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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GDNF-FYB (FusionGDB2 ID:32873) |
Fusion Gene Summary for GDNF-FYB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GDNF-FYB | Fusion gene ID: 32873 | Hgene | Tgene | Gene symbol | GDNF | FYB | Gene ID | 2668 | 2533 |
| Gene name | glial cell derived neurotrophic factor | FYN binding protein 1 | |
| Synonyms | ATF|ATF1|ATF2|HFB1-GDNF|HSCR3 | ADAP|FYB|PRO0823|SLAP-130|SLAP130|THC3 | |
| Cytomap | 5p13.2 | 5p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glial cell line-derived neurotrophic factorastrocyte-derived trophic factor | FYN-binding protein 1FYB-120/130FYN-T-binding proteinFYN-binding proteinSLP-76-associated phosphoproteinadhesion and degranulation-promoting adaptor proteinp120/p130 | |
| Modification date | 20200314 | 20200313 | |
| UniProtAcc | GFRAL | O15117 | |
| Ensembl transtripts involved in fusion gene | ENST00000344622, ENST00000381826, ENST00000515058, ENST00000326524, ENST00000427982, | ENST00000503065, ENST00000351578, ENST00000505428, ENST00000512982, ENST00000515010, ENST00000540520, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 14 X 11 X 6=924 |
| # samples | 1 | 15 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(15/924*10)=-2.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GDNF [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GDNF(37834826)-FYB(39119736), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GDNF | GO:0001755 | neural crest cell migration | 15242795 |
| Hgene | GDNF | GO:0008284 | positive regulation of cell proliferation | 22897442 |
| Hgene | GDNF | GO:0031175 | neuron projection development | 15242795 |
| Hgene | GDNF | GO:0032770 | positive regulation of monooxygenase activity | 12358785 |
| Hgene | GDNF | GO:0043524 | negative regulation of neuron apoptotic process | 8493557 |
| Hgene | GDNF | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12358785 |
| Hgene | GDNF | GO:0048255 | mRNA stabilization | 12358785 |
| Hgene | GDNF | GO:0051584 | regulation of dopamine uptake involved in synaptic transmission | 8493557 |
| Hgene | GDNF | GO:0072107 | positive regulation of ureteric bud formation | 8657307 |
| Hgene | GDNF | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis | 8657307|17229286 |
| Hgene | GDNF | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 10921886 |
| Fusion gene breakpoints across GDNF (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FYB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-98-A53B-01A | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
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Fusion Gene ORF analysis for GDNF-FYB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000344622 | ENST00000503065 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| 5CDS-intron | ENST00000381826 | ENST00000503065 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| 5CDS-intron | ENST00000515058 | ENST00000503065 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000381826 | ENST00000351578 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000381826 | ENST00000505428 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000381826 | ENST00000512982 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000381826 | ENST00000515010 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000381826 | ENST00000540520 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000515058 | ENST00000351578 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000515058 | ENST00000505428 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000515058 | ENST00000512982 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000515058 | ENST00000515010 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| Frame-shift | ENST00000515058 | ENST00000540520 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| In-frame | ENST00000344622 | ENST00000351578 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| In-frame | ENST00000344622 | ENST00000505428 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| In-frame | ENST00000344622 | ENST00000512982 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| In-frame | ENST00000344622 | ENST00000515010 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| In-frame | ENST00000344622 | ENST00000540520 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000326524 | ENST00000351578 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000326524 | ENST00000505428 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000326524 | ENST00000512982 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000326524 | ENST00000515010 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000326524 | ENST00000540520 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000427982 | ENST00000351578 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000427982 | ENST00000505428 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000427982 | ENST00000512982 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000427982 | ENST00000515010 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-3CDS | ENST00000427982 | ENST00000540520 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-intron | ENST00000326524 | ENST00000503065 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| intron-intron | ENST00000427982 | ENST00000503065 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000344622 | GDNF | chr5 | 37834826 | - | ENST00000351578 | FYB | chr5 | 39119736 | - | 2755 | 196 | 131 | 547 | 138 |
| ENST00000344622 | GDNF | chr5 | 37834826 | - | ENST00000515010 | FYB | chr5 | 39119736 | - | 707 | 196 | 131 | 547 | 138 |
| ENST00000344622 | GDNF | chr5 | 37834826 | - | ENST00000505428 | FYB | chr5 | 39119736 | - | 689 | 196 | 131 | 547 | 138 |
| ENST00000344622 | GDNF | chr5 | 37834826 | - | ENST00000512982 | FYB | chr5 | 39119736 | - | 689 | 196 | 131 | 547 | 138 |
| ENST00000344622 | GDNF | chr5 | 37834826 | - | ENST00000540520 | FYB | chr5 | 39119736 | - | 689 | 196 | 131 | 547 | 138 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000344622 | ENST00000351578 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - | 0.004362238 | 0.99563783 |
| ENST00000344622 | ENST00000515010 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - | 0.004229203 | 0.99577075 |
| ENST00000344622 | ENST00000505428 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - | 0.00451284 | 0.99548715 |
| ENST00000344622 | ENST00000512982 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - | 0.00451284 | 0.99548715 |
| ENST00000344622 | ENST00000540520 | GDNF | chr5 | 37834826 | - | FYB | chr5 | 39119736 | - | 0.00451284 | 0.99548715 |
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Fusion Genomic Features for GDNF-FYB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GDNF-FYB |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:37834826/chr5:39119736) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GDNF | FYB |
| 394 | FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 700_768 | 666 | 784.0 | Domain | SH3 2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 700_768 | 666 | 784.0 | Domain | SH3 2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 674_700 | 666 | 784.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 674_700 | 666 | 784.0 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 456_507 | 666 | 784.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 456_507 | 712 | 830.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 456_507 | 712 | 830.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 456_507 | 666 | 784.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 456_507 | 722 | 840.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 355_360 | 666 | 784.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 393_397 | 666 | 784.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 617_620 | 666 | 784.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 355_360 | 712 | 830.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 393_397 | 712 | 830.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 617_620 | 712 | 830.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 355_360 | 712 | 830.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 393_397 | 712 | 830.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 617_620 | 712 | 830.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 355_360 | 666 | 784.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 393_397 | 666 | 784.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 617_620 | 666 | 784.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 355_360 | 722 | 840.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 393_397 | 722 | 840.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 617_620 | 722 | 840.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 511_572 | 666 | 784.0 | Domain | SH3 1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 511_572 | 712 | 830.0 | Domain | SH3 1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 700_768 | 712 | 830.0 | Domain | SH3 2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 511_572 | 712 | 830.0 | Domain | SH3 1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 700_768 | 712 | 830.0 | Domain | SH3 2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 511_572 | 666 | 784.0 | Domain | SH3 1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 511_572 | 722 | 840.0 | Domain | SH3 1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 700_768 | 722 | 840.0 | Domain | SH3 2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 462_465 | 666 | 784.0 | Motif | SH2-binding | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 469_505 | 666 | 784.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 595_598 | 666 | 784.0 | Motif | Note=SH2-binding%3B to LCP2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 625_628 | 666 | 784.0 | Motif | Note=SH2-binding%3B to FYN | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 462_465 | 712 | 830.0 | Motif | SH2-binding | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 469_505 | 712 | 830.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 595_598 | 712 | 830.0 | Motif | Note=SH2-binding%3B to LCP2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 625_628 | 712 | 830.0 | Motif | Note=SH2-binding%3B to FYN | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 674_700 | 712 | 830.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 462_465 | 712 | 830.0 | Motif | SH2-binding | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 469_505 | 712 | 830.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 595_598 | 712 | 830.0 | Motif | Note=SH2-binding%3B to LCP2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 625_628 | 712 | 830.0 | Motif | Note=SH2-binding%3B to FYN | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 674_700 | 712 | 830.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 462_465 | 666 | 784.0 | Motif | SH2-binding | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 469_505 | 666 | 784.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 595_598 | 666 | 784.0 | Motif | Note=SH2-binding%3B to LCP2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 625_628 | 666 | 784.0 | Motif | Note=SH2-binding%3B to FYN | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 462_465 | 722 | 840.0 | Motif | SH2-binding | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 469_505 | 722 | 840.0 | Motif | Nuclear localization signal | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 595_598 | 722 | 840.0 | Motif | Note=SH2-binding%3B to LCP2 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 625_628 | 722 | 840.0 | Motif | Note=SH2-binding%3B to FYN | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 674_700 | 722 | 840.0 | Motif | Nuclear localization signal |
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Fusion Gene Sequence for GDNF-FYB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >32873_32873_1_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000351578_length(transcript)=2755nt_BP=196nt CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA GAAAATTAATGCACAAAACCACTTATTATCATTTGTTATGAAATCCCAATTATCTTTACAAAGTGTTTAAAGTTTGAACATAGAAAATAA TCTCTCTGCTTAATTGTTAACTCAGAAGACTACATTAGTGAGATGTAAGAATTATTAAATATTCCATTTCCGCTTTGGCTACAATTATGA AGAAGTTGAAGGTACTTCTTTTAGACCACCAGTAAATAATCCTCCTTCAAAAAATAAAAATAAAAGAAAAAGGAAAATCATTCAGGAAGA AATGACCTGTCTAAAAAAACCTAAGGAAGAATAATAATATAAGAAAGGAAATTTAAAAACATTCCACAAGAAGAAAAATTATTGTTTATA CTTCTACTTATGGTTATATCTTATATTCTCTATTCAAGTGACCTGTCTTTTAAAAAGGCAGTGCTGTCTTACCTCTTGCTAGTGGGTTAA ATGTTTTCAAAAATTATAGCAGTAGTAGAAGTTTTGTATAAAATTTGTCCTTATTTGTTAATTGTATATAAATGTTAATTATTTGATACG AATGTTATGCATTTAGTATGCACATTGAAGTCTAAACTGTAGAAGAGTCTAAAACAAGTTCTCTTTTTGCAGATTCACATACTAATGGTT TAATTCTGTGCTCTGTTTAAAGTACTATTATAACTAGAGTAGATCTGAATGAGGATAACCCTAAAATCATGAGGAATGGAAGAATGGACC TTGAAACTACCTAGGCTTTTATGCATGGCACCTCTTTATAATGAAGACACTTTTTAAAGTTTTTGTTTTTGTTTCAATTACCGCTAGATT TTTTTTTCTCTTTTTTTAAAATCCATTTTACTGGAAAGTTGGCCAGCAGAGGGAGTAGAAATTATTAAAATTCTAGTGTTTGGATTGGGC CCTTCTCTAACAGTACATACTCATTCCCAAAGCAATCCAAAAACAAAATGTGAACCATTTGGGTTTCAAATGTTAAGAACACTAAATAGC ATGATTTAAAAAATGAAAAATGCTAACACCCAAGAAAAGAAGATATTAAGTGCTTTTTAACAACTCCTAGAGTACAAAATGAGTACATCA TAATGCTGGCTCTTCTACTAATGAACCATCGAGTGATATTGAATAAATTATTTATCTTCTCAGTTTCCTTATCTGTAAATTACAATATTA GACTAAGTAAGTTTTTCCAACTCTTCACTACCAATTACCTTAGGCTTTTATAATGCTCCGCCTACTTCAGTCCCATGTTTCAGAAGCTTT TGTCTATTTTTTAAACTCATTGATTAAATAATGATTAATGCATTCTCCACATTTTAATATTGCAAAGGCCCATTGGAGTTTCTGAAGTGG CTCCACAGAATTGAAATAATTTCAAATAACTGTAAAGGAACTGAAAATCTTCACAGAGATGAAGTGGGGTTTCCATTAGGTGCTTTGAAA TTTGATAACAAATCATCAACTTCCACTGGTCAATATATAGATTTTGGGTGTCTGAGGCCCCAAGATTAGATGCCACTAATCTCCAAAGAT TCCCTCCAATTATGAAATATTTTAATGTCTACTTTTAGAGAGCACTAGCCAGTATATGACCATGTGATTAATTTCTTTTCACACTAGATA AAATTACCTGGTTCAAAAGTGGTTTTTGTTTATTAAATTTGGTAATAAATATATATAATACACAGACAGGATAGTTTTTATGCTGAAGTT TTTGGCCAGCTTTAGTTTGAGGACTCCTTGATAAGCTTGCTAAACTTTCAGAGTGCCCTGAGACACTTCCAGCCATCCCTCCTCCTGCCT TCATTGGGGCAGACTTGCATTGCAGTCTGACAGTAATTTTTTTTCTGATTGAGAATTATGTAAATTCAGTACAATGTCAGTTTTTAAAAG TCAAAGTTAGATCAAGAGAATATTTCAGAGTTTTGGTTTACACATCAAGAAACAGACACACATACCTAGGAAAGATTTACACAATAGATA ATCATCTTAATGTGAAAGATATTTGAAGTATTAATTTTAATATATTAAATATGATTTCTGTTATAGTCTTCTGTATGGAATTTTGTCACT >32873_32873_1_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000351578_length(amino acids)=138AA_BP=22 MGCRGCLPGAAPHRVRLPAARRQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESL -------------------------------------------------------------- >32873_32873_2_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000505428_length(transcript)=689nt_BP=196nt CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA >32873_32873_2_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000505428_length(amino acids)=138AA_BP=22 MGCRGCLPGAAPHRVRLPAARRQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESL -------------------------------------------------------------- >32873_32873_3_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000512982_length(transcript)=689nt_BP=196nt CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA >32873_32873_3_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000512982_length(amino acids)=138AA_BP=22 MGCRGCLPGAAPHRVRLPAARRQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESL -------------------------------------------------------------- >32873_32873_4_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000515010_length(transcript)=707nt_BP=196nt CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA >32873_32873_4_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000515010_length(amino acids)=138AA_BP=22 MGCRGCLPGAAPHRVRLPAARRQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESL -------------------------------------------------------------- >32873_32873_5_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000540520_length(transcript)=689nt_BP=196nt CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA >32873_32873_5_GDNF-FYB_GDNF_chr5_37834826_ENST00000344622_FYB_chr5_39119736_ENST00000540520_length(amino acids)=138AA_BP=22 MGCRGCLPGAAPHRVRLPAARRQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GDNF-FYB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000351578 | 12 | 18 | 348_448 | 666.6666666666666 | 784.0 | SKAP1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000505428 | 13 | 19 | 348_448 | 712.6666666666666 | 830.0 | SKAP1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000512982 | 13 | 19 | 348_448 | 712.6666666666666 | 830.0 | SKAP1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000515010 | 11 | 17 | 348_448 | 666.6666666666666 | 784.0 | SKAP1 | |
| Tgene | FYB | chr5:37834826 | chr5:39119736 | ENST00000540520 | 13 | 19 | 348_448 | 722.6666666666666 | 840.0 | SKAP1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GDNF-FYB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GDNF-FYB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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