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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLRX-GLRX (FusionGDB2 ID:33351)

Fusion Gene Summary for GLRX-GLRX

check button Fusion gene summary
Fusion gene informationFusion gene name: GLRX-GLRX
Fusion gene ID: 33351
HgeneTgene
Gene symbol

GLRX

GLRX

Gene ID

2745

2745

Gene nameglutaredoxinglutaredoxin
SynonymsGRX|GRX1GRX|GRX1
Cytomap

5q15

5q15

Type of geneprotein-codingprotein-coding
Descriptionglutaredoxin-1TTase-1thioltransferasethioltransferase-1glutaredoxin-1TTase-1thioltransferasethioltransferase-1
Modification date2020031320200313
UniProtAcc

P35754

O76003

Ensembl transtripts involved in fusion geneENST00000237858, ENST00000379979, 
ENST00000505427, ENST00000507605, 
ENST00000508780, ENST00000512469, 
ENST00000237858, ENST00000379979, 
ENST00000505427, ENST00000507605, 
ENST00000508780, ENST00000512469, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: GLRX [Title/Abstract] AND GLRX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLRX(95149735)-GLRX(95149888), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLRX

GO:0045838

positive regulation of membrane potential

19542013

HgeneGLRX

GO:2000651

positive regulation of sodium ion transmembrane transporter activity

19542013

TgeneGLRX

GO:0045838

positive regulation of membrane potential

19542013

TgeneGLRX

GO:2000651

positive regulation of sodium ion transmembrane transporter activity

19542013


check buttonFusion gene breakpoints across GLRX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GLRX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABU674954GLRXchr5

95149735

+GLRXchr5

95149888

-


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Fusion Gene ORF analysis for GLRX-GLRX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000237858ENST00000237858GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000237858ENST00000379979GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000379979ENST00000237858GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000379979ENST00000379979GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000505427ENST00000237858GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000505427ENST00000379979GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000507605ENST00000237858GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000507605ENST00000379979GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000508780ENST00000237858GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000508780ENST00000379979GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000512469ENST00000237858GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-3UTRENST00000512469ENST00000379979GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000237858ENST00000505427GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000237858ENST00000507605GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000237858ENST00000508780GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000237858ENST00000512469GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000379979ENST00000505427GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000379979ENST00000507605GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000379979ENST00000508780GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000379979ENST00000512469GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000505427ENST00000505427GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000505427ENST00000507605GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000505427ENST00000508780GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000505427ENST00000512469GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000507605ENST00000505427GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000507605ENST00000507605GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000507605ENST00000508780GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000507605ENST00000512469GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000508780ENST00000505427GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000508780ENST00000507605GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000508780ENST00000508780GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000508780ENST00000512469GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000512469ENST00000505427GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000512469ENST00000507605GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000512469ENST00000508780GLRXchr5

95149735

+GLRXchr5

95149888

-
intron-intronENST00000512469ENST00000512469GLRXchr5

95149735

+GLRXchr5

95149888

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GLRX-GLRX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GLRX-GLRX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:95149735/:95149888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLRX

P35754

GLRX

O76003

FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.FUNCTION: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GLRX-GLRX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GLRX-GLRX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLRX-GLRX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GLRX-GLRX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource