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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GGCX-KCMF1 (FusionGDB2 ID:33021)

Fusion Gene Summary for GGCX-KCMF1

Fusion gene summary

Fusion gene information	Fusion gene name: GGCX-KCMF1
	Fusion gene ID: 33021
		Hgene	Tgene
	Gene symbol	GGCX	KCMF1
	Gene ID	2677	56888
	Gene name	gamma-glutamyl carboxylase	potassium channel modulatory factor 1
	Synonyms	VKCFD1	DEBT91\|FIGC\|PCMF\|ZZZ1
	Cytomap	2p11.2	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	vitamin K-dependent gamma-carboxylasepeptidyl-glutamate 4-carboxylase	E3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9
	Modification date	20200313	20200313
	UniProtAcc	P38435	Q9P0J7
	Ensembl transtripts involved in fusion gene	ENST00000233838, ENST00000430215, ENST00000473665,	ENST00000409785,
Fusion gene scores	* DoF score	3 X 3 X 2=18	5 X 6 X 3=90
	# samples	3	8
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/90*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GGCX [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KCMF1(85198590)-GGCX(85783383), # samples:2 GGCX(85787938)-KCMF1(85255012), # samples:1
Anticipated loss of major functional domain due to fusion event.	KCMF1-GGCX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KCMF1-GGCX seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. KCMF1-GGCX seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. KCMF1-GGCX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KCMF1-GGCX seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GGCX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KCMF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-A76X-01A	GGCX	chr2	85787938	-	KCMF1	chr2	85255012	+

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Fusion Gene ORF analysis for GGCX-KCMF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000233838	ENST00000409785	GGCX	chr2	85787938	-	KCMF1	chr2	85255012	+
intron-3CDS	ENST00000430215	ENST00000409785	GGCX	chr2	85787938	-	KCMF1	chr2	85255012	+
intron-3CDS	ENST00000473665	ENST00000409785	GGCX	chr2	85787938	-	KCMF1	chr2	85255012	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000233838

GGCX

chr2

85787938

ENST00000409785

KCMF1

chr2

85255012

7488

295

1424

447

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000233838	ENST00000409785	GGCX	chr2	85787938	-	KCMF1	chr2	85255012	+	0.000522479	0.99947757

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Fusion Genomic Features for GGCX-KCMF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GGCX	chr2	85787937	-	KCMF1	chr2	85255011	+	1.76E-09	1
GGCX	chr2	85787937	-	KCMF1	chr2	85255011	+	1.76E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GGCX-KCMF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:85198590/chr2:85783383)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GGCX P38435	KCMF1 Q9P0J7
FUNCTION: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. {ECO:0000269\|PubMed:17073445}.	FUNCTION: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. {ECO:0000269\|PubMed:15581609}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

2_60

759.0

Topological domain

Cytoplasmic

Tgene

KCMF1

chr2:85787938

chr2:85255012

ENST00000409785

225_257

382.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KCMF1

chr2:85787938

chr2:85255012

ENST00000409785

333_336

382.0

Compositional bias

Note=Poly-Ser

Tgene

KCMF1

chr2:85787938

chr2:85255012

ENST00000409785

376_380

382.0

Compositional bias

Note=Poly-Pro

Tgene

KCMF1

chr2:85787938

chr2:85255012

ENST00000409785

3_50

382.0

Zinc finger

ZZ-type

Tgene

KCMF1

chr2:85787938

chr2:85255012

ENST00000409785

78_101

382.0

Zinc finger

C2H2-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

135_136

759.0

Topological domain

Cytoplasmic

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

158_292

759.0

Topological domain

Lumenal

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

314_361

759.0

Topological domain

Cytoplasmic

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

383_758

759.0

Topological domain

Lumenal

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

82_113

759.0

Topological domain

Lumenal

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

135_136

702.0

Topological domain

Cytoplasmic

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

158_292

702.0

Topological domain

Lumenal

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

2_60

702.0

Topological domain

Cytoplasmic

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

314_361

702.0

Topological domain

Cytoplasmic

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

383_758

702.0

Topological domain

Lumenal

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

82_113

702.0

Topological domain

Lumenal

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

114_134

759.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

137_157

759.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

293_313

759.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

362_382

759.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000233838

61_81

759.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

114_134

702.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

137_157

702.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

293_313

702.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

362_382

702.0

Transmembrane

Helical

Hgene

GGCX

chr2:85787938

chr2:85255012

ENST00000430215

61_81

702.0

Transmembrane

Helical

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Fusion Gene Sequence for GGCX-KCMF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33021_33021_1_GGCX-KCMF1_GGCX_chr2_85787938_ENST00000233838_KCMF1_chr2_85255012_ENST00000409785_length(transcript)=7488nt_BP=295nt
CGGAGCCTAGGGAAGCAAATTCTCCTGGCGGCCTCCGTTCAGACGCGGCAGCTGTGACCCACCTGCCTCCTCCGCAGAGCAATGGCGGTG
TCTGCCGGGTCCGCGCGGACCTCGCCCAGCTCAGATAAAGTACAGAAAGACAAGGCTGAACTGATCTCAGGGCCCAGGCAGGACAGCCGA
ATAGGGAAACTCTTGGGTTTTGAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACCCTGCTGAATCGACCAACGGACCCTGCAAGC
TTAGCTGTCTTTCGTTTTCTTTTTGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGC
TACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACA
AGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGC
TATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCT
GGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGT
GTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCT
ACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCA
GGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAA
CGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATC
ACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAAT
GATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACT
TTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCT
TTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCG
CAGACAATGTCCTCTGTGCTGTATTTGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCAC
TCTTGTTACATTGTGTACATTCAAAAGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAA
TGTAGGTAGCAGTGCAGGGGTGATCTCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAA
AATTGAAATCTCTAATGAAGCTGCTGTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAG
GTTTTTTGCAGCGTGCATGAGTTTTAGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCA
AAGCTTTCCCAAACATTATTCAATGGTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTAC
GCACAAAGCCAGCTCTGCAGTGGAATCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCAT
CTTGCCTGTGTGGAGCTCAGCCTGTCTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTT
TGTGTGCCCTAAAAACAAATCCTGTTCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTT
TTATTCAGGTGTAGATGAATTTCATTTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCT
CAATCATATTTTGCATTATTTATGTATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGA
TTTGTCAGTATATTACAACCAAATTCTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTT
AATTGAATCATGCCACCTATATGCCTATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGA
AGGGCCGGGTTATTTTTTATTTCCTGTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTG
GGAGGGCAGTTTTTGGAATGTAAATTTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATG
TCTCGTTCCAGTTCTCTTTTCTCTGAGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCG
TTTCTTCAACATGACAAGCATACAGACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAA
AAAAGAAGTCACCCTACATGTCTGAAAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTT
CTTTAGTTCTGTAATGGATAATGTTTAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATT
TTTTTTCATTTGGTTGTTGAGAAGTTTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAAT
AAAGCATTTTCAAGACTGTTGACCACTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCC
AGTATTTTTTTTCTTTTTATGCTAAACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATA
TGTACTTTCCCTTTTCTGCACAAATTCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCA
GAGCAGTTTAATTTAGATGATCACTTTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAAT
TATTTTTTACCAGATATTTTACAAATACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATC
AATATAAAAATATATTCAAGCCCTTGAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAA
TAAAAATTAATTGCAAAGACTTTGATGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGA
TCCTGAATTTTGAGAATTTTTTGTTTCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCC
TGTTTAGAAATCATTTAAATCTTTCCCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCT
TGTATGGCTGCAATCATAAGACAGAATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAA
AATCCACAGAAGTAGAACCTAGGTTTGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCC
CTGTGGCCCCCAGAGAAATGAAGTAGGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCAC
CCCCCATTTTCCCTCTCAATATTAGAAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCT
GTGGGCCACAGTTAAAAGAACGGGTAACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCA
CTGCAAATATTAACGCTTTATATATTTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGT
GGGTTGGGGGGTAGAAGGAGAATACTAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTG
TTCAGTACCAATATTAAGTCTACTGTAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAAT
GGGTGCTAAAAGCTCTTAACAGTTTTGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACA
GTTTAAGGGGCACATGCAATATTGGTTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACT
TTGCGAGGCCGAGGCGGGTGGATCACGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAA
AAGTTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGT
TGCAGTGAGCTGAGATCACGCCGCCATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTA
GGTACGAAATTATCCCAGAATTATACGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACT
AGACACTAAAACAGTTCTCTCCTTGAGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTC
ATCTCATTTCAGCCTCAACAGTAATTGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGT
CTGCAGACTTTCAGGTTGTGACGATGTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCC
AAATTCAAGTGACTGTTTTTCTGAATAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTA
ATTCGTACTCTTGCCTCTTGGTTTCTGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCC
TGCAGCAGACCTCGAATAAAATGTGACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTC
TCAGAGAAGTTGATCCTGAACCTCCACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCAC
AAAGGAGAATGCTCTCAAGTCCTCATGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAA
GTCTGACTGTCCCAGGTAACTTTACTTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTG
GGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGC
CAAGATGGTGAAACCCCATCTCTACTAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTG
AGGCAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACT
CTCCTCAAAACAAAAAAAAAAGAAAGAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGT
TTCTCTTCAAGGAGGCCTTTACTAACCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGG
CTCCTCTGTCTATAGAAACCATCAGTTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACA
TTATTTACCAACTGCGATTTTTACAGACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAG
GTCATCAAGCCGGTTGCGTTTGGTCAGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACA
GCATTTGGAATCTGCCTCACACATAAGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGA
GTCCCAGCTCTCTCTCCTTGTATATAAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGA
TTCTATAATACTCCTGTATTGGCAAGTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGA
TTCTTACCCCCTAGTCATGAAAGCTATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGAC
ACTAGTTTCCCCATAAAAGTCCATTTTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCAT
GTGTGCTGACCACTCACGATTCAGACTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGC
TCCGAGACTAATTTGTACTGAACCCTTGATATAGATTACCTTTTATAACATCACCACCTGTCATGAAGCTTATCTGTTTTCTGATTTGAA

>33021_33021_1_GGCX-KCMF1_GGCX_chr2_85787938_ENST00000233838_KCMF1_chr2_85255012_ENST00000409785_length(amino acids)=447AA_BP=66
MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGVSCDACLKGNFRGRRYKC
LICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICA
ALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLS
QLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLT

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Fusion Gene PPI Analysis for GGCX-KCMF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GGCX-KCMF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GGCX-KCMF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source