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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP2-AGTPBP1 (FusionGDB2 ID:3343)

Fusion Gene Summary for AKAP2-AGTPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP2-AGTPBP1
Fusion gene ID: 3343
HgeneTgene
Gene symbol

AKAP2

AGTPBP1

Gene ID

445815

23287

Gene namePALM2 and AKAP2 fusionATP/GTP binding protein 1
SynonymsAKAP-2|AKAP-KL|AKAP2|AKAPKL|MISP2|PALM2|PALM2-AKAP2|PRKA2CCP1|CONDCA|NNA1
Cytomap

9q31.3

9q21.33

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 2PALM2-AKAP2 proteinparalemmin-2A kinase (PRKA) anchor protein 2A-kinase anchoring protein 2PALM2-AKAP2 fusionPALM2-AKAP2 readthroughparalemmin 2protein kinase A anchoring protein 2protein kinase A2cytosolic carboxypeptidase 1carboxypeptidase-tubulinnervous system nuclear protein induced by axotomy protein 1 homologsoluble carboxypeptidasetubulinyl-Tyr carboxypeptidasetyrosine carboxypeptidase
Modification date2020031320200313
UniProtAcc

Q9Y2D5

Q9UPW5

Ensembl transtripts involved in fusion geneENST00000374525, ENST00000434623, 
ENST00000259318, ENST00000482335, 
ENST00000510514, ENST00000555236, 
ENST00000337006, ENST00000357081, 
ENST00000376081, ENST00000376083, 
ENST00000376080, ENST00000376109, 
ENST00000432218, ENST00000491784, 
Fusion gene scores* DoF score3 X 3 X 2=1813 X 9 X 7=819
# samples 413
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/819*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP2 [Title/Abstract] AND AGTPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP2(112811135)-AGTPBP1(88327481), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AKAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AGTPBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-K1-A6RU-01AAKAP2chr9

112811135

-AGTPBP1chr9

88327481

-
ChimerDB4SARCTCGA-K1-A6RU-01AAKAP2chr9

112811135

+AGTPBP1chr9

88327481

-


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Fusion Gene ORF analysis for AKAP2-AGTPBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000374525ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AKAP2-AGTPBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP2-AGTPBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:112811135/:88327481)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP2

Q9Y2D5

AGTPBP1

Q9UPW5

FUNCTION: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity). {ECO:0000250}.FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins (PubMed:30420557). Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q641K1, ECO:0000269|PubMed:30420557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AKAP2-AGTPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AKAP2-AGTPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP2-AGTPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP2-AGTPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource