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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GIGYF2-ASB18 (FusionGDB2 ID:33088)

Fusion Gene Summary for GIGYF2-ASB18

check button Fusion gene summary
Fusion gene informationFusion gene name: GIGYF2-ASB18
Fusion gene ID: 33088
HgeneTgene
Gene symbol

GIGYF2

ASB18

Gene ID

26058

401036

Gene nameGRB10 interacting GYF protein 2ankyrin repeat and SOCS box containing 18
SynonymsGYF2|PARK11|PERQ2|PERQ3|TNRC15ASB-18
Cytomap

2q37.1

2q37.2

Type of geneprotein-codingprotein-coding
DescriptionGRB10-interacting GYF protein 2PERQ amino acid rich, with GYF domain 3PERQ amino acid-rich with GYF domain-containing protein 2Parkinson disease (autosomal recessive, early onset) 11trinucleotide repeat-containing gene 15 proteinankyrin repeat and SOCS box protein 18
Modification date2020031320200313
UniProtAcc

Q6Y7W6

Q6ZVZ8

Ensembl transtripts involved in fusion geneENST00000482666, ENST00000373563, 
ENST00000373566, ENST00000409451, 
ENST00000409480, ENST00000409547, 
ENST00000409196, ENST00000452341, 
ENST00000330842, ENST00000409749, 
ENST00000469508, 
Fusion gene scores* DoF score24 X 20 X 15=72001 X 1 X 1=1
# samples 341
** MAII scorelog2(34/7200*10)=-4.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: GIGYF2 [Title/Abstract] AND ASB18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGIGYF2(233568199)-ASB18(237146599), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGIGYF2

GO:0016441

posttranscriptional gene silencing

27157137

HgeneGIGYF2

GO:0061157

mRNA destabilization

27157137


check buttonFusion gene breakpoints across GIGYF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASB18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B3-01AGIGYF2chr2

233568199

+ASB18chr2

237146599

-


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Fusion Gene ORF analysis for GIGYF2-ASB18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482666ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
3UTR-3CDSENST00000482666ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
3UTR-intronENST00000482666ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000373563ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000373563ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000373566ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000373566ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000409451ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000409451ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000409480ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000409480ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000409547ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-3CDSENST00000409547ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-intronENST00000373563ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-intronENST00000373566ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-intronENST00000409451ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-intronENST00000409480ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
5UTR-intronENST00000409547ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
intron-3CDSENST00000409196ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
intron-3CDSENST00000409196ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
intron-3CDSENST00000452341ENST00000330842GIGYF2chr2

233568199

+ASB18chr2

237146599

-
intron-3CDSENST00000452341ENST00000409749GIGYF2chr2

233568199

+ASB18chr2

237146599

-
intron-intronENST00000409196ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-
intron-intronENST00000452341ENST00000469508GIGYF2chr2

233568199

+ASB18chr2

237146599

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GIGYF2-ASB18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GIGYF2-ASB18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:233568199/:237146599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GIGYF2

Q6Y7W6

ASB18

Q6ZVZ8

FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631}.FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GIGYF2-ASB18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GIGYF2-ASB18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GIGYF2-ASB18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GIGYF2-ASB18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource