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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AKAP13-KLK2 (FusionGDB2 ID:3304) |
Fusion Gene Summary for AKAP13-KLK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKAP13-KLK2 | Fusion gene ID: 3304 | Hgene | Tgene | Gene symbol | AKAP13 | KLK2 | Gene ID | 11214 | 3817 |
| Gene name | A-kinase anchoring protein 13 | kallikrein related peptidase 2 | |
| Synonyms | AKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47 | KLK2A2|hGK-1|hK2 | |
| Cytomap | 15q25.3 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase anchor protein 13A kinase (PRKA) anchor protein 13LBC oncogenebreast cancer nuclear receptor-binding auxiliary proteinguanine nucleotide exchange factor Lbchuman thyroid-anchoring protein 31lymphoid blast crisis oncogenenon-oncogenic Rho G | kallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q12802 | P20151 | |
| Ensembl transtripts involved in fusion gene | ENST00000361243, ENST00000394510, ENST00000394518, ENST00000560302, ENST00000560579, | ENST00000325321, ENST00000358049, ENST00000391810, ENST00000597509, | |
| Fusion gene scores | * DoF score | 37 X 24 X 13=11544 | 15 X 20 X 2=600 |
| # samples | 41 | 21 | |
| ** MAII score | log2(41/11544*10)=-4.81537548498575 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/600*10)=-1.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AKAP13 [Title/Abstract] AND KLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AKAP13(86109878)-KLK2(51383823), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AKAP13 | GO:0007186 | G protein-coupled receptor signaling pathway | 11546812 |
| Hgene | AKAP13 | GO:0035025 | positive regulation of Rho protein signal transduction | 11546812 |
| Fusion gene breakpoints across AKAP13 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KLK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | AA534173 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
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Fusion Gene ORF analysis for AKAP13-KLK2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000361243 | ENST00000325321 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000361243 | ENST00000358049 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000361243 | ENST00000391810 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000361243 | ENST00000597509 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394510 | ENST00000325321 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394510 | ENST00000358049 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394510 | ENST00000391810 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394510 | ENST00000597509 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394518 | ENST00000325321 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394518 | ENST00000358049 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394518 | ENST00000391810 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000394518 | ENST00000597509 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560302 | ENST00000325321 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560302 | ENST00000358049 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560302 | ENST00000391810 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560302 | ENST00000597509 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560579 | ENST00000325321 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560579 | ENST00000358049 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560579 | ENST00000391810 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| intron-intron | ENST00000560579 | ENST00000597509 | AKAP13 | chr15 | 86109878 | + | KLK2 | chr19 | 51383823 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for AKAP13-KLK2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AKAP13-KLK2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:86109878/:51383823) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKAP13 | KLK2 |
| FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. | FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for AKAP13-KLK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for AKAP13-KLK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AKAP13-KLK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AKAP13-KLK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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