Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GGNBP2-NEBL (FusionGDB2 ID:33031)

Fusion Gene Summary for GGNBP2-NEBL

Fusion gene summary

Fusion gene information	Fusion gene name: GGNBP2-NEBL
	Fusion gene ID: 33031
		Hgene	Tgene
	Gene symbol	GGNBP2	NEBL
	Gene ID	79893	10529
	Gene name	gametogenetin binding protein 2	nebulette
	Synonyms	DIF-3\|DIF3\|LCRG1\|LZK1\|ZFP403\|ZNF403	C10orf113\|LASP2\|LNEBL\|bA165O3.1
	Cytomap	17q12	10p12.31
	Type of gene	protein-coding	protein-coding
	Description	gametogenetin-binding protein 2C3HC4-type zinc finger proteinlaryngeal carcinoma related gene 1laryngeal carcinoma-related protein 1zinc finger protein 403	nebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk protein
	Modification date	20200313	20200313
	UniProtAcc	Q9H3C7	O76041
	Ensembl transtripts involved in fusion gene	ENST00000304718, ENST00000485685,	ENST00000377119, ENST00000464278, ENST00000377122, ENST00000377159, ENST00000417816,
Fusion gene scores	* DoF score	6 X 7 X 6=252	12 X 11 X 6=792
	# samples	6	13
	** MAII score	log2(6/252*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/792*10)=-2.60698880705116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GGNBP2 [Title/Abstract] AND NEBL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GGNBP2(34901666)-NEBL(21101869), # samples:3
Anticipated loss of major functional domain due to fusion event.	GGNBP2-NEBL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GGNBP2-NEBL seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GGNBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-C5-A3HD-01B	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
ChimerDB4	CESC	TCGA-C5-A3HD-01B	GGNBP2	chr17	34901666	-	NEBL	chr10	21101869	-
ChimerDB4	CESC	TCGA-C5-A3HD-01B	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-

Top

Fusion Gene ORF analysis for GGNBP2-NEBL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000304718	ENST00000377119	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
5CDS-intron	ENST00000304718	ENST00000464278	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
5CDS-intron	ENST00000485685	ENST00000377119	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
5CDS-intron	ENST00000485685	ENST00000464278	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
5UTR-3CDS	ENST00000304718	ENST00000377122	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-3CDS	ENST00000304718	ENST00000377159	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-3CDS	ENST00000304718	ENST00000417816	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-3CDS	ENST00000485685	ENST00000377122	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-3CDS	ENST00000485685	ENST00000377159	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-3CDS	ENST00000485685	ENST00000417816	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-intron	ENST00000304718	ENST00000377119	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-intron	ENST00000304718	ENST00000464278	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-intron	ENST00000485685	ENST00000377119	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
5UTR-intron	ENST00000485685	ENST00000464278	GGNBP2	chr17	34900946	+	NEBL	chr10	21101869	-
Frame-shift	ENST00000485685	ENST00000377122	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
Frame-shift	ENST00000485685	ENST00000377159	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
Frame-shift	ENST00000485685	ENST00000417816	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
In-frame	ENST00000304718	ENST00000377122	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
In-frame	ENST00000304718	ENST00000377159	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-
In-frame	ENST00000304718	ENST00000417816	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304718	GGNBP2	chr17	34901666	+	ENST00000377122	NEBL	chr10	21101869	-	6882	409	217	1107	296
ENST00000304718	GGNBP2	chr17	34901666	+	ENST00000417816	NEBL	chr10	21101869	-	2706	409	217	864	215
ENST00000304718	GGNBP2	chr17	34901666	+	ENST00000377159	NEBL	chr10	21101869	-	1141	409	217	864	215

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304718	ENST00000377122	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-	0.000326463	0.9996736
ENST00000304718	ENST00000417816	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-	0.000854117	0.99914587
ENST00000304718	ENST00000377159	GGNBP2	chr17	34901666	+	NEBL	chr10	21101869	-	0.003626789	0.99637324

Top

Fusion Genomic Features for GGNBP2-NEBL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GGNBP2-NEBL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:34901666/chr10:21101869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GGNBP2 Q9H3C7	NEBL O76041
FUNCTION: May be involved in spermatogenesis.	FUNCTION: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269\|PubMed:15004028, ECO:0000269\|PubMed:27733623}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

