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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP13-RPL35A (FusionGDB2 ID:3315)

Fusion Gene Summary for AKAP13-RPL35A

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP13-RPL35A
Fusion gene ID: 3315
HgeneTgene
Gene symbol

AKAP13

RPL35A

Gene ID

11214

6165

Gene nameA-kinase anchoring protein 13ribosomal protein L35a
SynonymsAKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47DBA5|L35A|eL33
Cytomap

15q25.3

3q29

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 13A kinase (PRKA) anchor protein 13LBC oncogenebreast cancer nuclear receptor-binding auxiliary proteinguanine nucleotide exchange factor Lbchuman thyroid-anchoring protein 31lymphoid blast crisis oncogenenon-oncogenic Rho G60S ribosomal protein L35acell growth-inhibiting gene 33 proteinlarge ribosomal subunit protein eL33
Modification date2020031320200313
UniProtAcc

Q12802

.
Ensembl transtripts involved in fusion geneENST00000560579, ENST00000361243, 
ENST00000394518, ENST00000394510, 
ENST00000560302, 		ENST00000464167, 
ENST00000329092, ENST00000448864, 
Fusion gene scores* DoF score37 X 24 X 13=1154411 X 12 X 4=528
# samples 4114
** MAII scorelog2(41/11544*10)=-4.81537548498575
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP13 [Title/Abstract] AND RPL35A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP13(86198989)-RPL35A(197678052), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP13

GO:0007186

G protein-coupled receptor signaling pathway

11546812

HgeneAKAP13

GO:0035025

positive regulation of Rho protein signal transduction

11546812


check buttonFusion gene breakpoints across AKAP13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPL35A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF852302AKAP13chr15

86198989

-RPL35Achr3

197678052

+


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Fusion Gene ORF analysis for AKAP13-RPL35A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000560579ENST00000464167AKAP13chr15

86198989

-RPL35Achr3

197678052

+
3UTR-3UTRENST00000560579ENST00000329092AKAP13chr15

86198989

-RPL35Achr3

197678052

+
3UTR-3UTRENST00000560579ENST00000448864AKAP13chr15

86198989

-RPL35Achr3

197678052

+
5CDS-3UTRENST00000361243ENST00000329092AKAP13chr15

86198989

-RPL35Achr3

197678052

+
5CDS-3UTRENST00000361243ENST00000448864AKAP13chr15

86198989

-RPL35Achr3

197678052

+
5CDS-3UTRENST00000394518ENST00000329092AKAP13chr15

86198989

-RPL35Achr3

197678052

+
5CDS-3UTRENST00000394518ENST00000448864AKAP13chr15

86198989

-RPL35Achr3

197678052

+
In-frameENST00000361243ENST00000464167AKAP13chr15

86198989

-RPL35Achr3

197678052

+
In-frameENST00000394518ENST00000464167AKAP13chr15

86198989

-RPL35Achr3

197678052

+
intron-3CDSENST00000394510ENST00000464167AKAP13chr15

86198989

-RPL35Achr3

197678052

+
intron-3CDSENST00000560302ENST00000464167AKAP13chr15

86198989

-RPL35Achr3

197678052

+
intron-3UTRENST00000394510ENST00000329092AKAP13chr15

86198989

-RPL35Achr3

197678052

+
intron-3UTRENST00000394510ENST00000448864AKAP13chr15

86198989

-RPL35Achr3

197678052

+
intron-3UTRENST00000560302ENST00000329092AKAP13chr15

86198989

-RPL35Achr3

197678052

+
intron-3UTRENST00000560302ENST00000448864AKAP13chr15

86198989

-RPL35Achr3

197678052

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394518AKAP13chr1586198989-ENST00000464167RPL35Achr3197678052+563444989545071470
ENST00000361243AKAP13chr1586198989-ENST00000464167RPL35Achr3197678052+562044848144931470

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394518ENST00000464167AKAP13chr1586198989-RPL35Achr3197678052+0.0005352830.9994647
ENST00000361243ENST00000464167AKAP13chr1586198989-RPL35Achr3197678052+0.0005246340.9994754

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Fusion Genomic Features for AKAP13-RPL35A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP13-RPL35A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:86198989/chr3:197678052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP13

Q12802

.
FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1371758_179002818.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1372345_238102818.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1372568_268302818.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1371758_179002814.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1372345_238102814.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1372568_268302814.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-141758_17900180.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-142345_23810180.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-142568_26830180.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1371471_147402818.0Compositional biasNote=Poly-Ser
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1371534_153702818.0Compositional biasNote=Poly-Glu
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1372778_279002818.0Compositional biasNote=Poly-Lys
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1371471_147402814.0Compositional biasNote=Poly-Ser
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1371534_153702814.0Compositional biasNote=Poly-Glu
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1372778_279002814.0Compositional biasNote=Poly-Lys
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-141471_14740180.0Compositional biasNote=Poly-Ser
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-141534_15370180.0Compositional biasNote=Poly-Glu
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-142778_27900180.0Compositional biasNote=Poly-Lys
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1371994_219102818.0DomainDH
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1372231_233302818.0DomainPH
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1371994_219102814.0DomainDH
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1372231_233302814.0DomainPH
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-141994_21910180.0DomainDH
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-142231_23330180.0DomainPH
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1371791_183802818.0Zinc fingerPhorbol-ester/DAG-type
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1371791_183802814.0Zinc fingerPhorbol-ester/DAG-type
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-141791_18380180.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for AKAP13-RPL35A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3315_3315_1_AKAP13-RPL35A_AKAP13_chr15_86198989_ENST00000361243_RPL35A_chr3_197678052_ENST00000464167_length(transcript)=5620nt_BP=4484nt
TGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGCCGCACGTGTCCTGGGTCATGAAACTT
AATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGATGATGTAGTGTTTTAC
TTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGTCATGAT
TGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAG
GATGAAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGA
CCCCCATCTGGGGATGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGG
ACAGATCAGAGTTTGCATGATGCTGGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTG
TTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTATCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCAC
AAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGACTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCT
GTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCACATCATGAACACCCATTTCCTGGAGACGGTTGCACT
GGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGGACAGTCTTATGCCCTTAATGATGACA
GCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCAGCGACTTTCTTCTTCT
GAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAGGAGGAG
AATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACT
GTATCTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAA
GAAACTGGAACAAAATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAG
CCAGGCACAGCCCAGTATTCCTCTGGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAA
CATGGGCTCATGAACCCAGATGCCACTGTTTGGAAGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATT
GGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGTGGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTG
GATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCCACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGT
CGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAGACAAGATTTCAGATGGATTAGAACCT
TATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGATGTAATGCCACACCAG
AACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCA
GACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACC
ACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGG
GATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACA
AATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGT
ACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACA
GCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGG
GCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAG
GGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCT
TTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACC
TGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTT
CATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCA
GAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGT
CTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGG
TCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTG
AGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAA
GACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGAC
CCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGAC
GCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCC
CATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATG
GTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTC
AAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAG
AGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCA
GGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCT
GAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCA
ATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAA
TGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTC
TTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGGCCAGCGATGCAGAAATGAACCACCGGAGCTGGCTATAAGCGGGG
TCTCCGGAACCAAAGGGAGCACACAGCTCTTCTTAAAATTGAAGGTGTTTACGCCCGAGATGAAACAGAATTCTATTTGGGCAAGAGATG
CGCTTATGTATATAAAGCAAAGAACAACACAGTCACTCCTGGCGGCAAACCAAACAAAACCAGAGTCATCTGGGGAAAAGTAACTCGGGC
CCATGGAAACAGTGGCATGGTTCGTGCCAAATTCCGAAGCAATCTTCCTGCTAAGGCCATTGGACACAGAATCCGAGTGATGCTGTACCC
CTCAAGGATTTAAACTAACGAAAAATCAATAAATAAATGTGGATTTGTGCTCTTGTATTTTTAAGTGGATTAAAAAACTTACTACCTTAA
ATTGATTTGCTACATGCTTAAAATGATAGAGGTTGCTCAGCATTTTTGGAGTACAAGGGGGTCAGAGAGACATGTGATGAAAATTACAGG
GCGAGTACAGAGATTTAGAAGGGAACGGGTTTTAATGCGAGTATCTTTGACAGAGTCTTGCTCTGTTGCCCATGCTGGAGTGTAGTGGTG
CTCGCTGCAGCCTCACATTCAAAGGCTCAAGCAATCCTCCCTTGGCCTTTGAAGTAGCTGGGACCACAGGCTCATGCCACCATCCCTGGG
TCATTTTTAAATTTTTTGTAGAGAGGGTCTGACTCTTGCCTATGCTGGCTTCAAACTCCTGGGCTCAAGCAATCCTCCTTCCTTGGCCTC
TCCTGAAGTGCTGGGATACAGTTATGAGCCACCACACCTGCCAAGTGCTTTGTGATACTATGCATTTGTTCAATGCAGATTGGGAAACTT
AAAATTTGAATGGAGATTATGTTGATGGGCTTTGGCAGTTCATTTGGATAGACTGGGATGAGAAGCTCTTGGGACTTGTGACTGGACAAA
GCATTCCAGTATATTAAAATAAAATTAAGCCATATTACTCCACTCATAAAAAGCAATCCTATGGTAGGTACATGGAGGTTGGGAATAGTG
CACGGAAAGGTGGCAGCTTTCTTTGGCTTCATGTTTTAATCTGGTAAAGTTCAAGATTGCACTTTAAGCAGGCCTCCTAAATATTTTAGA

>3315_3315_1_AKAP13-RPL35A_AKAP13_chr15_86198989_ENST00000361243_RPL35A_chr3_197678052_ENST00000464167_length(amino acids)=1470AA_BP=
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFH
FVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGD
GCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDL
VMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVM
PHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAF
LKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCT
MGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPD
VKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD

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>3315_3315_2_AKAP13-RPL35A_AKAP13_chr15_86198989_ENST00000394518_RPL35A_chr3_197678052_ENST00000464167_length(transcript)=5634nt_BP=4498nt
GAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGCCGCACGTGTCCT
GGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGATG
ATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTG
CTCCTGGTCATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACT
TTCATTTCGTCCAGGATGAAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTC
TTGACCAGTCAGGACCCCCATCTGGGGATGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGT
GGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCTGGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGT
TGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTATCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGG
AGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGACTCCTGGAGCAGTTTATCCTATGAAATACCGT
ATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCACATCATGAACACCCATTTCCTG
GAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGGACAGTCTTATGC
CCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCAGC
GACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCA
TAGTTGAGGAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTG
TGGACTCTGGAACTGTATCTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTG
GAAACAGAAATGAAGAAACTGGAACAAAATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAG
ACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCTGGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTG
CAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGAAGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTG
AGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGTGGATAAAATCAGTGTTCCAAACTGTGCCCCTG
CTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCCACTGAAAAAACAGCAGAAACGG
AAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAGACAAGATTTCAG
ATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGATG
TAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACG
ATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCG
AGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCT
CTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAG
ATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAG
TAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGA
AAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGC
CACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTG
GTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTA
AGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGG
ATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAG
ATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTG
CCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGC
CACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAG
ATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTA
GTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATAT
CACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACA
AAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCT
GTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACA
TGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCT
CTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTG
TCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCA
CTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCA
CGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGC
CAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGA
TGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCA
AGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACTTAAAAGAGAATCTGGGA
GTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGGCCAGCGATGCAGAAATGAACCACCGGAGCT
GGCTATAAGCGGGGTCTCCGGAACCAAAGGGAGCACACAGCTCTTCTTAAAATTGAAGGTGTTTACGCCCGAGATGAAACAGAATTCTAT
TTGGGCAAGAGATGCGCTTATGTATATAAAGCAAAGAACAACACAGTCACTCCTGGCGGCAAACCAAACAAAACCAGAGTCATCTGGGGA
AAAGTAACTCGGGCCCATGGAAACAGTGGCATGGTTCGTGCCAAATTCCGAAGCAATCTTCCTGCTAAGGCCATTGGACACAGAATCCGA
GTGATGCTGTACCCCTCAAGGATTTAAACTAACGAAAAATCAATAAATAAATGTGGATTTGTGCTCTTGTATTTTTAAGTGGATTAAAAA
ACTTACTACCTTAAATTGATTTGCTACATGCTTAAAATGATAGAGGTTGCTCAGCATTTTTGGAGTACAAGGGGGTCAGAGAGACATGTG
ATGAAAATTACAGGGCGAGTACAGAGATTTAGAAGGGAACGGGTTTTAATGCGAGTATCTTTGACAGAGTCTTGCTCTGTTGCCCATGCT
GGAGTGTAGTGGTGCTCGCTGCAGCCTCACATTCAAAGGCTCAAGCAATCCTCCCTTGGCCTTTGAAGTAGCTGGGACCACAGGCTCATG
CCACCATCCCTGGGTCATTTTTAAATTTTTTGTAGAGAGGGTCTGACTCTTGCCTATGCTGGCTTCAAACTCCTGGGCTCAAGCAATCCT
CCTTCCTTGGCCTCTCCTGAAGTGCTGGGATACAGTTATGAGCCACCACACCTGCCAAGTGCTTTGTGATACTATGCATTTGTTCAATGC
AGATTGGGAAACTTAAAATTTGAATGGAGATTATGTTGATGGGCTTTGGCAGTTCATTTGGATAGACTGGGATGAGAAGCTCTTGGGACT
TGTGACTGGACAAAGCATTCCAGTATATTAAAATAAAATTAAGCCATATTACTCCACTCATAAAAAGCAATCCTATGGTAGGTACATGGA
GGTTGGGAATAGTGCACGGAAAGGTGGCAGCTTTCTTTGGCTTCATGTTTTAATCTGGTAAAGTTCAAGATTGCACTTTAAGCAGGCCTC

>3315_3315_2_AKAP13-RPL35A_AKAP13_chr15_86198989_ENST00000394518_RPL35A_chr3_197678052_ENST00000464167_length(amino acids)=1470AA_BP=
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFH
FVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGD
GCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDL
VMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVM
PHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAF
LKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCT
MGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPD
VKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD

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Fusion Gene PPI Analysis for AKAP13-RPL35A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAKAP13chr15:86198989chr3:197678052ENST00000361243-1371919_281302818.0ESR1
HgeneAKAP13chr15:86198989chr3:197678052ENST00000394518-1371919_281302814.0ESR1
HgeneAKAP13chr15:86198989chr3:197678052ENST00000560302-141919_28130180.0ESR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP13-RPL35A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP13-RPL35A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource