
AGAGCTTGGTGTAAAAATTGCCAAAGCAGTTGCCTGCCACAACTTTGTAAAAGCCAAAAAGGAGGTTGAAAATTCACAGGCTGCCCGAAA
AAAGAAGAAACTTGCATGGGGGTTTGAAGCAAAGAAGAGATGGGAAACCAAAAGCAACATGGGATACATGTAACTTGCCAGAGTGCTTCA
AGACATTTGTAGACTCAAATGCTCAATTTACTGAGAATGTTTTCCTGCCTATGTTAATATGTCAGAAAATTGATAGCACTAAAACAAAAA
TAAGCATAAAATTTGGGATTTTGATTATCAGCTCTTTTCAGTCTTTCTTTAAGGACTTTGTCCTATTGAAGTGAATAAAATGAAGCATTC
TGTTATTTGTATAAGAAATGTAAGAAAAAAAATATAGAAAGAAGAGGATAGGATTTTGTTTATTTGTATGGATGGACCCTTGGTATAAAA
TCACTTTTGGCGCTTTCCATTCATTTGGTTTAGCACAGCCAGTGAGCTTCTCGTACTTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAG
CCTCGCTTGCTCTGTCACCCAGGCTAGAGTGCAGTAGCACGATCTTGGCTCACTGCAACCACTGCTTCCTGGGTTCAAGTGATTCTCATG
CCTCAGCCTCCTGAGTAGCTGGGATTATGGACAAATGCCACCACACCCGGCTAATTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACAGA
GTTTTGCTGTGTTGGTCAGGCTGGTCTTGAACTCCTGGCCTCATATGATTCACCTGCCTCTGCCTCCCAAAGTTCTGGGAGTACAGACAT
GAGCTACCATGCTGCCCTTGTATTTTCTTATCTGTACCCAGTGTAACTACACGTTTACTGGAACTGTGTTTTTAAGACTGACAGTTGTTT
ATAATGGATTAGTCGTAAGTACCAAAAAGTCTCAGTTGATATTATCTTTACAAATGACTTGACCTTAATGTTATAAAAGTAGTTACTGTT
TTTTTTTAATTGGAGGCAGACTTGATATTTCAGAGTTGCATAGTAAAAGCAATTTGTTAATTTTTGTGTACTTTCAGATAAACTATTACA
ATAAAGAAAGGAGCAGAATGTAGTATTTGGAAGATGATTTAAATTCAGCAACGCCTAAAAATGTCTTCCTAAGTATTTTTCTCAGCCATG
TCATTCTTTAAATTATGAGATGGTTCTTAGAAGAGAAAATGGTGTAATTGTATTAAACAGACAATTATAACTCAAGATAATATAACTTTG
AACCTTCTAAGAACTGATTTGTTTGGTTTTCCTCCCATTCCCCATTCCTCCTTAAAAGATTGAATGAATTAATGAGCAGAAAGAGAGGAT
TGGTAACATGGGAAATCGTTTTCATTAGATGTACATTTCCTGGTTCTGACAGGAAAGGGGCTCCAGAAAATCATAAAACAAGCAGGTGAA
CAAGACCAGGTGTGTCGGCACCTCCCTGCTCAGTGCCCAGCGGAGGTAAAGAACCACTCAGCATGGTTTTTGTCAGTTCACCTCTTCTGT
CGTTGTCAGAGGTTTCCTACCTGTCTGATATAAACTTTCTCTGGGTTGATAATATAAATTCAGAAACATGTAAAATGAATCATGATTATA
TTACTGTTATTTTTAGACTTAAAATAGTAACAAAATTTTATTTATGGTGGCACATTTAATGGCTTTTTTTTTCTGTGTTCTGGAATAAGA
GAATACCTAGCTACTATTTAAGCATCCAAAAATCATATCTTGCTTTCATTTAGTTGAGAAAAGCCAGCATAGAGAAAGCAAAGTTTTAGA
ATATTATGTGTCATACTAATTCAGTATCCAGACCAAATGTTGGAAAGTCTTATTTTATGATTTAATATCCCTTGTTCCATTTTACAGATA
TGATCATGTAAAACTTACCTACAATATTCATTTCAAACTGCTAAATTAGGTAAATACAGACTTTTAGTATAGAAACCTTTCCTCTAAAAA
TCCATTATGGGGGAAATATTCACTATACAATCCAGTGGTTTTGTCTGAAATCCTAAAAATGTTATTTTTGAGCAGGCGAGTGGTATAGAT
ATTCTCACACTTGGGGCCCCGATATGGGCATTTCCCTTTGACTTCAGTCTCATTTTTTTTTTTTTTTCTGTTTCTACTCCTTAGAGCATT
TAGTGACCCCTGCAGGCATGTTGCACTTCCCATACTGAAGCCTTGCCAGAGTGGCCTCCTGTAGGGTCTGACTTGGGATCCTGTCCAGCC
AAGGAAGCCCTTCTTCAGCCTGCTCCAGTGCCCGCAGTTGCCCCCTCAGCATCCCCTCGGGGTTCTCATGTAGATGGGAACATTTTAACT
ACGCGGAAGGCAGGCATTTCAGCAGAATTAAGTATAGCGGGGGCTCATCTAATAAAGGAAGCCACTTCTCCCAAGTCGTCACTCCTTTCT
GGGCATGGGTTGTGGAAAGCTCTAAAACGTTATGTGTAGCAGAAGAAGGGGTTGGAGGGAAGATTTGTGGGGACAGGTTGTCTTGGATTG
GCCCTGCTGACATGTCATTTGAGAGCAGTTTTATTTTATCCTTTCTAATAGGAATTAGGTATTTTACTCCTAGAAACATTATTCCTTGAG
TACGCATGCTGCTCAAAGGATGTAGTCATTTGTCCACTCCATTCTAGTCACAGCAAAATAAGGATTCTTTTTGGATCAGTAATAACTTTG
GTTCCTAAAACTTCAATATGTGCATTTACTACCACCAGAATGCCTGAGTTAGATCAGTAATGTAAACGTCAGTTATTGTTAACTGAGATT
AATATGTTTCAGGCCGTTGGTATGGCATTAATGTAACTATGATTTACTATTTAAGTACTTTAGGCTAAAACATCTTACTAAAGAACAGTA
ATTTTGAGCTTTACAGCACTGGTTCTGAGAAAGGGAAGTTGGCAGTGCATTCTTGTTTGGGAGCCCTCAGGATGTTTCTGATTTTCAGCA
GAACATTCTATGTCTTTCACCGAAAGGAGAGATTGAATATATAATCTTAGGTTTGCTATAATTAGTTCTGATGACAGAGTTAAATACCTC
AGCCAAGACTGTAAATCAGTACGTAAACAGGTTTCTGCAACTGATCATAAATCTCAAACTGCATATTTTAAACACTTATTTTTTTAGGAT
GACAGATAAGGGAGCAGCAGGCTAAGGATAGGAATAAAATGTTATCTGAACTTTTAAGTCACAACTTAGAACTCACATTAAAATCTTCTG
ATTTTCTTTATACCTTTTGTCTAAAATATTATCTTTTAGCTTATTAATAACTTTAATAAGACAAGTTTGAATTTAATTCACAAAAAATGA
AGATATAATTTATAAAATGTCCAAATTTTTGTTAAGACATTACTTTTTAAGAAATGTGTGTCTTGCTAAATATAAAACATATTGTATGAG
GTTGTTGTTTAAACAAAATGAGAGTTGTACATTATTTTTTAAGAGATGATAAAGTTTGAGGAGGCAAGCCGATGTTATGTCAGATCTCAT
TTTGAAGTTAGTGAAACCTAGTCTAATCCAGAACCAACTGAATCCAAGTTTTCCATTTTGGCAGAAGTTGCTTTTATTTTTAGTATCTGG
CAGAGCAACAAATGCTTTGCATGTCAGTTCAATATTTTTTCCTGCCAACTGTTTATTCATTGGCTTAAAATTTACACTCTACTAAAGTCT
TAGCTCTGACTTTCATGAAACAAATAGTAATATTTGGACAAAATATGTACATGAAAATCTTTTTCCAGAACCAAATGTAGACTGGTATTT
GTGACATCAGTGCCTTCTAGCATGGTGACGGGTCGAAAAATACTTTGAAAAGTTGAAGGCTGTGTAAACCCACGGCAGTGCATCTCAAGT
GATTTTTATTATGAGGTAATCAGAGTATCTAGGTTTTCAAATTTAAATTAGTGGGTGACTTTATGCTAGAAAGTAGAATATGTGTTAGAA
TAAATTTATCAATATATATTCTTGGCCTTTGTAGGATACTGAGACAATAAGGTCCATTTTTCATTTTTGAGGTTGGGGAGCTCTGTAGAT
TTTGATAAAATGTGCAGAACTGCATTCTTTAATCTTTATTATTTCATCCTCCCTCCACACTGCTTGCTTTAAAAGAAAAAAATACCTACA
CACATTTTCTAGTGTTAACTGCTGTAATCAGCATAGACTTCCTGGGAAGGGATTCTTGCCTTCAGTAAAGGACATGACAGCATGTGGCCA
ATGGAGATTGCCACGAGGAAACCTGGAAAGGCATTGAACCATTTTGTGCTACTGTTAAAATGAGGTGTGTTGTCTCTTTATTATCTCCTA
CTCAATAGTGAGTATTCTGGAGGTGTCTGTTCCCTTTCCGGAATTTCTTCAAATACAGAGATGCTTCAGAGTAGCTTCCTGCCACATTGG
CTTTCATGATCTTAATCCCTGGAACACAGCTATAGGCTTCTGGGAGATAGTTTATTAAATGCCATGCAGAATGCTATGTTTTTAGATGTG
CATGTAAATCAAGAATTAGCTGAGGAATATCTTTTTATTAGTAGTAGTAGTAACTCATTTTTAGATTCAAGTAAAGTTTGTTTTCCAGGT
GAGATGACATTTTTAAGAAATTGAATTTAAGTATGTGCTTTTATATCCGGACCAGGTTTCTCAAGGAAGCAGAATACAAGGGAATGAAAG
GGGAAGGGAGGGTAGTGCCCAAGAGAAACCTCGGCTCCTAAGTGCTCCCCTGCCAGGTTTCCCCCGTGCCTGCCCACTGGCACCATCCTG
GCAGCTCCAGCCCACACCCCCTCCTGGACCCTGGGCTGCCTCTCGCTGAATAGCTGCAGGGGGCCTGCTATGTGACAGGTATGGAATGAG
GTAATCCTTTTCCACCTCTAATTTCTGAAGGGTGTGTCTGTCCAGTTTTTACTTGTTCATTGAATTTAAAGCCTTAGGAACCAACAGCTA
CAGTGCAAGCTGTAATTATTGATGTCTGTTTCATATTCATCTGTAAGTTCTGGCATTTGATCAAGAAGTCAATATATCACTTCATCTTCA
GGCTGAATGTGTCTCAGCTATAAAGGTTTTATTGTTTGATGGATAGCATACAATTATGACTGCCCACAATAAAAAGTGTTTTCATTTGTA

>32763_32763_1_GCLC-FAM204A_GCLC_chr6_53409293_ENST00000229416_FAM204A_chr10_120085755_ENST00000369183_length(amino acids)=182AA_BP=
MVTSRKKPVHQTGKEKREPPRQRGRGVRRRRIGAGGGAAGRARPPGREPSRLLSVFCLRLRAVRRTQGLSPGRQGPPPGSRSGQDPPSAD
CGPRAPPRGGAAAAFCGRLSVRLAPGAGDRRQPGGGGGGGGGGHGAAVPGLAAELGGNQAPCRPRAAARDPPVPAHLPRRQGPAQGRSQV

--------------------------------------------------------------
>32763_32763_2_GCLC-FAM204A_GCLC_chr6_53409293_ENST00000514004_FAM204A_chr10_120085755_ENST00000369183_length(transcript)=5755nt_BP=538nt
AGGAAGAAGCCAGTGCACCAGACCGGCAAAGAGAAGCGGGAGCCGCCGCGGCAGCGCGGCCGTGGGGTCCGCCGCCGCCGCATCGGAGCG
GGAGGAGGAGCAGCGGGGAGGGCGAGGCCGCCGGGCCGAGAGCCGTCCCGCCTGCTCTCGGTCTTCTGCCTTCGCCTCCGCGCGGTGCGT
CGGACCCAGGGTCTGTCACCTGGGCGCCAGGGGCCGCCGCCGGGGAGCCGGAGCGGGCAGGACCCTCCCTCCGCCGACTGCGGCCCGAGA
GCGCCCCCGCGGGGTGGAGCGGCAGCCGCCTTCTGCGGGCGGCTGAGTGTCCGTCTCGCGCCCGGAGCGGGCGACCGCCGTCAGCCCGGA
GGAGGAGGAGGAGGAGGAGGGGGCGGCCATGGGGCTGCTGTCCCAGGGCTCGCCGCTGAGCTGGGAGGAAACCAAGCGCCATGCCGACCA
CGTGCGGCGGCACGGGATCCTCCAGTTCCTGCACATCTACCACGCCGTCAAGGACCGGCACAAGGACGTTCTCAAGTGGGGCGATGAGTC
AGGCCTTGAAAAGAGGATAGACCAGGCTGTGGAGGAGTGGAATATTGAGAAGGCTGAGGAACTCAGCAACCAGCTAGCTACTCGAGAGCT
TGGTGTAAAAATTGCCAAAGCAGTTGCCTGCCACAACTTTGTAAAAGCCAAAAAGGAGGTTGAAAATTCACAGGCTGCCCGAAAAAAGAA
GAAACTTGCATGGGGGTTTGAAGCAAAGAAGAGATGGGAAACCAAAAGCAACATGGGATACATGTAACTTGCCAGAGTGCTTCAAGACAT
TTGTAGACTCAAATGCTCAATTTACTGAGAATGTTTTCCTGCCTATGTTAATATGTCAGAAAATTGATAGCACTAAAACAAAAATAAGCA
TAAAATTTGGGATTTTGATTATCAGCTCTTTTCAGTCTTTCTTTAAGGACTTTGTCCTATTGAAGTGAATAAAATGAAGCATTCTGTTAT
TTGTATAAGAAATGTAAGAAAAAAAATATAGAAAGAAGAGGATAGGATTTTGTTTATTTGTATGGATGGACCCTTGGTATAAAATCACTT
TTGGCGCTTTCCATTCATTTGGTTTAGCACAGCCAGTGAGCTTCTCGTACTTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGCCTCGC
TTGCTCTGTCACCCAGGCTAGAGTGCAGTAGCACGATCTTGGCTCACTGCAACCACTGCTTCCTGGGTTCAAGTGATTCTCATGCCTCAG
CCTCCTGAGTAGCTGGGATTATGGACAAATGCCACCACACCCGGCTAATTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACAGAGTTTTG
CTGTGTTGGTCAGGCTGGTCTTGAACTCCTGGCCTCATATGATTCACCTGCCTCTGCCTCCCAAAGTTCTGGGAGTACAGACATGAGCTA
CCATGCTGCCCTTGTATTTTCTTATCTGTACCCAGTGTAACTACACGTTTACTGGAACTGTGTTTTTAAGACTGACAGTTGTTTATAATG
GATTAGTCGTAAGTACCAAAAAGTCTCAGTTGATATTATCTTTACAAATGACTTGACCTTAATGTTATAAAAGTAGTTACTGTTTTTTTT
TAATTGGAGGCAGACTTGATATTTCAGAGTTGCATAGTAAAAGCAATTTGTTAATTTTTGTGTACTTTCAGATAAACTATTACAATAAAG
AAAGGAGCAGAATGTAGTATTTGGAAGATGATTTAAATTCAGCAACGCCTAAAAATGTCTTCCTAAGTATTTTTCTCAGCCATGTCATTC
TTTAAATTATGAGATGGTTCTTAGAAGAGAAAATGGTGTAATTGTATTAAACAGACAATTATAACTCAAGATAATATAACTTTGAACCTT
CTAAGAACTGATTTGTTTGGTTTTCCTCCCATTCCCCATTCCTCCTTAAAAGATTGAATGAATTAATGAGCAGAAAGAGAGGATTGGTAA
CATGGGAAATCGTTTTCATTAGATGTACATTTCCTGGTTCTGACAGGAAAGGGGCTCCAGAAAATCATAAAACAAGCAGGTGAACAAGAC
CAGGTGTGTCGGCACCTCCCTGCTCAGTGCCCAGCGGAGGTAAAGAACCACTCAGCATGGTTTTTGTCAGTTCACCTCTTCTGTCGTTGT
CAGAGGTTTCCTACCTGTCTGATATAAACTTTCTCTGGGTTGATAATATAAATTCAGAAACATGTAAAATGAATCATGATTATATTACTG
TTATTTTTAGACTTAAAATAGTAACAAAATTTTATTTATGGTGGCACATTTAATGGCTTTTTTTTTCTGTGTTCTGGAATAAGAGAATAC
CTAGCTACTATTTAAGCATCCAAAAATCATATCTTGCTTTCATTTAGTTGAGAAAAGCCAGCATAGAGAAAGCAAAGTTTTAGAATATTA
TGTGTCATACTAATTCAGTATCCAGACCAAATGTTGGAAAGTCTTATTTTATGATTTAATATCCCTTGTTCCATTTTACAGATATGATCA
TGTAAAACTTACCTACAATATTCATTTCAAACTGCTAAATTAGGTAAATACAGACTTTTAGTATAGAAACCTTTCCTCTAAAAATCCATT
ATGGGGGAAATATTCACTATACAATCCAGTGGTTTTGTCTGAAATCCTAAAAATGTTATTTTTGAGCAGGCGAGTGGTATAGATATTCTC
ACACTTGGGGCCCCGATATGGGCATTTCCCTTTGACTTCAGTCTCATTTTTTTTTTTTTTTCTGTTTCTACTCCTTAGAGCATTTAGTGA
CCCCTGCAGGCATGTTGCACTTCCCATACTGAAGCCTTGCCAGAGTGGCCTCCTGTAGGGTCTGACTTGGGATCCTGTCCAGCCAAGGAA
GCCCTTCTTCAGCCTGCTCCAGTGCCCGCAGTTGCCCCCTCAGCATCCCCTCGGGGTTCTCATGTAGATGGGAACATTTTAACTACGCGG
AAGGCAGGCATTTCAGCAGAATTAAGTATAGCGGGGGCTCATCTAATAAAGGAAGCCACTTCTCCCAAGTCGTCACTCCTTTCTGGGCAT
GGGTTGTGGAAAGCTCTAAAACGTTATGTGTAGCAGAAGAAGGGGTTGGAGGGAAGATTTGTGGGGACAGGTTGTCTTGGATTGGCCCTG
CTGACATGTCATTTGAGAGCAGTTTTATTTTATCCTTTCTAATAGGAATTAGGTATTTTACTCCTAGAAACATTATTCCTTGAGTACGCA
TGCTGCTCAAAGGATGTAGTCATTTGTCCACTCCATTCTAGTCACAGCAAAATAAGGATTCTTTTTGGATCAGTAATAACTTTGGTTCCT
AAAACTTCAATATGTGCATTTACTACCACCAGAATGCCTGAGTTAGATCAGTAATGTAAACGTCAGTTATTGTTAACTGAGATTAATATG
TTTCAGGCCGTTGGTATGGCATTAATGTAACTATGATTTACTATTTAAGTACTTTAGGCTAAAACATCTTACTAAAGAACAGTAATTTTG
AGCTTTACAGCACTGGTTCTGAGAAAGGGAAGTTGGCAGTGCATTCTTGTTTGGGAGCCCTCAGGATGTTTCTGATTTTCAGCAGAACAT
TCTATGTCTTTCACCGAAAGGAGAGATTGAATATATAATCTTAGGTTTGCTATAATTAGTTCTGATGACAGAGTTAAATACCTCAGCCAA
GACTGTAAATCAGTACGTAAACAGGTTTCTGCAACTGATCATAAATCTCAAACTGCATATTTTAAACACTTATTTTTTTAGGATGACAGA
TAAGGGAGCAGCAGGCTAAGGATAGGAATAAAATGTTATCTGAACTTTTAAGTCACAACTTAGAACTCACATTAAAATCTTCTGATTTTC
TTTATACCTTTTGTCTAAAATATTATCTTTTAGCTTATTAATAACTTTAATAAGACAAGTTTGAATTTAATTCACAAAAAATGAAGATAT
AATTTATAAAATGTCCAAATTTTTGTTAAGACATTACTTTTTAAGAAATGTGTGTCTTGCTAAATATAAAACATATTGTATGAGGTTGTT
GTTTAAACAAAATGAGAGTTGTACATTATTTTTTAAGAGATGATAAAGTTTGAGGAGGCAAGCCGATGTTATGTCAGATCTCATTTTGAA
GTTAGTGAAACCTAGTCTAATCCAGAACCAACTGAATCCAAGTTTTCCATTTTGGCAGAAGTTGCTTTTATTTTTAGTATCTGGCAGAGC
AACAAATGCTTTGCATGTCAGTTCAATATTTTTTCCTGCCAACTGTTTATTCATTGGCTTAAAATTTACACTCTACTAAAGTCTTAGCTC
TGACTTTCATGAAACAAATAGTAATATTTGGACAAAATATGTACATGAAAATCTTTTTCCAGAACCAAATGTAGACTGGTATTTGTGACA
TCAGTGCCTTCTAGCATGGTGACGGGTCGAAAAATACTTTGAAAAGTTGAAGGCTGTGTAAACCCACGGCAGTGCATCTCAAGTGATTTT
TATTATGAGGTAATCAGAGTATCTAGGTTTTCAAATTTAAATTAGTGGGTGACTTTATGCTAGAAAGTAGAATATGTGTTAGAATAAATT
TATCAATATATATTCTTGGCCTTTGTAGGATACTGAGACAATAAGGTCCATTTTTCATTTTTGAGGTTGGGGAGCTCTGTAGATTTTGAT
AAAATGTGCAGAACTGCATTCTTTAATCTTTATTATTTCATCCTCCCTCCACACTGCTTGCTTTAAAAGAAAAAAATACCTACACACATT
TTCTAGTGTTAACTGCTGTAATCAGCATAGACTTCCTGGGAAGGGATTCTTGCCTTCAGTAAAGGACATGACAGCATGTGGCCAATGGAG
ATTGCCACGAGGAAACCTGGAAAGGCATTGAACCATTTTGTGCTACTGTTAAAATGAGGTGTGTTGTCTCTTTATTATCTCCTACTCAAT
AGTGAGTATTCTGGAGGTGTCTGTTCCCTTTCCGGAATTTCTTCAAATACAGAGATGCTTCAGAGTAGCTTCCTGCCACATTGGCTTTCA
TGATCTTAATCCCTGGAACACAGCTATAGGCTTCTGGGAGATAGTTTATTAAATGCCATGCAGAATGCTATGTTTTTAGATGTGCATGTA
AATCAAGAATTAGCTGAGGAATATCTTTTTATTAGTAGTAGTAGTAACTCATTTTTAGATTCAAGTAAAGTTTGTTTTCCAGGTGAGATG
ACATTTTTAAGAAATTGAATTTAAGTATGTGCTTTTATATCCGGACCAGGTTTCTCAAGGAAGCAGAATACAAGGGAATGAAAGGGGAAG
GGAGGGTAGTGCCCAAGAGAAACCTCGGCTCCTAAGTGCTCCCCTGCCAGGTTTCCCCCGTGCCTGCCCACTGGCACCATCCTGGCAGCT
CCAGCCCACACCCCCTCCTGGACCCTGGGCTGCCTCTCGCTGAATAGCTGCAGGGGGCCTGCTATGTGACAGGTATGGAATGAGGTAATC
CTTTTCCACCTCTAATTTCTGAAGGGTGTGTCTGTCCAGTTTTTACTTGTTCATTGAATTTAAAGCCTTAGGAACCAACAGCTACAGTGC
AAGCTGTAATTATTGATGTCTGTTTCATATTCATCTGTAAGTTCTGGCATTTGATCAAGAAGTCAATATATCACTTCATCTTCAGGCTGA

>32763_32763_2_GCLC-FAM204A_GCLC_chr6_53409293_ENST00000514004_FAM204A_chr10_120085755_ENST00000369183_length(amino acids)=158AA_BP=
MEDPVPPHVVGMALGFLPAQRRALGQQPHGRPLLLLLLLRADGGRPLRARDGHSAARRRRLPLHPAGALSGRSRRREGPARSGSPAAAPG

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Fusion Gene PPI Analysis for GCLC-FAM204A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GCLC-FAM204A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GCLC-FAM204A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source