954_1014

782

1015.0

Domain

SH3

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

954_1014

119

271.0

Domain

SH3

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

836_953

782

1015.0

Region

Note=Linker

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

836_953

119

271.0

Region

Note=Linker

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

795_830

782

1015.0

Repeat

Note=Nebulin 23

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

137_172

119

271.0

Repeat

Note=Nebulin 4

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

173_205

119

271.0

Repeat

Note=Nebulin 5

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

206_241

119

271.0

Repeat

Note=Nebulin 6

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

242_278

119

271.0

Repeat

Note=Nebulin 7

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

279_313

119

271.0

Repeat

Note=Nebulin 8

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

314_348

119

271.0

Repeat

Note=Nebulin 9

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

349_385

119

271.0

Repeat

Note=Nebulin 10

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

386_422

119

271.0

Repeat

Note=Nebulin 11

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

423_459

119

271.0

Repeat

Note=Nebulin 12

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

460_496

119

271.0

Repeat

Note=Nebulin 13

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

497_533

119

271.0

Repeat

Note=Nebulin 14

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

534_569

119

271.0

Repeat

Note=Nebulin 15

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

570_599

119

271.0

Repeat

Note=Nebulin 16

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

600_635

119

271.0

Repeat

Note=Nebulin 17

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

636_666

119

271.0

Repeat

Note=Nebulin 18

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

667_693

119

271.0

Repeat

Note=Nebulin 19

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

694_728

119

271.0

Repeat

Note=Nebulin 20

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

729_759

119

271.0

Repeat

Note=Nebulin 21

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

760_794

119

271.0

Repeat

Note=Nebulin 22

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

795_830

119

271.0

Repeat

Note=Nebulin 23

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

100_136

782

1015.0

Repeat

Note=Nebulin 3

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

137_172

782

1015.0

Repeat

Note=Nebulin 4

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

173_205

782

1015.0

Repeat

Note=Nebulin 5

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

206_241

782

1015.0

Repeat

Note=Nebulin 6

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

242_278

782

1015.0

Repeat

Note=Nebulin 7

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

279_313

782

1015.0

Repeat

Note=Nebulin 8

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

29_63

782

1015.0

Repeat

Note=Nebulin 1

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

314_348

782

1015.0

Repeat

Note=Nebulin 9

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

349_385

782

1015.0

Repeat

Note=Nebulin 10

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

386_422

782

1015.0

Repeat

Note=Nebulin 11

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

423_459

782

1015.0

Repeat

Note=Nebulin 12

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

460_496

782

1015.0

Repeat

Note=Nebulin 13

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

497_533

782

1015.0

Repeat

Note=Nebulin 14

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

534_569

782

1015.0

Repeat

Note=Nebulin 15

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

570_599

782

1015.0

Repeat

Note=Nebulin 16

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

600_635

782

1015.0

Repeat

Note=Nebulin 17

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

636_666

782

1015.0

Repeat

Note=Nebulin 18

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

64_99

782

1015.0

Repeat

Note=Nebulin 2

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

667_693

782

1015.0

Repeat

Note=Nebulin 19

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

694_728

782

1015.0

Repeat

Note=Nebulin 20

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

729_759

782

1015.0

Repeat

Note=Nebulin 21

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000377122

760_794

782

1015.0

Repeat

Note=Nebulin 22

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

100_136

119

271.0

Repeat

Note=Nebulin 3

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

29_63

119

271.0

Repeat

Note=Nebulin 1

Tgene

NEBL

chr17:34901666

chr10:21101869

ENST00000417816

64_99

119

271.0

Repeat

Note=Nebulin 2

Top

Fusion Gene Sequence for GGNBP2-NEBL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33031_33031_1_GGNBP2-NEBL_GGNBP2_chr17_34901666_ENST00000304718_NEBL_chr10_21101869_ENST00000377122_length(transcript)=6882nt_BP=409nt
ACCTTCCCCTCGTCCCCCGCCCTCCTTCTTCCACTCCCCGCGGCGCGAGCGGCTGACTGCCCGTAGAGGAAACGACATTCGGAGCTGCGC
TCCCGCCCAGGCCGGCCCTGACGCGGGCCTCGTCAGCCAGTAACAGGGAGCAGAGGTGGGAGTTAGCGAGGCGACCACGAAAACGGTGAA
GGTCGGAACCGACAGCCTCCTCCGAGAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGAAACAGCAGCGGCGGCGGCGGCGG
CAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTT
CCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTGACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGG
CTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCC
TCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGACCTCAAAGTTTGGCGCACAGATCCTGGCTCCATCTTCGACCTTGATCC
CCTGGAAGACAATATTCAGTCTAGAAGTCTCCATATGCTCTCTGAAAAGGCGAGTCACTATAGGCGACACTGGTCTCGATCCCATTCCAG
CAGTACTTTCGGTACAGGTCTCGGAGACGACAGGTCAGAAATCTCCGAGATTTACCCTAGCTTTTCATGCTGCAGTGAGGTAACAAGACC
GTCTGATGAAGGAGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATC
CATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAG
AGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCC
AGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTTTTAAAAGA
TAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGGAAGAAGGA
ATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTAATTGTGTT
CATGGTTTCCTTTGATTGGCTATTGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAGAGAAGTTGATTGTCCCTTAAATGTAGT
GTGTGTTTGAAACTTCTTAGCTGTCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGTAATGCAGCCAATAATTTCAAACCCGTT
TTGCTTTTGAGTCATGAGGCAATTTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAAACAGTGGCAGAAGGACAGTCTGGTTAA
AATTATATTGACTGGTGGCCTTAGGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGTTCCCTAGGCTGACTGGTATCTATTTAT
TTCTCATTTGTACCAAGGCATCTCCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCTCAGTTCCACAGAATGTCAGGACCAAAT
AACTTCACAGCTACTCTGCAAAGGGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCATTTACCCTGTTGCATGTCATGTAGATT
CAAGCTTCTGTAACATAGGCAGCTGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACTGATACCTAAAAGCCCTTTCTTCCTCTA
GTCGCCAGCTCATCAGAAAAACATACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCACTCTAGTTTTGAAGGATTTACATCTTA
GGAAATAACATGTATACTCTAGTAAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTAACTTAATGCCACCATTGATTTCAAAGT
GAAGAAAATGTAACAGAAGCCAGTGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCAGCAAACAAAGTTACCAATTCCATACAG
AGATGATCTGGTATCTTCTTTTGGAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACCAAAACGGGTTAATCAAAAGACGTCCTT
TTCCATTTTTTTTTGCTTTTATTTTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATCAGAGATTTTTTAGTACAGGCCCAAGAG
CCTGTTCTCTAAGAAAGAAATTGTTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCTTTATGCTAGCCCTTGCTGGTGGGTCTT
GAAATTTCATCCAGAGTCTGCAGTCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGTGTTTTTCTGATTGTGCCGTTTACTGTG
ACCTGCAACGGGGTGGCATTCACTTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGCAAAACTGCAAAAAAGTACTAAGATGTA
CGGGTCTTGGGGATATCTGCCTTATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAAACATCGTTTAAGGAAACGTTTACTAGT
CCAAAGGCCAAAGCTAATTTATTTCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGTGATTTCATTTTATTAGGCTAAAAGGGT
AAATAGGCTTTATTACACTGAAGCTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAATGCAGGCAAATAACTAGAGACTTCTTT
TAAGGGGGTTTGGCTGGTTTTCTCTCACTGAAATGGCCAGTCGTGATTAAAGTGATAAAACCCCATATCTGTTTTGGTATATTGTACACA
AACCTACAAAAATAAACTGAACTTGCAATATTTTTGCAAAAAAATCTGTCGTTAAAACTGAGGATAAAATACCTGCTCAATTTTATTTTA
CTAAGTATATATTTACATTTCACCCAGGCAGGCCATTTTCTTTTGTGATTATAAGAAAGAGTAGTTGTTGATTAAATTTTCAGACTAAAT
ATAGGACAGGTACAATTTTGGATAAATAGCACATTTATAAGAACCGCAATGAAAACTGACTTGAAATAATGCTTGTAATCAGGAAAGTAA
TTTCATCCACCGATTTCAAAACCAGATTCACTGAGCATAAAAGTCAATACATATTTGAGGAATAAGTCTCCTAAAATTTTAAGCTTCACG
TAATAATGTTTGCATAGCAAAATATTTCTGCTTCAAGCCTTTAGGAATTAAGATCTGATCAGAATTTAACTAAAGGGTAGTTGTTTTACA
ATGAAGACTAAAACTGAACAAGATGTTGCATGCTCTTGAGGCCATAATTTGGTAGTGTTGGCAGTTGTTAATAAAGCTTGTCAGGATGTT
AAGCATCTCAGGAGAAATATTGGAAAATTATATGTATAAAACCAAAGTGCTATTTTTAAAAGCATCATTTAAAAAAAAATGACATGCCTG
AACAACTTTTCCACTTTCCACGTGCTTCCCTCCCACCTTTGGTTTGGCAACAGGTATCTCGTGCATGAAGCTGACAGCTAAAGAAGATTT
TAAAAATTGAGTTAAAGATGACTGTGTAAATGTCCAAGCACAGAGAGCATGCACCTGACTTTCTAAAGTTTGATGTGTTCTCAAGCCTGA
CAGAAGCACAAGGAACAGTTTGATACACTTTTAAAAGGTTCTGAAAACAAAGCTGTATAGGGATCCTCTCTCTCTTGAGCAAAGTATAGC
AACAGAATATATTGCTTTTGTTGTAAGCTTTTGTAGTACATGTTTTTACTAATAATTCTTGTTCTCTAGAAAGCTTTCTATTTCTAACCT
ATGGCAAAATGAATCCTTCATGTCTTCTTGTTATTGTTTACACACTTGCAGTGTAGCCCAGTTTGAAATATTTATTTGGTTATCAACTGC
CCATGGAGGAGGCTCTTGATGATCCCAGGTCTCCTCGACCTCCATACACCACACAGGCATTTGTAAGCACAGTTTCCACAAGCACCTTGT
AGGAATATGGATAAGATTAGACCAGCCCCTCTCTGTCCACTGGGTTTATTTCTTGAAGAAGATGCAGATCTGGTTTTTCCAATGTGCCAC
AGTCTTTCCTTATCCTCTCCATGCTGAGCTTGACAACACTCTGGGAATGAGGAACAAGACTTTTTCTAAAAAGATAGTGGAAGTTCAAGG
GATGTACCTCGTTTTCAGGTTCATCCATCTCCAGTGGAATGTTTTCAATAAAAGATGAAGAAAATGTGTGTGATCTTTAATAACACATCC
CTATAGAAAGTGGATAAAAGATATACCAAAACTGTAATACAGATATATACAAATATAGGTGCCTTTTTGATTACTCTTGTTTGTCTAGTA
TGCTCTTGGAAAGAAAACCAAGCAAGCAAGTTGCTGCCTATTCTATAGTAATATTTTATTACACATGATTGATATTTTTGTGGTAGGGAA
GTGGGATGCTCCTCAGATATTAAAGGTGTTAGCTGATTGTATTTTATCTCTAAAGATTTAGAACTTTAGAAAATGCCGACTTCTTCCATC
TATTTCTGAAAGGTTCTTTGTGGATTTATATAGAGTTGAGCTATATAAACATTAACTTTAGATTTGGGATTTAAAATGCCTATTGTAAGA
TAGAATAATTGTGAGGCTGGATTCACTACACAAGATGAACTTCACTTCATAAATTAATTATACCTTAGCGATTTGCTTCTGATAATCTAA
AAGTGGCTAGATTGTGGTTGTTTTGGTTAAGGTGATATGGAGGTGGGAGAGCTTTTAGTTAAGTAAGAAGCTATGTAAACTGACAAGGAT
GCTAAAATAAAAGTCTCTGAAGTATTCCATGCCTTTTGGACCCTTTCCTCGCAACTAACTGTCAACTGTTGATCAAAAAAGTCAAGGCAT
TGTATGTTGCTTCTGTGGTTATTATTCTGTGATGCTTAGACTACTTGAACCCATAAACTTGGAAGAATCTTTGAGCAAATTTTCTCAGTT
GTCTGTATGACTTCAGTATATTCCTGGGAATGCCATAGGATTTTTTGTGCTTGATACATGGTATCCAGTTTGCATAGTATCACTTCTTTG
TAATCCAGTTGCTGTTAAGAATGATGTACTTTAAAGGAAAAGAGAAAACTGCATCACAGTCCCATTCTCCAGTGTCCATGCAATGAATTG
CTGAGCATTTAGGAAGCAGCACCAAGTCTATTACAGGCATGGTGTGAAACTTGATGTTTGACCTGTGATCAAAATTGAACCATTGTACAG
TTTGGCTTCTGTTTGCTTCAAAATATGTAGAATTGTGGTTGATGATTAATTTGCGAGACTAACTTTGAGAGTGTAACAGTTTTGAAGAAA
ACATTGAATGTTTTGCAAATGAAGGGGCTTCACGGAATGTTACAATGTTACTAATATAATTTGGCTTTTGTTATGCAAATTGTTAACACC
AGCTATTAAAATATATTTTAGTAGAAATGCTTTAATTCATATTTTTTTCCTCTACACTGTGAATCTTTAAGCCTTGGTGGACTAGAGCAA
CATCGTGCTGCCCAAAGGACTAACCTATGCAAACTAGTTCACATTTTAGTGGATGTCGCAGTTAATGTGTAATAAGACATTATTTCCCCT
GCATAATGTACAACAGCATTGAAATGACACATTAAGCCTAGCATCACATTGTATAGTACAGTCACTCACAAACCCTTCAAGGCTACCCTA
ATCATTAACATTAATATTTGTTTAAAAGCAAATCACCGATTTATCTATTGAAACTACTTAAATGACGGCAAACCAGGAATGACAGATGGC
TGTGTCAGCAATGGCTTTAATGTGTTCCCTGCAAGTGGTCTCCTATGATAGAACTGCGTTCTCAAATGCACTCTCTTCAGGGTCTTAATA
TTCTGTGTTTTCTCTCTGTATTTGTAAAACATTATAACACATTAATTTCCTATCTCTACACATTTGGTTTGCTTAAATAAATGCAGGATA
TAAAAAAAATGGTTCACTTCTTGGCTCTCACCGTGGTTTCTTGGAGCATGGGTTGTTAGATGCAAGCAATGCACCCTAATAATACCCCGG
GTCTGAGATTTAACATGACAACTCACATCAAATCGCATCAGAGGTGTGTGCTGCCTTCAGTGCATTTACATTGGTGAATCAGTCAAGATA
TTTTCCTCCCCCAAATAAACTTAGTTGTAAGTGATAACAATATTATGCTTCTCCAAGCTCAGTATCTTTCTGATTTTATATCAAAGTACC
GCAACAATGCATCATTGTAGTTAATTTATTTCAAGAATAAATTCCTCATATGTCCTCAATAGTACAATTCTAATTTTCTTCTATTCATAA
GATGAAAGAAATGGTTTGGAGCATAGAATAGAAAGTGCACAAATTGAGTACATAAAATGGGAAGCAACTGATTTCTCAGCTAAGAAAGGC
TCATTTATCACAGAACACAATTGCTTTTCTCCCCCCACTACGCTTCCCATAATTGAAAAAGTGAGTCCCTATTTTTCACACTCATATAAA
TCTATGCGATTTGGATGCTAGTCTTATTGTATTATTTTGTAAAACTTTCTCTTTGGCTCATAATCCTTCCTAATTGTAAATTGATAAACT

>33031_33031_1_GGNBP2-NEBL_GGNBP2_chr17_34901666_ENST00000304718_NEBL_chr10_21101869_ENST00000377122_length(amino acids)=296AA_BP=64
MGGGGSGGGRNSSGGGGGSWEEVVTVATAASGTMARLVAVCRDGEEEFPFERRQIPLYIDDTLTVKYHEDFEKTKGRGFTPVVDDPVTER
VRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRS
EISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPID

--------------------------------------------------------------
>33031_33031_2_GGNBP2-NEBL_GGNBP2_chr17_34901666_ENST00000304718_NEBL_chr10_21101869_ENST00000377159_length(transcript)=1141nt_BP=409nt
ACCTTCCCCTCGTCCCCCGCCCTCCTTCTTCCACTCCCCGCGGCGCGAGCGGCTGACTGCCCGTAGAGGAAACGACATTCGGAGCTGCGC
TCCCGCCCAGGCCGGCCCTGACGCGGGCCTCGTCAGCCAGTAACAGGGAGCAGAGGTGGGAGTTAGCGAGGCGACCACGAAAACGGTGAA
GGTCGGAACCGACAGCCTCCTCCGAGAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGAAACAGCAGCGGCGGCGGCGGCGG
CAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTT
CCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTGACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGG
CTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCC
TCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGG
CTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGC
CCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCA
GAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATG
TATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAAT
TAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTC

>33031_33031_2_GGNBP2-NEBL_GGNBP2_chr17_34901666_ENST00000304718_NEBL_chr10_21101869_ENST00000377159_length(amino acids)=215AA_BP=64
MGGGGSGGGRNSSGGGGGSWEEVVTVATAASGTMARLVAVCRDGEEEFPFERRQIPLYIDDTLTVKYHEDFEKTKGRGFTPVVDDPVTER
VRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGD

--------------------------------------------------------------
>33031_33031_3_GGNBP2-NEBL_GGNBP2_chr17_34901666_ENST00000304718_NEBL_chr10_21101869_ENST00000417816_length(transcript)=2706nt_BP=409nt
ACCTTCCCCTCGTCCCCCGCCCTCCTTCTTCCACTCCCCGCGGCGCGAGCGGCTGACTGCCCGTAGAGGAAACGACATTCGGAGCTGCGC
TCCCGCCCAGGCCGGCCCTGACGCGGGCCTCGTCAGCCAGTAACAGGGAGCAGAGGTGGGAGTTAGCGAGGCGACCACGAAAACGGTGAA
GGTCGGAACCGACAGCCTCCTCCGAGAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGAAACAGCAGCGGCGGCGGCGGCGG
CAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTT
CCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTGACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGG
CTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCC
TCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGG
CTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGC
CCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCA
GAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATG
TATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAAT
TAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTC
TGGACACCTGGTGCTGCTAATTGTGTTCATGGTTTCCTTTGATTGGCTATTGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAG
AGAAGTTGATTGTCCCTTAAATGTAGTGTGTGTTTGAAACTTCTTAGCTGTCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGT
AATGCAGCCAATAATTTCAAACCCGTTTTGCTTTTGAGTCATGAGGCAATTTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAA
ACAGTGGCAGAAGGACAGTCTGGTTAAAATTATATTGACTGGTGGCCTTAGGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGT
TCCCTAGGCTGACTGGTATCTATTTATTTCTCATTTGTACCAAGGCATCTCCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCT
CAGTTCCACAGAATGTCAGGACCAAATAACTTCACAGCTACTCTGCAAAGGGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCA
TTTACCCTGTTGCATGTCATGTAGATTCAAGCTTCTGTAACATAGGCAGCTGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACT
GATACCTAAAAGCCCTTTCTTCCTCTAGTCGCCAGCTCATCAGAAAAACATACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCA
CTCTAGTTTTGAAGGATTTACATCTTAGGAAATAACATGTATACTCTAGTAAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTA
ACTTAATGCCACCATTGATTTCAAAGTGAAGAAAATGTAACAGAAGCCAGTGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCA
GCAAACAAAGTTACCAATTCCATACAGAGATGATCTGGTATCTTCTTTTGGAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACC
AAAACGGGTTAATCAAAAGACGTCCTTTTCCATTTTTTTTTGCTTTTATTTTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATC
AGAGATTTTTTAGTACAGGCCCAAGAGCCTGTTCTCTAAGAAAGAAATTGTTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCT
TTATGCTAGCCCTTGCTGGTGGGTCTTGAAATTTCATCCAGAGTCTGCAGTCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGT
GTTTTTCTGATTGTGCCGTTTACTGTGACCTGCAACGGGGTGGCATTCACTTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGC
AAAACTGCAAAAAAGTACTAAGATGTACGGGTCTTGGGGATATCTGCCTTATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAA
ACATCGTTTAAGGAAACGTTTACTAGTCCAAAGGCCAAAGCTAATTTATTTCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGT
GATTTCATTTTATTAGGCTAAAAGGGTAAATAGGCTTTATTACACTGAAGCTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAA

>33031_33031_3_GGNBP2-NEBL_GGNBP2_chr17_34901666_ENST00000304718_NEBL_chr10_21101869_ENST00000417816_length(amino acids)=215AA_BP=64
MGGGGSGGGRNSSGGGGGSWEEVVTVATAASGTMARLVAVCRDGEEEFPFERRQIPLYIDDTLTVKYHEDFEKTKGRGFTPVVDDPVTER
VRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GGNBP2-NEBL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GGNBP2-NEBL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GGNBP2-NEBL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source