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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GLIS3-GOLM1 (FusionGDB2 ID:33308) |
Fusion Gene Summary for GLIS3-GOLM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLIS3-GOLM1 | Fusion gene ID: 33308 | Hgene | Tgene | Gene symbol | GLIS3 | GOLM1 | Gene ID | 169792 | 51280 |
| Gene name | GLIS family zinc finger 3 | golgi membrane protein 1 | |
| Synonyms | NDH|ZNF515 | C9orf155|GOLPH2|GP73|HEL46|PSEC0257|bA379P1.3 | |
| Cytomap | 9p24.2 | 9q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein GLIS3GLI-similar 3OK/KNS-cl.4zinc finger protein 515 | Golgi membrane protein 1epididymis luminal protein 46golgi membrane protein GP73golgi phosphoprotein 2golgi protein, 73-kD | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8NEA6 | Q8NBJ4 | |
| Ensembl transtripts involved in fusion gene | ENST00000381971, ENST00000324333, ENST00000461870, | ENST00000257504, ENST00000388711, ENST00000388712, | |
| Fusion gene scores | * DoF score | 13 X 7 X 7=637 | 12 X 11 X 5=660 |
| # samples | 13 | 13 | |
| ** MAII score | log2(13/637*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GLIS3 [Title/Abstract] AND GOLM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GLIS3(4286038)-GOLM1(88661487), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across GLIS3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GOLM1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-UB-A7MB-01A | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
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Fusion Gene ORF analysis for GLIS3-GOLM1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000381971 | ENST00000257504 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| In-frame | ENST00000381971 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| In-frame | ENST00000381971 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000324333 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000324333 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000461870 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000461870 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-5UTR | ENST00000324333 | ENST00000257504 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-5UTR | ENST00000461870 | ENST00000257504 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000381971 | GLIS3 | chr9 | 4286038 | - | ENST00000388712 | GOLM1 | chr9 | 88661487 | - | 3495 | 982 | 594 | 1823 | 409 |
| ENST00000381971 | GLIS3 | chr9 | 4286038 | - | ENST00000388711 | GOLM1 | chr9 | 88661487 | - | 3494 | 982 | 594 | 1823 | 409 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000381971 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - | 0.001152074 | 0.99884796 |
| ENST00000381971 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - | 0.001155452 | 0.9988445 |
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Fusion Genomic Features for GLIS3-GOLM1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GLIS3-GOLM1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:4286038/chr9:88661487) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLIS3 | GOLM1 |
| FUNCTION: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}. | FUNCTION: Unknown. Cellular response protein to viral infection. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 289_306 | 0 | 776.0 | Compositional bias | Note=Pro-rich |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 41_154 | 0 | 776.0 | Compositional bias | Note=Ser-rich |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 289_306 | 129 | 931.0 | Compositional bias | Note=Pro-rich |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 41_154 | 129 | 931.0 | Compositional bias | Note=Ser-rich |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 491_507 | 0 | 776.0 | Motif | Bipartite nuclear localization signal |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 491_507 | 129 | 931.0 | Motif | Bipartite nuclear localization signal |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 345_370 | 0 | 776.0 | Zinc finger | C2H2-type 1 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 379_406 | 0 | 776.0 | Zinc finger | C2H2-type 2%3B atypical |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 412_436 | 0 | 776.0 | Zinc finger | C2H2-type 3 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 442_466 | 0 | 776.0 | Zinc finger | C2H2-type 4 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 472_496 | 0 | 776.0 | Zinc finger | C2H2-type 5 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 345_370 | 129 | 931.0 | Zinc finger | C2H2-type 1 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 379_406 | 129 | 931.0 | Zinc finger | C2H2-type 2%3B atypical |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 412_436 | 129 | 931.0 | Zinc finger | C2H2-type 3 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 442_466 | 129 | 931.0 | Zinc finger | C2H2-type 4 |
| Hgene | GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 472_496 | 129 | 931.0 | Zinc finger | C2H2-type 5 |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | 3 | 10 | 40_205 | 121 | 402.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | 3 | 10 | 40_205 | 121 | 402.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | 3 | 10 | 1_12 | 121 | 402.0 | Topological domain | Cytoplasmic | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | 3 | 10 | 36_401 | 121 | 402.0 | Topological domain | Lumenal | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | 3 | 10 | 1_12 | 121 | 402.0 | Topological domain | Cytoplasmic | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | 3 | 10 | 36_401 | 121 | 402.0 | Topological domain | Lumenal | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | 3 | 10 | 13_35 | 121 | 402.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein | |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | 3 | 10 | 13_35 | 121 | 402.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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Fusion Gene Sequence for GLIS3-GOLM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >33308_33308_1_GLIS3-GOLM1_GLIS3_chr9_4286038_ENST00000381971_GOLM1_chr9_88661487_ENST00000388711_length(transcript)=3494nt_BP=982nt CGGGACCCCCTGTACGCCGTCCGCGCCGTCCAGGGTCACACCGGCGACGGAACCCGCCGGCAGCAATTAGCCAGCATCCCGGGGTCGGCC CCCAGAAGCATTCCCCGGCCCAGGACGAGGATGAACAGGACAGGCGAGGCACAAAGTCGCAACTGAACTTTTTAGAAACATTATTTGTGT GTGTATGTGTGTAGCAGGGGAGAATGAGCTGATGCCGAGGGTCCAGCCACCCCGCCTCTGCCTCCTCCTCCCCCTGCCGCCGCTGCCCTC GCAGACGCGCGCGCACACACGGCACTTGGGCCGGGTTTCCGCGCTCCGTCCCCCCGTTTGGATGGGGGTTTTCATTTCCGAAGGAGGCAC AGCCCGCGGAGCGCTCTGAAGGGCTGGAGCCCCAAGTTACTCCTCGCCAGCGCCGGCCGCCCGCTGTCACTCGCGCTGGCCGGCCGGGGG AAGGGACCCGCACGCCGGGCTTTGTTGTGGAAATCCCGGTTACCTGGCTTATAACCCACACCATGGATAACTTATTGGACTTTGCCTGAA AGGAGTCATTAGTGACATTGGATATTTGACCGTCTTGGCCACAGGTTTTTCAGAATGAATGGAAGATCATGCAGCATGAGTCTCCACCGG ACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCCATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCC TGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTCAAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAAC AACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATGCTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAG GCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGAAGCCCTTTTCCTCCAAATCCTGGGAAAGACCAGTTA AAGACCCTGCAGAGGAATTACGGCAGGCTGCAGCAGGATGTCCTCCAGTTTCAGAAGAACCAGACCAACCTGGAGAGGAAGTTCTCCTAC GACCTGAGCCAGTGCATCAATCAGATGAAGGAGGTGAAGGAACAGTGTGAGGAGCGAATAGAAGAGGTCACCAAAAAGGGGAATGAAGCT GTAGCTTCCAGAGACCTGAGTGAAAACAACGACCAGAGACAGCAGCTCCAAGCCCTCAGTGAGCCTCAGCCCAGGCTGCAGGCAGCAGGC CTGCCACACACAGAGGTGCCACAAGGGAAGGGAAACGTGCTTGGTAACAGCAAGTCCCAGACACCAGCCCCCAGTTCCGAAGTGGTTTTG GATTCAAAGAGACAAGTTGAGAAAGAGGAAACCAATGAGATCCAGGTGGTGAATGAGGAGCCTCAGAGGGACAGGCTGCCGCAGGAGCCA GGCCGGGAGCAGGTGGTGGAAGACAGACCTGTAGGTGGAAGAGGCTTCGGGGGAGCCGGAGAACTGGGCCAGACCCCACAGGTGCAGGCT GCCCTGTCAGTGAGCCAGGAAAATCCAGAGATGGAGGGCCCTGAGCGAGACCAGCTTGTCATCCCCGACGGACAGGAGGAGGAGCAGGAA GCTGCCGGGGAAGGGAGAAACCAGCAGAAACTGAGAGGAGAAGATGACTACAACATGGATGAAAATGAAGCAGAATCTGAGACAGACAAG CAAGCAGCCCTGGCAGGGAATGACAGAAACATAGATGTTTTTAATGTTGAAGATCAGAAAAGAGACACCATAAATTTACTTGATCAGCGT GAAAAGCGGAATCATACACTCTGAATTGAACTGGAATCACATATTTCACAACAGGGCCGAAGAGATGACTATAAAATGTTCATGAGGGAC TGAATACTGAAAACTGTGAAATGTACTAAATAAAATGTACATCTGAAGATGATTATTGTGAAATTTTAGTATGCACTTTGTGTAGGAAAA AATGGAATGGTCTTTTAAACAGCTTTTGGGGGGTACTTTGGAAGTGTCTAATAAGGTGTCACAATTTTTGGTAGTAGGTATTTCGTGAGA AGTTCAACACCAAAACTGGAACATAGTTCTCCTTCAAGTGTTGGCGACAGCGGGGCTTCCTGATTCTGGAATATAACTTTGTGTAAATTA ACAGCCACCTATAGAAGAGTCCATCTGCTGTGAAGGAGAGACAGAGAACTCTGGGTTCCGTCGTCCTGTCCACGTGCTGTACCAAGTGCT GGTGCCAGCCTGTTACCTGTTCTCACTGAAAAGTCTGGCTAATGCTCTTGTGTAGTCACTTCTGATTCTGACAATCAATCAATCAATGGC CTAGAGCACTGACTGTTAACACAAACGTCACTAGCAAAGTAGCAACAGCTTTAAGTCTAAATACAAAGCTGTTCTGTGTGAGAATTTTTT AAAAGGCTACTTGTATAATAACCCTTGTCATTTTTAATGTACAAAACGCTATTAAGTGGCTTAGAATTTGAACATTTGTGGTCTTTATTT ACTTTGCTTCGTGTGTGGGCAAAGCAACATCTTCCCTAAATATATATTACCAAGAAAAGCAAGAAGCAGATTAGGTTTTTGACAAAACAA ACAGGCCAAAAGGGGGCTGACCTGGAGCAGAGCATGGTGAGAGGCAAGGCATGAGAGGGCAAGTTTGTTGTGGACAGATCTGTGCCTACT TTATTACTGGAGTAAAAGAAAACAAAGTTCATTGATGTCGAAGGATATATACAGTGTTAGAAATTAGGACTGTTTAGAAAAACAGGAATA CAATGGTTGTTTTTATCATAGTGTACACATTTAGCTTGTGGTAAATGACTCACAAAACTGATTTTAAAATCAAGTTAATGTGAATTTTGA AAATTACTACTTAATCCTAATTCACAATAACAATGGCATTAAGGTTTGACTTGAGTTGGTTCTTAGTATTATTTATGGTAAATAGGCTCT TACCACTTGCAAATAACTGGCCACATCATTAATGACTGACTTCCCAGTAAGGCTCTCTAAGGGGTAAGTAGGAGGATCCACAGGATTTGA GATGCTAAGGCCCCAGAGATCGTTTGATCCAACCCTCTTATTTTCAGAGGGGAAAATGGGGCCTAGAAGTTACAGAGCATCTAGCTGGTG CGCTGGCACCCCTGGCCTCACACAGACTCCCGAGTAGCTGGGACTACAGGCACACAGTCACTGAAGCAGGCCCTGTTTGCAATTCACGTT GCCACCTCCAACTTAAACATTCTTCATATGTGATGTCCTTAGTCACTAAGGTTAAACTTTCCCACCCAGAAAAGGCAACTTAGATAAAAT CTTAGAGTACTTTCATACTCTTCTAAGTCCTCTTCCAGCCTCACTTTGAGTCCTCCTTGGGGTTGATAGGAATTTTCTCTTGCTTTCTCA >33308_33308_1_GLIS3-GOLM1_GLIS3_chr9_4286038_ENST00000381971_GOLM1_chr9_88661487_ENST00000388711_length(amino acids)=409AA_BP=127 MNGRSCSMSLHRTSGTPQGPRMVSGHHIPAIRAHSGTPGPSPCGSTSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQM LTNGKPRFQVTQAGGMSGSHTLKPKQQEFGSPFPPNPGKDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEE RIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVN EEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYN -------------------------------------------------------------- >33308_33308_2_GLIS3-GOLM1_GLIS3_chr9_4286038_ENST00000381971_GOLM1_chr9_88661487_ENST00000388712_length(transcript)=3495nt_BP=982nt CGGGACCCCCTGTACGCCGTCCGCGCCGTCCAGGGTCACACCGGCGACGGAACCCGCCGGCAGCAATTAGCCAGCATCCCGGGGTCGGCC CCCAGAAGCATTCCCCGGCCCAGGACGAGGATGAACAGGACAGGCGAGGCACAAAGTCGCAACTGAACTTTTTAGAAACATTATTTGTGT GTGTATGTGTGTAGCAGGGGAGAATGAGCTGATGCCGAGGGTCCAGCCACCCCGCCTCTGCCTCCTCCTCCCCCTGCCGCCGCTGCCCTC GCAGACGCGCGCGCACACACGGCACTTGGGCCGGGTTTCCGCGCTCCGTCCCCCCGTTTGGATGGGGGTTTTCATTTCCGAAGGAGGCAC AGCCCGCGGAGCGCTCTGAAGGGCTGGAGCCCCAAGTTACTCCTCGCCAGCGCCGGCCGCCCGCTGTCACTCGCGCTGGCCGGCCGGGGG AAGGGACCCGCACGCCGGGCTTTGTTGTGGAAATCCCGGTTACCTGGCTTATAACCCACACCATGGATAACTTATTGGACTTTGCCTGAA AGGAGTCATTAGTGACATTGGATATTTGACCGTCTTGGCCACAGGTTTTTCAGAATGAATGGAAGATCATGCAGCATGAGTCTCCACCGG ACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCCATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCC TGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTCAAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAAC AACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATGCTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAG GCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGAAGCCCTTTTCCTCCAAATCCTGGGAAAGACCAGTTA AAGACCCTGCAGAGGAATTACGGCAGGCTGCAGCAGGATGTCCTCCAGTTTCAGAAGAACCAGACCAACCTGGAGAGGAAGTTCTCCTAC GACCTGAGCCAGTGCATCAATCAGATGAAGGAGGTGAAGGAACAGTGTGAGGAGCGAATAGAAGAGGTCACCAAAAAGGGGAATGAAGCT GTAGCTTCCAGAGACCTGAGTGAAAACAACGACCAGAGACAGCAGCTCCAAGCCCTCAGTGAGCCTCAGCCCAGGCTGCAGGCAGCAGGC CTGCCACACACAGAGGTGCCACAAGGGAAGGGAAACGTGCTTGGTAACAGCAAGTCCCAGACACCAGCCCCCAGTTCCGAAGTGGTTTTG GATTCAAAGAGACAAGTTGAGAAAGAGGAAACCAATGAGATCCAGGTGGTGAATGAGGAGCCTCAGAGGGACAGGCTGCCGCAGGAGCCA GGCCGGGAGCAGGTGGTGGAAGACAGACCTGTAGGTGGAAGAGGCTTCGGGGGAGCCGGAGAACTGGGCCAGACCCCACAGGTGCAGGCT GCCCTGTCAGTGAGCCAGGAAAATCCAGAGATGGAGGGCCCTGAGCGAGACCAGCTTGTCATCCCCGACGGACAGGAGGAGGAGCAGGAA GCTGCCGGGGAAGGGAGAAACCAGCAGAAACTGAGAGGAGAAGATGACTACAACATGGATGAAAATGAAGCAGAATCTGAGACAGACAAG CAAGCAGCCCTGGCAGGGAATGACAGAAACATAGATGTTTTTAATGTTGAAGATCAGAAAAGAGACACCATAAATTTACTTGATCAGCGT GAAAAGCGGAATCATACACTCTGAATTGAACTGGAATCACATATTTCACAACAGGGCCGAAGAGATGACTATAAAATGTTCATGAGGGAC TGAATACTGAAAACTGTGAAATGTACTAAATAAAATGTACATCTGAAGATGATTATTGTGAAATTTTAGTATGCACTTTGTGTAGGAAAA AATGGAATGGTCTTTTAAACAGCTTTTGGGGGGTACTTTGGAAGTGTCTAATAAGGTGTCACAATTTTTGGTAGTAGGTATTTCGTGAGA AGTTCAACACCAAAACTGGAACATAGTTCTCCTTCAAGTGTTGGCGACAGCGGGGCTTCCTGATTCTGGAATATAACTTTGTGTAAATTA ACAGCCACCTATAGAAGAGTCCATCTGCTGTGAAGGAGAGACAGAGAACTCTGGGTTCCGTCGTCCTGTCCACGTGCTGTACCAAGTGCT GGTGCCAGCCTGTTACCTGTTCTCACTGAAAAGTCTGGCTAATGCTCTTGTGTAGTCACTTCTGATTCTGACAATCAATCAATCAATGGC CTAGAGCACTGACTGTTAACACAAACGTCACTAGCAAAGTAGCAACAGCTTTAAGTCTAAATACAAAGCTGTTCTGTGTGAGAATTTTTT AAAAGGCTACTTGTATAATAACCCTTGTCATTTTTAATGTACAAAACGCTATTAAGTGGCTTAGAATTTGAACATTTGTGGTCTTTATTT ACTTTGCTTCGTGTGTGGGCAAAGCAACATCTTCCCTAAATATATATTACCAAGAAAAGCAAGAAGCAGATTAGGTTTTTGACAAAACAA ACAGGCCAAAAGGGGGCTGACCTGGAGCAGAGCATGGTGAGAGGCAAGGCATGAGAGGGCAAGTTTGTTGTGGACAGATCTGTGCCTACT TTATTACTGGAGTAAAAGAAAACAAAGTTCATTGATGTCGAAGGATATATACAGTGTTAGAAATTAGGACTGTTTAGAAAAACAGGAATA CAATGGTTGTTTTTATCATAGTGTACACATTTAGCTTGTGGTAAATGACTCACAAAACTGATTTTAAAATCAAGTTAATGTGAATTTTGA AAATTACTACTTAATCCTAATTCACAATAACAATGGCATTAAGGTTTGACTTGAGTTGGTTCTTAGTATTATTTATGGTAAATAGGCTCT TACCACTTGCAAATAACTGGCCACATCATTAATGACTGACTTCCCAGTAAGGCTCTCTAAGGGGTAAGTAGGAGGATCCACAGGATTTGA GATGCTAAGGCCCCAGAGATCGTTTGATCCAACCCTCTTATTTTCAGAGGGGAAAATGGGGCCTAGAAGTTACAGAGCATCTAGCTGGTG CGCTGGCACCCCTGGCCTCACACAGACTCCCGAGTAGCTGGGACTACAGGCACACAGTCACTGAAGCAGGCCCTGTTTGCAATTCACGTT GCCACCTCCAACTTAAACATTCTTCATATGTGATGTCCTTAGTCACTAAGGTTAAACTTTCCCACCCAGAAAAGGCAACTTAGATAAAAT CTTAGAGTACTTTCATACTCTTCTAAGTCCTCTTCCAGCCTCACTTTGAGTCCTCCTTGGGGTTGATAGGAATTTTCTCTTGCTTTCTCA >33308_33308_2_GLIS3-GOLM1_GLIS3_chr9_4286038_ENST00000381971_GOLM1_chr9_88661487_ENST00000388712_length(amino acids)=409AA_BP=127 MNGRSCSMSLHRTSGTPQGPRMVSGHHIPAIRAHSGTPGPSPCGSTSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQM LTNGKPRFQVTQAGGMSGSHTLKPKQQEFGSPFPPNPGKDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEE RIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVN EEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GLIS3-GOLM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GLIS3-GOLM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GLIS3-GOLM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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