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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLE1-ODF2 (FusionGDB2 ID:33234)

Fusion Gene Summary for GLE1-ODF2

check button Fusion gene summary
Fusion gene informationFusion gene name: GLE1-ODF2
Fusion gene ID: 33234
HgeneTgene
Gene symbol

GLE1

ODF2

Gene ID

2733

4957

Gene nameGLE1 RNA export mediatorouter dense fiber of sperm tails 2
SynonymsCAAHC|CAAHD|GLE1L|LCCS|LCCS1|hGLE1CT134|ODF2/1|ODF2/2|ODF84
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionnucleoporin GLE1GLE1 RNA export mediator homologGLE1 RNA export mediator-likeGLE1-like proteinGLE1-like, RNA export mediatorouter dense fiber protein 2cancer/testis antigen 134cenexin 1outer dense fiber of sperm tails, 84-kDsperm tail structural proteintestis tissue sperm-binding protein Li 51e
Modification date2020031320200313
UniProtAcc

Q53GS7

.
Ensembl transtripts involved in fusion geneENST00000309971, ENST00000372770, 
ENST00000539582, ENST00000494417, 
ENST00000372791, ENST00000372807, 
ENST00000393527, ENST00000434106, 
ENST00000444119, ENST00000448249, 
ENST00000535026, ENST00000546203, 
ENST00000351030, ENST00000372814, 
ENST00000393533, ENST00000604420, 
Fusion gene scores* DoF score5 X 4 X 5=1006 X 7 X 4=168
# samples 56
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLE1 [Title/Abstract] AND ODF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLE1(131267183)-ODF2(131254705), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GLE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ODF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1998-01AGLE1chr9

131267183

-ODF2chr9

131254705

+
ChimerDB4OVTCGA-61-1998-01AGLE1chr9

131267183

+ODF2chr9

131254705

+


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Fusion Gene ORF analysis for GLE1-ODF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000309971ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GLE1-ODF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GLE1chr9131267183+ODF2chr9131254704+8.68E-131
GLE1chr9131267183+ODF2chr9131254704+8.68E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GLE1-ODF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131267183/chr9:131254705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLE1

Q53GS7

.
FUNCTION: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneODF2chr9:131267183chr9:131254705ENST000004482491216461_798431577.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116151_27733699.0Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116305_35633699.0Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114151_27733660.0Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114305_35633660.0Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116444_48333699.0RegionNote=Mediates the shuttling between the nucleus and the cytoplasm
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114444_48333660.0RegionNote=Mediates the shuttling between the nucleus and the cytoplasm
TgeneODF2chr9:131267183chr9:131254705ENST000003510301321144_217507825.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003510301321245_423507825.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003510301321461_798507825.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003727911317144_217493639.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003727911317245_423493639.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003727911317461_798493639.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003728071119144_217507825.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003728071119245_423507825.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003728071119461_798507825.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003728141216144_217556702.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003728141216245_423556702.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003728141216461_798556702.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003935331216144_217512658.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003935331216245_423512658.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000003935331216461_798512658.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004341061321144_217512830.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004341061321245_423512830.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004341061321461_798512830.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004441191119144_217488806.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004441191119245_423488806.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004441191119461_798488806.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004482491216144_217431577.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000004482491216245_423431577.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000005462031216144_217493639.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000005462031216245_423493639.0Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST000005462031216461_798493639.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for GLE1-ODF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GLE1-ODF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+1161_2933.0699.0NUP155
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+1141_2933.0660.0NUP155


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116656_69833.0699.0NUP42
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114656_69833.0660.0NUP42


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLE1-ODF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLE1-ODF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource