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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GIGYF2-LRRC28 (FusionGDB2 ID:33102)

Fusion Gene Summary for GIGYF2-LRRC28

check button Fusion gene summary
Fusion gene informationFusion gene name: GIGYF2-LRRC28
Fusion gene ID: 33102
HgeneTgene
Gene symbol

GIGYF2

LRRC28

Gene ID

26058

123355

Gene nameGRB10 interacting GYF protein 2leucine rich repeat containing 28
SynonymsGYF2|PARK11|PERQ2|PERQ3|TNRC15-
Cytomap

2q37.1

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionGRB10-interacting GYF protein 2PERQ amino acid rich, with GYF domain 3PERQ amino acid-rich with GYF domain-containing protein 2Parkinson disease (autosomal recessive, early onset) 11trinucleotide repeat-containing gene 15 proteinleucine-rich repeat-containing protein 28
Modification date2020031320200313
UniProtAcc

Q6Y7W6

Q86X40

Ensembl transtripts involved in fusion geneENST00000373563, ENST00000373566, 
ENST00000409196, ENST00000409451, 
ENST00000409480, ENST00000409547, 
ENST00000452341, ENST00000482666, 
ENST00000331450, ENST00000442993, 
ENST00000447360, ENST00000559399, 
ENST00000301981, ENST00000422500, 
ENST00000558879, 
Fusion gene scores* DoF score24 X 20 X 15=720015 X 11 X 9=1485
# samples 3419
** MAII scorelog2(34/7200*10)=-4.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1485*10)=-2.96639160735718
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GIGYF2 [Title/Abstract] AND LRRC28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGIGYF2(233621044)-LRRC28(99926235), # samples:1
Anticipated loss of major functional domain due to fusion event.GIGYF2-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGIGYF2

GO:0016441

posttranscriptional gene silencing

27157137

HgeneGIGYF2

GO:0061157

mRNA destabilization

27157137


check buttonFusion gene breakpoints across GIGYF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7722-01AGIGYF2chr2

233621044

+LRRC28chr15

99926235

+


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Fusion Gene ORF analysis for GIGYF2-LRRC28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373563ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373563ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373563ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373563ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373566ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373566ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373566ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000373566ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409196ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409196ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409196ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409196ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409451ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409451ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409451ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409451ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409480ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409480ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409480ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409480ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409547ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409547ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409547ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
5CDS-intronENST00000409547ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
Frame-shiftENST00000373563ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
Frame-shiftENST00000373566ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
Frame-shiftENST00000409196ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
Frame-shiftENST00000409451ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
Frame-shiftENST00000409480ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
Frame-shiftENST00000409547ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000373563ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000373563ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000373566ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000373566ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409196ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409196ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409451ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409451ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409480ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409480ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409547ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
In-frameENST00000409547ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-3CDSENST00000452341ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-3CDSENST00000452341ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-3CDSENST00000452341ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-3CDSENST00000482666ENST00000301981GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-3CDSENST00000482666ENST00000422500GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-3CDSENST00000482666ENST00000558879GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000452341ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000452341ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000452341ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000452341ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000482666ENST00000331450GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000482666ENST00000442993GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000482666ENST00000447360GIGYF2chr2

233621044

+LRRC28chr15

99926235

+
intron-intronENST00000482666ENST00000559399GIGYF2chr2

233621044

+LRRC28chr15

99926235

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373566GIGYF2chr2233621044+ENST00000558879LRRC28chr1599926235+749576197643148
ENST00000373566GIGYF2chr2233621044+ENST00000422500LRRC28chr1599926235+981576771322149
ENST00000373563GIGYF2chr2233621044+ENST00000558879LRRC28chr1599926235+747574195641148
ENST00000373563GIGYF2chr2233621044+ENST00000422500LRRC28chr1599926235+979574769320149
ENST00000409480GIGYF2chr2233621044+ENST00000558879LRRC28chr1599926235+814641262708148
ENST00000409480GIGYF2chr2233621044+ENST00000422500LRRC28chr1599926235+1046641836387149
ENST00000409547GIGYF2chr2233621044+ENST00000558879LRRC28chr1599926235+863690311757148
ENST00000409547GIGYF2chr2233621044+ENST00000422500LRRC28chr1599926235+1095690885436149
ENST00000409196GIGYF2chr2233621044+ENST00000558879LRRC28chr1599926235+65047798544148
ENST00000409196GIGYF2chr2233621044+ENST00000422500LRRC28chr1599926235+882477672223149
ENST00000409451GIGYF2chr2233621044+ENST00000558879LRRC28chr1599926235+778605226672148
ENST00000409451GIGYF2chr2233621044+ENST00000422500LRRC28chr1599926235+1010605800351149

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373566ENST00000558879GIGYF2chr2233621044+LRRC28chr1599926235+0.033678650.9663214
ENST00000373566ENST00000422500GIGYF2chr2233621044+LRRC28chr1599926235+0.063183430.9368166
ENST00000373563ENST00000558879GIGYF2chr2233621044+LRRC28chr1599926235+0.0298940610.97010595
ENST00000373563ENST00000422500GIGYF2chr2233621044+LRRC28chr1599926235+0.0541108470.9458891
ENST00000409480ENST00000558879GIGYF2chr2233621044+LRRC28chr1599926235+0.0411878820.9588121
ENST00000409480ENST00000422500GIGYF2chr2233621044+LRRC28chr1599926235+0.061025830.93897414
ENST00000409547ENST00000558879GIGYF2chr2233621044+LRRC28chr1599926235+0.066267750.9337323
ENST00000409547ENST00000422500GIGYF2chr2233621044+LRRC28chr1599926235+0.111431710.8885683
ENST00000409196ENST00000558879GIGYF2chr2233621044+LRRC28chr1599926235+0.04346410.9565359
ENST00000409196ENST00000422500GIGYF2chr2233621044+LRRC28chr1599926235+0.078751620.92124844
ENST00000409451ENST00000558879GIGYF2chr2233621044+LRRC28chr1599926235+0.0492200370.95078
ENST00000409451ENST00000422500GIGYF2chr2233621044+LRRC28chr1599926235+0.0956822860.90431774

Top

Fusion Genomic Features for GIGYF2-LRRC28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GIGYF2chr2233621044+LRRC28chr1599926234+4.17E-091
GIGYF2chr2233621044+LRRC28chr1599926234+4.17E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GIGYF2-LRRC28


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233621044/chr15:99926235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GIGYF2

Q6Y7W6

LRRC28

Q86X40

FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629106_1111261300.0Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731106_1111261321.0Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831106_1111261300.0Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+62940_501261300.0Motif4EHP-binding motif
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+73140_501261321.0Motif4EHP-binding motif
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+83140_501261300.0Motif4EHP-binding motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629118_2721261300.0Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+6291198_12521261300.0Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629436_4731261300.0Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629607_10251261300.0Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629738_8881261300.0Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731118_2721261321.0Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+7311198_12521261321.0Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731436_4731261321.0Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731607_10251261321.0Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731738_8881261321.0Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831118_2721261300.0Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+8311198_12521261300.0Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831436_4731261300.0Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831607_10251261300.0Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831738_8881261300.0Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629533_5811261300.0DomainGYF
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731533_5811261321.0DomainGYF
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831533_5811261300.0DomainGYF
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629280_3101261300.0MotifDDX6 binding motif
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731280_3101261321.0MotifDDX6 binding motif
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831280_3101261300.0MotifDDX6 binding motif
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000373563+629547_5631261300.0RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409451+731547_5631261321.0RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233621044chr15:99926235ENST00000409547+831547_5631261300.0RegionRequired for GRB10-binding
TgeneLRRC28chr2:233621044chr15:99926235ENST00000301981810112_133343368.0RepeatNote=LRR 5
TgeneLRRC28chr2:233621044chr15:99926235ENST00000301981810135_156343368.0RepeatNote=LRR 6
TgeneLRRC28chr2:233621044chr15:99926235ENST00000301981810158_180343368.0RepeatNote=LRR 7
TgeneLRRC28chr2:233621044chr15:99926235ENST0000030198181016_36343368.0RepeatNote=LRR 1
TgeneLRRC28chr2:233621044chr15:99926235ENST00000301981810181_202343368.0RepeatNote=LRR 8
TgeneLRRC28chr2:233621044chr15:99926235ENST00000301981810204_226343368.0RepeatNote=LRR 9
TgeneLRRC28chr2:233621044chr15:99926235ENST0000030198181042_63343368.0RepeatNote=LRR 2
TgeneLRRC28chr2:233621044chr15:99926235ENST0000030198181066_87343368.0RepeatNote=LRR 3
TgeneLRRC28chr2:233621044chr15:99926235ENST0000030198181089_110343368.0RepeatNote=LRR 4
TgeneLRRC28chr2:233621044chr15:99926235ENST0000044736079112_133290313.0RepeatNote=LRR 5
TgeneLRRC28chr2:233621044chr15:99926235ENST0000044736079135_156290313.0RepeatNote=LRR 6
TgeneLRRC28chr2:233621044chr15:99926235ENST0000044736079158_180290313.0RepeatNote=LRR 7
TgeneLRRC28chr2:233621044chr15:99926235ENST000004473607916_36290313.0RepeatNote=LRR 1
TgeneLRRC28chr2:233621044chr15:99926235ENST0000044736079181_202290313.0RepeatNote=LRR 8
TgeneLRRC28chr2:233621044chr15:99926235ENST0000044736079204_226290313.0RepeatNote=LRR 9
TgeneLRRC28chr2:233621044chr15:99926235ENST000004473607942_63290313.0RepeatNote=LRR 2
TgeneLRRC28chr2:233621044chr15:99926235ENST000004473607966_87290313.0RepeatNote=LRR 3
TgeneLRRC28chr2:233621044chr15:99926235ENST000004473607989_110290313.0RepeatNote=LRR 4


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Fusion Gene Sequence for GIGYF2-LRRC28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33102_33102_1_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373563_LRRC28_chr15_99926235_ENST00000422500_length(transcript)=979nt_BP=574nt
GACGTGCGTGGCGACGTGTCGGCCATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGCGTT
AAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAACAGGTTTCTTCACATATAAAAATCTATTGTA
AAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTACA
TCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAGAC
AACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTACA
GAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGGGG
GCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTT
TTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCA
TCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCA
AGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTT

>33102_33102_1_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373563_LRRC28_chr15_99926235_ENST00000422500_length(amino acids)=149AA_BP=0
MTFLESSAVPPHWTGQDGRVCWTGWIPQCQAGSAPEVLECLSTQQVKSLQTLGGAAVSHKTNSCLPRPLEELRPLGAPTTVPPPPRPVNR

--------------------------------------------------------------
>33102_33102_2_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373563_LRRC28_chr15_99926235_ENST00000558879_length(transcript)=747nt_BP=574nt
GACGTGCGTGGCGACGTGTCGGCCATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGCGTT
AAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAACAGGTTTCTTCACATATAAAAATCTATTGTA
AAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTACA
TCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAGAC
AACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTACA
GAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGGGG
GCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTT
TTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCA

>33102_33102_2_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373563_LRRC28_chr15_99926235_ENST00000558879_length(amino acids)=148AA_BP=126
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQR

--------------------------------------------------------------
>33102_33102_3_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373566_LRRC28_chr15_99926235_ENST00000422500_length(transcript)=981nt_BP=576nt
GTGACGTGCGTGGCGACGTGTCGGCCATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGCG
TTAAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAACAGGTTTCTTCACATATAAAAATCTATTG
TAAAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTA
CATCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAG
ACAACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTA
CAGAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGG
GGGCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGAC
TTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTC
CATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCC
CAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCAT

>33102_33102_3_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373566_LRRC28_chr15_99926235_ENST00000422500_length(amino acids)=149AA_BP=0
MTFLESSAVPPHWTGQDGRVCWTGWIPQCQAGSAPEVLECLSTQQVKSLQTLGGAAVSHKTNSCLPRPLEELRPLGAPTTVPPPPRPVNR

--------------------------------------------------------------
>33102_33102_4_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373566_LRRC28_chr15_99926235_ENST00000558879_length(transcript)=749nt_BP=576nt
GTGACGTGCGTGGCGACGTGTCGGCCATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGCG
TTAAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAACAGGTTTCTTCACATATAAAAATCTATTG
TAAAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTA
CATCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAG
ACAACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTA
CAGAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGG
GGGCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGAC
TTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTC

>33102_33102_4_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000373566_LRRC28_chr15_99926235_ENST00000558879_length(amino acids)=148AA_BP=126
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQR

--------------------------------------------------------------
>33102_33102_5_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409196_LRRC28_chr15_99926235_ENST00000422500_length(transcript)=882nt_BP=477nt
GTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGGTTTCTTCACATATAAAAATCTATTGTAAAAATAC
GGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTACATCCCCTC
CTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAGACAACAAGA
TACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTACAGAAGAAG
AACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTA
GAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCT
GCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTC
CTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGA
ATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGA

>33102_33102_5_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409196_LRRC28_chr15_99926235_ENST00000422500_length(amino acids)=149AA_BP=0
MTFLESSAVPPHWTGQDGRVCWTGWIPQCQAGSAPEVLECLSTQQVKSLQTLGGAAVSHKTNSCLPRPLEELRPLGAPTTVPPPPRPVNR

--------------------------------------------------------------
>33102_33102_6_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409196_LRRC28_chr15_99926235_ENST00000558879_length(transcript)=650nt_BP=477nt
GTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGGTTTCTTCACATATAAAAATCTATTGTAAAAATAC
GGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTACATCCCCTC
CTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAGACAACAAGA
TACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTACAGAAGAAG
AACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTA
GAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCT
GCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTC

>33102_33102_6_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409196_LRRC28_chr15_99926235_ENST00000558879_length(amino acids)=148AA_BP=126
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQR

--------------------------------------------------------------
>33102_33102_7_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409451_LRRC28_chr15_99926235_ENST00000422500_length(transcript)=1010nt_BP=605nt
GGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGATTATAGTGGGACCAGTCTCATTAGGTTGAATCTACAGCCTAT
GTTGGTGTTAACCCAGGTCTCTTAGAGCGTTAAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAA
CAGGTTTCTTCACATATAAAAATCTATTGTAAAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCT
CCGAGCTCTGTCCAGTGGTGGGAGTATTACATCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAG
AGAAGAAATGTTAGCACTTTTCCTTAAAGACAACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACC
CCTTCCACCATTGGCTCTGGTACCCTTTACAGAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGAC
AGGACGAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCT
TACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTG
GGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCT
TCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTT
TATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGT

>33102_33102_7_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409451_LRRC28_chr15_99926235_ENST00000422500_length(amino acids)=149AA_BP=0
MTFLESSAVPPHWTGQDGRVCWTGWIPQCQAGSAPEVLECLSTQQVKSLQTLGGAAVSHKTNSCLPRPLEELRPLGAPTTVPPPPRPVNR

--------------------------------------------------------------
>33102_33102_8_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409451_LRRC28_chr15_99926235_ENST00000558879_length(transcript)=778nt_BP=605nt
GGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGATTATAGTGGGACCAGTCTCATTAGGTTGAATCTACAGCCTAT
GTTGGTGTTAACCCAGGTCTCTTAGAGCGTTAAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAA
CAGGTTTCTTCACATATAAAAATCTATTGTAAAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCT
CCGAGCTCTGTCCAGTGGTGGGAGTATTACATCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAG
AGAAGAAATGTTAGCACTTTTCCTTAAAGACAACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACC
CCTTCCACCATTGGCTCTGGTACCCTTTACAGAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGAC
AGGACGAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCT
TACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTG

>33102_33102_8_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409451_LRRC28_chr15_99926235_ENST00000558879_length(amino acids)=148AA_BP=126
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQR

--------------------------------------------------------------
>33102_33102_9_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409480_LRRC28_chr15_99926235_ENST00000422500_length(transcript)=1046nt_BP=641nt
GTGCGTGGCGACGTGTCGGCCATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGATTATAG
TGGGACCAGTCTCATTAGGTTGAATCTACAGCCTATGTTGGTGTTAACCCAGGTCTCTTAGAGCGTTAAAAGGATCTGAACAAAGTCTGC
TCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAACAGGTTTCTTCACATATAAAAATCTATTGTAAAAATACGGAAAAGAATGGCAGC
GGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTACATCCCCTCCTCTTTCTCCAGCATT
GCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAGACAACAAGATACCTTCAGACCTTCT
GGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTACAGAAGAAGAACAGAGAAACTTTTC
CATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTAGAGGTCGAAGTTCTTC
AAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACA
CTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGG
CACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAA
ATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATC

>33102_33102_9_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409480_LRRC28_chr15_99926235_ENST00000422500_length(amino acids)=149AA_BP=0
MTFLESSAVPPHWTGQDGRVCWTGWIPQCQAGSAPEVLECLSTQQVKSLQTLGGAAVSHKTNSCLPRPLEELRPLGAPTTVPPPPRPVNR

--------------------------------------------------------------
>33102_33102_10_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409480_LRRC28_chr15_99926235_ENST00000558879_length(transcript)=814nt_BP=641nt
GTGCGTGGCGACGTGTCGGCCATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGATTATAG
TGGGACCAGTCTCATTAGGTTGAATCTACAGCCTATGTTGGTGTTAACCCAGGTCTCTTAGAGCGTTAAAAGGATCTGAACAAAGTCTGC
TCAAATCTCCTGCTGTGAACCAGCAGAATTTTTGAACAGGTTTCTTCACATATAAAAATCTATTGTAAAAATACGGAAAAGAATGGCAGC
GGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAGCTCTGTCCAGTGGTGGGAGTATTACATCCCCTCCTCTTTCTCCAGCATT
GCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAGAAATGTTAGCACTTTTCCTTAAAGACAACAAGATACCTTCAGACCTTCT
GGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTCCACCATTGGCTCTGGTACCCTTTACAGAAGAAGAACAGAGAAACTTTTC
CATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGACGAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTAGAGGTCGAAGTTCTTC
AAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACA
CTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGG

>33102_33102_10_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409480_LRRC28_chr15_99926235_ENST00000558879_length(amino acids)=148AA_BP=126
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQR

--------------------------------------------------------------
>33102_33102_11_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409547_LRRC28_chr15_99926235_ENST00000422500_length(transcript)=1095nt_BP=690nt
ATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGATTATAGTGGGACCAGTCTCATTAGGTT
GAATCTACAGCCTATGTTGGTGTTAACCCAGGTCTCTTAGAGCGTTAAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACC
AGCAGAATTTTTGAACAGAGACCACGTCTCCACCTCCTGGGCTCCAACGATTCTCCCATCTTGGCCTCCCAAAGCGCTGGATTTACAGGT
TTCTTCACATATAAAAATCTATTGTAAAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAG
CTCTGTCCAGTGGTGGGAGTATTACATCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAG
AAATGTTAGCACTTTTCCTTAAAGACAACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTC
CACCATTGGCTCTGGTACCCTTTACAGAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGAC
GAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTG
CTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAA
TCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGA
GCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGT
GAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGTGACTT

>33102_33102_11_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409547_LRRC28_chr15_99926235_ENST00000422500_length(amino acids)=149AA_BP=0
MTFLESSAVPPHWTGQDGRVCWTGWIPQCQAGSAPEVLECLSTQQVKSLQTLGGAAVSHKTNSCLPRPLEELRPLGAPTTVPPPPRPVNR

--------------------------------------------------------------
>33102_33102_12_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409547_LRRC28_chr15_99926235_ENST00000558879_length(transcript)=863nt_BP=690nt
ATCTTGTGTTGTTGAGGCTGAGGACTGACTGGGGTTCTGAGACTCCCTGTCCCGGACCGCAGATTATAGTGGGACCAGTCTCATTAGGTT
GAATCTACAGCCTATGTTGGTGTTAACCCAGGTCTCTTAGAGCGTTAAAAGGATCTGAACAAAGTCTGCTCAAATCTCCTGCTGTGAACC
AGCAGAATTTTTGAACAGAGACCACGTCTCCACCTCCTGGGCTCCAACGATTCTCCCATCTTGGCCTCCCAAAGCGCTGGATTTACAGGT
TTCTTCACATATAAAAATCTATTGTAAAAATACGGAAAAGAATGGCAGCGGAAACGCAGACACTGAACTTTGGGCCTGAATGGCTCCGAG
CTCTGTCCAGTGGTGGGAGTATTACATCCCCTCCTCTTTCTCCAGCATTGCCGAAGTATAAATTAGCAGATTATCGTTACGGCAGAGAAG
AAATGTTAGCACTTTTCCTTAAAGACAACAAGATACCTTCAGACCTTCTGGATAAAGAATTTCTGCCTATCCTCCAGGAGGAACCCCTTC
CACCATTGGCTCTGGTACCCTTTACAGAAGAAGAACAGAGAAACTTTTCCATGTCTGTAAATAGTGCTGCTGTCCTGCGATTGACAGGAC
GAGGAGGAGGAGGAACAGTGGTGGGGGCTCCTAGAGGTCGAAGTTCTTCAAGAGGGCGAGGAAGACAACTGTTAGTTTTGTGGCTTACTG
CTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAA

>33102_33102_12_GIGYF2-LRRC28_GIGYF2_chr2_233621044_ENST00000409547_LRRC28_chr15_99926235_ENST00000558879_length(amino acids)=148AA_BP=126
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GIGYF2-LRRC28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GIGYF2-LRRC28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GIGYF2-LRRC28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource