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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLG1-MRPS6 (FusionGDB2 ID:33256)

Fusion Gene Summary for GLG1-MRPS6

check button Fusion gene summary
Fusion gene informationFusion gene name: GLG1-MRPS6
Fusion gene ID: 33256
HgeneTgene
Gene symbol

GLG1

MRPS6

Gene ID

2734

64968

Gene namegolgi glycoprotein 1mitochondrial ribosomal protein S6
SynonymsCFR-1|ESL-1|MG-160|MG160C21orf101|MRP-S6|RPMS6|S6mt
Cytomap

16q23.1

21q22.11

Type of geneprotein-codingprotein-coding
DescriptionGolgi apparatus protein 1E-selectin ligand 1cysteine-rich fibroblast growth factor receptorgolgi sialoglycoprotein MG-16028S ribosomal protein S6, mitochondrialmitochondrial small ribosomal subunit protein bS6m
Modification date2020031320200313
UniProtAcc

Q92896

P82932

Ensembl transtripts involved in fusion geneENST00000205061, ENST00000422840, 
ENST00000447066, 		ENST00000482679, 
ENST00000399312, 
Fusion gene scores* DoF score23 X 21 X 12=579613 X 6 X 7=546
# samples 2915
** MAII scorelog2(29/5796*10)=-4.320932789542
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/546*10)=-1.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLG1 [Title/Abstract] AND MRPS6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLG1(74640554)-MRPS6(35497640), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GLG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6458GLG1chr16

74640554

-MRPS6chr21

35497640

+


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Fusion Gene ORF analysis for GLG1-MRPS6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000205061ENST00000482679GLG1chr16

74640554

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000422840ENST00000482679GLG1chr16

74640554

-MRPS6chr21

35497640

+
5CDS-3UTRENST00000447066ENST00000482679GLG1chr16

74640554

-MRPS6chr21

35497640

+
In-frameENST00000205061ENST00000399312GLG1chr16

74640554

-MRPS6chr21

35497640

+
In-frameENST00000422840ENST00000399312GLG1chr16

74640554

-MRPS6chr21

35497640

+
In-frameENST00000447066ENST00000399312GLG1chr16

74640554

-MRPS6chr21

35497640

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000205061GLG1chr1674640554-ENST00000399312MRPS6chr2135497640+122545820790256
ENST00000422840GLG1chr1674640554-ENST00000399312MRPS6chr2135497640+12054380770256
ENST00000447066GLG1chr1674640554-ENST00000399312MRPS6chr2135497640+122345618788256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000205061ENST00000399312GLG1chr1674640554-MRPS6chr2135497640+0.0230064950.9769935
ENST00000422840ENST00000399312GLG1chr1674640554-MRPS6chr2135497640+0.0199287250.98007125
ENST00000447066ENST00000399312GLG1chr1674640554-MRPS6chr2135497640+0.0227677560.9772323

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Fusion Genomic Features for GLG1-MRPS6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GLG1chr1674640554-MRPS6chr2135497640+5.82E-081
GLG1chr1674640554-MRPS6chr2135497640+5.82E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GLG1-MRPS6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:74640554/chr21:35497640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLG1

Q92896

MRPS6

P82932

FUNCTION: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). {ECO:0000269|PubMed:8985126}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-12754_571461204.0Compositional biasNote=Poly-Gly
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-12771_861461204.0Compositional biasNote=Poly-Gln
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-12654_571461180.0Compositional biasNote=Poly-Gly
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-12671_861461180.0Compositional biasNote=Poly-Gln
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-12654_571461193.0Compositional biasNote=Poly-Gly
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-12671_861461193.0Compositional biasNote=Poly-Gln
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127116_1491461204.0RepeatNote=Cys-rich GLG1 1
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126116_1491461180.0RepeatNote=Cys-rich GLG1 1
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126116_1491461193.0RepeatNote=Cys-rich GLG1 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-1271041_11011461204.0RepeatNote=Cys-rich GLG1 16
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127150_2121461204.0RepeatNote=Cys-rich GLG1 2
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127215_2781461204.0RepeatNote=Cys-rich GLG1 3
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127286_3461461204.0RepeatNote=Cys-rich GLG1 4
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127347_4131461204.0RepeatNote=Cys-rich GLG1 5
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127414_4731461204.0RepeatNote=Cys-rich GLG1 6
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127475_5371461204.0RepeatNote=Cys-rich GLG1 7
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127538_6041461204.0RepeatNote=Cys-rich GLG1 8
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127609_6681461204.0RepeatNote=Cys-rich GLG1 9
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127670_7281461204.0RepeatNote=Cys-rich GLG1 10
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127729_7881461204.0RepeatNote=Cys-rich GLG1 11
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127796_8561461204.0RepeatNote=Cys-rich GLG1 12
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127858_9111461204.0RepeatNote=Cys-rich GLG1 13
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127912_9791461204.0RepeatNote=Cys-rich GLG1 14
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-127980_10351461204.0RepeatNote=Cys-rich GLG1 15
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-1261041_11011461180.0RepeatNote=Cys-rich GLG1 16
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126150_2121461180.0RepeatNote=Cys-rich GLG1 2
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126215_2781461180.0RepeatNote=Cys-rich GLG1 3
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126286_3461461180.0RepeatNote=Cys-rich GLG1 4
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126347_4131461180.0RepeatNote=Cys-rich GLG1 5
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126414_4731461180.0RepeatNote=Cys-rich GLG1 6
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126475_5371461180.0RepeatNote=Cys-rich GLG1 7
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126538_6041461180.0RepeatNote=Cys-rich GLG1 8
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126609_6681461180.0RepeatNote=Cys-rich GLG1 9
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126670_7281461180.0RepeatNote=Cys-rich GLG1 10
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126729_7881461180.0RepeatNote=Cys-rich GLG1 11
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126796_8561461180.0RepeatNote=Cys-rich GLG1 12
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126858_9111461180.0RepeatNote=Cys-rich GLG1 13
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126912_9791461180.0RepeatNote=Cys-rich GLG1 14
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-126980_10351461180.0RepeatNote=Cys-rich GLG1 15
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-1261041_11011461193.0RepeatNote=Cys-rich GLG1 16
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126150_2121461193.0RepeatNote=Cys-rich GLG1 2
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126215_2781461193.0RepeatNote=Cys-rich GLG1 3
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126286_3461461193.0RepeatNote=Cys-rich GLG1 4
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126347_4131461193.0RepeatNote=Cys-rich GLG1 5
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126414_4731461193.0RepeatNote=Cys-rich GLG1 6
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126475_5371461193.0RepeatNote=Cys-rich GLG1 7
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126538_6041461193.0RepeatNote=Cys-rich GLG1 8
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126609_6681461193.0RepeatNote=Cys-rich GLG1 9
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126670_7281461193.0RepeatNote=Cys-rich GLG1 10
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126729_7881461193.0RepeatNote=Cys-rich GLG1 11
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126796_8561461193.0RepeatNote=Cys-rich GLG1 12
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126858_9111461193.0RepeatNote=Cys-rich GLG1 13
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126912_9791461193.0RepeatNote=Cys-rich GLG1 14
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-126980_10351461193.0RepeatNote=Cys-rich GLG1 15
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-1271167_11791461204.0Topological domainCytoplasmic
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-12730_11451461204.0Topological domainExtracellular
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-1261167_11791461180.0Topological domainCytoplasmic
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-12630_11451461180.0Topological domainExtracellular
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-1261167_11791461193.0Topological domainCytoplasmic
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-12630_11451461193.0Topological domainExtracellular
HgeneGLG1chr16:74640554chr21:35497640ENST00000205061-1271146_11661461204.0TransmembraneHelical
HgeneGLG1chr16:74640554chr21:35497640ENST00000422840-1261146_11661461180.0TransmembraneHelical
HgeneGLG1chr16:74640554chr21:35497640ENST00000447066-1261146_11661461193.0TransmembraneHelical


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Fusion Gene Sequence for GLG1-MRPS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33256_33256_1_GLG1-MRPS6_GLG1_chr16_74640554_ENST00000205061_MRPS6_chr21_35497640_ENST00000399312_length(transcript)=1225nt_BP=458nt
GAGCTCGCCGCGGACTCAAGATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCG
CGGCCGGGGCCGAGAAACTCCCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCG
GAGGCGGCGGCCCGGCGGGTCAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGC
AGCCTCAGCCGCCGCAGCCGCCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGG
AGGAAGAGTCCTGCAGGGAGGACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATG
TGAGGGAGCCAGAGACTGCTGCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGG
GTGAACGAGCGCTTCCTTATAGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCG
CAGCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAA
AAGAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTA
GCCTTATATGTAATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGT
GCTGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACC
TGCAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCAT
TTTTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCA

>33256_33256_1_GLG1-MRPS6_GLG1_chr16_74640554_ENST00000205061_MRPS6_chr21_35497640_ENST00000399312_length(amino acids)=256AA_BP=146
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPETAATLKRTIEALMDRGAIVRDLENLGERALPY

--------------------------------------------------------------
>33256_33256_2_GLG1-MRPS6_GLG1_chr16_74640554_ENST00000422840_MRPS6_chr21_35497640_ENST00000399312_length(transcript)=1205nt_BP=438nt
ATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCGCGGCCGGGGCCGAGAAACTC
CCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCGGAGGCGGCGGCCCGGCGGGT
CAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGCAGCCTCAGCCGCCGCAGCCG
CCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGGAGGAAGAGTCCTGCAGGGAG
GACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATGTGAGGGAGCCAGAGACTGCT
GCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGGGTGAACGAGCGCTTCCTTAT
AGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCGCAGCTGTTGAAAGCATGGTG
GAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAAAAGAATGTGAAGGGATTGTC
CCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTAGCCTTATATGTAATTCCTTC
ACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGTGCTGTTTGATTTTTCTAAGG
TATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACCTGCAGTACCAGTGGATCGTT
CTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCATTTTTTGAAGAGCAAAACTTA
TAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCAATGTATTATATGGACAACTT

>33256_33256_2_GLG1-MRPS6_GLG1_chr16_74640554_ENST00000422840_MRPS6_chr21_35497640_ENST00000399312_length(amino acids)=256AA_BP=146
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPETAATLKRTIEALMDRGAIVRDLENLGERALPY

--------------------------------------------------------------
>33256_33256_3_GLG1-MRPS6_GLG1_chr16_74640554_ENST00000447066_MRPS6_chr21_35497640_ENST00000399312_length(transcript)=1223nt_BP=456nt
GCTCGCCGCGGACTCAAGATGGCGGCGTGTGGACGTGTACGGAGGATGTTCCGCTTGTCGGCGGCGCTGCATCTGCTGCTGCTATTCGCG
GCCGGGGCCGAGAAACTCCCCGGCCAGGGCGTCCACAGCCAGGGCCAGGGTCCCGGGGCCAACTTTGTGTCCTTCGTAGGGCAGGCCGGA
GGCGGCGGCCCGGCGGGTCAGCAGCTGCCCCAGCTGCCTCAGTCATCGCAGCTTCAGCAGCAACAGCAGCAGCAGCAACAGCAACAGCAG
CCTCAGCCGCCGCAGCCGCCTTTCCCGGCGGGTGGGCCTCCGGCCCGGCGGGGAGGAGCGGGGGCTGGTGGGGGCTGGAAGCTGGCGGAG
GAAGAGTCCTGCAGGGAGGACGTGACCCGCGTGTGCCCTAAGCACACCTGGAGCAACAACCTGGCGGTGCTCGAGTGCCTGCAGGATGTG
AGGGAGCCAGAGACTGCTGCTACTTTGAAACGTACGATAGAGGCCCTGATGGACAGAGGAGCAATAGTGAGGGACTTGGAAAACCTGGGT
GAACGAGCGCTTCCTTATAGGATCTCTGCCCACAGTCAGCAGCACAACAGAGGCGGGTATTTCTTGGTGGATTTTTATGCACCCACCGCA
GCTGTTGAAAGCATGGTGGAGCACTTGTCTCGAGATATAGATGTGATTAGAGGGAATATTGTCAAACACCCTCTGACCCAGGAACTAAAA
GAATGTGAAGGGATTGTCCCAGTCCCACTCGCAGAAAAATTATATTCCACAAAGAAGAGGAAGAAGTGAGAAGATTCGCCAGATTTTAGC
CTTATATGTAATTCCTTCACATTTGGGCAGCATGGACGAGAAGGAAGAATTTGCAAGTTTGGCCTTTATATAAGCATGTGTTGCAGGTGC
TGTTTGATTTTTCTAAGGTATTTTTAGCCCTTGATCCCCTTTGCTTGCGAGAGGTGGGGAACTGCTCACTGACAGCTTCTCTGTAACCTG
CAGTACCAGTGGATCGTTCTTGATTTTGTTTTCATTAGTGTCATTTCTTTGTCATTGAGGACTTTTCCCCTTACAACAGTAACACCATTT
TTTGAAGAGCAAAACTTATAATACCTCCTGGGATTGTGAGCTAGTCATTCAGCCTGTGTAACCATGTGGAAATAAAAATTGACGACCAAT

>33256_33256_3_GLG1-MRPS6_GLG1_chr16_74640554_ENST00000447066_MRPS6_chr21_35497640_ENST00000399312_length(amino acids)=256AA_BP=146
MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQP
PFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPETAATLKRTIEALMDRGAIVRDLENLGERALPY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GLG1-MRPS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLG1-MRPS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLG1-MRPS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource