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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GMDS-EXOC2 (FusionGDB2 ID:33457)

Fusion Gene Summary for GMDS-EXOC2

check button Fusion gene summary
Fusion gene informationFusion gene name: GMDS-EXOC2
Fusion gene ID: 33457
HgeneTgene
Gene symbol

GMDS

EXOC2

Gene ID

2762

55770

Gene nameGDP-mannose 4,6-dehydrataseexocyst complex component 2
SynonymsGMD|SDR3E1SEC5|SEC5L1|Sec5p
Cytomap

6p25.3

6p25.3

Type of geneprotein-codingprotein-coding
DescriptionGDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1exocyst complex component 2SEC5-like 1exocyst complex component Sec5
Modification date2020031320200313
UniProtAcc.

Q96KP1

Ensembl transtripts involved in fusion geneENST00000380815, ENST00000530927, 
ENST00000467288, 		ENST00000475028, 
ENST00000230449, ENST00000448181, 
Fusion gene scores* DoF score28 X 19 X 15=79806 X 6 X 6=216
# samples 326
** MAII scorelog2(32/7980*10)=-4.64024493622235
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GMDS [Title/Abstract] AND EXOC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEXOC2(572520)-GMDS(1742820), # samples:2
GMDS(1726650)-EXOC2(556564), # samples:2
Anticipated loss of major functional domain due to fusion event.EXOC2-GMDS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EXOC2-GMDS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMDS

GO:0019673

GDP-mannose metabolic process

9525924

HgeneGMDS

GO:0042351

'de novo' GDP-L-fucose biosynthetic process

9525924


check buttonFusion gene breakpoints across GMDS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BU-01AGMDSchr6

1726650

-EXOC2chr6

556564

-
ChimerDB4SARCTCGA-DX-AB2J-01AGMDSchr6

1726650

-EXOC2chr6

556564

-


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Fusion Gene ORF analysis for GMDS-EXOC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000380815ENST00000475028GMDSchr6

1726650

-EXOC2chr6

556564

-
5CDS-intronENST00000530927ENST00000475028GMDSchr6

1726650

-EXOC2chr6

556564

-
In-frameENST00000380815ENST00000230449GMDSchr6

1726650

-EXOC2chr6

556564

-
In-frameENST00000380815ENST00000448181GMDSchr6

1726650

-EXOC2chr6

556564

-
In-frameENST00000530927ENST00000230449GMDSchr6

1726650

-EXOC2chr6

556564

-
In-frameENST00000530927ENST00000448181GMDSchr6

1726650

-EXOC2chr6

556564

-
intron-3CDSENST00000467288ENST00000230449GMDSchr6

1726650

-EXOC2chr6

556564

-
intron-3CDSENST00000467288ENST00000448181GMDSchr6

1726650

-EXOC2chr6

556564

-
intron-intronENST00000467288ENST00000475028GMDSchr6

1726650

-EXOC2chr6

556564

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000530927GMDSchr61726650-ENST00000230449EXOC2chr6556564-3407945481868606
ENST00000530927GMDSchr61726650-ENST00000448181EXOC2chr6556564-2022945481868606
ENST00000380815GMDSchr61726650-ENST00000230449EXOC2chr6556564-37191257422180712
ENST00000380815GMDSchr61726650-ENST00000448181EXOC2chr6556564-23341257422180712

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000530927ENST00000230449GMDSchr61726650-EXOC2chr6556564-0.0002996120.9997004
ENST00000530927ENST00000448181GMDSchr61726650-EXOC2chr6556564-0.000831580.9991684
ENST00000380815ENST00000230449GMDSchr61726650-EXOC2chr6556564-0.000428770.99957126
ENST00000380815ENST00000448181GMDSchr61726650-EXOC2chr6556564-0.0014203480.9985796

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Fusion Genomic Features for GMDS-EXOC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GMDS-EXOC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:572520/chr6:1742820)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EXOC2

Q96KP1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGMDSchr6:1726650chr6:556564ENST00000380815-911108_112329373.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000380815-91130_35329373.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000380815-91155_58329373.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000380815-91186_87329373.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000530927-911108_112299343.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000530927-91130_35299343.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000530927-91155_58299343.0Nucleotide bindingNADP
HgeneGMDSchr6:1726650chr6:556564ENST00000530927-91186_87299343.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEXOC2chr6:1726650chr6:556564ENST000002304491628240_260617925.0Coiled coilOntology_term=ECO:0000255
TgeneEXOC2chr6:1726650chr6:556564ENST0000023044916288_93617925.0DomainNote=IPT/TIG


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Fusion Gene Sequence for GMDS-EXOC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33457_33457_1_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000380815_EXOC2_chr6_556564_ENST00000230449_length(transcript)=3719nt_BP=1257nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT
ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTC
TACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAG
AGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGAC
TTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGCCA
TGTCAGTTTGAACAGTGCATCGTGTGTTCTCTGCAGTCACTGAAGGGGGTTCTGGAGTGCAAGCCGGGAGAGGCCAGTGTCTTCCAACAA
CCTAAAACACAGGAGGAGGTTTGCCAGCTAAGCATCAATATAATGCAGGTTTTTATATACTGTCTGGAACAGTTGAGCACCAAGCCTGAT
GCAGATATAGATACTACACATCTCTCTGTTGATGTTTCTTCCCCTGACTTGTTTGGAAGTATCCATGAAGACTTCAGCTTGACCTCAGAA
CAGCGCCTTTTGATAGTCCTAAGTAATTGCTGCTATCTAGAACGTCACACCTTCCTAAATATCGCAGAACATTTTGAAAAGCACAACTTC
CAGGGAATAGAAAAAATCACACAGGTTAGCATGGCCTCATTGAAAGAACTAGATCAAAGACTCTTTGAAAATTACATCGAGTTGAAAGCA
GATCCCATCGTTGGCTCCTTAGAACCTGGAATTTATGCAGGATATTTTGATTGGAAGGACTGCCTGCCTCCAACAGGTGTCAGAAACTAT
TTAAAAGAAGCACTGGTGAATATAATTGCCGTGCATGCAGAGGTGTTCACCATTTCCAAAGAACTGGTCCCTCGGGTACTATCCAAGGTG
ATAGAAGCAGTTTCTGAAGAGCTCAGTCGACTGATGCAGTGTGTTTCATCCTTCAGCAAAAATGGAGCTTTACAGGCGAGACTTGAAATC
TGTGCTTTGAGGGACACTGTGGCTGTTTACCTGACACCCGAAAGCAAGTCAAGTTTTAAGCAGGCTTTGGAAGCCCTGCCCCAGCTTTCC
AGTGGAGCAGATAAAAAGTTACTGGAAGAGCTCCTGAACAAGTTCAAGAGTAGCATGCACTTGCAGCTCACCTGTTTCCAAGCAGCTTCT
TCAACCATGATGAAAACATAAATATCTGCCACATAAAAGAAGTCCAGGAAAATAACACGTAATAAGACTGTTCACTCTCTAAGTACCCTA
AAGGTATTTGGTGTATTAAACATTGGGTTTGCCATTTTTCTCTTTTTTCTTCCTCTGACTTCGAAAATTGTTGGTATACATTTCAACCAA
AATGACCTCATTTGAAATGCCCAGGAAGTATTTGTTTTGCCATTCTTACTAGATCAGATCCTGTATGACTTTAAAATACATTTTAAAATA
TATTTTGCATCTCAGCAGAAGGTTGAGTGCTGCAGGAAGAGCTGCTTCTGCAGGGAGTTTTCTGGAATGGCGTGGCACATATTGAAGCAT
TTCTCAGTGTCCCGTTCACGGAAGCGCAGGCAGCTCCCACGACACACGGAGAGACTGACTGATACGAGATTTGGAAAGCTATGTAGACAT
CTTTGGAGCTCTTACTGTCCTAAACTGTACAGCTGTGCTTAAAACCCTCATTTCATATAAATGGCCTTAAGTTTTCTAATTCAAGCGGGT
TTTTGGAAAAATTTATGGTCTCCATTAAAATACATATTACAACTGGGGTAGATTATTTGTGGTCCAGGTGTCTGTGATTTAACTTTGCGT
TTTGCTATCTGATTTTTATTTTTCACAGGGCTAAGCATGAGCTTTCATTCTCACTCACTCTTAATTTGTCGTGCGTCACTACACATGCAC
GTGTTGCAGTCCCTGAGGCCCTGTGTGTTATCTGTGATGGAGTGTGAATGTGTAACGGGCACTGTGTTACACTCTGAGGTGTTGGCGGGG
CGGTCGCAGACTTCAGGGTCCCCTAACGGAAAGGCCAGGCTCCGCGTGGACGGCCAACTCCCTGCCCGCTCCTTCAGCAGGTGACTGTCT
CTGCCACTTCTTACCTGCTGAAGGATCTTGCTCAGTAGCTGGAACAATGCTGCTGTCACACAGTCTCTTCTCTGAAACTTCAGGATGCTC
CTTGGTCACCAGGCAATGGGAGCTGTAGACCAGCCGCATGCACTTGCCCCACATTCACTGCTGACTGGCTTCACTGGAATAGGTTCAGGT
CACCGGGACTTCTCTCAGAGTCAGCGGCCCACCCAACTCCCTCATACCGTCGCATCTGAAAATTTTCAGAGAGGAATTCTCTTTGTAGTC
GGCTTGTCAGGGTTTTCAAGTTTTTCTATGGTTATTTTTAAATCTCTTTTTTTAAATGCTAAAATTAATGTCCTCATTAATGCAAGTAAT
TTTAGAGCACAGTGTAGCCATGTACAGTTTCCATTATTTAAAATAAATAAATGTGTTGGTTCATTTGGTGTATGGGGGGACATCATGGTA
ACTGGAAATGAAAGTTTAATCTTTCACAAATGTGCTTGATAAAGCTGTTAAGAATTGTCTTTCCTAAGTATGTTAACTGTTGTATCTAAC
TCAACTGTGAGCTAAGTTTAAAAACTGCAATCATGAATGTTTGTGATATTTTAAATATCTACTACAGCACATTCAGCCAATAAAGAATCT

>33457_33457_1_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000380815_EXOC2_chr6_556564_ENST00000230449_length(amino acids)=712AA_BP=405
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE
IYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFR
EAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREF
VEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVPCQFEQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINI
MQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASL
KELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLMQC

--------------------------------------------------------------
>33457_33457_2_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000380815_EXOC2_chr6_556564_ENST00000448181_length(transcript)=2334nt_BP=1257nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT
ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTC
TACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAG
AGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGAC
TTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGCCA
TGTCAGTTTGAACAGTGCATCGTGTGTTCTCTGCAGTCACTGAAGGGGGTTCTGGAGTGCAAGCCGGGAGAGGCCAGTGTCTTCCAACAA
CCTAAAACACAGGAGGAGGTTTGCCAGCTAAGCATCAATATAATGCAGGTTTTTATATACTGTCTGGAACAGTTGAGCACCAAGCCTGAT
GCAGATATAGATACTACACATCTCTCTGTTGATGTTTCTTCCCCTGACTTGTTTGGAAGTATCCATGAAGACTTCAGCTTGACCTCAGAA
CAGCGCCTTTTGATAGTCCTAAGTAATTGCTGCTATCTAGAACGTCACACCTTCCTAAATATCGCAGAACATTTTGAAAAGCACAACTTC
CAGGGAATAGAAAAAATCACACAGGTTAGCATGGCCTCATTGAAAGAACTAGATCAAAGACTCTTTGAAAATTACATCGAGTTGAAAGCA
GATCCCATCGTTGGCTCCTTAGAACCTGGAATTTATGCAGGATATTTTGATTGGAAGGACTGCCTGCCTCCAACAGGTGTCAGAAACTAT
TTAAAAGAAGCACTGGTGAATATAATTGCCGTGCATGCAGAGGTGTTCACCATTTCCAAAGAACTGGTCCCTCGGGTACTATCCAAGGTG
ATAGAAGCAGTTTCTGAAGAGCTCAGTCGACTGATGCAGTGTGTTTCATCCTTCAGCAAAAATGGAGCTTTACAGGCGAGACTTGAAATC
TGTGCTTTGAGGGACACTGTGGCTGTTTACCTGACACCCGAAAGCAAGTCAAGTTTTAAGCAGGCTTTGGAAGCCCTGCCCCAGCTTTCC
AGTGGAGCAGATAAAAAGTTACTGGAAGAGCTCCTGAACAAGTTCAAGAGTAGCATGCACTTGCAGCTCACCTGTTTCCAAGCAGCTTCT
TCAACCATGATGAAAACATAAATATCTGCCACATAAAAGAAGTCCAGGAAAATAACACGTAATAAGACTGTTCACTCTCTAAGTACCCTA

>33457_33457_2_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000380815_EXOC2_chr6_556564_ENST00000448181_length(amino acids)=712AA_BP=405
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE
IYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFR
EAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREF
VEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVPCQFEQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINI
MQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASL
KELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLMQC

--------------------------------------------------------------
>33457_33457_3_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000530927_EXOC2_chr6_556564_ENST00000230449_length(transcript)=3407nt_BP=945nt
TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG
GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT
CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG
ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGA
CTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAA
ATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGT
GAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGC
CGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGAC
TATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTT
GTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAA
GTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGCCATGTCAGTTTGAACAGTGCATCGTGTGTTCTCTGCAGTCACTG
AAGGGGGTTCTGGAGTGCAAGCCGGGAGAGGCCAGTGTCTTCCAACAACCTAAAACACAGGAGGAGGTTTGCCAGCTAAGCATCAATATA
ATGCAGGTTTTTATATACTGTCTGGAACAGTTGAGCACCAAGCCTGATGCAGATATAGATACTACACATCTCTCTGTTGATGTTTCTTCC
CCTGACTTGTTTGGAAGTATCCATGAAGACTTCAGCTTGACCTCAGAACAGCGCCTTTTGATAGTCCTAAGTAATTGCTGCTATCTAGAA
CGTCACACCTTCCTAAATATCGCAGAACATTTTGAAAAGCACAACTTCCAGGGAATAGAAAAAATCACACAGGTTAGCATGGCCTCATTG
AAAGAACTAGATCAAAGACTCTTTGAAAATTACATCGAGTTGAAAGCAGATCCCATCGTTGGCTCCTTAGAACCTGGAATTTATGCAGGA
TATTTTGATTGGAAGGACTGCCTGCCTCCAACAGGTGTCAGAAACTATTTAAAAGAAGCACTGGTGAATATAATTGCCGTGCATGCAGAG
GTGTTCACCATTTCCAAAGAACTGGTCCCTCGGGTACTATCCAAGGTGATAGAAGCAGTTTCTGAAGAGCTCAGTCGACTGATGCAGTGT
GTTTCATCCTTCAGCAAAAATGGAGCTTTACAGGCGAGACTTGAAATCTGTGCTTTGAGGGACACTGTGGCTGTTTACCTGACACCCGAA
AGCAAGTCAAGTTTTAAGCAGGCTTTGGAAGCCCTGCCCCAGCTTTCCAGTGGAGCAGATAAAAAGTTACTGGAAGAGCTCCTGAACAAG
TTCAAGAGTAGCATGCACTTGCAGCTCACCTGTTTCCAAGCAGCTTCTTCAACCATGATGAAAACATAAATATCTGCCACATAAAAGAAG
TCCAGGAAAATAACACGTAATAAGACTGTTCACTCTCTAAGTACCCTAAAGGTATTTGGTGTATTAAACATTGGGTTTGCCATTTTTCTC
TTTTTTCTTCCTCTGACTTCGAAAATTGTTGGTATACATTTCAACCAAAATGACCTCATTTGAAATGCCCAGGAAGTATTTGTTTTGCCA
TTCTTACTAGATCAGATCCTGTATGACTTTAAAATACATTTTAAAATATATTTTGCATCTCAGCAGAAGGTTGAGTGCTGCAGGAAGAGC
TGCTTCTGCAGGGAGTTTTCTGGAATGGCGTGGCACATATTGAAGCATTTCTCAGTGTCCCGTTCACGGAAGCGCAGGCAGCTCCCACGA
CACACGGAGAGACTGACTGATACGAGATTTGGAAAGCTATGTAGACATCTTTGGAGCTCTTACTGTCCTAAACTGTACAGCTGTGCTTAA
AACCCTCATTTCATATAAATGGCCTTAAGTTTTCTAATTCAAGCGGGTTTTTGGAAAAATTTATGGTCTCCATTAAAATACATATTACAA
CTGGGGTAGATTATTTGTGGTCCAGGTGTCTGTGATTTAACTTTGCGTTTTGCTATCTGATTTTTATTTTTCACAGGGCTAAGCATGAGC
TTTCATTCTCACTCACTCTTAATTTGTCGTGCGTCACTACACATGCACGTGTTGCAGTCCCTGAGGCCCTGTGTGTTATCTGTGATGGAG
TGTGAATGTGTAACGGGCACTGTGTTACACTCTGAGGTGTTGGCGGGGCGGTCGCAGACTTCAGGGTCCCCTAACGGAAAGGCCAGGCTC
CGCGTGGACGGCCAACTCCCTGCCCGCTCCTTCAGCAGGTGACTGTCTCTGCCACTTCTTACCTGCTGAAGGATCTTGCTCAGTAGCTGG
AACAATGCTGCTGTCACACAGTCTCTTCTCTGAAACTTCAGGATGCTCCTTGGTCACCAGGCAATGGGAGCTGTAGACCAGCCGCATGCA
CTTGCCCCACATTCACTGCTGACTGGCTTCACTGGAATAGGTTCAGGTCACCGGGACTTCTCTCAGAGTCAGCGGCCCACCCAACTCCCT
CATACCGTCGCATCTGAAAATTTTCAGAGAGGAATTCTCTTTGTAGTCGGCTTGTCAGGGTTTTCAAGTTTTTCTATGGTTATTTTTAAA
TCTCTTTTTTTAAATGCTAAAATTAATGTCCTCATTAATGCAAGTAATTTTAGAGCACAGTGTAGCCATGTACAGTTTCCATTATTTAAA
ATAAATAAATGTGTTGGTTCATTTGGTGTATGGGGGGACATCATGGTAACTGGAAATGAAAGTTTAATCTTTCACAAATGTGCTTGATAA
AGCTGTTAAGAATTGTCTTTCCTAAGTATGTTAACTGTTGTATCTAACTCAACTGTGAGCTAAGTTTAAAAACTGCAATCATGAATGTTT

>33457_33457_3_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000530927_EXOC2_chr6_556564_ENST00000230449_length(amino acids)=606AA_BP=299
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHE
SPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVPCQFEQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINIMQVFIYCLEQLSTKPD
ADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKA
DPIVGSLEPGIYAGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLMQCVSSFSKNGALQARLEI

--------------------------------------------------------------
>33457_33457_4_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000530927_EXOC2_chr6_556564_ENST00000448181_length(transcript)=2022nt_BP=945nt
TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG
GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT
CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG
ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGA
CTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAA
ATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGT
GAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGC
CGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGAC
TATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTT
GTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAA
GTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGCCATGTCAGTTTGAACAGTGCATCGTGTGTTCTCTGCAGTCACTG
AAGGGGGTTCTGGAGTGCAAGCCGGGAGAGGCCAGTGTCTTCCAACAACCTAAAACACAGGAGGAGGTTTGCCAGCTAAGCATCAATATA
ATGCAGGTTTTTATATACTGTCTGGAACAGTTGAGCACCAAGCCTGATGCAGATATAGATACTACACATCTCTCTGTTGATGTTTCTTCC
CCTGACTTGTTTGGAAGTATCCATGAAGACTTCAGCTTGACCTCAGAACAGCGCCTTTTGATAGTCCTAAGTAATTGCTGCTATCTAGAA
CGTCACACCTTCCTAAATATCGCAGAACATTTTGAAAAGCACAACTTCCAGGGAATAGAAAAAATCACACAGGTTAGCATGGCCTCATTG
AAAGAACTAGATCAAAGACTCTTTGAAAATTACATCGAGTTGAAAGCAGATCCCATCGTTGGCTCCTTAGAACCTGGAATTTATGCAGGA
TATTTTGATTGGAAGGACTGCCTGCCTCCAACAGGTGTCAGAAACTATTTAAAAGAAGCACTGGTGAATATAATTGCCGTGCATGCAGAG
GTGTTCACCATTTCCAAAGAACTGGTCCCTCGGGTACTATCCAAGGTGATAGAAGCAGTTTCTGAAGAGCTCAGTCGACTGATGCAGTGT
GTTTCATCCTTCAGCAAAAATGGAGCTTTACAGGCGAGACTTGAAATCTGTGCTTTGAGGGACACTGTGGCTGTTTACCTGACACCCGAA
AGCAAGTCAAGTTTTAAGCAGGCTTTGGAAGCCCTGCCCCAGCTTTCCAGTGGAGCAGATAAAAAGTTACTGGAAGAGCTCCTGAACAAG
TTCAAGAGTAGCATGCACTTGCAGCTCACCTGTTTCCAAGCAGCTTCTTCAACCATGATGAAAACATAAATATCTGCCACATAAAAGAAG
TCCAGGAAAATAACACGTAATAAGACTGTTCACTCTCTAAGTACCCTAAAGGTATTTGGTGTATTAAACATTGGGTTTGCCATTTTTCTC

>33457_33457_4_GMDS-EXOC2_GMDS_chr6_1726650_ENST00000530927_EXOC2_chr6_556564_ENST00000448181_length(amino acids)=606AA_BP=299
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHE
SPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVPCQFEQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINIMQVFIYCLEQLSTKPD
ADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKA
DPIVGSLEPGIYAGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLMQCVSSFSKNGALQARLEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GMDS-EXOC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GMDS-EXOC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GMDS-EXOC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource