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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLMN-FXYD5 (FusionGDB2 ID:33318)

Fusion Gene Summary for GLMN-FXYD5

check button Fusion gene summary
Fusion gene informationFusion gene name: GLMN-FXYD5
Fusion gene ID: 33318
HgeneTgene
Gene symbol

GLMN

FXYD5

Gene ID

11146

53827

Gene nameglomulin, FKBP associated proteinFXYD domain containing ion transport regulator 5
SynonymsFAP|FAP48|FAP68|FKBPAP|GLML|GVM|VMGLOMDYSAD|HSPC113|IWU1|KCT1|OIT2|PRO6241|RIC
Cytomap

1p22.1

19q13.12

Type of geneprotein-codingprotein-coding
DescriptionglomulinFK506-binding protein-associated proteinFKBP-associated proteinFXYD domain-containing ion transport regulator 5dysadherinkeratinocytes associated transmembrane protein 1
Modification date2020031320200313
UniProtAcc

Q92990

Q96DB9

Ensembl transtripts involved in fusion geneENST00000370360, ENST00000534881, 
ENST00000342879, ENST00000392217, 
ENST00000392219, ENST00000423817, 
ENST00000541435, ENST00000588699, 
ENST00000590686, ENST00000591716, 
ENST00000392218, ENST00000543307, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 5 X 4=80
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLMN [Title/Abstract] AND FXYD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLMN(92726599)-FXYD5(35660726), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLMN

GO:0007166

cell surface receptor signaling pathway

12604780

HgeneGLMN

GO:0008285

negative regulation of cell proliferation

12604780

HgeneGLMN

GO:0042130

negative regulation of T cell proliferation

12604780

HgeneGLMN

GO:0042327

positive regulation of phosphorylation

11571281

HgeneGLMN

GO:0045086

positive regulation of interleukin-2 biosynthetic process

12604780


check buttonFusion gene breakpoints across GLMN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FXYD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAV692154GLMNchr1

92726599

-FXYD5chr19

35660726

+


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Fusion Gene ORF analysis for GLMN-FXYD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000370360ENST00000342879GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000392217GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000392219GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000423817GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000541435GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000588699GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000590686GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000591716GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000342879GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000392217GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000392219GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000423817GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000541435GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000588699GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000590686GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000591716GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000370360ENST00000392218GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000370360ENST00000543307GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000534881ENST00000392218GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000534881ENST00000543307GLMNchr1

92726599

-FXYD5chr19

35660726

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GLMN-FXYD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GLMN-FXYD5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:92726599/:35660726)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLMN

Q92990

FXYD5

Q96DB9

FUNCTION: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). {ECO:0000250|UniProtKB:Q8BZM1, ECO:0000269|PubMed:11571281, ECO:0000269|PubMed:11845407, ECO:0000269|PubMed:22405651, ECO:0000269|PubMed:22748924}.FUNCTION: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. {ECO:0000269|PubMed:11756660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GLMN-FXYD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GLMN-FXYD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLMN-FXYD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLMN-FXYD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource