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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLI4-GALT (FusionGDB2 ID:33283)

Fusion Gene Summary for GLI4-GALT

check button Fusion gene summary
Fusion gene informationFusion gene name: GLI4-GALT
Fusion gene ID: 33283
HgeneTgene
Gene symbol

GLI4

GALT

Gene ID

2738

2592

Gene nameGLI family zinc finger 4galactose-1-phosphate uridylyltransferase
SynonymsHKR4|ZNF928-
Cytomap

8q24.3

9p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein GLI4GLI-Kruppel family member GLI4 (oncogene HKR4)glioma-associated oncogene family zinc finger 4krueppel-related zinc finger protein 4galactose-1-phosphate uridylyltransferaseUDP-glucose--hexose-1-phosphate uridylyltransferasegal-1-P uridylyltransferasegalactose-1-phosphate uridyl transferase
Modification date2020031320200327
UniProtAcc

P10075

P07902

Ensembl transtripts involved in fusion geneENST00000340042, ENST00000344692, 
ENST00000517468, ENST00000521682, 
ENST00000523522, ENST00000523812, 
ENST00000488412, ENST00000378842, 
ENST00000556278, ENST00000450095, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 4 X 4=80
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLI4 [Title/Abstract] AND GALT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLI4(144351690)-GALT(34649406), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGALT

GO:0006011

UDP-glucose metabolic process

27005423

TgeneGALT

GO:0006012

galactose metabolic process

27005423


check buttonFusion gene breakpoints across GLI4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GALT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A43HGLI4chr8

144351690

+GALTchr9

34649406

+


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Fusion Gene ORF analysis for GLI4-GALT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000340042ENST00000488412GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-3UTRENST00000344692ENST00000488412GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-3UTRENST00000517468ENST00000488412GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-3UTRENST00000521682ENST00000488412GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-3UTRENST00000523522ENST00000488412GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000340042ENST00000378842GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000340042ENST00000556278GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000344692ENST00000378842GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000344692ENST00000556278GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000517468ENST00000378842GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000517468ENST00000556278GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000521682ENST00000378842GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000521682ENST00000556278GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000523522ENST00000378842GLI4chr8

144351690

+GALTchr9

34649406

+
5CDS-intronENST00000523522ENST00000556278GLI4chr8

144351690

+GALTchr9

34649406

+
In-frameENST00000340042ENST00000450095GLI4chr8

144351690

+GALTchr9

34649406

+
In-frameENST00000344692ENST00000450095GLI4chr8

144351690

+GALTchr9

34649406

+
In-frameENST00000517468ENST00000450095GLI4chr8

144351690

+GALTchr9

34649406

+
In-frameENST00000521682ENST00000450095GLI4chr8

144351690

+GALTchr9

34649406

+
In-frameENST00000523522ENST00000450095GLI4chr8

144351690

+GALTchr9

34649406

+
intron-3CDSENST00000523812ENST00000450095GLI4chr8

144351690

+GALTchr9

34649406

+
intron-3UTRENST00000523812ENST00000488412GLI4chr8

144351690

+GALTchr9

34649406

+
intron-intronENST00000523812ENST00000378842GLI4chr8

144351690

+GALTchr9

34649406

+
intron-intronENST00000523812ENST00000556278GLI4chr8

144351690

+GALTchr9

34649406

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000521682GLI4chr8144351690+ENST00000450095GALTchr934649406+52520985444119
ENST00000340042GLI4chr8144351690+ENST00000450095GALTchr934649406+52520985444119
ENST00000344692GLI4chr8144351690+ENST00000450095GALTchr934649406+47916339398119
ENST00000517468GLI4chr8144351690+ENST00000450095GALTchr934649406+47916339398119
ENST00000523522GLI4chr8144351690+ENST00000450095GALTchr934649406+47916339398119

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000521682ENST00000450095GLI4chr8144351690+GALTchr934649406+0.0738748240.9261252
ENST00000340042ENST00000450095GLI4chr8144351690+GALTchr934649406+0.0738748240.9261252
ENST00000344692ENST00000450095GLI4chr8144351690+GALTchr934649406+0.1223023160.8776977
ENST00000517468ENST00000450095GLI4chr8144351690+GALTchr934649406+0.1223023160.8776977
ENST00000523522ENST00000450095GLI4chr8144351690+GALTchr934649406+0.1223023160.8776977

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Fusion Genomic Features for GLI4-GALT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GLI4chr8144351690+GALTchr934649406+0.0183643070.9816357
GLI4chr8144351690+GALTchr934649406+0.0183643070.9816357

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GLI4-GALT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:144351690/chr9:34649406)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLI4

P10075

GALT

P07902

FUNCTION: Plays an important role in galactose metabolism. {ECO:0000269|PubMed:22461411, ECO:0000269|PubMed:27005423}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGALTchr8:144351690chr9:34649406ENST00000378842811334_337301380.0RegionUDP-alpha-D-glucose binding
TgeneGALTchr8:144351690chr9:34649406ENST00000378842811339_340301380.0RegionUDP-alpha-D-glucose binding
TgeneGALTchr8:144351690chr9:34649406ENST0000045009569334_337192271.0RegionUDP-alpha-D-glucose binding
TgeneGALTchr8:144351690chr9:34649406ENST0000045009569339_340192271.0RegionUDP-alpha-D-glucose binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24183_20541377.0Zinc fingerC2H2-type 1
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24211_23341377.0Zinc fingerC2H2-type 2
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24239_26141377.0Zinc fingerC2H2-type 3
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24267_28941377.0Zinc fingerC2H2-type 4
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24295_31741377.0Zinc fingerC2H2-type 5
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24323_34541377.0Zinc fingerC2H2-type 6
HgeneGLI4chr8:144351690chr9:34649406ENST00000340042+24351_37341377.0Zinc fingerC2H2-type 7
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13183_20541377.0Zinc fingerC2H2-type 1
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13211_23341377.0Zinc fingerC2H2-type 2
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13239_26141377.0Zinc fingerC2H2-type 3
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13267_28941377.0Zinc fingerC2H2-type 4
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13295_31741377.0Zinc fingerC2H2-type 5
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13323_34541377.0Zinc fingerC2H2-type 6
HgeneGLI4chr8:144351690chr9:34649406ENST00000523522+13351_37341377.0Zinc fingerC2H2-type 7
TgeneGALTchr8:144351690chr9:34649406ENST0000037884281197_98301380.0RegionUDP-alpha-D-glucose binding
TgeneGALTchr8:144351690chr9:34649406ENST000004500956997_98192271.0RegionUDP-alpha-D-glucose binding


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Fusion Gene Sequence for GLI4-GALT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33283_33283_1_GLI4-GALT_GLI4_chr8_144351690_ENST00000340042_GALT_chr9_34649406_ENST00000450095_length(transcript)=525nt_BP=209nt
GGCCGGACACTTCCGTCCGGCGCGCGGCGTCCTCCTCCCGCTCGGAAGGTCCCAGGTGTGACACCTTCAGCAGGTCTCAGGGAAGATGGC
AGCCCTAGGGGACATTCAGGAGTCCCCTTCTGTCCCGTCCCCTGTCAGTCTCTCATCACCAGGGACACCTGGAACCCAGCACCACGAGCC
TCAGCTTCACCTCCATGGGCATCAACATGGGGCTCCCACAGGATCAGAGGCTGGGGCCAACTGGAACCATTGGCAGCTGCACGCTCATTA
CTACCCTCCGCTCCTGCGCTCTGCCACTGTCCGGAAATTCATGGTTGGCTACGAAATGCTTGCTCAGGCTCAGAGGGACCTCACCCCTGA
GCAGGCTGCAGAGAGACTAAGGGCACTTCCTGAGGTTCATTACCACCTGGGGCAGAAGGACAGGGAGACAGCAACCATCGCCTGACCACG

>33283_33283_1_GLI4-GALT_GLI4_chr8_144351690_ENST00000340042_GALT_chr9_34649406_ENST00000450095_length(amino acids)=119AA_BP=41
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLT

--------------------------------------------------------------
>33283_33283_2_GLI4-GALT_GLI4_chr8_144351690_ENST00000344692_GALT_chr9_34649406_ENST00000450095_length(transcript)=479nt_BP=163nt
AGGTCCCAGGTGTGACACCTTCAGCAGGTCTCAGGGAAGATGGCAGCCCTAGGGGACATTCAGGAGTCCCCTTCTGTCCCGTCCCCTGTC
AGTCTCTCATCACCAGGGACACCTGGAACCCAGCACCACGAGCCTCAGCTTCACCTCCATGGGCATCAACATGGGGCTCCCACAGGATCA
GAGGCTGGGGCCAACTGGAACCATTGGCAGCTGCACGCTCATTACTACCCTCCGCTCCTGCGCTCTGCCACTGTCCGGAAATTCATGGTT
GGCTACGAAATGCTTGCTCAGGCTCAGAGGGACCTCACCCCTGAGCAGGCTGCAGAGAGACTAAGGGCACTTCCTGAGGTTCATTACCAC
CTGGGGCAGAAGGACAGGGAGACAGCAACCATCGCCTGACCACGCCGACCACAGGGCCTTGAATCCTTTTTTGTTTTCAACAGTCTTGCT

>33283_33283_2_GLI4-GALT_GLI4_chr8_144351690_ENST00000344692_GALT_chr9_34649406_ENST00000450095_length(amino acids)=119AA_BP=41
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLT

--------------------------------------------------------------
>33283_33283_3_GLI4-GALT_GLI4_chr8_144351690_ENST00000517468_GALT_chr9_34649406_ENST00000450095_length(transcript)=479nt_BP=163nt
AGGTCCCAGGTGTGACACCTTCAGCAGGTCTCAGGGAAGATGGCAGCCCTAGGGGACATTCAGGAGTCCCCTTCTGTCCCGTCCCCTGTC
AGTCTCTCATCACCAGGGACACCTGGAACCCAGCACCACGAGCCTCAGCTTCACCTCCATGGGCATCAACATGGGGCTCCCACAGGATCA
GAGGCTGGGGCCAACTGGAACCATTGGCAGCTGCACGCTCATTACTACCCTCCGCTCCTGCGCTCTGCCACTGTCCGGAAATTCATGGTT
GGCTACGAAATGCTTGCTCAGGCTCAGAGGGACCTCACCCCTGAGCAGGCTGCAGAGAGACTAAGGGCACTTCCTGAGGTTCATTACCAC
CTGGGGCAGAAGGACAGGGAGACAGCAACCATCGCCTGACCACGCCGACCACAGGGCCTTGAATCCTTTTTTGTTTTCAACAGTCTTGCT

>33283_33283_3_GLI4-GALT_GLI4_chr8_144351690_ENST00000517468_GALT_chr9_34649406_ENST00000450095_length(amino acids)=119AA_BP=41
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLT

--------------------------------------------------------------
>33283_33283_4_GLI4-GALT_GLI4_chr8_144351690_ENST00000521682_GALT_chr9_34649406_ENST00000450095_length(transcript)=525nt_BP=209nt
GGCCGGACACTTCCGTCCGGCGCGCGGCGTCCTCCTCCCGCTCGGAAGGTCCCAGGTGTGACACCTTCAGCAGGTCTCAGGGAAGATGGC
AGCCCTAGGGGACATTCAGGAGTCCCCTTCTGTCCCGTCCCCTGTCAGTCTCTCATCACCAGGGACACCTGGAACCCAGCACCACGAGCC
TCAGCTTCACCTCCATGGGCATCAACATGGGGCTCCCACAGGATCAGAGGCTGGGGCCAACTGGAACCATTGGCAGCTGCACGCTCATTA
CTACCCTCCGCTCCTGCGCTCTGCCACTGTCCGGAAATTCATGGTTGGCTACGAAATGCTTGCTCAGGCTCAGAGGGACCTCACCCCTGA
GCAGGCTGCAGAGAGACTAAGGGCACTTCCTGAGGTTCATTACCACCTGGGGCAGAAGGACAGGGAGACAGCAACCATCGCCTGACCACG

>33283_33283_4_GLI4-GALT_GLI4_chr8_144351690_ENST00000521682_GALT_chr9_34649406_ENST00000450095_length(amino acids)=119AA_BP=41
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLT

--------------------------------------------------------------
>33283_33283_5_GLI4-GALT_GLI4_chr8_144351690_ENST00000523522_GALT_chr9_34649406_ENST00000450095_length(transcript)=479nt_BP=163nt
AGGTCCCAGGTGTGACACCTTCAGCAGGTCTCAGGGAAGATGGCAGCCCTAGGGGACATTCAGGAGTCCCCTTCTGTCCCGTCCCCTGTC
AGTCTCTCATCACCAGGGACACCTGGAACCCAGCACCACGAGCCTCAGCTTCACCTCCATGGGCATCAACATGGGGCTCCCACAGGATCA
GAGGCTGGGGCCAACTGGAACCATTGGCAGCTGCACGCTCATTACTACCCTCCGCTCCTGCGCTCTGCCACTGTCCGGAAATTCATGGTT
GGCTACGAAATGCTTGCTCAGGCTCAGAGGGACCTCACCCCTGAGCAGGCTGCAGAGAGACTAAGGGCACTTCCTGAGGTTCATTACCAC
CTGGGGCAGAAGGACAGGGAGACAGCAACCATCGCCTGACCACGCCGACCACAGGGCCTTGAATCCTTTTTTGTTTTCAACAGTCTTGCT

>33283_33283_5_GLI4-GALT_GLI4_chr8_144351690_ENST00000523522_GALT_chr9_34649406_ENST00000450095_length(amino acids)=119AA_BP=41
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GLI4-GALT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLI4-GALT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLI4-GALT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource