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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLG1-FA2H (FusionGDB2 ID:33246)

Fusion Gene Summary for GLG1-FA2H

check button Fusion gene summary
Fusion gene informationFusion gene name: GLG1-FA2H
Fusion gene ID: 33246
HgeneTgene
Gene symbol

GLG1

FA2H

Gene ID

2734

79152

Gene namegolgi glycoprotein 1fatty acid 2-hydroxylase
SynonymsCFR-1|ESL-1|MG-160|MG160FAAH|FAH1|FAXDC1|SCS7|SPG35
Cytomap

16q23.1

16q23.1

Type of geneprotein-codingprotein-coding
DescriptionGolgi apparatus protein 1E-selectin ligand 1cysteine-rich fibroblast growth factor receptorgolgi sialoglycoprotein MG-160fatty acid 2-hydroxylasefatty acid alpha-hydroxylasefatty acid hydroxylase domain containing 1spastic paraplegia 35 (autosomal recessive)
Modification date2020031320200313
UniProtAcc

Q92896

Q7L5A8

Ensembl transtripts involved in fusion geneENST00000205061, ENST00000422840, 
ENST00000447066, 		ENST00000219368, 
ENST00000544337, 
Fusion gene scores* DoF score23 X 21 X 12=57963 X 3 X 2=18
# samples 293
** MAII scorelog2(29/5796*10)=-4.320932789542
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GLG1 [Title/Abstract] AND FA2H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFA2H(74773921)-GLG1(74506309), # samples:2
GLG1(74508444)-FA2H(74748167), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFA2H

GO:0046513

ceramide biosynthetic process

15337768


check buttonFusion gene breakpoints across GLG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FA2H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-RL-AAAS-01AGLG1chr16

74508444

-FA2Hchr16

74748167

-


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Fusion Gene ORF analysis for GLG1-FA2H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000205061ENST00000219368GLG1chr16

74508444

-FA2Hchr16

74748167

-
In-frameENST00000205061ENST00000544337GLG1chr16

74508444

-FA2Hchr16

74748167

-
In-frameENST00000422840ENST00000219368GLG1chr16

74508444

-FA2Hchr16

74748167

-
In-frameENST00000422840ENST00000544337GLG1chr16

74508444

-FA2Hchr16

74748167

-
In-frameENST00000447066ENST00000219368GLG1chr16

74508444

-FA2Hchr16

74748167

-
In-frameENST00000447066ENST00000544337GLG1chr16

74508444

-FA2Hchr16

74748167

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000205061GLG1chr1674508444-ENST00000219368FA2Hchr1674748167-33872072202140706
ENST00000205061GLG1chr1674508444-ENST00000544337FA2Hchr1674748167-27442072202140706
ENST00000422840GLG1chr1674508444-ENST00000219368FA2Hchr1674748167-3367205202120706
ENST00000422840GLG1chr1674508444-ENST00000544337FA2Hchr1674748167-2724205202120706
ENST00000447066GLG1chr1674508444-ENST00000219368FA2Hchr1674748167-33522037182105695
ENST00000447066GLG1chr1674508444-ENST00000544337FA2Hchr1674748167-27092037182105695

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000205061ENST00000219368GLG1chr1674508444-FA2Hchr1674748167-0.0020343180.9979657
ENST00000205061ENST00000544337GLG1chr1674508444-FA2Hchr1674748167-0.0036816070.99631834
ENST00000422840ENST00000219368GLG1chr1674508444-FA2Hchr1674748167-0.0019151540.9980849
ENST00000422840ENST00000544337GLG1chr1674508444-FA2Hchr1674748167-0.0034302230.99656975
ENST00000447066ENST00000219368GLG1chr1674508444-FA2Hchr1674748167-0.0029689150.9970311
ENST00000447066ENST00000544337GLG1chr1674508444-FA2Hchr1674748167-0.0053056130.9946944

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Fusion Genomic Features for GLG1-FA2H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GLG1-FA2H


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:74773921/chr16:74506309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLG1

Q92896

FA2H

Q7L5A8

FUNCTION: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). {ECO:0000269|PubMed:8985126}.FUNCTION: Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). {ECO:0000250|UniProtKB:Q5MPP0, ECO:0000269|PubMed:15337768, ECO:0000269|PubMed:15863841, ECO:0000269|PubMed:17355976, ECO:0000269|PubMed:22517924}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-132754_576841204.0Compositional biasNote=Poly-Gly
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-132771_866841204.0Compositional biasNote=Poly-Gln
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-132654_576841180.0Compositional biasNote=Poly-Gly
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-132671_866841180.0Compositional biasNote=Poly-Gln
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-122654_576731193.0Compositional biasNote=Poly-Gly
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-122671_866731193.0Compositional biasNote=Poly-Gln
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327116_1496841204.0RepeatNote=Cys-rich GLG1 1
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327150_2126841204.0RepeatNote=Cys-rich GLG1 2
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327215_2786841204.0RepeatNote=Cys-rich GLG1 3
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327286_3466841204.0RepeatNote=Cys-rich GLG1 4
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327347_4136841204.0RepeatNote=Cys-rich GLG1 5
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327414_4736841204.0RepeatNote=Cys-rich GLG1 6
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327475_5376841204.0RepeatNote=Cys-rich GLG1 7
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327538_6046841204.0RepeatNote=Cys-rich GLG1 8
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327609_6686841204.0RepeatNote=Cys-rich GLG1 9
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326116_1496841180.0RepeatNote=Cys-rich GLG1 1
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326150_2126841180.0RepeatNote=Cys-rich GLG1 2
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326215_2786841180.0RepeatNote=Cys-rich GLG1 3
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326286_3466841180.0RepeatNote=Cys-rich GLG1 4
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326347_4136841180.0RepeatNote=Cys-rich GLG1 5
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326414_4736841180.0RepeatNote=Cys-rich GLG1 6
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326475_5376841180.0RepeatNote=Cys-rich GLG1 7
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326538_6046841180.0RepeatNote=Cys-rich GLG1 8
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326609_6686841180.0RepeatNote=Cys-rich GLG1 9
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226116_1496731193.0RepeatNote=Cys-rich GLG1 1
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226150_2126731193.0RepeatNote=Cys-rich GLG1 2
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226215_2786731193.0RepeatNote=Cys-rich GLG1 3
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226286_3466731193.0RepeatNote=Cys-rich GLG1 4
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226347_4136731193.0RepeatNote=Cys-rich GLG1 5
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226414_4736731193.0RepeatNote=Cys-rich GLG1 6
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226475_5376731193.0RepeatNote=Cys-rich GLG1 7
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226538_6046731193.0RepeatNote=Cys-rich GLG1 8
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226609_6686731193.0RepeatNote=Cys-rich GLG1 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-13271041_11016841204.0RepeatNote=Cys-rich GLG1 16
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327670_7286841204.0RepeatNote=Cys-rich GLG1 10
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327729_7886841204.0RepeatNote=Cys-rich GLG1 11
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327796_8566841204.0RepeatNote=Cys-rich GLG1 12
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327858_9116841204.0RepeatNote=Cys-rich GLG1 13
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327912_9796841204.0RepeatNote=Cys-rich GLG1 14
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-1327980_10356841204.0RepeatNote=Cys-rich GLG1 15
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-13261041_11016841180.0RepeatNote=Cys-rich GLG1 16
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326670_7286841180.0RepeatNote=Cys-rich GLG1 10
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326729_7886841180.0RepeatNote=Cys-rich GLG1 11
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326796_8566841180.0RepeatNote=Cys-rich GLG1 12
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326858_9116841180.0RepeatNote=Cys-rich GLG1 13
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326912_9796841180.0RepeatNote=Cys-rich GLG1 14
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-1326980_10356841180.0RepeatNote=Cys-rich GLG1 15
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-12261041_11016731193.0RepeatNote=Cys-rich GLG1 16
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226670_7286731193.0RepeatNote=Cys-rich GLG1 10
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226729_7886731193.0RepeatNote=Cys-rich GLG1 11
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226796_8566731193.0RepeatNote=Cys-rich GLG1 12
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226858_9116731193.0RepeatNote=Cys-rich GLG1 13
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226912_9796731193.0RepeatNote=Cys-rich GLG1 14
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-1226980_10356731193.0RepeatNote=Cys-rich GLG1 15
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-13271167_11796841204.0Topological domainCytoplasmic
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-132730_11456841204.0Topological domainExtracellular
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-13261167_11796841180.0Topological domainCytoplasmic
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-132630_11456841180.0Topological domainExtracellular
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-12261167_11796731193.0Topological domainCytoplasmic
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-122630_11456731193.0Topological domainExtracellular
HgeneGLG1chr16:74508444chr16:74748167ENST00000205061-13271146_11666841204.0TransmembraneHelical
HgeneGLG1chr16:74508444chr16:74748167ENST00000422840-13261146_11666841180.0TransmembraneHelical
HgeneGLG1chr16:74508444chr16:74748167ENST00000447066-12261146_11666731193.0TransmembraneHelical
TgeneFA2Hchr16:74508444chr16:74748167ENST0000021936857219_361346373.0DomainFatty acid hydroxylase
TgeneFA2Hchr16:74508444chr16:74748167ENST00000219368578_86346373.0DomainCytochrome b5 heme-binding
TgeneFA2Hchr16:74508444chr16:74748167ENST0000021936857168_188346373.0TransmembraneHelical
TgeneFA2Hchr16:74508444chr16:74748167ENST0000021936857213_233346373.0TransmembraneHelical
TgeneFA2Hchr16:74508444chr16:74748167ENST0000021936857268_288346373.0TransmembraneHelical
TgeneFA2Hchr16:74508444chr16:74748167ENST0000021936857290_310346373.0TransmembraneHelical


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Fusion Gene Sequence for GLG1-FA2H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33246_33246_1_GLG1-FA2H_GLG1_chr16_74508444_ENST00000205061_FA2H_chr16_74748167_ENST00000219368_length(transcript)=3387nt_BP=2072nt
GAGCTCGCCGCGGACTCAAGATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCG
CGGCCGGGGCCGAGAAACTCCCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCG
GAGGCGGCGGCCCGGCGGGTCAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGC
AGCCTCAGCCGCCGCAGCCGCCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGG
AGGAAGAGTCCTGCAGGGAGGACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATG
TGAGGGAGCCTGAAAATGAAATTTCTTCAGACTGCAATCATTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAAT
CTGTGGCCAGAGAGGTTTGCAAATCTACTATAACAGAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCT
TGGTGGATCACCGAGGCAACATCACTGAGTATCAGTGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAA
TCTGTGGCTTCATGGATGACTGCAAAAATGACATCAACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAG
GTGAGGTGGTATCATGCTTGGAGAAAGGCCTGGTGAAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAG
CCATTCTCCGGGTGGCTGAGCTGTCATCGGATGACTTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTT
GTGAAAATACACAAGCTGGTGAGGGCAGAGTGTATAAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAG
CACTTACAACCCGCCAAAAGCTGATTGCCCAGGATTATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACC
GGTGCAATGTGGAAAACCTTCCGCGATCGCGTGAAGCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGAC
AAGTCAGCAGTGAGTGCCAGGGGGAGATGCTGGATTACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCT
GTCGGGGGGAGATTGAACACCATTGTTCCGGATTACATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGG
GGAACCTTGGAATGAACTGCCAGCAGGCGCTTCAAACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGA
ATGAAGCTTGTGAATCTGTAATCCAGACAGCCTGCAAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTAT
ACACAGAGAAGATGGTAGAAGACTGTGAACACCGTCTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGT
ACCGCAAGTGCCAGGGAGACGCTTCTCGTCTTTGCCACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCT
CTTGTTTATACAGACACGCCTACCGCACTGAGGAACAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACC
AGCGTGCCATGGATGTCAAGCTGGATCCTGCCCTCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTG
GACAGGAGCTGGAGTGCCTTCAGGACCATCTGGATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAG
AGGATTTGGTATCAGCACTAAATTGTGGGATTACTGTTTCCACACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGACAACTCCC
ACCCCCTCCGTCCTGCCCTCAGCCCGGCCCTGGCCCCTTCCCGACCCCCACCCGCCATTCAGACCCCATTAAGAAGGTTGGCTTGGCCAG
GCAGGATGGGCTGTGTCCGGCCCTGCAGCCTAGTGGAAGGTGCTGAGGGGGCCCTGAGGCAGGACCGCCCTCCTGACCCCTGGTAGGAGG
GTCACATCCACTTGGTGGCCAGGTGGCCCTTGGTGACCCACTTCTTCCTGGAGCGTCCCTGCCTAGAGCTCAGCCCACAGGACTGCTTCA
GGCCGTGGCCACAGGTAGCAGCCGCAAGGGGAAATGAAGAAAACTGAGCCCTCGTGGCCACCTGTGTCACCCTTGTGCCTTAGCCTCATG
GGCTGCCTAGGAGCTGCCTGCACGGCACAGCTCGCTTTCACAGTCAGAAGTGGGTCTGTGGGATCTGTGGTCCCTGTCCTCCCTGCTGTC
CCTTCTGGGGAGGCTTTGGTGGCTCTGAGGTGGACAAAGAGCTCTCGCAAGAAGAGACAGCGTGATGCCTCCCACAGTCCACCCCAGACC
CTGGGGCAGCCCCTCTGGCCCTGCCAGCTGCCTGCGTCGTTGGGCCCAGGGTGGCTGGCAGGAGTCCCAGCTGCTTGCTTTAGGACCTGG
CAGCTTTTCTTGCCGTCCCTCCCCTGCCTCCAGAATCACAGCCCTTCTCCCCAAGGGAGGCTGAGGAGGCTTCTCCACCAGTGGCAGCCC
CACCCCGTCCCTGGCCATTCTTGGCCTCCACCCCGCTCAGGCCCCTACTCGGGCGCTCCCAGAAGGAGCCACCTCTCAGTGCCTCACCTC
CCCCTGCCTCCCAGCCTCCGCAGATGAGGTTCCTGCCCCTTCCTCCTCGTAACCAAAACCCTCACTGCTCCCAGGACGGTCTTATTTATA
AACCAGATACATGTTCTTAGTCTGGTCCCAGACCAAGGAGCTGGTCAGACGGCCCTTTCTAATCCTACATGTTGAGCTTATGTAAAAAAT
GTTGTTTCCTCCTGTTTTTGGTTCCTTTCTTACCCACAAACCATTACTACTTGAAACTTAAAAAACTCGCCAAGTGTAAAGGCTAAAGAG
AAGCAGTTTGACGGACCTTGTGATTTGTACTGTTTGCTGCGGAGCTATTTAAAGATTTTGGAATAAATATACAAAACTACGGTTGTGAAA

>33246_33246_1_GLG1-FA2H_GLG1_chr16_74508444_ENST00000205061_FA2H_chr16_74748167_ENST00000219368_length(amino acids)=706AA_BP=684
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVC
KSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCL
EKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQK
LIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEH
HCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVE
DCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVK

--------------------------------------------------------------
>33246_33246_2_GLG1-FA2H_GLG1_chr16_74508444_ENST00000205061_FA2H_chr16_74748167_ENST00000544337_length(transcript)=2744nt_BP=2072nt
GAGCTCGCCGCGGACTCAAGATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCG
CGGCCGGGGCCGAGAAACTCCCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCG
GAGGCGGCGGCCCGGCGGGTCAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGC
AGCCTCAGCCGCCGCAGCCGCCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGG
AGGAAGAGTCCTGCAGGGAGGACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATG
TGAGGGAGCCTGAAAATGAAATTTCTTCAGACTGCAATCATTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAAT
CTGTGGCCAGAGAGGTTTGCAAATCTACTATAACAGAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCT
TGGTGGATCACCGAGGCAACATCACTGAGTATCAGTGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAA
TCTGTGGCTTCATGGATGACTGCAAAAATGACATCAACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAG
GTGAGGTGGTATCATGCTTGGAGAAAGGCCTGGTGAAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAG
CCATTCTCCGGGTGGCTGAGCTGTCATCGGATGACTTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTT
GTGAAAATACACAAGCTGGTGAGGGCAGAGTGTATAAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAG
CACTTACAACCCGCCAAAAGCTGATTGCCCAGGATTATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACC
GGTGCAATGTGGAAAACCTTCCGCGATCGCGTGAAGCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGAC
AAGTCAGCAGTGAGTGCCAGGGGGAGATGCTGGATTACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCT
GTCGGGGGGAGATTGAACACCATTGTTCCGGATTACATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGG
GGAACCTTGGAATGAACTGCCAGCAGGCGCTTCAAACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGA
ATGAAGCTTGTGAATCTGTAATCCAGACAGCCTGCAAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTAT
ACACAGAGAAGATGGTAGAAGACTGTGAACACCGTCTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGT
ACCGCAAGTGCCAGGGAGACGCTTCTCGTCTTTGCCACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCT
CTTGTTTATACAGACACGCCTACCGCACTGAGGAACAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACC
AGCGTGCCATGGATGTCAAGCTGGATCCTGCCCTCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTG
GACAGGAGCTGGAGTGCCTTCAGGACCATCTGGATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAG
AGGATTTGGTATCAGCACTAAATTGTGGGATTACTGTTTCCACACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGACAACTCCC
ACCCCCTCCGTCCTGCCCTCAGCCCGGCCCTGGCCCCTTCCCGACCCCCACCCGCCATTCAGACCCCATTAAGAAGGTTGGCTTGGCCAG
GCAGGATGGGCTGTGTCCGGCCCTGCAGCCTAGTGGAAGGTGCTGAGGGGGCCCTGAGGCAGGACCGCCCTCCTGACCCCTGGTAGGAGG
GTCACATCCACTTGGTGGCCAGGTGGCCCTTGGTGACCCACTTCTTCCTGGAGCGTCCCTGCCTAGAGCTCAGCCCACAGGACTGCTTCA
GGCCGTGGCCACAGGTAGCAGCCGCAAGGGGAAATGAAGAAAACTGAGCCCTCGTGGCCACCTGTGTCACCCTTGTGCCTTAGCCTCATG
GGCTGCCTAGGAGCTGCCTGCACGGCACAGCTCGCTTTCACAGTCAGAAGTGGGTCTGTGGGATCTGTGGTCCCTGTCCTCCCTGCTGTC
CCTTCTGGGGAGGCTTTGGTGGCTCTGAGGTGGACAAAGAGCTCTCGCAAGAAGAGACAGCGTGATGCCTCCCACAGTCCACCCCAGACC

>33246_33246_2_GLG1-FA2H_GLG1_chr16_74508444_ENST00000205061_FA2H_chr16_74748167_ENST00000544337_length(amino acids)=706AA_BP=684
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVC
KSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCL
EKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQK
LIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEH
HCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVE
DCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVK

--------------------------------------------------------------
>33246_33246_3_GLG1-FA2H_GLG1_chr16_74508444_ENST00000422840_FA2H_chr16_74748167_ENST00000219368_length(transcript)=3367nt_BP=2052nt
ATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCGCGGCCGGGGCCGAGAAACTC
CCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCGGAGGCGGCGGCCCGGCGGGT
CAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGCAGCCTCAGCCGCCGCAGCCG
CCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGGAGGAAGAGTCCTGCAGGGAG
GACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATGTGAGGGAGCCTGAAAATGAA
ATTTCTTCAGACTGCAATCATTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAATCTGTGGCCAGAGAGGTTTGC
AAATCTACTATAACAGAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCTTGGTGGATCACCGAGGCAAC
ATCACTGAGTATCAGTGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAATCTGTGGCTTCATGGATGAC
TGCAAAAATGACATCAACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAGGTGAGGTGGTATCATGCTTG
GAGAAAGGCCTGGTGAAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAGCCATTCTCCGGGTGGCTGAG
CTGTCATCGGATGACTTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTTGTGAAAATACACAAGCTGGT
GAGGGCAGAGTGTATAAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAGCACTTACAACCCGCCAAAAG
CTGATTGCCCAGGATTATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACCGGTGCAATGTGGAAAACCTT
CCGCGATCGCGTGAAGCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGACAAGTCAGCAGTGAGTGCCAG
GGGGAGATGCTGGATTACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCTGTCGGGGGGAGATTGAACAC
CATTGTTCCGGATTACATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGGGGAACCTTGGAATGAACTGC
CAGCAGGCGCTTCAAACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGAATGAAGCTTGTGAATCTGTA
ATCCAGACAGCCTGCAAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTATACACAGAGAAGATGGTAGAA
GACTGTGAACACCGTCTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGTACCGCAAGTGCCAGGGAGAC
GCTTCTCGTCTTTGCCACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCTCTTGTTTATACAGACACGCC
TACCGCACTGAGGAACAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACCAGCGTGCCATGGATGTCAAG
CTGGATCCTGCCCTCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTT
CAGGACCATCTGGATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATTTGGTATCAGCACTA
AATTGTGGGATTACTGTTTCCACACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGACAACTCCCACCCCCTCCGTCCTGCCCTC
AGCCCGGCCCTGGCCCCTTCCCGACCCCCACCCGCCATTCAGACCCCATTAAGAAGGTTGGCTTGGCCAGGCAGGATGGGCTGTGTCCGG
CCCTGCAGCCTAGTGGAAGGTGCTGAGGGGGCCCTGAGGCAGGACCGCCCTCCTGACCCCTGGTAGGAGGGTCACATCCACTTGGTGGCC
AGGTGGCCCTTGGTGACCCACTTCTTCCTGGAGCGTCCCTGCCTAGAGCTCAGCCCACAGGACTGCTTCAGGCCGTGGCCACAGGTAGCA
GCCGCAAGGGGAAATGAAGAAAACTGAGCCCTCGTGGCCACCTGTGTCACCCTTGTGCCTTAGCCTCATGGGCTGCCTAGGAGCTGCCTG
CACGGCACAGCTCGCTTTCACAGTCAGAAGTGGGTCTGTGGGATCTGTGGTCCCTGTCCTCCCTGCTGTCCCTTCTGGGGAGGCTTTGGT
GGCTCTGAGGTGGACAAAGAGCTCTCGCAAGAAGAGACAGCGTGATGCCTCCCACAGTCCACCCCAGACCCTGGGGCAGCCCCTCTGGCC
CTGCCAGCTGCCTGCGTCGTTGGGCCCAGGGTGGCTGGCAGGAGTCCCAGCTGCTTGCTTTAGGACCTGGCAGCTTTTCTTGCCGTCCCT
CCCCTGCCTCCAGAATCACAGCCCTTCTCCCCAAGGGAGGCTGAGGAGGCTTCTCCACCAGTGGCAGCCCCACCCCGTCCCTGGCCATTC
TTGGCCTCCACCCCGCTCAGGCCCCTACTCGGGCGCTCCCAGAAGGAGCCACCTCTCAGTGCCTCACCTCCCCCTGCCTCCCAGCCTCCG
CAGATGAGGTTCCTGCCCCTTCCTCCTCGTAACCAAAACCCTCACTGCTCCCAGGACGGTCTTATTTATAAACCAGATACATGTTCTTAG
TCTGGTCCCAGACCAAGGAGCTGGTCAGACGGCCCTTTCTAATCCTACATGTTGAGCTTATGTAAAAAATGTTGTTTCCTCCTGTTTTTG
GTTCCTTTCTTACCCACAAACCATTACTACTTGAAACTTAAAAAACTCGCCAAGTGTAAAGGCTAAAGAGAAGCAGTTTGACGGACCTTG
TGATTTGTACTGTTTGCTGCGGAGCTATTTAAAGATTTTGGAATAAATATACAAAACTACGGTTGTGAAATAAAAACTTAAATTGTATAT

>33246_33246_3_GLG1-FA2H_GLG1_chr16_74508444_ENST00000422840_FA2H_chr16_74748167_ENST00000219368_length(amino acids)=706AA_BP=684
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVC
KSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCL
EKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQK
LIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEH
HCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVE
DCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVK

--------------------------------------------------------------
>33246_33246_4_GLG1-FA2H_GLG1_chr16_74508444_ENST00000422840_FA2H_chr16_74748167_ENST00000544337_length(transcript)=2724nt_BP=2052nt
ATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCGCGGCCGGGGCCGAGAAACTC
CCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCGGAGGCGGCGGCCCGGCGGGT
CAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGCAGCCTCAGCCGCCGCAGCCG
CCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGGAGGAAGAGTCCTGCAGGGAG
GACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATGTGAGGGAGCCTGAAAATGAA
ATTTCTTCAGACTGCAATCATTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAATCTGTGGCCAGAGAGGTTTGC
AAATCTACTATAACAGAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCTTGGTGGATCACCGAGGCAAC
ATCACTGAGTATCAGTGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAATCTGTGGCTTCATGGATGAC
TGCAAAAATGACATCAACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAGGTGAGGTGGTATCATGCTTG
GAGAAAGGCCTGGTGAAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAGCCATTCTCCGGGTGGCTGAG
CTGTCATCGGATGACTTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTTGTGAAAATACACAAGCTGGT
GAGGGCAGAGTGTATAAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAGCACTTACAACCCGCCAAAAG
CTGATTGCCCAGGATTATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACCGGTGCAATGTGGAAAACCTT
CCGCGATCGCGTGAAGCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGACAAGTCAGCAGTGAGTGCCAG
GGGGAGATGCTGGATTACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCTGTCGGGGGGAGATTGAACAC
CATTGTTCCGGATTACATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGGGGAACCTTGGAATGAACTGC
CAGCAGGCGCTTCAAACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGAATGAAGCTTGTGAATCTGTA
ATCCAGACAGCCTGCAAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTATACACAGAGAAGATGGTAGAA
GACTGTGAACACCGTCTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGTACCGCAAGTGCCAGGGAGAC
GCTTCTCGTCTTTGCCACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCTCTTGTTTATACAGACACGCC
TACCGCACTGAGGAACAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACCAGCGTGCCATGGATGTCAAG
CTGGATCCTGCCCTCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTT
CAGGACCATCTGGATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATTTGGTATCAGCACTA
AATTGTGGGATTACTGTTTCCACACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGACAACTCCCACCCCCTCCGTCCTGCCCTC
AGCCCGGCCCTGGCCCCTTCCCGACCCCCACCCGCCATTCAGACCCCATTAAGAAGGTTGGCTTGGCCAGGCAGGATGGGCTGTGTCCGG
CCCTGCAGCCTAGTGGAAGGTGCTGAGGGGGCCCTGAGGCAGGACCGCCCTCCTGACCCCTGGTAGGAGGGTCACATCCACTTGGTGGCC
AGGTGGCCCTTGGTGACCCACTTCTTCCTGGAGCGTCCCTGCCTAGAGCTCAGCCCACAGGACTGCTTCAGGCCGTGGCCACAGGTAGCA
GCCGCAAGGGGAAATGAAGAAAACTGAGCCCTCGTGGCCACCTGTGTCACCCTTGTGCCTTAGCCTCATGGGCTGCCTAGGAGCTGCCTG
CACGGCACAGCTCGCTTTCACAGTCAGAAGTGGGTCTGTGGGATCTGTGGTCCCTGTCCTCCCTGCTGTCCCTTCTGGGGAGGCTTTGGT
GGCTCTGAGGTGGACAAAGAGCTCTCGCAAGAAGAGACAGCGTGATGCCTCCCACAGTCCACCCCAGACCCTGGGGCAGCCCCTCTGGCC

>33246_33246_4_GLG1-FA2H_GLG1_chr16_74508444_ENST00000422840_FA2H_chr16_74748167_ENST00000544337_length(amino acids)=706AA_BP=684
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVC
KSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCL
EKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQK
LIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEH
HCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVE
DCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVK

--------------------------------------------------------------
>33246_33246_5_GLG1-FA2H_GLG1_chr16_74508444_ENST00000447066_FA2H_chr16_74748167_ENST00000219368_length(transcript)=3352nt_BP=2037nt
GCTCGCCGCGGACTCAAGATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCGCG
GCCGGGGCCGAGAAACTCCCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCGGA
GGCGGCGGCCCGGCGGGTCAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGCAG
CCTCAGCCGCCGCAGCCGCCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGGAG
GAAGAGTCCTGCAGGGAGGACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATGTG
AGGGAGTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAATCTGTGGCCAGAGAGGTTTGCAAATCTACTATAACA
GAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCTTGGTGGATCACCGAGGCAACATCACTGAGTATCAG
TGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAATCTGTGGCTTCATGGATGACTGCAAAAATGACATC
AACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAGGTGAGGTGGTATCATGCTTGGAGAAAGGCCTGGTG
AAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAGCCATTCTCCGGGTGGCTGAGCTGTCATCGGATGAC
TTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTTGTGAAAATACACAAGCTGGTGAGGGCAGAGTGTAT
AAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAGCACTTACAACCCGCCAAAAGCTGATTGCCCAGGAT
TATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACCGGTGCAATGTGGAAAACCTTCCGCGATCGCGTGAA
GCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGACAAGTCAGCAGTGAGTGCCAGGGGGAGATGCTGGAT
TACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCTGTCGGGGGGAGATTGAACACCATTGTTCCGGATTA
CATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGGGGAACCTTGGAATGAACTGCCAGCAGGCGCTTCAA
ACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGAATGAAGCTTGTGAATCTGTAATCCAGACAGCCTGC
AAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTATACACAGAGAAGATGGTAGAAGACTGTGAACACCGT
CTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGTACCGCAAGTGCCAGGGAGACGCTTCTCGTCTTTGC
CACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCTCTTGTTTATACAGACACGCCTACCGCACTGAGGAA
CAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACCAGCGTGCCATGGATGTCAAGCTGGATCCTGCCCTC
CAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTTCAGGACCATCTGGAT
GACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATTTGGTATCAGCACTAAATTGTGGGATTACT
GTTTCCACACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGACAACTCCCACCCCCTCCGTCCTGCCCTCAGCCCGGCCCTGGCC
CCTTCCCGACCCCCACCCGCCATTCAGACCCCATTAAGAAGGTTGGCTTGGCCAGGCAGGATGGGCTGTGTCCGGCCCTGCAGCCTAGTG
GAAGGTGCTGAGGGGGCCCTGAGGCAGGACCGCCCTCCTGACCCCTGGTAGGAGGGTCACATCCACTTGGTGGCCAGGTGGCCCTTGGTG
ACCCACTTCTTCCTGGAGCGTCCCTGCCTAGAGCTCAGCCCACAGGACTGCTTCAGGCCGTGGCCACAGGTAGCAGCCGCAAGGGGAAAT
GAAGAAAACTGAGCCCTCGTGGCCACCTGTGTCACCCTTGTGCCTTAGCCTCATGGGCTGCCTAGGAGCTGCCTGCACGGCACAGCTCGC
TTTCACAGTCAGAAGTGGGTCTGTGGGATCTGTGGTCCCTGTCCTCCCTGCTGTCCCTTCTGGGGAGGCTTTGGTGGCTCTGAGGTGGAC
AAAGAGCTCTCGCAAGAAGAGACAGCGTGATGCCTCCCACAGTCCACCCCAGACCCTGGGGCAGCCCCTCTGGCCCTGCCAGCTGCCTGC
GTCGTTGGGCCCAGGGTGGCTGGCAGGAGTCCCAGCTGCTTGCTTTAGGACCTGGCAGCTTTTCTTGCCGTCCCTCCCCTGCCTCCAGAA
TCACAGCCCTTCTCCCCAAGGGAGGCTGAGGAGGCTTCTCCACCAGTGGCAGCCCCACCCCGTCCCTGGCCATTCTTGGCCTCCACCCCG
CTCAGGCCCCTACTCGGGCGCTCCCAGAAGGAGCCACCTCTCAGTGCCTCACCTCCCCCTGCCTCCCAGCCTCCGCAGATGAGGTTCCTG
CCCCTTCCTCCTCGTAACCAAAACCCTCACTGCTCCCAGGACGGTCTTATTTATAAACCAGATACATGTTCTTAGTCTGGTCCCAGACCA
AGGAGCTGGTCAGACGGCCCTTTCTAATCCTACATGTTGAGCTTATGTAAAAAATGTTGTTTCCTCCTGTTTTTGGTTCCTTTCTTACCC
ACAAACCATTACTACTTGAAACTTAAAAAACTCGCCAAGTGTAAAGGCTAAAGAGAAGCAGTTTGACGGACCTTGTGATTTGTACTGTTT
GCTGCGGAGCTATTTAAAGATTTTGGAATAAATATACAAAACTACGGTTGTGAAATAAAAACTTAAATTGTATATTTTGAAAAATAAAAC

>33246_33246_5_GLG1-FA2H_GLG1_chr16_74508444_ENST00000447066_FA2H_chr16_74748167_ENST00000219368_length(amino acids)=695AA_BP=673
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVRELLWNYKLNLTTDPKFESVAREVCKSTITEIKECA
DEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEER
EPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYS
LAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRT
LHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQY
FISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLI

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>33246_33246_6_GLG1-FA2H_GLG1_chr16_74508444_ENST00000447066_FA2H_chr16_74748167_ENST00000544337_length(transcript)=2709nt_BP=2037nt
GCTCGCCGCGGACTCAAGATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCGCG
GCCGGGGCCGAGAAACTCCCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCGGA
GGCGGCGGCCCGGCGGGTCAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGCAG
CCTCAGCCGCCGCAGCCGCCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGGAG
GAAGAGTCCTGCAGGGAGGACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATGTG
AGGGAGTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAATCTGTGGCCAGAGAGGTTTGCAAATCTACTATAACA
GAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCTTGGTGGATCACCGAGGCAACATCACTGAGTATCAG
TGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAATCTGTGGCTTCATGGATGACTGCAAAAATGACATC
AACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAGGTGAGGTGGTATCATGCTTGGAGAAAGGCCTGGTG
AAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAGCCATTCTCCGGGTGGCTGAGCTGTCATCGGATGAC
TTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTTGTGAAAATACACAAGCTGGTGAGGGCAGAGTGTAT
AAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAGCACTTACAACCCGCCAAAAGCTGATTGCCCAGGAT
TATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACCGGTGCAATGTGGAAAACCTTCCGCGATCGCGTGAA
GCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGACAAGTCAGCAGTGAGTGCCAGGGGGAGATGCTGGAT
TACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCTGTCGGGGGGAGATTGAACACCATTGTTCCGGATTA
CATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGGGGAACCTTGGAATGAACTGCCAGCAGGCGCTTCAA
ACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGAATGAAGCTTGTGAATCTGTAATCCAGACAGCCTGC
AAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTATACACAGAGAAGATGGTAGAAGACTGTGAACACCGT
CTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGTACCGCAAGTGCCAGGGAGACGCTTCTCGTCTTTGC
CACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCTCTTGTTTATACAGACACGCCTACCGCACTGAGGAA
CAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACCAGCGTGCCATGGATGTCAAGCTGGATCCTGCCCTC
CAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTTCAGGACCATCTGGAT
GACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATTTGGTATCAGCACTAAATTGTGGGATTACT
GTTTCCACACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGACAACTCCCACCCCCTCCGTCCTGCCCTCAGCCCGGCCCTGGCC
CCTTCCCGACCCCCACCCGCCATTCAGACCCCATTAAGAAGGTTGGCTTGGCCAGGCAGGATGGGCTGTGTCCGGCCCTGCAGCCTAGTG
GAAGGTGCTGAGGGGGCCCTGAGGCAGGACCGCCCTCCTGACCCCTGGTAGGAGGGTCACATCCACTTGGTGGCCAGGTGGCCCTTGGTG
ACCCACTTCTTCCTGGAGCGTCCCTGCCTAGAGCTCAGCCCACAGGACTGCTTCAGGCCGTGGCCACAGGTAGCAGCCGCAAGGGGAAAT
GAAGAAAACTGAGCCCTCGTGGCCACCTGTGTCACCCTTGTGCCTTAGCCTCATGGGCTGCCTAGGAGCTGCCTGCACGGCACAGCTCGC
TTTCACAGTCAGAAGTGGGTCTGTGGGATCTGTGGTCCCTGTCCTCCCTGCTGTCCCTTCTGGGGAGGCTTTGGTGGCTCTGAGGTGGAC
AAAGAGCTCTCGCAAGAAGAGACAGCGTGATGCCTCCCACAGTCCACCCCAGACCCTGGGGCAGCCCCTCTGGCCCTGCCAGCTGCCTGC

>33246_33246_6_GLG1-FA2H_GLG1_chr16_74508444_ENST00000447066_FA2H_chr16_74748167_ENST00000544337_length(amino acids)=695AA_BP=673
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVRELLWNYKLNLTTDPKFESVAREVCKSTITEIKECA
DEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEER
EPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYS
LAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRT
LHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQY
FISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLI

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Fusion Gene PPI Analysis for GLG1-FA2H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLG1-FA2H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLG1-FA2H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource