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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GHITM-NRG3 (FusionGDB2 ID:33064)

Fusion Gene Summary for GHITM-NRG3

Fusion gene summary

Fusion gene information	Fusion gene name: GHITM-NRG3
	Fusion gene ID: 33064
		Hgene	Tgene
	Gene symbol	GHITM	NRG3
	Gene ID	27069	10718
	Gene name	growth hormone inducible transmembrane protein	neuregulin 3
	Synonyms	DERP2\|HSPC282\|MICS1\|My021\|PTD010\|TMBIM5	HRG3\|pro-NRG3
	Cytomap	10q23.1	10q23.1
	Type of gene	protein-coding	protein-coding
	Description	growth hormone-inducible transmembrane proteindermal papilla-derived protein 2mitochondrial morphology and cristae structure 1transmembrane BAX inhibitor motif containing 5transmembrane BAX inhibitor motif-containing protein 5	pro-neuregulin-3, membrane-bound isoformneuregulin-3-like polypeptide
	Modification date	20200313	20200313
	UniProtAcc	Q9H3K2	P56975
	Ensembl transtripts involved in fusion gene	ENST00000372134,	ENST00000372141, ENST00000372142, ENST00000404547, ENST00000404576, ENST00000537893, ENST00000545131, ENST00000556918,
Fusion gene scores	* DoF score	7 X 7 X 2=98	16 X 15 X 5=1200
	# samples	8	16
	** MAII score	log2(8/98*10)=-0.292781749227846 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1200*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GHITM [Title/Abstract] AND NRG3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GHITM(85902510)-NRG3(84711225), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GHITM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRG3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1322-01A	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+

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Fusion Gene ORF analysis for GHITM-NRG3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000372134	ENST00000372141	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+
In-frame	ENST00000372134	ENST00000372142	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+
In-frame	ENST00000372134	ENST00000404547	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+
In-frame	ENST00000372134	ENST00000404576	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+
In-frame	ENST00000372134	ENST00000537893	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+
In-frame	ENST00000372134	ENST00000545131	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+
In-frame	ENST00000372134	ENST00000556918	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372134	GHITM	chr10	85902510	+	ENST00000372141	NRG3	chr10	84711225	+	1499	422	193	1458	421
ENST00000372134	GHITM	chr10	85902510	+	ENST00000404547	NRG3	chr10	84711225	+	1531	422	193	1530	446
ENST00000372134	GHITM	chr10	85902510	+	ENST00000372142	NRG3	chr10	84711225	+	2893	422	193	1530	445
ENST00000372134	GHITM	chr10	85902510	+	ENST00000404576	NRG3	chr10	84711225	+	1459	422	193	1458	422
ENST00000372134	GHITM	chr10	85902510	+	ENST00000556918	NRG3	chr10	84711225	+	1459	422	193	1458	422
ENST00000372134	GHITM	chr10	85902510	+	ENST00000537893	NRG3	chr10	84711225	+	1459	422	193	1458	422
ENST00000372134	GHITM	chr10	85902510	+	ENST00000545131	NRG3	chr10	84711225	+	1688	422	193	1458	421

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372134	ENST00000372141	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.003891435	0.9961086
ENST00000372134	ENST00000404547	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.007687742	0.99231225
ENST00000372134	ENST00000372142	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.00089334	0.9991066
ENST00000372134	ENST00000404576	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.005071417	0.9949286
ENST00000372134	ENST00000556918	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.005071417	0.9949286
ENST00000372134	ENST00000537893	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.005071417	0.9949286
ENST00000372134	ENST00000545131	GHITM	chr10	85902510	+	NRG3	chr10	84711225	+	0.003097885	0.9969021

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Fusion Genomic Features for GHITM-NRG3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GHITM	chr10	85902510	+	NRG3	chr10	84711224	+	0.016505722	0.9834942
GHITM	chr10	85902510	+	NRG3	chr10	84711224	+	0.016505722	0.9834942

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GHITM-NRG3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:85902510/chr10:84711225)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GHITM Q9H3K2	NRG3 P56975
FUNCTION: Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. {ECO:0000269\|PubMed:18417609}.	FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269\|PubMed:16478787, ECO:0000269\|PubMed:9275162}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

252_260

130

500.0

Compositional bias

Note=Poly-Ser

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

262_265

130

500.0

Compositional bias

Note=Poly-Thr

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

286_329

130

500.0

Domain

EGF-like

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

382_720

351

697.0

Topological domain

Cytoplasmic

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

382_720

130

500.0

Topological domain

Cytoplasmic

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

382_720

351

721.0

Topological domain

Cytoplasmic

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

361_381

351

697.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

361_381

130

500.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

361_381

351

721.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

104_125

346.0

Topological domain

Mitochondrial intermembrane

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

147_159

346.0

Topological domain

Mitochondrial matrix

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

181_190

346.0

Topological domain

Mitochondrial intermembrane

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

212_213

346.0

Topological domain

Mitochondrial matrix

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

235_244

346.0

Topological domain

Mitochondrial intermembrane

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

266_271

346.0

Topological domain

Mitochondrial matrix

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

293_345

346.0

Topological domain

Mitochondrial intermembrane

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

46_82

346.0

Topological domain

Mitochondrial matrix

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

126_146

346.0

Transmembrane

Helical

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

160_180

346.0

Transmembrane

Helical

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

191_211

346.0

Transmembrane

Helical

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

214_234

346.0

Transmembrane

Helical

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

245_265

346.0

Transmembrane

Helical

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

272_292

346.0

Transmembrane

Helical

Hgene

GHITM

chr10:85902510

chr10:84711225

ENST00000372134

83_103

346.0

Transmembrane

Helical

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

105_285

351

697.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

127_135

351

697.0

Compositional bias

Note=Poly-Thr

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

13_21

351

697.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

252_260

351

697.0

Compositional bias

Note=Poly-Ser

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

262_265

351

697.0

Compositional bias

Note=Poly-Thr

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

26_34

351

697.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

5_8

351

697.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

105_285

130

500.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

127_135

130

500.0

Compositional bias

Note=Poly-Thr

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

13_21

130

500.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

26_34

130

500.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

5_8

130

500.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

105_285

351

721.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

127_135

351

721.0

Compositional bias

Note=Poly-Thr

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

13_21

351

721.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

252_260

351

721.0

Compositional bias

Note=Poly-Ser

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

262_265

351

721.0

Compositional bias

Note=Poly-Thr

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

26_34

351

721.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

5_8

351

721.0

Compositional bias

Note=Poly-Ala

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

286_329

351

697.0

Domain

EGF-like

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

286_329

351

721.0

Domain

EGF-like

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372141

1_360

351

697.0

Topological domain

Extracellular

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000372142

1_360

130

500.0

Topological domain

Extracellular

Tgene

NRG3

chr10:85902510

chr10:84711225

ENST00000404547

1_360

351

721.0

Topological domain

Extracellular

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Fusion Gene Sequence for GHITM-NRG3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33064_33064_1_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000372141_length(transcript)=1499nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATC
AATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGC
CAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTG
CAAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCT
AGAAACTGTCCAGGAGCAGATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGC
AAGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGA

>33064_33064_1_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000372141_length(amino acids)=421AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQ
LPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQ

--------------------------------------------------------------
>33064_33064_2_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000372142_length(transcript)=2893nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGATAGAGGTCAGGAAGACTATATCCCACCTGCCTATACA
GCTGTGGTGTGTTGAAAGACCCCTGGACTTAAAGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATCAATAAATATGCAACTGCC
TTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGCCAGTTCTGTGCCCATCAT
CCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTGCAAAAACTCCTATTCAGC
TGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCA
GATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGCAAGCGAAAACACAGCCTT
TCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGACTCTGCATTGACCAAGTG
ACTTGAGATGTAGGAATCTGTGCATTCTATGCTTTGCTCAACAGGAAAGAGAGGAAATCAAATACAAATTATTTATATGCATTAATTTAA
GAGCATCTACTTAGAAGAAACCAAATAGTCTATCGCCCTCATATCATAGTGTTTTTTAACAAAATATTTTTTTAAGGGAAAGAAATGTTT
CAGGAGGGATAAAGCTTACCATTAAAGCTTTTGGGTAGAATTCTGAATCCAATTTCGTTTAGTCCCAACACTGTCCTCTTTGGCTCTTAG
AAGATGTGGGCAATTCAGACCCTTGGCCCCACAGTGCCAGTGTCTCATTAAAAAACACTGGCAGTTACCTGGTTTCAAAAAGAGGAGAGC
TGCATCCCGCAGGTGGATGCACCAGTGAGCAGGTGGCTCTTGCCATTTGGCTTGCCAGTCCCAAGCCCTAAATTTCTATTCACCCAATAG
CCTCATCACAGGTTATGTCATGTCGACACATGTAGTGTTTTCTATTTGATTTTTGGAGAATGCCACAAAAGACTCTGCAATGGGAAGGAG
GACAGGAGATAGAAGGAGAAACCGGGGGCAATCTTAACTACTCTTGTGTGCCACCTTCCTCTGAGATTTGAATGCACAGATCTCAGCTGG
AGGTATGAAATTATTACAGAAAAAGAGACAAAAAAATCCTTATATCGTGTCACTAAAATCATGCTAATAGAAATGTTTTTCCTTGAGATT
GTTTAGAGGCTCTGGAGGAGCGTTTCTCAGTTTTTGTGTGCCTGTGTGCACATGTGTGTGCGAGCGTGTGTGTGTGTGGACTTGCTCACG
CGGGCACATATGCTGTAAGCACATGTGTTCATTGTGCGTATGTGTGTGCATGTGTGCGCGTATTACGCTTGCTAAAATTTGTTCTGAAAC
ATCAGGGAATCTACTATTCAGAAAAATTATTTCCCTCTTAGATCTTTTCACTTTAAATTTTTCCATTAAGTATAAAGTTCAGTTAGTTCT
TAAATCAAGGTCACTTGCATGGTGGGGTCGTATAAAACTCTTGACACTGTCTAGACCATTTTCTGATGTGAATACTTTTGAGAGGATCAA
CTATTGGCTCATTAATGATATCAGTATCATAAGGTGAGTTCATCAAGGATGTGTGTTTATTTTGAATCATGCCTACTTAAATTATTAATA
CAAGACAATTAACAAATTGACAGTTACCATTTGCTTTCTCATCATCCTCATTACCATTTATTTTATAGCAAGTCTGCTATGTGTGGACCA
AGGCTTCGGCTTCTGTGGTTAGTATGGGAAGAATAAATTGTTGAAATAAAAATACCCAGACTATTCAGTTCACAAGAAGCCCCCCAAAAG

>33064_33064_2_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000372142_length(amino acids)=445AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCV
ERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVN

--------------------------------------------------------------
>33064_33064_3_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000404547_length(transcript)=1531nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGATAGAGGTCAGGAAGACTATATCCCACCTGCCTATACA
GCTGTGGTGTGTTGAAAGACCCCTGGACTTAAAGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATCAATAAATATGCAACTGCC
TTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGCCAGTTCTGTGCCCATCAT
CCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTGCAAAAACTCCTATTCAGC
TGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCA
GATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGCAAGCGAAAACACAGCCTT
TCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGACTCTGCATTGACCAAGTG

>33064_33064_3_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000404547_length(amino acids)=446AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCV
ERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVN

--------------------------------------------------------------
>33064_33064_4_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000404576_length(transcript)=1459nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATC
AATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGC
CAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTG
CAAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCT
AGAAACTGTCCAGGAGCAGATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGC
AAGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGA

>33064_33064_4_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000404576_length(amino acids)=422AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQ
LPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQ

--------------------------------------------------------------
>33064_33064_5_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000537893_length(transcript)=1459nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATC
AATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGC
CAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTG
CAAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCT
AGAAACTGTCCAGGAGCAGATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGC
AAGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGA

>33064_33064_5_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000537893_length(amino acids)=422AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQ
LPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQ

--------------------------------------------------------------
>33064_33064_6_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000545131_length(transcript)=1688nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATC
AATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGC
CAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTG
CAAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCT
AGAAACTGTCCAGGAGCAGATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGC
AAGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGA
CTCTGCATTGACCAAGTGACTTGAGATGTAGGAATCTGTGCATTCTATGCTTTGCTCAACAGGAAAGAGAGGAAATCAAATACAAATTAT
TTATATGCATTAATTTAAGAGCATCTACTTAGAAGAAACCAAATAGTCTATCGCCCTCATATCATAGTGTTTTTTAACAAAATATTTTTT

>33064_33064_6_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000545131_length(amino acids)=421AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQ
LPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQ

--------------------------------------------------------------
>33064_33064_7_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000556918_length(transcript)=1459nt_BP=422nt
TTTTCCGACAGAGGCCTGCCCGTGATTGGCTGCTCGTACTATTTACGTCCTTTCGATGTTGCGTCATGCAGTGCGCCGGAGGAACTGTGC
TCTTTGAGGCCGACGCTAGGGGCCCGGAAGGGAAACTGCGAGGCGAAGGTGACCGGGGACCGAGCATTTCAGATCTGCTCGGTAGACCTG
GTGCACCACCACCATGTTGGCTGCAAGGCTGGTGTGTCTCCGGACACTACCTTCTAGGGTTTTCCACCCAGCTTTCACCAAGGCCTCCCC
TGTTGTGAAGAATTCCATCACGAAGAATCAATGGCTGTTAACACCTAGCAGGGAATATGCCACCAAAACAAGAATTGGGATCCGGCGTGG
GAGAACTGGCCAAGAACTCAAAGAGGCAGCATTGGAACCATCGATGGAAAAAATATTTAAAAAGAGTGAAGAAGTTTATCAAAGGCAGGT
GCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACA
AATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAA
GAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCC
CCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCA
AAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCA
GCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATC
AATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGGC
CAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTG
CAAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCT
AGAAACTGTCCAGGAGCAGATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGC
AAGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGA

>33064_33064_7_GHITM-NRG3_GHITM_chr10_85902510_ENST00000372134_NRG3_chr10_84711225_ENST00000556918_length(amino acids)=422AA_BP=77
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKKSEEVYQRQVLSIS
CIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFP
EVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQ
LPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GHITM-NRG3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GHITM-NRG3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GHITM-NRG3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source