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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GGA2-PRKCB (FusionGDB2 ID:33002)

Fusion Gene Summary for GGA2-PRKCB

check button Fusion gene summary
Fusion gene informationFusion gene name: GGA2-PRKCB
Fusion gene ID: 33002
HgeneTgene
Gene symbol

GGA2

PRKCB

Gene ID

23062

5579

Gene namegolgi associated, gamma adaptin ear containing, ARF binding protein 2protein kinase C beta
SynonymsVEARPKC-beta|PKCB|PKCI(2)|PKCbeta|PRKCB1|PRKCB2
Cytomap

16p12.2

16p12.2-p12.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-binding protein GGA2VHS domain and ear domain of gamma-adaptinVHS domain and ear domain-containing proteingamma-adaptin-related protein 2golgi-localized, gamma ear-containing, ARF-binding protein 2protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide
Modification date2020031320200313
UniProtAcc

Q9UJY4

.
Ensembl transtripts involved in fusion geneENST00000309859, ENST00000567468, 
ENST00000569182, 		ENST00000482000, 
ENST00000498058, ENST00000303531, 
ENST00000321728, 
Fusion gene scores* DoF score7 X 7 X 4=19620 X 15 X 13=3900
# samples 825
** MAII scorelog2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3900*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GGA2 [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGGA2(23502998)-PRKCB(23999829), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGGA2

GO:0034394

protein localization to cell surface

27901063

HgeneGGA2

GO:0043001

Golgi to plasma membrane protein transport

27901063

TgenePRKCB

GO:0010827

regulation of glucose transmembrane transport

25982116

TgenePRKCB

GO:0035408

histone H3-T6 phosphorylation

20228790


check buttonFusion gene breakpoints across GGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKCB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2929-03AGGA2chr16

23478534

-PRKCBchr16

24230943

+
ChimerDB4LGGTCGA-HT-A5RC-01AGGA2chr16

23502998

-PRKCBchr16

23999829

+
ChimerDB4LGGTCGA-HT-A5RCGGA2chr16

23502998

-PRKCBchr16

23999829

+


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Fusion Gene ORF analysis for GGA2-PRKCB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000309859ENST00000482000GGA2chr16

23502998

-PRKCBchr16

23999829

+
5CDS-intronENST00000309859ENST00000498058GGA2chr16

23502998

-PRKCBchr16

23999829

+
5CDS-intronENST00000567468ENST00000482000GGA2chr16

23502998

-PRKCBchr16

23999829

+
5CDS-intronENST00000567468ENST00000498058GGA2chr16

23502998

-PRKCBchr16

23999829

+
In-frameENST00000309859ENST00000303531GGA2chr16

23502998

-PRKCBchr16

23999829

+
In-frameENST00000309859ENST00000321728GGA2chr16

23502998

-PRKCBchr16

23999829

+
In-frameENST00000567468ENST00000303531GGA2chr16

23502998

-PRKCBchr16

23999829

+
In-frameENST00000567468ENST00000321728GGA2chr16

23502998

-PRKCBchr16

23999829

+
intron-3CDSENST00000569182ENST00000303531GGA2chr16

23502998

-PRKCBchr16

23999829

+
intron-3CDSENST00000569182ENST00000321728GGA2chr16

23502998

-PRKCBchr16

23999829

+
intron-3UTRENST00000309859ENST00000303531GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-3UTRENST00000567468ENST00000303531GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-3UTRENST00000569182ENST00000303531GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000309859ENST00000321728GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000309859ENST00000482000GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000309859ENST00000498058GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000567468ENST00000321728GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000567468ENST00000482000GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000567468ENST00000498058GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000569182ENST00000321728GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000569182ENST00000482000GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000569182ENST00000482000GGA2chr16

23502998

-PRKCBchr16

23999829

+
intron-intronENST00000569182ENST00000498058GGA2chr16

23478534

-PRKCBchr16

24230943

+
intron-intronENST00000569182ENST00000498058GGA2chr16

23502998

-PRKCBchr16

23999829

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309859GGA2chr1623502998-ENST00000321728PRKCBchr1623999829+2867558832368761
ENST00000309859GGA2chr1623502998-ENST00000303531PRKCBchr1623999829+8170558832374763
ENST00000567468GGA2chr1623502998-ENST00000321728PRKCBchr1623999829+2797488132298761
ENST00000567468GGA2chr1623502998-ENST00000303531PRKCBchr1623999829+8100488132304763

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309859ENST00000321728GGA2chr1623502998-PRKCBchr1623999829+0.0014798270.9985202
ENST00000309859ENST00000303531GGA2chr1623502998-PRKCBchr1623999829+0.0006263140.99937373
ENST00000567468ENST00000321728GGA2chr1623502998-PRKCBchr1623999829+0.0012974960.9987025
ENST00000567468ENST00000303531GGA2chr1623502998-PRKCBchr1623999829+0.0005949990.999405

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Fusion Genomic Features for GGA2-PRKCB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GGA2chr1623502997-PRKCBchr1623999828+4.13E-060.9999958
GGA2chr1623502997-PRKCBchr1623999828+4.13E-060.9999958
GGA2chr1623502997-PRKCBchr1623999828+4.13E-060.9999958
GGA2chr1623502997-PRKCBchr1623999828+4.13E-060.9999958

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GGA2-PRKCB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:23502998/chr16:23999829)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GGA2

Q9UJY4

.
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRKCBchr16:23502998chr16:23999829ENST00000303531117158_27568674.0DomainC2
TgenePRKCBchr16:23502998chr16:23999829ENST00000303531117342_60068674.0DomainProtein kinase
TgenePRKCBchr16:23502998chr16:23999829ENST00000303531117601_67168674.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:23502998chr16:23999829ENST00000321728117158_27568672.0DomainC2
TgenePRKCBchr16:23502998chr16:23999829ENST00000321728117342_60068672.0DomainProtein kinase
TgenePRKCBchr16:23502998chr16:23999829ENST00000321728117601_67168672.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:23502998chr16:23999829ENST0000049805802158_275058.0DomainC2
TgenePRKCBchr16:23502998chr16:23999829ENST0000049805802342_600058.0DomainProtein kinase
TgenePRKCBchr16:23502998chr16:23999829ENST0000049805802601_671058.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:23502998chr16:23999829ENST00000303531117348_35668674.0Nucleotide bindingATP
TgenePRKCBchr16:23502998chr16:23999829ENST00000321728117348_35668672.0Nucleotide bindingATP
TgenePRKCBchr16:23502998chr16:23999829ENST0000049805802348_356058.0Nucleotide bindingATP
TgenePRKCBchr16:23502998chr16:23999829ENST00000303531117101_15168674.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:23502998chr16:23999829ENST00000321728117101_15168672.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:23502998chr16:23999829ENST0000049805802101_151058.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:23502998chr16:23999829ENST000004980580236_86058.0Zinc fingerPhorbol-ester/DAG-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGGA2chr16:23502998chr16:23999829ENST00000309859-517188_315158614.0DomainGAT
HgeneGGA2chr16:23502998chr16:23999829ENST00000309859-51733_163158614.0DomainVHS
HgeneGGA2chr16:23502998chr16:23999829ENST00000309859-517484_605158614.0DomainGAE
HgeneGGA2chr16:23502998chr16:23999829ENST00000309859-517316_483158614.0RegionNote=Unstructured hinge
TgenePRKCBchr16:23502998chr16:23999829ENST0000030353111736_8668674.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCBchr16:23502998chr16:23999829ENST0000032172811736_8668672.0Zinc fingerPhorbol-ester/DAG-type 1


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Fusion Gene Sequence for GGA2-PRKCB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33002_33002_1_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000309859_PRKCB_chr16_23999829_ENST00000303531_length(transcript)=8170nt_BP=558nt
GCAGTCAGCAGAGGAGAGCGCCAGGACGCTACAGCGGCTGAAGAGGCAGTGGCGCCCGCGGCCGCAGCGTCGGGGCTGGAGCGATGGCGG
CGACCGCGGTGGCGGCGGCTGTGGCGGGAACCGAGTCGGCCCAGGGTCCCCCGGGCCCGGCAGCGTCGCTGGAGCTGTGGCTCAACAAAG
CCACAGACCCAAGCATGTCGGAACAGGATTGGTCAGCTATCCAGAATTTCTGTGAGCAGGTGAACACTGACCCCAATGGCCCCACACATG
CGCCCTGGCTACTGGCCCACAAGATCCAGTCTCCGCAAGAGAAGGAAGCTCTTTATGCCTTAACGGTGCTGGAGATGTGCATGAACCACT
GTGGGGAGAAGTTCCACAGCGAGGTGGCCAAATTTCGTTTCCTGAACGAACTGATCAAAGTGTTGTCCCCAAAGTACCTGGGGTCCTGGG
CCACAGGAAAAGTTAAAGGAAGAGTCATTGAAATACTCTTCAGTTGGACAGTCTGGTTTCCGGAAGACATCAAGATTCGAGACGCTTATC
AGATGCTGAAGAAACAAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTGCCCTGGCGCTGACAAGGGTC
CAGCCTCCGATGACCCCCGCAGCAAACACAAGTTTAAGATCCACACGTACTCCAGCCCCACGTTTTGTGACCACTGTGGGTCACTGCTGT
ATGGACTCATCCACCAGGGGATGAAATGTGACACCTGCATGATGAATGTGCACAAGCGCTGCGTGATGAATGTTCCCAGCCTGTGTGGCA
CGGACCACACGGAGCGCCGCGGCCGCATCTACATCCAGGCCCACATCGACAGGGACGTCCTCATTGTCCTCGTAAGAGATGCTAAAAACC
TTGTACCTATGGACCCCAATGGCCTGTCAGATCCCTACGTAAAACTGAAACTGATTCCCGATCCCAAAAGTGAGAGCAAACAGAAGACCA
AAACCATCAAATGCTCCCTCAACCCTGAGTGGAATGAGACATTTAGATTTCAGCTGAAAGAATCGGACAAAGACAGAAGACTGTCAGTAG
AGATTTGGGATTGGGATTTGACCAGCAGGAATGACTTCATGGGATCTTTGTCCTTTGGGATTTCTGAACTTCAGAAAGCCAGTGTTGATG
GCTGGTTTAAGTTACTGAGCCAGGAGGAAGGCGAGTACTTCAATGTGCCTGTGCCACCAGAAGGAAGTGAGGCCAATGAAGAACTGCGGC
AGAAATTTGAGAGGGCCAAGATCAGTCAGGGAACCAAGGTCCCGGAAGAAAAGACGACCAACACTGTCTCCAAATTTGACAACAATGGCA
ACAGAGACCGGATGAAACTGACCGATTTTAACTTCCTAATGGTGCTGGGGAAAGGCAGCTTTGGCAAGGTCATGCTTTCAGAACGAAAAG
GCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAAGATGATGACGTGGAGTGCACTATGGTGGAGAAGCGGG
TGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGTACTTTGTGATGGAGTACG
TGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTACGCTGCAGAAATTGCCATCG
GTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTG
CCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAA
TTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAG
GGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCA
AAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATA
TTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTT
TCACCCGCCATCCACCAGTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTA
ACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAAGTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTG
TGGTGACATTTTTATGTTTTTCATTGCCAAGTTGCATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATG
TCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGGATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGT
CCTCTTACAATTTATTTTCCGCAGCATGTCAGCTAAGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACT
GCCATATTCACCCCCAACCATCCAATCTGTGGATAATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCA
AGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCTATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAAT
GTTATCTGTTATTTTTGTAAACTCAAAGTTAAGATGATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGC
ACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGCTACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAA
ACTACTTGAAAAGGGCATTTGGCACCACTCTCTGAAACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATT
TCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTTGTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTG
TTACACATGCTTTAAAATATGTATTCAAATGTTATTAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAG
CAGACTCAGGCCTGTGGGAATGGGATTTGTTACAAATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACC
GTTTCTTGAAACAAAGATGGTTGTATTCCTCACTTTGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGT
TATGTGCCATTTTTCTTCTAGCATCGAGATACAATAAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTT
TTTGAGAAACGTGGACCTAAACTACAAAGTGGGAACTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCC
AGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGCCCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCA
ACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGACCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTC
CCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGCTTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCT
GTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCTCCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCAC
AGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTGAGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCC
TCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGCTTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTT
GGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAATCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAA
GAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACTTTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTC
AGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAAGTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCC
ACCAACAGGCCCTTATCTGGTGGTTGGATCATGATCCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGG
CCATTGACAAATGATCTGAGACAACTTTAGAAAACAATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAG
GAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAGGAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAAC
ATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTTTAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCC
ATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTATCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACA
GGGCCATAGCAACAAGGACCTTCTTGGGGGATTAATGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACAT
GGCTTCAGATGCTATCAACCTCAAAGAAATGATCTCAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTC
TCTGGGGATCTGCCCACAGGACAAAGTCCATAAAAGCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAA
CAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTCAGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGAT
GAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTGTGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTC
TCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCATACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGG
AATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTTCTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTT
CCTTCATTCCACAAATAATTACAAACAACCTACTGTGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGG
ACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCAAGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCA
ATAAGTGCAATCAAGATAATTAAAGGATGCTAAAGTGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCAT
TCGAGCTTTGTTGTGAACACCGGAAGTAACATGCCGAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGG
ACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGATGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCC
ACACATACCCACGTGTGCTCCTGAGTTCAGTGTGCCCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCA
TAGAGACATTTTACCTATCTCAGGGGAGCAGCCACAAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGA
GAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTAAACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTAC
CGACCCCCTGGCCTTTATAATCTGAGGCAACTTTGGCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGT
TGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTCCAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAAT
CAGGAACCCACTGAAATCTTGGGCAAGCCACCCTGCCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGC
TCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGGAAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCT
TTATTAGCCCACATTCTGATGTTCCCTGGTGAGACTTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACT
GAACAAAAAAAGAAATGCCAGACTTACTAGGAGAATCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTC
CCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCTCTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTG
ATAAACACCCAATTCTAGACTGTGGGTGGATTTTCGAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGG
CCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCAGCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAAT
GGTTTTCTCCAGGACGCTCTACCTAATGATTATTTCTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCA
AAGAAAATACAGCAACACACACACACACACACACACACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATT
CAATGACTTACTTCTTTTCTTAGAAAATTTCCACCACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGT
GCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTCTGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCT
GTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTACTTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCAC
CAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCC
AGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAG
TCTTCCAGGATTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTT
TGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAA
ATGAACAGACAATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAA
AAGTTTTTACAGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGT

>33002_33002_1_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000309859_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=763AA_BP=158
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCM
NHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI
AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFD

--------------------------------------------------------------
>33002_33002_2_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000309859_PRKCB_chr16_23999829_ENST00000321728_length(transcript)=2867nt_BP=558nt
GCAGTCAGCAGAGGAGAGCGCCAGGACGCTACAGCGGCTGAAGAGGCAGTGGCGCCCGCGGCCGCAGCGTCGGGGCTGGAGCGATGGCGG
CGACCGCGGTGGCGGCGGCTGTGGCGGGAACCGAGTCGGCCCAGGGTCCCCCGGGCCCGGCAGCGTCGCTGGAGCTGTGGCTCAACAAAG
CCACAGACCCAAGCATGTCGGAACAGGATTGGTCAGCTATCCAGAATTTCTGTGAGCAGGTGAACACTGACCCCAATGGCCCCACACATG
CGCCCTGGCTACTGGCCCACAAGATCCAGTCTCCGCAAGAGAAGGAAGCTCTTTATGCCTTAACGGTGCTGGAGATGTGCATGAACCACT
GTGGGGAGAAGTTCCACAGCGAGGTGGCCAAATTTCGTTTCCTGAACGAACTGATCAAAGTGTTGTCCCCAAAGTACCTGGGGTCCTGGG
CCACAGGAAAAGTTAAAGGAAGAGTCATTGAAATACTCTTCAGTTGGACAGTCTGGTTTCCGGAAGACATCAAGATTCGAGACGCTTATC
AGATGCTGAAGAAACAAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTGCCCTGGCGCTGACAAGGGTC
CAGCCTCCGATGACCCCCGCAGCAAACACAAGTTTAAGATCCACACGTACTCCAGCCCCACGTTTTGTGACCACTGTGGGTCACTGCTGT
ATGGACTCATCCACCAGGGGATGAAATGTGACACCTGCATGATGAATGTGCACAAGCGCTGCGTGATGAATGTTCCCAGCCTGTGTGGCA
CGGACCACACGGAGCGCCGCGGCCGCATCTACATCCAGGCCCACATCGACAGGGACGTCCTCATTGTCCTCGTAAGAGATGCTAAAAACC
TTGTACCTATGGACCCCAATGGCCTGTCAGATCCCTACGTAAAACTGAAACTGATTCCCGATCCCAAAAGTGAGAGCAAACAGAAGACCA
AAACCATCAAATGCTCCCTCAACCCTGAGTGGAATGAGACATTTAGATTTCAGCTGAAAGAATCGGACAAAGACAGAAGACTGTCAGTAG
AGATTTGGGATTGGGATTTGACCAGCAGGAATGACTTCATGGGATCTTTGTCCTTTGGGATTTCTGAACTTCAGAAAGCCAGTGTTGATG
GCTGGTTTAAGTTACTGAGCCAGGAGGAAGGCGAGTACTTCAATGTGCCTGTGCCACCAGAAGGAAGTGAGGCCAATGAAGAACTGCGGC
AGAAATTTGAGAGGGCCAAGATCAGTCAGGGAACCAAGGTCCCGGAAGAAAAGACGACCAACACTGTCTCCAAATTTGACAACAATGGCA
ACAGAGACCGGATGAAACTGACCGATTTTAACTTCCTAATGGTGCTGGGGAAAGGCAGCTTTGGCAAGGTCATGCTTTCAGAACGAAAAG
GCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAAGATGATGACGTGGAGTGCACTATGGTGGAGAAGCGGG
TGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGTACTTTGTGATGGAGTACG
TGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTACGCTGCAGAAATTGCCATCG
GTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTG
CCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAA
TTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAG
GGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCA
AAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATA
TTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAG
AGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATA
CTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCA
ATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTT
GCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAAC
TCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTC
CTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAG

>33002_33002_2_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000309859_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=761AA_BP=158
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCM
NHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI
AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF

--------------------------------------------------------------
>33002_33002_3_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000567468_PRKCB_chr16_23999829_ENST00000303531_length(transcript)=8100nt_BP=488nt
CGGGGCTGGAGCGATGGCGGCGACCGCGGTGGCGGCGGCTGTGGCGGGAACCGAGTCGGCCCAGGGTCCCCCGGGCCCGGCAGCGTCGCT
GGAGCTGTGGCTCAACAAAGCCACAGACCCAAGCATGTCGGAACAGGATTGGTCAGCTATCCAGAATTTCTGTGAGCAGGTGAACACTGA
CCCCAATGGCCCCACACATGCGCCCTGGCTACTGGCCCACAAGATCCAGTCTCCGCAAGAGAAGGAAGCTCTTTATGCCTTAACGGTGCT
GGAGATGTGCATGAACCACTGTGGGGAGAAGTTCCACAGCGAGGTGGCCAAATTTCGTTTCCTGAACGAACTGATCAAAGTGTTGTCCCC
AAAGTACCTGGGGTCCTGGGCCACAGGAAAAGTTAAAGGAAGAGTCATTGAAATACTCTTCAGTTGGACAGTCTGGTTTCCGGAAGACAT
CAAGATTCGAGACGCTTATCAGATGCTGAAGAAACAAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTG
CCCTGGCGCTGACAAGGGTCCAGCCTCCGATGACCCCCGCAGCAAACACAAGTTTAAGATCCACACGTACTCCAGCCCCACGTTTTGTGA
CCACTGTGGGTCACTGCTGTATGGACTCATCCACCAGGGGATGAAATGTGACACCTGCATGATGAATGTGCACAAGCGCTGCGTGATGAA
TGTTCCCAGCCTGTGTGGCACGGACCACACGGAGCGCCGCGGCCGCATCTACATCCAGGCCCACATCGACAGGGACGTCCTCATTGTCCT
CGTAAGAGATGCTAAAAACCTTGTACCTATGGACCCCAATGGCCTGTCAGATCCCTACGTAAAACTGAAACTGATTCCCGATCCCAAAAG
TGAGAGCAAACAGAAGACCAAAACCATCAAATGCTCCCTCAACCCTGAGTGGAATGAGACATTTAGATTTCAGCTGAAAGAATCGGACAA
AGACAGAAGACTGTCAGTAGAGATTTGGGATTGGGATTTGACCAGCAGGAATGACTTCATGGGATCTTTGTCCTTTGGGATTTCTGAACT
TCAGAAAGCCAGTGTTGATGGCTGGTTTAAGTTACTGAGCCAGGAGGAAGGCGAGTACTTCAATGTGCCTGTGCCACCAGAAGGAAGTGA
GGCCAATGAAGAACTGCGGCAGAAATTTGAGAGGGCCAAGATCAGTCAGGGAACCAAGGTCCCGGAAGAAAAGACGACCAACACTGTCTC
CAAATTTGACAACAATGGCAACAGAGACCGGATGAAACTGACCGATTTTAACTTCCTAATGGTGCTGGGGAAAGGCAGCTTTGGCAAGGT
CATGCTTTCAGAACGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAAGATGATGACGTGGAGTG
CACTATGGTGGAGAAGCGGGTGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCT
GTACTTTGTGATGGAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTA
CGCTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTC
TGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGA
CTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGC
TGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAA
GGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGA
GCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGC
TGAAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATT
CGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAAGTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCA
TTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGTTTTTCATTGCCAAGTTGCATCCATGTTTGATTTTCTGATGAGACTAGAGTGAC
AGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGGATTATGCAGATGGCCTATGGAAAATGCAGCTGCAT
AATTAACACATTATCAAAGTCCTCTTACAATTTATTTTCCGCAGCATGTCAGCTAAGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTC
TTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAACCATCCAATCTGTGGATAATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCC
TGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCTATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAA
GAACATGCTCAAAATAAAATGTTATCTGTTATTTTTGTAAACTCAAAGTTAAGATGATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTA
GACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGCTACCTCAGTGTTGTAGTTTCTGATACTTTATGTCT
TTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCATTTGGCACCACTCTCTGAAACAACACAGTCACTCTAGCAAGGCCCCCAAAGGG
CCCTGGTTTTACATTACATTTCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTTGTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAA
AAAAAAGGTGACTCACATTGTTACACATGCTTTAAAATATGTATTCAAATGTTATTAACCACAATGACGACCTGCTTTGATTTAACCAAG
AAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGGGAATGGGATTTGTTACAAATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTA
AGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGATGGTTGTATTCCTCACTTTGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTC
ATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTTCTAGCATCGAGATACAATAAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTA
TTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACCTAAACTACAAAGTGGGAACTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGC
GGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGCCCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTG
GGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGACCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCT
TATCAAAATCACCACTCCTCCCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGCTTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCG
GTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCTCCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCT
CTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTGAGAGACCATCAAGGGAACTTTAACAACTTGACAAA
TGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGCTTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGT
CCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAATCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTAT
CTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACTTTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAG
GAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAAGTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCA
GACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATCTGGTGGTTGGATCATGATCCCATTTTGCTTGGACATGCTCTCAGGAAGATAAA
AACCATGGAGAAACACTAGGCCATTGACAAATGATCTGAGACAACTTTAGAAAACAATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAG
AAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAGGAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTG
TTATAAATACTGCACTCAACATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTTTAATAGTTTGCAGAAATAGATACTCAAGCCAAAGT
CTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTATCCACATTTCCAGTGCAGAAGAAACTGAGAAACAG
AGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGGACCTTCTTGGGGGATTAATGGGAGGTCAGTAGAATTAATAACCCTCCTTGGAT
GAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCAACCTCAAAGAAATGATCTCAACAGAGAAGCTTATTCTCTCCCAACTTCTACGG
TAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCACAGGACAAAGTCCATAAAAGCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGC
ATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTCAGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGG
GAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTGTGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCT
CACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCATACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGG
AGACCTTTAGGATCAATGGGAATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTTCTGGCTCGGGGACAATTATAAGTTGCAAAAAGGAT
AGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATAATTACAAACAACCTACTGTGTGCCAGGCACTATTCTTAGCACTGGAAATACAC
TAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCAAGAATATTGTTTCTTGGAGAGAAATAATAAATAAA
CAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGATAATTAAAGGATGCTAAAGTGTGACTTGTGGGGATTGGGAGAGAGATGCACAGA
CAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAACACCGGAAGTAACATGCCGAGCGCCTGGGGGATGGAAACTCCTATAGCACCCC
ACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGATGGACCCTACCCAGGAAACAGCTCCATCAGCATCT
TAGCCTGCCCCACTCTAGCCACACATACCCACGTGTGCTCCTGAGTTCAGTGTGCCCACCTCACTCCCACACCCTCACATAGACTTGGCA
AGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTATCTCAGGGGAGCAGCCACAAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAG
GAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTAAACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTA
ATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTATAATCTGAGGCAACTTTGGCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAAT
ACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTCCAGTCCGAGAGACTGTGATGAGGCCTACATAGCAG
CGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAATCTTGGGCAAGCCACCCTGCCTGCTTGTGCCTCGGTTCTCTCATATGTCATATA
TAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGGAAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTC
GGAGCATCATACAGATTCCTTTATTAGCCCACATTCTGATGTTCCCTGGTGAGACTTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAAT
TTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATGCCAGACTTACTAGGAGAATCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGT
TTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCTCTCTTATAGTTTGTTGACACATGCTAAAAATGTCT
TTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTAGACTGTGGGTGGATTTTCGAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGT
GATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCAGCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGC
CACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGCTCTACCTAATGATTATTTCTATAACATTAAGCATGGTAATAAGTAGCTTCCAA
TTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACACACACACACACACACACACACACACACACACACACACACACACACCACTTTAT
GGCAATTCTTAACTGACATTCAATGACTTACTTCTTTTCTTAGAAAATTTCCACCACATTTCTATCCCCAAGCCAACATACAATGTGAAA
TGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTCTGACTCTGCTCATGAGATGGTATCAGCCACCCAAT
GACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTACTTTCCATTTGGCAGAGAGACAAGAGAGACACCTCC
AACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCT
GGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCA
AGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTT
GTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCA
AACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCA
GAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGA
GTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAAGAATTGATATGATTAAACTGAATTAATATATGCAA

>33002_33002_3_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000567468_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=763AA_BP=158
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCM
NHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI
AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFD

--------------------------------------------------------------
>33002_33002_4_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000567468_PRKCB_chr16_23999829_ENST00000321728_length(transcript)=2797nt_BP=488nt
CGGGGCTGGAGCGATGGCGGCGACCGCGGTGGCGGCGGCTGTGGCGGGAACCGAGTCGGCCCAGGGTCCCCCGGGCCCGGCAGCGTCGCT
GGAGCTGTGGCTCAACAAAGCCACAGACCCAAGCATGTCGGAACAGGATTGGTCAGCTATCCAGAATTTCTGTGAGCAGGTGAACACTGA
CCCCAATGGCCCCACACATGCGCCCTGGCTACTGGCCCACAAGATCCAGTCTCCGCAAGAGAAGGAAGCTCTTTATGCCTTAACGGTGCT
GGAGATGTGCATGAACCACTGTGGGGAGAAGTTCCACAGCGAGGTGGCCAAATTTCGTTTCCTGAACGAACTGATCAAAGTGTTGTCCCC
AAAGTACCTGGGGTCCTGGGCCACAGGAAAAGTTAAAGGAAGAGTCATTGAAATACTCTTCAGTTGGACAGTCTGGTTTCCGGAAGACAT
CAAGATTCGAGACGCTTATCAGATGCTGAAGAAACAAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTG
CCCTGGCGCTGACAAGGGTCCAGCCTCCGATGACCCCCGCAGCAAACACAAGTTTAAGATCCACACGTACTCCAGCCCCACGTTTTGTGA
CCACTGTGGGTCACTGCTGTATGGACTCATCCACCAGGGGATGAAATGTGACACCTGCATGATGAATGTGCACAAGCGCTGCGTGATGAA
TGTTCCCAGCCTGTGTGGCACGGACCACACGGAGCGCCGCGGCCGCATCTACATCCAGGCCCACATCGACAGGGACGTCCTCATTGTCCT
CGTAAGAGATGCTAAAAACCTTGTACCTATGGACCCCAATGGCCTGTCAGATCCCTACGTAAAACTGAAACTGATTCCCGATCCCAAAAG
TGAGAGCAAACAGAAGACCAAAACCATCAAATGCTCCCTCAACCCTGAGTGGAATGAGACATTTAGATTTCAGCTGAAAGAATCGGACAA
AGACAGAAGACTGTCAGTAGAGATTTGGGATTGGGATTTGACCAGCAGGAATGACTTCATGGGATCTTTGTCCTTTGGGATTTCTGAACT
TCAGAAAGCCAGTGTTGATGGCTGGTTTAAGTTACTGAGCCAGGAGGAAGGCGAGTACTTCAATGTGCCTGTGCCACCAGAAGGAAGTGA
GGCCAATGAAGAACTGCGGCAGAAATTTGAGAGGGCCAAGATCAGTCAGGGAACCAAGGTCCCGGAAGAAAAGACGACCAACACTGTCTC
CAAATTTGACAACAATGGCAACAGAGACCGGATGAAACTGACCGATTTTAACTTCCTAATGGTGCTGGGGAAAGGCAGCTTTGGCAAGGT
CATGCTTTCAGAACGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAAGATGATGACGTGGAGTG
CACTATGGTGGAGAAGCGGGTGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCT
GTACTTTGTGATGGAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTA
CGCTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTC
TGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGA
CTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGC
TGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAA
GGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGA
GCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGA
CACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGA
ATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTT
CAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCT
TTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAA
TTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTT
CAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAA
ATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAAGAATTGATATGATTAAACTGAATTAATA

>33002_33002_4_GGA2-PRKCB_GGA2_chr16_23502998_ENST00000567468_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=761AA_BP=158
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCM
NHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQVCCFVVHKRCHEFVTFSCPGAD
KGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS
VDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI
AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF

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Fusion Gene PPI Analysis for GGA2-PRKCB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GGA2-PRKCB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GGA2-PRKCB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource