Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GMCL1-MXD1 (FusionGDB2 ID:33440)

Fusion Gene Summary for GMCL1-MXD1

Fusion gene summary

Fusion gene information	Fusion gene name: GMCL1-MXD1
	Fusion gene ID: 33440
		Hgene	Tgene
	Gene symbol	GMCL1	MXD1
	Gene ID	64395	4084
	Gene name	germ cell-less 1, spermatogenesis associated	MAX dimerization protein 1
	Synonyms	BTBD13\|GCL\|GCL1\|SPATA29	BHLHC58\|MAD\|MAD1
	Cytomap	2p13.3	2p13.3
	Type of gene	protein-coding	protein-coding
	Description	germ cell-less protein-like 1germ cell-less homolog 1germ cell-less, spermatogenesis associated 1spermatogenesis associated 29	max dimerization protein 1MAX-binding proteinantagonizer of myc transcriptional activitymax dimerizer 1
	Modification date	20200327	20200313
	UniProtAcc	Q96IK5	Q05195
	Ensembl transtripts involved in fusion gene	ENST00000468386, ENST00000282570,	ENST00000264444, ENST00000540449, ENST00000465446,
Fusion gene scores	* DoF score	5 X 3 X 5=75	2 X 2 X 2=8
	# samples	5	2
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: GMCL1 [Title/Abstract] AND MXD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GMCL1(70057284)-MXD1(70162483), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MXD1	GO:0000122	negative regulation of transcription by RNA polymerase II	10723141\|12837246

Fusion gene breakpoints across GMCL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MXD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-BT-A42C-01A	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+

Top

Fusion Gene ORF analysis for GMCL1-MXD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000468386	ENST00000264444	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+
3UTR-3CDS	ENST00000468386	ENST00000540449	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+
3UTR-intron	ENST00000468386	ENST00000465446	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+
5CDS-intron	ENST00000282570	ENST00000465446	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+
In-frame	ENST00000282570	ENST00000264444	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+
In-frame	ENST00000282570	ENST00000540449	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000282570

GMCL1

chr2

70057284

ENST00000264444

MXD1

chr2

70162483

5635

511

251

973

240

ENST00000282570

GMCL1

chr2

70057284

ENST00000540449

MXD1

chr2

70162483

1007

511

251

973

240

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000282570	ENST00000264444	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+	0.002202794	0.99779725
ENST00000282570	ENST00000540449	GMCL1	chr2	70057284	+	MXD1	chr2	70162483	+	0.009285036	0.990715

Top

Fusion Genomic Features for GMCL1-MXD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GMCL1	chr2	70057284	+	MXD1	chr2	70162482	+	6.31E-05	0.9999368
GMCL1	chr2	70057284	+	MXD1	chr2	70162482	+	6.31E-05	0.9999368

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GMCL1-MXD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:70057284/chr2:70162483)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GMCL1 Q96IK5	MXD1 Q05195
FUNCTION: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). {ECO:0000250}.	FUNCTION: Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). {ECO:0000269\|PubMed:12837246, ECO:0000269\|PubMed:8425218}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GMCL1

chr2:70057284

chr2:70162483

ENST00000282570

49_55

516.0

Motif

Nuclear localization signal

Tgene

MXD1

chr2:70057284

chr2:70162483

ENST00000540449

56_108

212.0

Domain

bHLH

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GMCL1

chr2:70057284

chr2:70162483

ENST00000282570

108_178

516.0

Domain

BTB

Hgene

GMCL1

chr2:70057284

chr2:70162483

ENST00000282570

85_91

516.0

Motif

Nuclear localization signal

Tgene

MXD1

chr2:70057284

chr2:70162483

ENST00000264444

56_108

222.0

Domain

bHLH

Tgene

MXD1

chr2:70057284

chr2:70162483

ENST00000264444

21_49

222.0

Motif

Nuclear localization signal

Tgene

MXD1

chr2:70057284

chr2:70162483

ENST00000540449

21_49

212.0

Motif

Nuclear localization signal

Top

Fusion Gene Sequence for GMCL1-MXD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33440_33440_1_GMCL1-MXD1_GMCL1_chr2_70057284_ENST00000282570_MXD1_chr2_70162483_ENST00000264444_length(transcript)=5635nt_BP=511nt
ATGCGCCCTCCGTCCCGCGCTTTGTTGCGAAAGCGAGGGGGCGAGGTGCTGCGGTGCTAGAGCGCGGCGCGACCGGACGCTGCGGGCGGG
GAAGAGGATGGAGACTGTGGCGTCCGCTGCAACGGTTGGGGCTGCGCGTGAGAAGGTGGCGGTGTAGGCACCTGCGCTCGGGGAAGGCTG
GCGGCGGCGGCCGAGCCATGGCGGGAGACCCCCTTCTCTGGGCTCCCTGAAGTCTCGGGGAGCCGTGACCCATGGGATCGTTGAGCAGCC
GGGTGCTGCGCCAGCCAAGACCAGCCCTTGCCCAGCAGGCGCAGGGTGCCAGGGCGGGGGGCTCGGCCCGGAGGCCGGACACTGGAGACG
ATGCGGCGGGCCACGGATTCTGTTACTGTGCGGGCAGCCACAAGCGCAAGCGGAGCAGCGGGTCCTTCTGCTACTGTCACCCTGACTCGG
AGACGGACGAGGATGAGGAGGAGGGGGACGAGCAGCAGCGGCTCCTCAACACCCCTCGAAGACGGGCTCATCTTCGCTTGTGCCTGGAGA
AGTTGAAGGGGCTGGTGCCACTTGGACCCGAATCAAGTCGACACACTACGTTGAGTTTATTAACAAAAGCCAAATTGCACATAAAGAAAC
TTGAAGATTGTGACAGAAAAGCCGTTCACCAAATCGACCAGCTTCAGCGAGAGCAGCGACACCTGAAGAGGCAGCTGGAGAAGCTGGGCA
TTGAGAGGATCCGGATGGACAGCATCGGCTCCACCGTCTCCTCGGAGCGCTCCGACTCCGACAGGGAAGAAATCGACGTTGACGTGGAGA
GCACGGACTATCTCACAGGTGATCTGGACTGGAGCAGCAGCAGTGTGAGCGACTCTGACGAGCGGGGCAGCATGCAGAGCCTCGGCAGTG
ATGAGGGCTATTCCAGCACCAGCATCAAGAGAATAAAGCTGCAGGACAGTCACAAGGCGTGTCTTGGTCTCTAAGAGAGTGGGCACTGCG
GCTGTCTCCTTGAAGGTTCTCCCTGTTGGTTCTGATTAGGTAACGTATTGGACCTGCCCACAACTCCCTTGCACGTAAACTTCAGTGTCC
CACCTTGACCAAAATCAGCTTTGTAACTGTTTTCAAGGAGGTGCTTAGGATTGTGGGTTTCTGATTGCATCCACTAGCTTCTCTTTTTCT
CGCCATAAAAATTTGTCTCTGAGAGACTATACATTCCAATCAATTTGAAGCATCCAAGAATTCTTAGACCGAATAAGCAATGTCCACATC
TCAGCAATCCCCCTCTTTGCTCTCCTCGTGTCCTCTCCCAGACCTTTCTTCCAGTTTTCTGGCTTACTGTGTTACTTGCCTAGGAGGAAT
GTCCAAGTGTGTCTTGTACTTAGGAAACTGAAGGAAACAAACTTTTGAAATTGAGATCCTGATCTCAGAACTCCAAAGTAAGCTTTGAAA
GCAGCATTTAAGAGCACTTAACCATGGACCTCACCACCAGTGAGGAAGTCAGGAATACCTCTAGAAAACACGCCCTTCACACCGCGCATG
CTCATTCCCCCGACGCGCCGCGTGTGGATGGGAGCAGTATTTCTCACTTTAAAATGGACACCTTGATAGTGTGTCTCTGGGGTTGCACAG
CTCATCAAAGTTCCAAATTGTTTGTTCTCACAAACAAAACGGTACAATCTATTTTTGTGCGATGTTCTTGGGACCTCGCTGTGTTCTGCT
ATCTCGAGGCACATTCTCCCCTCCAACTTTGTTAATGCTACTTGTCTCTGGAACATTTTTTTTTCCTACCTCAGAGATAAATGAGATCTC
CATTTCCCACTTAACACAGTGATTATCCTTTTTTCCCCCCCCAAAATAGTGACATTTGGTCCAATTATAATCTATTTTCCTATTGAACTT
TCAGCAATAACTGAGCTGTGGCACTAGCAGAGCTAGTAGCCATTATCAGTGAAAGAAAAAGTCCACATTTCTACTCTCTGTTGCAGGTGA
ACAGGAGAGGATGGTACACTGTTACTAGAACTCCTCTCCTTATTGATTATTTTTGGACACACCCAGAAACTTCTTTATGGAGGCTTTTGG
GTTGATAGTTTAAAAGGCTGATTTTTCTTTTTGGTTATGATTTCTCCCTTAAGTGGTCTCCGACTTTGTAGCATTTTTATTTAAGCTAAA
ACAGAGCACATGTATATGTACATAAGACACATTAAATCTATAAATACTATTTATTCATTTTATATAAACTAATGTAATGGAAAACAAATT
CTTATGACTTTGTGGTTTTATAGATGTTCTAGAAACTTTGTATGTAGGTATCTACAAAATTAGTTCATTCCCCTGAATATTTTTGCATTC
ATATTTTTGAGGTCTTGATGTTTTCAGCCTCTGGCGAATCTTTTTCATTGAATTTGAACCATTTGTAAAATCTGTGATGCTGAAGCAGAG
TGTGTCACAAAGTGATGAGAACATTACTAAAATCCACGGACGCACTGCGACCTAAGGGCTCAACGGCTGACTCGGCAGCGGGCAGCCACC
CCACGCTCCCCTGCGGTCACTCGCACACCACAGCCTGAAGCTCCCCCAGCGCCTGCACCTCGCACACAGCTAAGGTCAAAGTTCAAACGC
ACTCCACACGGAAGCTCATTCTATACCCGAAGAGCAGTCTCAGAAAGCAAGATTACTTTTGTGTTTTTTAAAAAATGATTCTTTAATGTA
TTTTTCTAAACATTCTGATTGGAAGTAGTGGATTCCTAAATGATTCCAAAGTCACCTGTAATTCTTCTGTTTTTGTTTTGTTCTGTCTTT
TCTTCATTTTGGCTTTGGGTGGGGGGAGGGGCAGGTGACACAAAGGATTTTTTTTTTTTTTTTTTAATTTTTGGAATCTTTTCCAATAAC
CAGCTAAAGATTTGCACTGAAATACAACTTGTATGCCTTTTGCATTTTTAAAGCCTGCTTCCTGGATTTAAGCAGAGTGATAGTGTTCAA
AGAGCCAGTTCAGCCTGTAACATATTTGAAAAAGATATGTCTGCACTTTGAGGTCCCTTTTGAATGCCATTCACTAGACCTCTCAAGCAT
TTTGTTTCATTGCTACATCCAAGCGCCTCACAAGTCCACAATGCGGGACAGCATCAAAAGCTCAAGACTTTGGAAAAAGCTTGTGGGCTT
GCACTGGGGGAGGGAAGGGAACAAAATTTGTGTACTTCTTTGTTTAATTTAGAAATAAGGCATCCAAGAGATGCCATTATTTTCTGTGTT
TCAATTGTTGTGCCTTTGAGTTAAACTGCATTTTTGTCTTTTGGTTGAAATCTGAAATGTACTGTCCCAATATAAAACAGTAATTATTTG
ACCTTTGCACTGTTTGTCTGGTCCTTTTCAGTTTGATTGCATATAAATGTGGAACTTGATAGATCTCTATATTTTTAATGCACTTGTGAT
AAACTGGCAGCAGGGTTAGACATTACTTTCAAAGCTTGAGGTAGACCGAGTCAGCATGCTAGACAGGCTTCTCTCTCTAACCAAAACTGT
AATCTTCAGGACCAGCAAACTCAGCCCAAGGCAGCTAATCCCCCCAACCCCATCCTCCGCGCCCCGTGCGGCTGATCGGCAGCCCTGATT
CGCCAATTTGTCCTCTCTCATTCACTGATCCACCAGCCTGACTGCTAAGAGCTATAGTCTTTTTAGTTGTTTTGTCTTTTTAAGCAAGAT
GAAAACCTTTCTATTAGGGATTTTGGGGTTGGGAGGGGATGGGCAGAGATATAAACCCCAGCCTTTAAGACTTTGACAATTGTACGTAAA
TACAGATGTGTATAAATATAGGCACATGCATATTTTTATGTGAAAGTTGATTTTAAAAAACTAAAAAAATCTAAACTGCACTCTTATTGA
TACCATCATAACGCAAGTGGGAAAAATAAGAGTACGCAGTCTAATTTAATTTCATGCAGTGGGAAAATATATATGTGTGCTTCTGTAACA
TCCTGAAAACATAGCTTTCCATCCCCTGTTGGCTTTGAATGGTGGGCCGAGCACCCAGGTCGTCTGTATTTTGGTTTTCTTTTGCTAAGC
AGAGATCTTGAATTCTTCAAGGTGCTGATAGCAACTGCTGGCTCCTTTCTGTAGTCACACACCTAATGCTAGTTTAGTGATTCAAAATGC
ATCACATTTTTAGGCAGGACCTAGATTTTCCCTGTCAACCTAAGATGAAAATAATTTCAGTGTTGATTCAGAACTGAACATTAAGTAGGC
CCTCGTCCTGCAGTTGGCCACTTGAGTGTTTTGTTTTGTTTTTATTTTTTAAGGTGGGCATTTTCCTTTAACCTCTACTTTTTCAAAAGC
AACAAAGGGGCCTCAACCTGAGTTTCCTATGGGCCTCTCTTCTGCATCCCCAAAGCGGCCAAGAGCAAATCCTGGGGGATAAGAAAAAAG
TGTAAACTAGGTAGGATTGTGATGCTCAAAATAACCATCTAGCAATATCTTGGAGCTTGAGAATAGATTTTGTGGGCTTATTTCTTCTTG
CCTCTTCCCCATCCTTTCAAGAGAGAACTTATTTTTGAAAAGTATCTATATATACACACACACACACACACACACATATTATTATTTAGG
TTTTTATACCATACTGTATTGGCGAGAATACCACTATCATTGTCCTTTACAGTCTATTTCTTCCCCCAAGTCTTGGTCTTTTTTTATTTT
CTATTTTTTCATGAACCACACAGGAGACTTTAACATCCTGGTCTTTTCTGTTTCTTCTTTGTTTCCCCAAGTTTGTCTGTCCCCCTTTGC
CTTCCCTGAGTGTTGAACATCAGGTAGTAAAAGGCTAAACGCAATTTCTTGCATGTCAATCTATTCTTTTTCTATGTTTGACTCTGATGC
AGTGTGTTTAGCGTGTCTAGTAGCTGGCTACTCCTATTTAAAAACTCTTCCTGGTAGAAGACAACCCAAAGACCCTTTTCGATGAGGTGG
TTTCTCATTCTACATCCTCTGATCTCTATAGACTGTAGGATGCTTTGCTTTCAAAGATAACTGGGTTAGAGGGTGGGGTGTGCAATAGGT
GATTTATCATGGTTTTTTTCATTATCAATATTACATGGATGATTTTCTCAGATTCTTCTGAAAGAAGAAATTGACAGGCACTGCTAGATT
CAGCTATTGAATGGCTGAAGAGATTGAGTATTTGACCTTCTCTCAAAATCATAAAGTGAGAATTCATAAGGCACCCAATGTTAAGATTTA
TCCAGATTTTTACATTTTGATTTCTTCTCTCTGTGGGGTGGCAAGTTGAGGGAGCATTCTTCATTTTAGCTTTTACCTGACAACCAAACT
TGCCTTTACCCCATCCCTAGAATTGGTGCTCTTGGAATATTGCTGTTACCATCATTTTTGGGGGGCCATCTTCCTAATGCTACACACAGC
CTGACAGGGGAGCAGCAGATGAAAGGGTATGCTATTCTGTTTCCAGATGTTTCTTTATGTAAATATGACGCCAATGTAAATCCTGTGTCA
AGATCATAGAGAATGGTGCTTTTTACTACAGTTAGCACATGCATTTTTAGAAACTACTACATGTTTTAGAGAATCTTTGCTGTGTATATG

>33440_33440_1_GMCL1-MXD1_GMCL1_chr2_70057284_ENST00000282570_MXD1_chr2_70162483_ENST00000264444_length(amino acids)=240AA_BP=0
MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFCYCAGSHKRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRRAH
LRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREE

--------------------------------------------------------------
>33440_33440_2_GMCL1-MXD1_GMCL1_chr2_70057284_ENST00000282570_MXD1_chr2_70162483_ENST00000540449_length(transcript)=1007nt_BP=511nt
ATGCGCCCTCCGTCCCGCGCTTTGTTGCGAAAGCGAGGGGGCGAGGTGCTGCGGTGCTAGAGCGCGGCGCGACCGGACGCTGCGGGCGGG
GAAGAGGATGGAGACTGTGGCGTCCGCTGCAACGGTTGGGGCTGCGCGTGAGAAGGTGGCGGTGTAGGCACCTGCGCTCGGGGAAGGCTG
GCGGCGGCGGCCGAGCCATGGCGGGAGACCCCCTTCTCTGGGCTCCCTGAAGTCTCGGGGAGCCGTGACCCATGGGATCGTTGAGCAGCC
GGGTGCTGCGCCAGCCAAGACCAGCCCTTGCCCAGCAGGCGCAGGGTGCCAGGGCGGGGGGCTCGGCCCGGAGGCCGGACACTGGAGACG
ATGCGGCGGGCCACGGATTCTGTTACTGTGCGGGCAGCCACAAGCGCAAGCGGAGCAGCGGGTCCTTCTGCTACTGTCACCCTGACTCGG
AGACGGACGAGGATGAGGAGGAGGGGGACGAGCAGCAGCGGCTCCTCAACACCCCTCGAAGACGGGCTCATCTTCGCTTGTGCCTGGAGA
AGTTGAAGGGGCTGGTGCCACTTGGACCCGAATCAAGTCGACACACTACGTTGAGTTTATTAACAAAAGCCAAATTGCACATAAAGAAAC
TTGAAGATTGTGACAGAAAAGCCGTTCACCAAATCGACCAGCTTCAGCGAGAGCAGCGACACCTGAAGAGGCAGCTGGAGAAGCTGGGCA
TTGAGAGGATCCGGATGGACAGCATCGGCTCCACCGTCTCCTCGGAGCGCTCCGACTCCGACAGGGAAGAAATCGACGTTGACGTGGAGA
GCACGGACTATCTCACAGGTGATCTGGACTGGAGCAGCAGCAGTGTGAGCGACTCTGACGAGCGGGGCAGCATGCAGAGCCTCGGCAGTG
ATGAGGGCTATTCCAGCACCAGCATCAAGAGAATAAAGCTGCAGGACAGTCACAAGGCGTGTCTTGGTCTCTAAGAGAGTGGGCACTGCG

>33440_33440_2_GMCL1-MXD1_GMCL1_chr2_70057284_ENST00000282570_MXD1_chr2_70162483_ENST00000540449_length(amino acids)=240AA_BP=0
MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFCYCAGSHKRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRRAH
LRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GMCL1-MXD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GMCL1-MXD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GMCL1-MXD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source