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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLIPR2-GALT (FusionGDB2 ID:33295)

Fusion Gene Summary for GLIPR2-GALT

check button Fusion gene summary
Fusion gene informationFusion gene name: GLIPR2-GALT
Fusion gene ID: 33295
HgeneTgene
Gene symbol

GLIPR2

GALT

Gene ID

152007

2592

Gene nameGLI pathogenesis related 2galactose-1-phosphate uridylyltransferase
SynonymsC9orf19|GAPR-1|GAPR1-
Cytomap

9p13.3

9p13.3

Type of geneprotein-codingprotein-coding
DescriptionGolgi-associated plant pathogenesis-related protein 117kD fetal brain proteingliPR 2glioma pathogenesis-related protein 2golgi-associated PR-1 proteingalactose-1-phosphate uridylyltransferaseUDP-glucose--hexose-1-phosphate uridylyltransferasegal-1-P uridylyltransferasegalactose-1-phosphate uridyl transferase
Modification date2020031320200327
UniProtAcc

Q9H4G4

P07902

Ensembl transtripts involved in fusion geneENST00000396613, ENST00000474050, 
ENST00000377960, ENST00000377959, 
ENST00000378842, ENST00000450095, 
ENST00000556278, ENST00000488412, 
Fusion gene scores* DoF score6 X 5 X 3=905 X 4 X 4=80
# samples 65
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLIPR2 [Title/Abstract] AND GALT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLIPR2(36150946)-GALT(34646674), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLIPR2

GO:0010634

positive regulation of epithelial cell migration

23516513

HgeneGLIPR2

GO:0010718

positive regulation of epithelial to mesenchymal transition

23516513

HgeneGLIPR2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

23516513

TgeneGALT

GO:0006011

UDP-glucose metabolic process

27005423

TgeneGALT

GO:0006012

galactose metabolic process

27005423


check buttonFusion gene breakpoints across GLIPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GALT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7238-01AGLIPR2chr9

36150946

+GALTchr9

34646674

+


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Fusion Gene ORF analysis for GLIPR2-GALT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000396613ENST00000378842GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-5UTRENST00000396613ENST00000450095GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-5UTRENST00000396613ENST00000556278GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-5UTRENST00000474050ENST00000378842GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-5UTRENST00000474050ENST00000450095GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-5UTRENST00000474050ENST00000556278GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-intronENST00000396613ENST00000488412GLIPR2chr9

36150946

+GALTchr9

34646674

+
3UTR-intronENST00000474050ENST00000488412GLIPR2chr9

36150946

+GALTchr9

34646674

+
5CDS-5UTRENST00000377960ENST00000378842GLIPR2chr9

36150946

+GALTchr9

34646674

+
5CDS-5UTRENST00000377960ENST00000450095GLIPR2chr9

36150946

+GALTchr9

34646674

+
5CDS-5UTRENST00000377960ENST00000556278GLIPR2chr9

36150946

+GALTchr9

34646674

+
5CDS-intronENST00000377960ENST00000488412GLIPR2chr9

36150946

+GALTchr9

34646674

+
intron-5UTRENST00000377959ENST00000378842GLIPR2chr9

36150946

+GALTchr9

34646674

+
intron-5UTRENST00000377959ENST00000450095GLIPR2chr9

36150946

+GALTchr9

34646674

+
intron-5UTRENST00000377959ENST00000556278GLIPR2chr9

36150946

+GALTchr9

34646674

+
intron-intronENST00000377959ENST00000488412GLIPR2chr9

36150946

+GALTchr9

34646674

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GLIPR2-GALT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GLIPR2-GALT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36150946/:34646674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLIPR2

Q9H4G4

GALT

P07902

FUNCTION: Plays an important role in galactose metabolism. {ECO:0000269|PubMed:22461411, ECO:0000269|PubMed:27005423}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GLIPR2-GALT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GLIPR2-GALT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLIPR2-GALT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLIPR2-GALT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource